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09.09.2026journal-article

World Journal of Clinical Pediatrics

Association of Helicobacter pylori infection with insulin resistance, tumor necrosis factor-alpha, and dyslipidemia in obese children with metabolic syndrome

Noura M Ibrahim Elbakry, Mohamed S Hemeda, Ayat Mostafa Mohamed Ahmed, Hager Adel Zaky, Aya Nabil Gamil, Abd Elmoaty Arafat Abd Elmoaty, Mahmoud M Khafagi, Ashraf Mohamed Alkabeer, Aldosoky Abd Elaziz Alsaid, Ahmed A Elhagary, Walid Mohammed Aboassy, Ahmed Nabil Gamil Mohammed

BACKGROUND Previous studies have suggested a link between Helicobacter pylori (H. pylori ) and metabolic complications outside the gastrointestinal tract, but the relationship with pediatric obesity remains unclear. We aim to study the correlation between H. pylori infection and components of insulin resistance (IR), inflammation [tumor necrosis factor-alpha (TNF-α)], and cardiometabolic parameters in obese children/adolescents with a metabolic syndrome (MetS) phenotype. AIM To elucidate the association between H. …

09.09.2026journal-article

World Journal of Clinical Pediatrics

Phenomenology in pediatric nursing: Lessons from studies of mothers caring for children with chronic illnesses

Khulood K Shattnawi

Phenomenology offers a powerful methodological lens through which pediatric nursing researchers can explore the emotional, cultural, and relational dimensions of caring for children with chronic illnesses. Drawing on a series of qualitative studies conducted with Jordanian mothers of children living with conditions such as type 1 diabetes mellitus, cerebral palsy, autism spectrum disorder, end-stage renal failure, and glycogen storage disease, this article reflects on the practical and philosophical applications of …

09.09.2026journal-article

World Journal of Critical Care Medicine

Dissipation of the mitochondrial proton motive force drives sepsis pathogenesis and explains hyperlactatemia’s predictive value in sepsis mortality

Jay Pravda

Sepsis remains a major cause of global mortality, yet its underlying pathogenesis is still incompletely understood. The current Sepsis-3 definition describes sepsis as a “life-threatening organ dysfunction caused by a dysregulated host response to infection ”, but offers no mechanistic explanation for how infection or inflammation lead to metabolic collapse and organ failure. This work proposes a unifying biochemical model in which sepsis originates as an intramitochondrial disturbance of redox homeostasis triggere …

09.09.2026journal-article

Annals of African Medicine

Beyond Hemorrhage: A Case of Acute Dengue Infection Presenting with Budd–Chiari Syndrome and Bilateral Sensory Polyneuropathy

Krushna Keshav Dalvi, Priya Khaire, Mohammed Hassan Shaik

Abstract Budd–Chiari syndrome (BCS) is a rare hepatic vascular disorder characterized by hepatic venous outflow obstruction with an incidence of 1–2 per million population annually. While dengue fever is primarily associated with hemorrhagic complications, thrombotic events are rarely reported. To our knowledge, this represents the first documented case of BCS occurring in association with dengue fever. A 22-year-old male from a rural area presented with a 4-day history of abdominal pain, fever, vomiting, and loose …

09.09.2026journal-article

Clinical Cancer Research

Phase 1 trial and biomarker analysis of Buparlisib with weekly Cisplatin and Radiotherapy in high risk locally advanced squamous cell cancer of the Head and Neck.

Jochen H. Lorch, Kristine Wong, Roy B. Tishler, Robert I. Haddad, Anne O'Neill, Kee-Young Shin, Mofei Liu, Glenn J. Hanna, Nicole G. Chau, Guilherme Rabinowits, Jonathan D. Schoenfeld, Danielle N. Margalit, Laura Goguen, Ravindra Uppaluri, Tom Thomas, Alec Kacew, Patricia McHugh, Ethan Harris, Kimberly Austin, Julian Huang, Umair Mahmood, Bose S. Kochupurakkal, Lynette M. Sholl, Jennifer M. Spangle

Abstract Purpose: We evaluated the pan-PI3K inhibitor buparlisib with weekly cisplatin and radiotherapy among patients with locally advanced (LA) squamous cell cancer of the head and neck (SCCHN) and tobacco history. Patients and Methods: Patients with stage III/IV LA-SCCHN (AJCC7), ≥10 pack-year tobacco use treated with curative intent were enrolled. Patients received buparlisib during a 2-week run-in phase and during standard 70Gy of radiotherapy plus weekly cisplatin. An exploratory analysis of genomic sequencin …

09.09.2026journal-article

Langmuir

ROS-Responsive Silica Cross-Linked Micelle Drug Delivery System for Myocardial Ischemia-Reperfusion Injury Therapy

Wenjun Mu, Jian Wang, Fang Zhang, Wenyan Ding, Yi Yang, Xinna Xu, Jingbin Zhang, Hao Yu, Lingzhi Zhao, Hongwei Hou, Huan Chen

Abstract Myocardial ischemia-reperfusion injury (MIRI) remains a formidable clinical and therapeutic obstacle, which is primarily driven by excessive oxidative stress, calcium overload, and persistent inflammatory cascades. Natural polyphenols, renowned for their superior antioxidant and anti-inflammatory bioactivities, are regarded as high-potency therapeutic candidates for MIRI alleviation. To achieve targeted and efficient polyphenol delivery for MIRI treatment, a reactive oxygen species (ROS)-responsive silica …

09.09.2026journal-article

Frontiers in Digital Health

Artificial intelligence is transforming disease surveillance, but governance is failing to keep pace

Abdullahi Osman Mohamed, Abdifatah Afyare, Abdinasir Mohamed Abdi, Yusuf Hassan Muhumed, Mohamed Adam Abdihashi

Artificial intelligence (AI) is transforming disease surveillance by enabling early outbreak detection, predictive modeling, and real-time analysis of diverse health data sources. These advances can strengthen epidemic preparedness and improve public health decision-making. However, AI adoption has progressed faster than the development of effective governance frameworks, creating challenges related to algorithmic bias, transparency, privacy, cybersecurity, accountability, and global equity. Low- and middle-income …

09.09.2026journal-article

Nursing Ethics

Ethical dimensions of living with one leg: A qualitative study

Lisbeth Uhrenfeldt, Ane Simony, Bente Skovsby Toft, Inge Hansen Bruun

Purpose To explore experiences of prosthetic leg provision, focusing on information, activities, and communication during hospitalization and after discharge. Material and methods A hermeneutic analysis of unstructured dialogues with three adults aged 85+ living at home after leg amputation, pragmatically recruited by an outpatient surgeon. Ethical considerations The study is registered (j.nr. 26/2105) in the Danish regional research registry. Informed consent was obtained, stored, and handled in accordance with ap …

09.09.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Providing a management tool for the performance assessment of occupational health and safety management system in the face of an emerging infectious disease

Rasoul Yarahmadi, Sobhan Abedi, Somayeh Soleimani-Alyar, Igor Burstyn, Narges Moghaddasi, Sara Dalvand, Maryam Soleimani-Alyar, Milad Mohammadi, Mohammad Najafi- Majareh, Mahbobe Najarian

Background It is not clear how efficacious occupational health and safety management systems (OHS-MS) are in preventing the spread of infectious diseases in workplaces, exemplified by the outbreak of COVID-19 in 2020. Objective Our specific aim is to provide a management tool to investigate how OHS-MS managed the consequences of COVID-19 pandemic in workplaces. Methods We first defined an OHS-performance model (OHS-PM) based on key performance indicators (KPIs). The 20 weighted KPIs (were in the seven functional el …

09.09.2026journal-article

Acta Ophthalmologica

Clinical outcomes of the PAUL ® glaucoma implant for secondary glaucoma

Carolin Deubel, Benjamin Aretz, Wolfgang Walz, Michael Petrak, Frank G. Holz, Raffael Liegl, Karl Mercieca, Constance Liegl

Abstract Purpose Secondary glaucoma encompasses a broad spectrum of disease entities arising from diverse ocular pathologies and is often refractory to conventional treatment. Glaucoma drainage devices (GDDs) have therefore become an important surgical option. This study evaluates the efficacy and safety of the PAUL® Glaucoma Implant (PGI) across a broad spectrum of secondary glaucoma types. Methods This retrospective observational cohort study included 96 eyes from 92 patients who underwent PGI implantation for se …

09.09.2026journal-article

Asian Journal of Engineering, Social and Health

Building Customer Loyalty in Indonesian Social Commerce: AI-Driven Personalization, Perceived Financial Value, and Seller Digital Competence Through Customer Experience

Maya Sova, Muhammad Iqbal Ismail, Forbis Ahamed

The rapid growth of social commerce has transformed consumer purchasing behavior by integrating artificial intelligence (AI), digital interaction, and platform-based shopping experiences. In this environment, customer loyalty is no longer determined only by product quality and price, but also by personalized services, perceived economic benefits, seller capabilities, and overall customer experience. This study aims to examine the influence of AI-driven personalization, perceived financial value, and seller digital …

09.09.2026journal-article

Prevention Science

Role Status Changes During Emerging Adulthood and Their Association with Substance Use, Mental Health, and Well-Being Outcomes over a 4-Year Period

Elizabeth J. D’Amico, Anthony Rodriguez, Joan S. Tucker, Wendy Troxel, Eric R. Pedersen, Rachana Seelam, Jordan P. Davis

Abstract Emerging adulthood encompasses important life changes; however, few studies examine how combinations of role status changes (e.g., living situation, pursuit of education) affect behavioral health over time. This study examines how changes in combinations of role statuses over 4 years are associated with substance use, mental health, and life satisfaction outcomes. Participants are from a cohort ( N = 2174) of young people surveyed annually since 2008 (55% female; 47% Hispanic, 23% Asian, 22% White). This s …

09.09.2026journal-article

Frontiers in Medicine

Routine laboratory composite indices and geriatric multisyndrome burden: a head to head evaluation against serum albumin

Kübra Erdoğan, Rıdvan Erten

Introduction Routine blood tests are often combined into composite indices meant to summarize nutritional, inflammatory, or metabolic status in a single value. Whether these indices reflect the broad syndrome burden seen in geriatric outpatients is unclear, since most of the supporting evidence comes from oncological or surgical cohorts. Methods We reviewed the records of 289 patients seen consecutively at a geriatric outpatient clinic over an approximately one-year period and calculated thirteen indices from the f …

09.09.2026journal-article

Acta Universitatis Lodziensis. Folia Iuridica

Jurisprudencial Siblings? The Rule of Law and the Rechtsstaat as the Two Tracks to the Society, Public Sphere and their Normative Framework

Karolina M. Cern, Barbara Janusz-Pohl

In this paper, we engage with Professor Martin Loughlin’s article The Rule of Law: A Slogan in Search of a Concept (2024). Considering the above, (1) we put forward three research theses. To substantiate them, (2) we briefly outline and discuss arguments concerning the emergence of the concept of the Rule of Law in twelfth-century English common law, as formulated by the American constitutional historian Charles Howard McIlwain. (3) Since McIlwain’s thesis on the medieval distinction between jurisdictio and guberna …

09.09.2026journal-article

Working Paper of Public Health

Il nesso causale e il danno estetico

Giuseppe Corsi

This article examines the role of causation in medical liability for aesthetic damage, arguing that compensation cannot be based solely on a patient's dissatisfaction with the outcome of cosmetic treatment. Instead, recovery requires proof of three cumulative elements: actual damage, professional negligence, and a causal link between the healthcare provider's conduct and the alleged injury. By analysing the evolution of Italian case law, the framework introduced by Law No. 24/2017 (the Gelli-Bianco Act), the Italia …

09.09.2026journal-article

Journal of Emergency Medicine, Trauma & Acute Care

Original Survey of Knowledge and Attitude About Basic Life Support and Advanced Cardiac Life Support Among Healthcare Professionals

Binoy Michael, Amit Rai, Sachin Narayan Kulkarni

ABSTRACT Background: Basic life support (BLS) focuses on providing immediate care to victims of cardiac arrest and other emergency situations. It offers simple, yet effective interventions that can sustain life until professional medical help arrives. Advanced cardiac life support (ACLS) builds upon the fundamentals of BLS but incorporates more advanced medical techniques and interventions. It is intended for healthcare professionals (including doctors, nurses, paramedics, and respiratory therapists). Our study aim …

09.09.2026journal-article

Diagnostics

Central Sensitization and Pain Catastrophizing Are More Strongly Associated with Health-Related Quality of Life than Bioelectrical Impedance Analysis-Derived Body-Composition Measures in Patients with Chronic Low Back Pain

Sebastian Tirla, Carmen Delia Nistor-Cseppento, Brigitte Osser, Dorina Maria Farcas, Nicoleta Anamaria Pascalau, Cristian Marge, Gyongyi Osser, Laura-Ioana Radoi

Background/Objectives: Chronic low back pain (LBP) is a multifactorial condition in which biological, psychological, and physical factors are associated with pain persistence and reduced health-related quality of life (HRQoL). Although central sensitization, pain catastrophizing, functional disability, and body composition have each been associated with CLBP, their relative contributions to HRQoL remain incompletely understood. This study investigated the relationships among these factors and identified factors ass …

09.09.2026journal-article

Journal of Clinical Medicine

Early Postoperative Remodeling of the Exhaled Volatilome Following Curative Surgery for Colorectal Cancer

Elizaveta Tyukanova, Zaki Fashafsha, Aleksandr Suvorov, Anastasia Fatyanova, Valeriy Ponomarev, Artemiy Silantyev, Denis Khlusov, Akmalbek Otabekov, Yaroslav Krasnov, Maksim Volgin, Bogdan Tkachenko, Albina Zubayraeva, Sergey Efetov, Philipp Kopylov, Marina Sekacheva

Background: Exhaled volatile organic compounds (VOCs) may provide a non-invasive readout of biological changes in colorectal cancer (CRC). We characterized early postoperative changes in the exhaled volatilome after curative CRC surgery and explored a multivariable VOC signature associated with clinical state. Methods: In this prospective paired pilot study, breath samples were obtained from 38 patients before surgery (Before) and on postoperative day 10 (After) and from 44 healthy controls (Control). Proton transf …

09.09.2026journal-article

International Journal of Environmental Research and Public Health

Reminiscence Therapy to Improve Self-Esteem, Loneliness, and Stress in Rural Thai Older Adults: A Quasi-Experimental Study

Yaowaluck Meebunmak, Kannika Kitnopkiat, Parinyaporn Thanaboonpuang

Background: Loneliness, psychological stress, and low self-esteem are important mental health concerns among community-dwelling older adults and may negatively affect healthy ageing and quality of life. This study examined psychosocial outcomes associated with participation in a 4-week Hybrid Happy Reminiscence Program among community-dwelling older adults. Methods: A quasi-experimental pretest–posttest control group study was conducted between September and November 2025 among community-dwelling older adults in Do …

09.09.2026journal-article

Nursing Reports

The Impact of Climate Change on Pregnant Women’s Health: A Scoping Review of Reviews

Cristina Álvarez-García, Cesar Ivan Aviles-Gonzalez, Sebastián Sanz-Martos, Carmen Álvarez-Nieto, Isabel M. López-Medina, Sergio Martínez-Vázquez, Maria Dolores López-Medina, Eva M. Montoro-Ramirez

Background/Objectives: Records through early 2026 mark 2025 as the warmest year in over 170 years. Pregnant women are among the populations most vulnerable to climate change. The objective of this study was to conduct a review that synthesizes existing knowledge on how the different dimensions of climate change are affecting the vulnerable population of pregnant women. Methods: A scoping review of reviews (PROSPERO: CRD420261400815) was conducted in the Health Sciences databases: PubMed, SCOPUS, PsycInfo, CINAHL an …

09.09.2026journal-article

PLOS Global Public Health

Assessing the impact of a gender-neutral approach to HPV vaccination on vaccination coverage for nine-year-old girls in Cameroon: A retrospective, cross-sectional study

Bridget C. Griffith, Shariffatou Iliassu, Clarence Mbanga, Budzi Michael Ngenge, Sonali Patel, Justin C. Graves, Navpreet Singh, Shalom Ndoula, Andreas Ateke Njoh, Efouba Gisele, Shadrack Mngemane, Tosin Ajayi, Laure-Anais Zultak, Yauba Saidu

Cameroon introduced the human papilloma virus vaccine (HPVV) into the routine immunization schedule in October 2020. By the end of 2022, coverage remained low. To increase coverage, Cameroon switched to a country-wide, gender-neutral vaccination (GNV) approach in 2023, coupled with a revamped delivery strategy of Community Dialogues (CDs) and Periodic Intensification of Routine Immunization (PIRIs) activities in selected health districts (HDs). We assessed the impact of these programmatic changes, notably the GNV a …

09.09.2026journal-article

Asian Journal of Engineering, Social and Health

Determining the Number of Workers Based on a Time-and-Motion Study to Meet Production Demand at the XYZ Tofu and Tempe Factory in Nabire

Jean Belynda Lalihatu, Julianus Hutabarat, Ellysa Nursanti

One of the food industries that plays an important role in meeting community needs is the tofu and tempeh production industry. Therefore, this role must be supported by adequate infrastructure and workforce capacity to ensure that the production process runs effectively. This research determines the appropriate number of workers using a time-and-motion study to identify and eliminate unnecessary activities and establish standard working times for tofu production. The XYZ tofu and tempeh factory in Nabire has operat …

09.09.2026journal-article

Communications Medicine

Resolution-dependent self-supervised transfer in chest radiograph classification

Soroosh Tayebi Arasteh, Mina Shaigan, Christiane Kuhl, Jakob Nikolas Kather, Sven Nebelung, Daniel Truhn

Abstract Background: Self-supervised learning (SSL) has improved visual representation learning, but its value in chest radiography remains uncertain. DINOv3 extends earlier SSL models through Gram-anchored self-distillation and explicit high-resolution adaptation. Whether these changes improve transfer learning for chest radiograph classification has not been established. Methods: We benchmarked DINOv3 against DINOv2 and supervised ImageNet initialization across seven chest radiograph datasets comprising 816,183 r …

09.09.2026journal-article

Frontiers in Medicine

Unilateral lower limb cellulitis-like edema as an atypical cutaneous manifestation of antisynthetase syndrome: a case report and targeted literature review

Yue Zhang, Jia Su, Ling Zhong, Lan Shang, Huiying Wan

Background Antisynthetase syndrome (ASyS) is a distinct subtype of idiopathic inflammatory myopathy (IIM), characterized by multisystem involvement, including the lungs, skin, skeletal muscles, and joints, as well as the presence of anti-aminoacyl-tRNA synthetase (ARS) antibodies. While 8% to 30% of patients present with classic dermatomyositis-like rashes, atypical skin involvement can also occur. Rarely, patients may develop cutaneous edema that mimics cellulitis, which is highly susceptible to misdiagnosis. Case …

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Aktuelle Forschung nach Fachgebiet

Association of Helicobacter pylori infection with insulin resistance, tumor necrosis factor-alpha, and dyslipidemia in obese children with metabolic syndrome

Phenomenology in pediatric nursing: Lessons from studies of mothers caring for children with chronic illnesses

Dissipation of the mitochondrial proton motive force drives sepsis pathogenesis and explains hyperlactatemia’s predictive value in sepsis mortality

Beyond Hemorrhage: A Case of Acute Dengue Infection Presenting with Budd–Chiari Syndrome and Bilateral Sensory Polyneuropathy

Phase 1 trial and biomarker analysis of Buparlisib with weekly Cisplatin and Radiotherapy in high risk locally advanced squamous cell cancer of the Head and Neck.

ROS-Responsive Silica Cross-Linked Micelle Drug Delivery System for Myocardial Ischemia-Reperfusion Injury Therapy

Artificial intelligence is transforming disease surveillance, but governance is failing to keep pace

Ethical dimensions of living with one leg: A qualitative study

Providing a management tool for the performance assessment of occupational health and safety management system in the face of an emerging infectious disease

Clinical outcomes of the PAUL ® glaucoma implant for secondary glaucoma

Building Customer Loyalty in Indonesian Social Commerce: AI-Driven Personalization, Perceived Financial Value, and Seller Digital Competence Through Customer Experience

Role Status Changes During Emerging Adulthood and Their Association with Substance Use, Mental Health, and Well-Being Outcomes over a 4-Year Period

Routine laboratory composite indices and geriatric multisyndrome burden: a head to head evaluation against serum albumin

Jurisprudencial Siblings? The Rule of Law and the Rechtsstaat as the Two Tracks to the Society, Public Sphere and their Normative Framework

Il nesso causale e il danno estetico

Original Survey of Knowledge and Attitude About Basic Life Support and Advanced Cardiac Life Support Among Healthcare Professionals

Central Sensitization and Pain Catastrophizing Are More Strongly Associated with Health-Related Quality of Life than Bioelectrical Impedance Analysis-Derived Body-Composition Measures in Patients with Chronic Low Back Pain

Early Postoperative Remodeling of the Exhaled Volatilome Following Curative Surgery for Colorectal Cancer

Reminiscence Therapy to Improve Self-Esteem, Loneliness, and Stress in Rural Thai Older Adults: A Quasi-Experimental Study

The Impact of Climate Change on Pregnant Women’s Health: A Scoping Review of Reviews

Assessing the impact of a gender-neutral approach to HPV vaccination on vaccination coverage for nine-year-old girls in Cameroon: A retrospective, cross-sectional study

Determining the Number of Workers Based on a Time-and-Motion Study to Meet Production Demand at the XYZ Tofu and Tempe Factory in Nabire

Resolution-dependent self-supervised transfer in chest radiograph classification

Unilateral lower limb cellulitis-like edema as an atypical cutaneous manifestation of antisynthetase syndrome: a case report and targeted literature review