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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Medicine

Ab interno trabeculotomy with vs. without cataract surgery for POAG: a retrospective study

Lei Zhang, Junjie Bian

Purpose To compare the 12-month efficacy and safety of ab interno trabeculotomy combined with phacoemulsification vs. ab interno trabeculotomy alone in patients with primary open-angle glaucoma(POAG). Methods A retrospective analysis was performed on clinical data from patients diagnosed with POAG between January 2021 and January 2025 who underwent either combined surgery (combined group, 39 cases)or ab interno trabeculotomy alone (ab interno trabeculotomy-only group,44 cases). The primary outcome measures were pos …

03.09.2026journal-article

Frontiers in Synaptic Neuroscience

Activation of silent synapses driven by emerging technologies: mechanisms, disease associations, and prospects for clinical translation

Yongli Li, Yong Liao, Shouyao Zhang, Chenggui Xu, Ruhua Lan, Pengbin Zhao, Ruilu Liu, Yongli Song, Xinghe Zhang

Silent synapses represent a unique class of synaptic connections that are non-functional at rest but possess the potential to become functional, serving as a critical reservoir for neural plasticity. Their activation mechanisms not only challenge traditional models of synaptic maturation but also provide novel insights into brain function regulation and disease pathology. This article provides a systematic review of the regulatory mechanisms underlying silent synapse activation, encompassing pre-synaptic calcium si …

03.09.2026journal-article

Journal of Health Organization and Management

Validity and reliability of measures of burnout, resilience, leadership and interprofessional relationships in a Frontline Healthcare Workers Crisis Survey (FHWCS) and Healthcare Leaders Crisis Survey (HLCS)

David Besong Tataw, Nana Arthur-Mensah, Sandra Spataro, Deborah Patten, Stephen Robert Poulin, Kinsey Bryant-Lee

Purpose The COVID-19 pandemic challenged and transformed the healthcare workplace and the interconnections between leaders and frontline workers, and interprofessional configurations thus necessitated holistic psychometric studies that encompassed frontline workers and leaders. Within a conceptual framework combining job demands-resources and open systems theories, two studies (2023 and 2025) assessed the validity and reliability of measures of burnout, resilience, leadership behavior, interprofessional relationshi …

03.09.2026journal-article

Frontiers in Public Health

When digital engagement becomes dysregulated: associations with aggression, achievement motivation, and academic performance in adolescents

Minghua Dong, Huitao He, Bowen Wei

Introduction Adolescents are embedded in digital environments that are increasingly central to social, academic, and emotional life. Yet the developmental implications of digital engagement remain contested, particularly when exposure metrics such as screen time are used as primary indicators. The present study examined digital engagement as a multidimensional construct while treating regulatory difficulty—the dimension most directly reflecting impaired control and difficulty disengaging—as the focal predictor of a …

03.09.2026journal-article

Frontiers in Medicine

Epstein–Barr virus-associated inflammatory polyp of the proximal cervical trachea causing central airway obstruction: a case report

Ziran Lei, Ning Zheng, Linlin Wang, Ling Fang, Xiang Wu

Background Intraluminal lesions of the central airway can cause severe obstruction and are usually malignant. Epstein–Barr virus (EBV)-associated inflammatory tracheal polyps are extremely rare and may mimic airway tumors or EBV-associated lymphoproliferative disorders. Case presentation A 35-year-old woman presented with progressive dyspnea and wheezing for 1 month. Contrast-enhanced chest computed tomography and bronchoscopy revealed a solitary intraluminal polypoid lesion arising from the left anterior wall of t …

03.09.2026journal-article

Frontiers in Allergy

Clinical phenotypes, endotypes, and biomarker profiles of immediate rituximab hypersensitivity reactions: a prospective pharmacovigilance study

Narapong Yotinnoratham, Wannada Laisuan, Kumutnart Chanprapaph, Silada Kanokrungsee, Chavachol Setthaudom, Supornchai Onpun, Pungjai Mongkolpathumrat, Supranee Buranapraditkun, Apinya Chungcharoenpanich, Nichapha Dechapaphapitak, Supa Oncham, Nattakirana Tongdee, Sananya Khamkaew, Ratchaya Lertnawapan, Jettanong Klaewsongkram

Background Rituximab (RTX) has been associated with immediate hypersensitivity reactions (HSRs) involving multiple phenotypes and endotypes. Objective To characterize the clinical phenotypes and endotypes of immediate RTX HSRs. Methods A prospective study was conducted as part of a pharmacovigilance program from July 2020 to December 2021. Participants who experienced immediate RTX HSRs were enrolled. Skin testing, basophil activation testing (BAT), IFN- γ ELISpot assays, and IgG anti-drug antibody (ADA) ELISA assa …

03.09.2026journal-article

IPS Journal of Basic and Clinical Medicine

Kidney Function Responses to Ethanol Extracts of Chia Seed (Salvia hispanica L.) and Tiger Nut (Cyperus esculentus L.) in Alloxan-Induced Diabetic Rats

Chinyere S. Nwaka, Andrew C. Nwaka

Diabetic nephropathy is a common and progressive complication of poorly controlled diabetes mellitus, and there is growing interest in plant-derived agents that can slow or reverse this damage. This study evaluated the effect of ethanol extracts of chia seed (Salvia hispanica), tiger nut (Cyperus esculentus), and their combination on kidney function parameters in alloxan-induced diabetic rats. Sixty-three male Wistar rats were assigned to nine groups (n = 7): normal control (A), diabetic untreated (B), diabetic rat …

03.09.2026journal-article

Cosmetics

Effect of Topical HealFast Silver Ointment on Pain and Early Wound-Healing Parameters After Caesarean Section: A Randomized Placebo-Controlled Clinical Trial

Wafaa Uthman Ahmed, Bafreen hawez Hamadameen, Dastan Abdullah Salih, Shukur Wasman Smail, Abubakr Mohammed Amin, Mohammed Awat Ali

Background: Caesarean section is associated with postoperative pain and wound-related morbidity. Topical agents that promote early wound healing may enhance postoperative recovery. This randomized, placebo-controlled clinical trial evaluated the effect of HealFast Silver Ointment on pain and early wound-healing parameters after Caesarean section. Methods: Two hundred women who underwent Caesarean section were randomly allocated into two groups: a placebo group and a HealFast Silver Ointment group, each consisting o …

03.09.2026journal-article

Journal of Pure and Applied Microbiology

Evaluating the Diagnostic Accuracy of Serological Tests for Brucellosis in Clinical Specimens

Hiba Sami, Kashish Noor, Parvez A. Khan, Lubna Zafar, Aamir Bin Sabir, Latif Zafar Jilani, S. Zeeshan Ahmad Hashmi, Haleema Ahmad, Adil Raza, Nazish Fatima

Brucellosis, a prevalent zoonotic disease in India, causes nonspecific symptoms. Humans contract it via infected animals or by consuming unpasteurized dairy products. This study evaluates the effectiveness of ELISA, Rose Bengal Plate Test (RBPT), and SAT in diagnosing brucellosis from clinical samples. A prospective study was conducted involving 218 patients with unknown fever, arthritis, and neurological symptoms. A detailed history was collected using a pre-designed questionnaire. This study aims to evaluate the …

03.09.2026journal-article

Nursing Education Perspectives

Monitoring Nursing Students’ Stress Levels During High-Fidelity Simulation Using an Electronic Wristband Device

Ayse Akalin, Dennis Demedts, Florence D’haenens, Maaike Fobelets, Joeri Vermeulen, Sandra Tricas-Sauras

Simulation can effectively enhance the clinical reasoning skills of nursing students. However, it can also lead to increased stress levels with a potential impact on learning outcomes. We monitored nursing students’ stress using the E4 © wristband and evaluated the effects of a brief debriefing intervention on stress and overall satisfaction during simulation. Using a randomized controlled study design, we collected quantitative data and real-time stress measurements. Tailored debriefing interventions have the pote …

03.09.2026journal-article

American Journal of Audiology

Survey of Audiologists' Clinical Practice Patterns and Perceptions of Electrophysiological Assessments

Kelsey Mankel, Caitlin N. Price, Allie Austin, Mira Milman

Purpose: Electrophysiological assessments in audiology are used for neurodiagnostic evaluations, newborn hearing screenings, and estimating auditory thresholds when behavioral responses are unobtainable or unreliable. Nonetheless, evidence suggests that many electrophysiological tools remain underutilized. This study examined current practice patterns, perceptions, and barriers related to electrophysiological testing among audiologists in the United States. Method: An online survey distributed between January and A …

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03.09.2026journal-article

Acupuncture & Electro-Therapeutics Research: International Journal of Integrated Medicine

Development of a Nomogram Prediction Model for Activities of Daily Living Improvement After Acupuncture Combined With Physiotherapy and Occupational Therapy in Patients With Ischaemic Stroke

Fang Li, Longlong Su, Peng Zhang

Objective To develop a nomogram for predicting ADL improvement among patients with ischaemic stroke receiving acupuncture combined with physiotherapy (PT) and occupational therapy (OT) and to identify independent predictors of poor ADL improvement. Methods A total of 253 patients with ischaemic stroke were retrospectively included, comprising a development cohort of 190 patients admitted between April 2024 and April 2026 and an earlier, nonoverlapping temporal validation cohort of 63 patients admitted between Decem …

03.09.2026journal-article

JAMA Oncology

Bicistronic CD19/CD22 CAR T-Cell Therapy in Pediatric B-Cell Acute Lymphoblastic Leukemia

Xinyu Wan, Yanjing Tang, Jiaoyang Cai, Lili Song, Tianyi Wang, Wenjie Li, Liu Yang, Xiang Wang, Chengjuan Luo, Hua Zhu, Kang An, Meng Su, Jing Zhang, Jing Yang, Wenhua Shi, Chengming Fei, Weidong Shen, Rujun Jia, Xiaomin Yang, Junqian Tang, Junxian Wu, Jiakang Gu, Jiayi Mo, Jun Huang, Yue Li, Geyao Zhou, Lixia Ding, Jianwei Liang, Jun Wang, Zichao Zhou, Xiaodong Wang, Qing Cao, Jian Zhang, Hong Ren, Juan Qian, Peifang Xiao, Hailong He, Hui Jiang, Shaoyan Hu, Ningling Wang

Importance CD19-directed chimeric antigen receptor (CAR) T-cell therapy induces high remission rates in relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL), but relapse, which is often due to antigen loss, remains a major challenge. Dual-targeting CD19/CD22 CAR T-cell strategies may be associated with reduced antigen-negative relapse and improved remission durability. Objective To evaluate the safety and efficacy of bicistronic CD19/CD22 CAR T-cell therapy in pediatric patients with relapsed or refra …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Effect of Health Education Intervention on Knowledge of Environmental Waste Management Among Residents of Bauchi State, Nigeria

Mohammed Inuwa

The study assessed the knowledge of environmental waste management among residents of Bauchi State, Nigeria. To achieve the two objectives ware identified to guide the paper The knowledge of environmental waste management among residents of Bauchi State, Nigeria before and after Health Education Intervention and attitude towards waste management among residents of Bauchi State, Nigeria before and after Health Education Intervention and in line with the research questions what are the knowledge of waste management a …

03.09.2026journal-article

Healthcare

Depressive Symptoms After Mechanical Thrombectomy in Ischaemic Stroke: A Longitudinal Descriptive Study with Gender Differences

Sara Ramírez Rozas, Maria Lara Martínez-Gimeno, Laura Carrasco San Andres, Francisco Gómez-Esquer, Jesús Esteban-Hernández, María-Gema Cid-Expósito

Introduction: Stroke accounts for one-third of global mortality each year; in Spain, it is the second leading cause of death. One of the most commonly reported complications is post-stroke depression, which affects up to 30% of patients who suffer a stroke. When an ischaemic stroke occurs, the treatment of choice is mechanical thrombectomy; this is an endovascular procedure whereby the thrombus causing the ischemia is removed, thereby reducing sequelae, in most cases, which is why it is of interest to examine its i …

03.09.2026journal-article

Journal of Developmental Biology

Diaphragmatic Mitochondrial Myopathy in a Patient-Derived Mouse Model of Barth Syndrome

Kristen Tentler, Paige L. Snider, Catalina Matias, Jeffrey J. Brault, Simon J. Conway

Barth syndrome (BTHS) is a rare, X-linked genetic disorder caused by mutations in the enzyme TAFAZZIN (TAZ), resulting in insufficient cardiolipin (CL) remodeling and mitochondrial dysfunction. While BTHS respiratory distress and breathing difficulties are commonly reported, the precise role of intrinsic respiratory tissue vulnerabilities has only recently begun to be appreciated. Historically, BTHS respiratory distress is frequently attributed to secondary consequences like cardiomyopathy or generalized skeletal m …

03.09.2026journal-article

Dementia

Social Interactions Between People Living With Dementia and Staff in Health and Social Care Settings: A Scoping Review

Stephanie Janka-Spurlock, Georgia Page, Gary Hodge, Helen Lloyd, Susie Pearce

Dementia is an umbrella term for progressive conditions affecting memory, thinking, communication and other cognitive functions. These changes can make social interaction challenging, particularly in unfamiliar or overstimulating environments . Although social interactions between staff and people living with dementia are recognised as an aspect of care, existing literature across health and social care settings largely focuses on general care needs and experiences rather than social interaction specifically. Conse …

03.09.2026journal-article

Greenation Computer and Information Review

Analysis of the Security of Off-Site Medical Record Storage in Relation to Patient Information Confidentiality at Hospital X

Ujang Rahmat, Yayang Ayu Nuraeni

This study employed a qualitative descriptive design to examine how the security of off-site medical record storage protects patient information confidentiality, particularly when records are stored outside the hospital because of limited filing-space capacity. Three informants were purposively selected: the Head of the Medical Records Unit, a Medical Records Filing Officer, and a Medical Records Archiving Officer. Data were collected through observation, interviews, and documentation. Data analysis followed the Mi …

03.09.2026journal-article

Public International and Private International Law

The Impact of Del Credere on Financial Stability in International Trade: Legal Regulation and Application Practice

Vladimir V. Kruglov

The article examines the del credere institution in the context of its impact on the financial stability of international trade entities. The research focuses on current Russian legislation, current judicial practice, and international trade standards. The article provides a comparative analysis of normative, doctrinal, and authorial definitions of del credere, highlighting the controversial nature of this institution. A special focus is placed on the analysis of del credere's functions in the context of current sa …

03.09.2026journal-article

Public International and Private International Law

A Comparative Legal Analysis of the Regulation of Digital Financial Assets in Various Jurisdictions

Mekhriban E. Gulieva

In the era of digitalization and the widespread adoption of digital instruments, such as digital assets and payment instruments, monitoring compliance with national legislation by relevant executive authorities is particularly important. Competent and consistent application of procedural principles of control and supervision by relevant governmental bodies is essential for achieving a balance in relations between governmental bodies and society, as well as business members, while reducing excessive pressure on busi …

03.09.2026journal-article

Journal of Clinical Medicine

Effects of Physical Activity on Motor Development, Balance, and Psychosocial Well-Being in Children and Adolescents with Down Syndrome: A Systematic Review

Ignazio Leale, Manuel Gómez-López, Martina Macaluso, Daniela Smirni, Michele Roccella, Marianna Alesi, Giuseppe Battaglia

Background: Physical activity is relevant for physical and psychosocial development in children and adolescents with Down syndrome. However, evidence regarding the effects of structured physical activity interventions across different motor and psychosocial domains remains limited and heterogeneous. This systematic review aimed to examine the effects of structured physical activity interventions on motor and psychosocial outcomes in this population. Methods: The review was conducted according to PRISMA guidelines a …

03.09.2026journal-article

Healthcare

Organization and Quality of Emergency Thoracic Surgical Care in Multidisciplinary Hospitals of Almaty, Kazakhstan: A Multicomponent Study Combining Hospital Data, Patient-Reported Experience, and Healthcare Professional Perspectives

Sultan Zhanbyrbaev, Maksut Kulzhanov, Aueskhan Dzhumabekov, Alfiya Igissenova, Gulstan Esetova, Nadira Aitambayeva, Gulbanu Berdiyarova, Nazerke Narymbayeva, Aigul Tazhiyeva

Background: Emergency thoracic conditions remain an important cause of hospitalization, emergency surgery, and mortality, requiring well-organized multidisciplinary thoracic surgical services. Objectives: To comprehensively evaluate the organization of emergency thoracic surgical care in multidisciplinary hospitals in Almaty using retrospective hospital data together with patient and healthcare professional-reported assessments. Methods: A multicomponent study was conducted comprising three complementary components …

03.09.2026journal-article

Frontiers in Medicine

Development and validation of an interpretable machine learning model for predicting postoperative fever after flexible ureteroscopic lithotripsy: a single-center retrospective cohort study

Xiaofei Lu, Chunping Yu, Zhiyong Ding, Sheng Luo, Xiaopeng Hu

Background This study aimed to develop and validate an interpretable machine learning model to predict postoperative fever (POF) after flexible ureteroscopic lithotripsy (fURL). Objective This study adopted a single-center retrospective temporal cohort design. Strictly adhering to predefined inclusion and exclusion criteria, patients with upper urinary tract stones (maximum diameter < 3 cm) who underwent flexible ureteroscopic lithotripsy (fURL) from January 2019 to December 2024 were enrolled as the derivation …

03.09.2026journal-article

BMC Psychiatry

Substance use and co-occurring mental health conditions among adolescents and young adults in North America: a systematic review

Gemy Kuriakose, Jenny Seo, Negar Asgharipourzahmati, Ashley Lew, Rishika Daswani, Martha J. Ignaszewski, Roberto Sassi, Fiona Choi, Vijay Seethapathy, Reinhard Michael Krausz

Abstract Background Substance use and co-occurring mental health conditions are common among adolescents and young adults and represent an important clinical and public health concern in North America. Trauma exposure, psychiatric symptoms, and social adversity frequently co-occur with substance-related problems in this population. This systematic review aimed to synthesize evidence on prevalence patterns, associated clinical and psychosocial factors, and care-related implications described in the literature on ado …