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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Oncology

Case Report: Metachronous oncocytic and colloid carcinoma arising from pancreatic intraductal neoplasms over four decades

Maria Imperatrice, Michael Johannes Pflüger, Mari Mino-Kenudson, Carlos Fernandez-del Castillo, M. Lisa Zhang

Intraductal papillary mucinous neoplasms (IPMN) are precursors of pancreatic ductal adenocarcinoma (PDAC) and may progress to distinct invasive phenotypes depending on epithelial subtypes. Tubular carcinoma, often arising from pancreatobiliary epithelium, is clinically aggressive and resembles PDAC, whereas colloid carcinoma, typically derived from intestinal epithelium, has a more indolent course. Intraductal oncocytic papillary neoplasms (IOPN), historically considered a subtype of IPMN, are now recognized as a d …

03.09.2026journal-article

Frontiers in Oncology

Artificial intelligence in ovarian cancer prevention and control: a brief review of detection, treatment, and equity (2021–2026)

Zhenyu Huang, Boyang Wei, Ying Shen

Ovarian cancer (OC) remains a leading cause of gynecologic cancer mortality worldwide because early symptoms are often vague, effective population-level screening strategies are lacking, and outcomes are shaped by biological heterogeneity and unequal access to diagnostic and molecular testing resources. This Mini Review summarizes advances from 2021 to 2026 in artificial intelligence (AI) applications across the OC care continuum, focusing on early detection, treatment decision-making, prognostic assessment, clinic …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Mature tertiary lymphoid structures in a metastatic urothelial carcinoma patient with an exceptional response to sequential immune checkpoint inhibitor and antibody-drug conjugate therapy

Kanta Hori, Takuto Ogasawara, Yuka Mizue, Hiroko Asanuma, Naoki Shijubou, Akihiro Yamashita, Ryo Kato, Jun Furumido, Takashige Abe, Keisuke Sato, Yoshihiko Hirohashi

Background Biomarkers that predict durable benefit from immune checkpoint inhibitors (ICIs) and antibody-drug conjugates (ADCs) in metastatic urothelial carcinoma (mUC) remain limited. Tertiary lymphoid structures (TLS), particularly mature TLS (mTLS) characterized by follicular dendritic cell networks and germinal centers, may reflect a highly compartmentalized antitumor immune niche. Case presentation A 77-year-old man with bladder cancer and lung metastases experienced disease progression after two cycles of gem …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Global research trends in Fusobacterium nucleatum and colorectal cancer: a bibliometric and visual analysis

Guanhua Lyu, Yingge Yue, Manfei Duan, Junhao Chen, Yanyan Chen, Junyu Liu, Xiangyu Wang

Background Fusobacterium nucleatum ( F. nucleatum ) is increasingly recognized as a key pathobiont in colorectal cancer (CRC), driving tumor progression through immune evasion, inflammation, and metabolic reprogramming. Nevertheless, a comprehensive bibliometric analysis of the literature on F. nucleatum and CRC remains a gap in the current research landscape. Here, we integrate bibliometric trend analysis with a narrative synthesis of key mechanistic insights. Unlike traditional narrative reviews, this study syste …

03.09.2026journal-article

Frontiers in Immunology

A case report of sequential efgartigimod and rituximab treatment for tSNMG

Hua Xie, Ting Ting Pan, Lin Zhang

Trible‐seronegative myasthenia gravis (tSNMG) is defined as myasthenia gravis (MG) without detectable or low affinity antibodies to acetylcholine receptor (AChR), muscle‐specific kinase (MuSK) andlipoprotein related protein 4(LRP-4). This article reports a case of a 39-year-old married female patient with thymoma-associated seronegative myasthenia gravis (tSNMG), which was accompanied by multiple positive autoantibodies and a benign mediastinal lesion. The primary manifestation was generalized muscle weakness, invo …

03.09.2026journal-article

Frontiers in Oncology

Malignancy-Aware Dual-Task Heatmap Decoupling for thyroid ultrasound nodule detection and classification

Yining Chen, Xiaxia Wang

Background Accurate thyroid nodule detection and benign-malignant classification on ultrasound are critical for early cancer diagnosis. Existing deep-learning detectors encode localization and classification in a shared feature space, causing inter-task feature redundancy and limiting task-specific performance. Methods We propose Malignancy-Aware Dual-Task Heatmap Decoupling (MADTHD), a CenterNet-based framework that decouples localization and classification through asymmetric dual heads. A Position Head with small …

03.09.2026journal-article

Frontiers in Oncology

Spatial-temporal epidemiological characteristics of thyroid cancer mortality in China cancer registration areas: analysis based on multiple models

Jiaqi Yang, Zhenhao Zheng, Jianjiang Shao, Yueze Gong, Yu Zhang, Han Wang, Yunhua Hu, Hao Liu, Wen Liu, Yizhong Yan

Objective This study analyzed spatial and temporal patterns of thyroid cancer mortality in China cancer registration areas and predicted future trends, thereby providing a scientific basis for the formulation of prevention and control strategies for thyroid cancer. Methods Thyroid cancer death data from 2005 to 2018 were obtained from the China Cancer Registry Annual Report from 2008 to 2021. Joinpoint regression model was used to describe the temporal trends. Age-period-cohort model was used to analyze the age, pe …

03.09.2026journal-article

Frontiers in Oncology

Lung squamous cell carcinoma complicated with immune checkpoint inhibitor-associated active tuberculosis: a case report and literature review

Xiufang Zhang, Yuqiao Zhou, Huiqing Qiu, Zheng Yang

Immune checkpoint inhibitors (ICIs) have become one of the standard therapeutic regimens for advanced lung cancer. However, the risk of infection-related complications induced by ICIs, particularly reactivation of tuberculosis, has attracted increasing clinical attention. Herein, we report a 72-year-old male patient with squamous cell carcinoma of the lung who developed reactivation of latent tuberculosis infection (LTBI) approximately 13 months after sequential PD-1 inhibitor therapy. During anti-tuberculosis trea …

03.09.2026journal-article

Frontiers in Immunology

Targeting bromodomain and extra-terminal proteins reprograms macrophages and inhibits breast cancer progression

Deeksha Sharma, Cody G. Hager, Grace G. Bushnell, Alexander P. Kalman, Grace F. Shapiro, Katherine A. Xendzova, Lynne Walenjus, Chloe M. Hutchens, Max S. Wicha, Monika L. Burness

Introduction Breast cancer (BC) remains a leading cause of cancer-related deaths, with resistance to therapy driving tumor progression. While immune checkpoint inhibitor (ICI) therapy is effective in some breast cancers, the heterogeneity of treatment responses is partly driven by cancer stem cells (CSCs) and an immunosuppressive tumor microenvironment (TME). Bromodomain and extra-terminal (BET) proteins regulate tumor and immune biology, but their role in innate anti-tumor immunity remains poorly understood. We in …

03.09.2026journal-article

Frontiers in Psychology

Pre-treatment consent framing shapes how laypeople evaluate CBT: a cross-cultural comparison of China and the United States

Yuanqing Wang, Feng Mei, Wei Zhao

People’s understanding of psychotherapy influences their treatment expectations and engagement. Informed consent is often one of the first formal processes through which this understanding is shaped. Yet, little cross-cultural research has examined its impact on lay people’s pre-treatment attitudes. This study investigated whether the perceived importance of common factors and cognitive behavioral therapy (CBT) techniques varies across cultural contexts and informed consent framing. Chinese ( n = 297) and U.S. ( n …

03.09.2026journal-article

Ege Tıp Dergisi

Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer

Esma Uğuztemur, Mustafa Özgür Arıcı

Aim: Early-onset gastric cancer (EOGC) represents a distinct subgroup with aggressive clinicopathological features; however, prognostic data in younger patients remain limited. This study aimed to evaluate clinicopathological characteristics and identify prognostic factors associated with survival in patients aged ≤ 50 years with gastric cancer.Materials and Methods: A total of 60 patients aged ≤ 50 years diagnosed with gastric cancer between 2014 and 2024 were included in this retrospective single-center study. Su …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Soft endoscopic treatment of Herlyn–Werner–Wunderlich syndrome: an innovative clinical procedure for hymen preservation

Yonghua Tian, Wei Fu, Yan Geng

Background Herlyn–Werner–Wunderlich syndrome (HWWS) management typically requires hymenotomy. We describe the fully endoscopic, hymen-sparing septotomy in a patient with no history of sexual intercourse. Case presentation A 20-year-old patient with no prior sexual intercourse and progressive dysmenorrhea was diagnosed by MRI with HWWS, presenting as uterus didelphys, obstructed right hemivagina, and left renal agenesis. A 9-mm flexible gastroscope and endoscopic submucosal dissection (ESD) knives were introduced th …

03.09.2026journal-article

Frontiers in Oncology

Explainable diffusion–perfusion radiomics using apparent diffusion coefficient and arterial spin labeling for ATRX status prediction in glioblastoma

Rafail C. Christodoulou, Revati Natu, Zinovia Fakidi, Georgios Vamvouras, Platon S. Papageorgiou, Evros Vassiliou, Elena E. Solomou, Sokratis G. Papageorgiou, Michalis F. Georgiou

Introduction ATRX status serves as a key biomarker for the molecular profiling of glioblastoma, but its evaluation currently depends on invasive tissue sampling. While radiomics has demonstrated promising potential in the molecular analysis of gliomas, the utility of physiological MRI biomarkers for ATRX prediction remains underexplored. Our goal was to develop and assess an explainable combined model utilizing the apparent diffusion coefficient (ADC) and arterial spin labeling (ASL) for the noninvasive prediction …

03.09.2026journal-article

Frontiers in Oncology

Case Report: High-grade endometrial adenocarcinoma with somatically derived yolk sac tumor differentiation

Juan Hao, Xiaomeng Wang, Min Cai, Shuxu Tian, Huangbei Song, Xuan Liu

Background Yolk sac tumors (YSTs) arising from somatic tumors of the female genital tract present with variable clinical manifestations depending on the organ of origin. Their diagnosis is highly challenging due to their rarity and the limited number of well-documented cases, and their prognosis remains unclear. The coexistence of high-grade endometrial adenocarcinoma with somatically derived yolk sac tumor differentiation (SDYST) is extremely rare, and evidence-based treatment strategies remain limited. Case highl …

03.09.2026journal-article

Asian Journal of Oncology

Integrating molecular engineering and artificial intelligence to overcome clinical and manufacturing challenges in CAR-T therapy

Lipi Singh, Narendra Singh, Rakesh Kumar Arya, Priya Kiran, Mahrosh Sohail, Parushi Verma, Manish Kumar Arya

Chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable efficacy in addressing hematological malignancies. However, its broader clinical application in other cancer types is still limited by key challenges like antigen escape, on-target/off-tumor toxicity, reduced efficacy for solid malignancies, and large variability in the production process for CAR T-cells. Traditional optimization approaches are increasingly insufficient to address these complex challenges. Notably, current studies do not ful …

03.09.2026journal-article

Frontiers in Oncology

Interpretable machine learning for prediction of leptomeningeal metastasis in lung adenocarcinoma: a multi-centre retrospective study via “Prompt” model

Xinyang Li, Jingxiang Su, Yitao Fan, Yingda Xie, Hongyan Liu, Tingting Wei, Ruoyu Yao, Renke Yu, Lu Zheng, Bo Sun, Xiangjun Qiu, Jiachun Sun

Background Leptomeningeal metastasis (LM) is a serious complication of lung adenocarcinoma (LUAD). Owing to the difficulty in early diagnosis and the limited clinical benefit of available treatments, affected patients experience extremely poor outcomes. Thus, the machine-learning-enhanced predictive framework Prompt was developed to optimise early clinical identification and prognostic assessment. This model was designed to determine major risk factors for LM in patients with LUAD, estimate the possibility of LM on …

03.09.2026journal-article

Frontiers in Oncology

Testicular intestinal-type adenocarcinoma without an identifiable extratesticular primary site: a case report and literature review

Jinrong Tang, Heng Jiang, Xiaoke Zeng

Background Testicular intestinal-type adenocarcinoma is an exceedingly rare malignant neoplasm characterized by intestinal epithelial differentiation and accounts for only a minute proportion of testicular malignancies. Its imaging features remain insufficiently characterized and may overlap with those of other testicular tumors, particularly seminoma. When intestinal-type adenocarcinoma is identified in the testis, metastatic adenocarcinoma from the gastrointestinal tract or other extratesticular sites must be exc …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Iparomlimab and Tuvonralimab-based therapy for epithelioid malignant peritoneal mesothelioma: a three-case series

Zhijin Xu, Lehe Zhu, Ying Fang, Yiyan Jiang

Background Epithelioid malignant peritoneal mesothelioma (EMPM) is a rare and aggressive malignancy of serosal origin. Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is generally reserved for carefully selected patients in whom adequate cytoreduction appears feasible, while evidence supporting systemic immunotherapy remains limited for patients with unresectable disease or those unable to tolerate intensive treatment. Iparomlimab and tuvonralimab (QL1706) is a fixed-ratio anti-PD-1/an …

03.09.2026journal-article

Frontiers in Oncology

The expression and clinical significance of SIRT5, H2A and TOP2A in cervical cancer

Fenghu Li, Xue Tian, Fan Mei, Yanjun Du, Lili Hu, Jiehui Li, Shengfa Su, Bing Lu

Objective To analyze the correlation between the expression of lysine deacetylase 5 (SIRT5), histone H2A and topoisomerase IIα (TOP2A) protein with clinical stage and survival in cervical cancer. Methods The expression levels of SIRT5, H2A and TOP2A proteins were detected by immunohistochemical two-step method in paraffin-embedded tissue blocks from 65 patients with cervical cancer (21 cases of stage IB, 9 cases of stage IIA and 35 cases of stage IIIC1p). The expression distribution and positive rate of SIRT5, H2A …

03.09.2026journal-article

European Geriatric Medicine

Improving diabetes management in older adults with cancer: a quality improvement project to enhance monitoring during steroid-based systemic anti-cancer therapy

Evelyne Liuu, Rose Evans, Nathanael Bassas-Letissier, Gitanjali Amaratunga, Sarah Compton, Alexandros Georgiou, Tania Kalsi, Yuk-Fun Liu, James Maguire, Clare Nottage, Hannah L. Rush, Carly Welch

Abstract Purpose Older adults undergoing systemic anti-cancer therapy (SACT) with steroids are at high risk of developing steroid-induced hyperglycaemia (SIH). However, monitoring and management remain inconsistent. This quality improvement project (QIP) involved developing and evaluating the GOLD diabetes enhanced monitoring pathway, a multidisciplinary, age-adapted initiative for older patients at intermediate SIH risk. Methods The pathway was implemented at Guy’s and St Thomas’ NHS Foundation Trust between Febru …

03.09.2026journal-article

Frontiers in Oncology

SYTL5 drives malignant progression in differentiated thyroid carcinoma: unveiling its regulatory mechanisms

Xiaohui Zhu, Xia Pan, Dongmei Jiang, Hengfeng Cui, Haiyan Wu, Yuying Wang, Xia Li

Objective To investigate the expression of SYTL5 in differentiated thyroid carcinoma (DTC) and elucidate its clinical significance and underlying molecular mechanisms. Methods SYTL5 expression in 107 paired DTC and adjacent normal tissues was evaluated by immunohistochemistry, qRT-PCR, and Western blot. Associations with clinicopathological variables were assessed using chi-square or Fisher’s exact tests with Benjamini-Hochberg false discovery rate adjustment, and the distant metastasis subgroup was summarized desc …

03.09.2026journal-article

Frontiers in Oncology

Prognostic significance of pretreatment peripheral blood inflammatory biomarkers in elderly patients with locally advanced cervical cancer undergoing definitive chemoradiotherapy

Xiuhua Li, Jianjian Qiu, Ting Lin, Yuling Ye

Background Systemic inflammatory response plays a critical role in tumor progression and immune evasion. Elderly patients with locally advanced cervical squamous cell carcinoma (CSCC) receiving definitive chemoradiotherapy (dCRT) exhibit high prognostic heterogeneity, and there is a lack of simple and effective risk stratification tools. This study aimed to evaluate the prognostic value of pretreatment peripheral blood inflammatory biomarkers and to construct a recursive partitioning analysis (RPA) risk stratificat …

03.09.2026journal-article

Frontiers in Neurology

Treatment first, transport second: rethinking stroke management with mobile stroke units—A systematic review and meta-analysis of controlled trials

Aishah Ibrahim Albakr, Ziyad Masoud Alqahtani, Abdulmonem Mohammed AlSharidah, Adel Abdalla Zeidan, Ahmed Abdulrahman Al Ibrahim, Mohammed Abdulmonem Al Zaher, Khurshid Khan

Background Stroke is a significant cause of morbidity and mortality, with profound medical and economic consequences. Accurate diagnosis and minimizing delays in acute stroke management has become a global priority. Mobile stroke units (MSUs) have the potential to effectively shorten key time intervals. Objective We conducted this review aiming to investigate the benefits of MSU implementation on functional, safety and time metrics outcomes in acute stroke care. Moreover, we assessed whether the presence of an onbo …

03.09.2026journal-article

Frontiers in Oncology

Predictive modeling of axillary web syndrome in Chinese postoperative breast cancer patients using interpretable machine learning

Jiali Du, Jing Yang, Xujin Chen, Zhiyan Cheng, Tong Xiang

Objective This study aimed to develop and validate a series of risk prediction models for axillary web syndrome (AWS) after breast cancer surgery using machine learning algorithms, enabling postoperative risk identification to facilitate timely targeted interventions. Methods This retrospective cross-sectional study was conducted at a tertiary cancer hospital between April 2021 and July 2024. After collecting clinical data, the least absolute shrinkage and selection operator (LASSO) regression was employed to scree …