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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Oncology

Artificial intelligence in ovarian cancer prevention and control: a brief review of detection, treatment, and equity (2021–2026)

Zhenyu Huang, Boyang Wei, Ying Shen

Ovarian cancer (OC) remains a leading cause of gynecologic cancer mortality worldwide because early symptoms are often vague, effective population-level screening strategies are lacking, and outcomes are shaped by biological heterogeneity and unequal access to diagnostic and molecular testing resources. This Mini Review summarizes advances from 2021 to 2026 in artificial intelligence (AI) applications across the OC care continuum, focusing on early detection, treatment decision-making, prognostic assessment, clinic …

03.09.2026journal-article

Frontiers in Medicine

The impact of chemoimmunotherapy on primary cold agglutinin disease and Waldenström macroglobulinemia-associated cold agglutinin syndrome

Kenichi Ito, Tomoko Kitagawa, Saya Motohashi, Kazuhiko Hirano, Naohiro Sekiguchi

Background Cold agglutinin-associated hemolysis (CAH) occurs in diverse clinical contexts, such as primary cold agglutinin disease (pCAD) and Waldenström macroglobulinemia-associated cold agglutinin syndrome (WM-CAS). The differentiation of these entities is often challenging, particularly in MYD88 L265P-negative cases. Since studies that examined the effects of chemoimmunotherapy (CIT) frequently predated routine molecular testing, it remains unclear whether disease classification impacts treatment response and du …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Mature tertiary lymphoid structures in a metastatic urothelial carcinoma patient with an exceptional response to sequential immune checkpoint inhibitor and antibody-drug conjugate therapy

Kanta Hori, Takuto Ogasawara, Yuka Mizue, Hiroko Asanuma, Naoki Shijubou, Akihiro Yamashita, Ryo Kato, Jun Furumido, Takashige Abe, Keisuke Sato, Yoshihiko Hirohashi

Background Biomarkers that predict durable benefit from immune checkpoint inhibitors (ICIs) and antibody-drug conjugates (ADCs) in metastatic urothelial carcinoma (mUC) remain limited. Tertiary lymphoid structures (TLS), particularly mature TLS (mTLS) characterized by follicular dendritic cell networks and germinal centers, may reflect a highly compartmentalized antitumor immune niche. Case presentation A 77-year-old man with bladder cancer and lung metastases experienced disease progression after two cycles of gem …

03.09.2026journal-article

Frontiers in Immunology

A case report of sequential efgartigimod and rituximab treatment for tSNMG

Hua Xie, Ting Ting Pan, Lin Zhang

Trible‐seronegative myasthenia gravis (tSNMG) is defined as myasthenia gravis (MG) without detectable or low affinity antibodies to acetylcholine receptor (AChR), muscle‐specific kinase (MuSK) andlipoprotein related protein 4(LRP-4). This article reports a case of a 39-year-old married female patient with thymoma-associated seronegative myasthenia gravis (tSNMG), which was accompanied by multiple positive autoantibodies and a benign mediastinal lesion. The primary manifestation was generalized muscle weakness, invo …

03.09.2026journal-article

Frontiers in Dental Medicine

Clinical and perioperative outcomes of computer-guided versus conventional plan-transfer workflows in orthognathic surgery for skeletal anterior open bite: a randomized controlled trial

Ammar Abu Shama, Dirar Dibs

Introduction Skeletal anterior open bite (AOB) often requires orthognathic surgery. This study compared the clinical and perioperative outcomes of computer-guided and conventional plan-transfer workflows following virtual surgical planning. Methods Eighteen adults with skeletal AOB underwent virtual surgical planning and were subsequently randomized to computer-guided transfer of the established surgical plan using CAD/CAM guides ( n = 9) or conventional model-surgery transfer using articulator-mounted casts and oc …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Clinical outcomes of external fenestration TEVAR in Stanford type B aortic dissection involving the left subclavian artery: a retrospective study

Chunshui Liang, Hong Liu, Xiaobo Peng, Tianbo Li, Chencheng Liu, Yong Wang, Yingbin Xiao, Ruiyan Ma

Objective This study assessed the clinical efficacy and hemodynamic effects of external fenestration thoracic endovascular aortic repair (TEVAR) in patients with type B aortic dissection (TBAD) involving the left subclavian artery (LSA). Methods A retrospective analysis of 110 patients who underwent this procedure between 2020 and 2024 was conducted, evaluating procedural success, complications, and follow-up outcomes. Hemodynamic changes were analyzed in 1 patient using computational fluid dynamics (CFD) based on …

03.09.2026journal-article

Cosmoderma

Sorafenib-induced hand-foot syndrome in a patient with desmoid fibromatosis

Deepthi Konda, Varsha Gudipati

Sorafenib is an oral multikinase inhibitor widely used in the treatment of various solid malignancies and has recently emerged as a therapeutic option for desmoid fibromatosis. Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysesthesia, is a common cutaneous adverse effect associated with sorafenib therapy. Although sorafenib-induced HFS has been well documented in patients with renal cell carcinoma and hepatocellular carcinoma, reports in patients with desmoid fibromatosis (DF) remain limited. We re …

03.09.2026journal-article

Frontiers in Psychology

Pre-treatment consent framing shapes how laypeople evaluate CBT: a cross-cultural comparison of China and the United States

Yuanqing Wang, Feng Mei, Wei Zhao

People’s understanding of psychotherapy influences their treatment expectations and engagement. Informed consent is often one of the first formal processes through which this understanding is shaped. Yet, little cross-cultural research has examined its impact on lay people’s pre-treatment attitudes. This study investigated whether the perceived importance of common factors and cognitive behavioral therapy (CBT) techniques varies across cultural contexts and informed consent framing. Chinese ( n = 297) and U.S. ( n …

03.09.2026journal-article

Haematologica

Real-world minimal residual disease assessment in multiple myeloma using a standardized flow cytometry approach: feasibility, clinical implications, and immune correlates from a single-center experience

Cirino Botta, Andrea Rizzuto, Maria Speciale, Emilia Gigliotta, Anna Maria Corsale, Francesco Romano, Irene Mussotto, Cristina Aquilina, Andrea Romano, Marta Biondo, Elena Tofacchi, Marta Di Simone, Miriam Sciortino, Fulvio Brucato, Gianluca Guercio, Miriam Di Caro, Anxur Merenda, Stefania Vasta, Concetta Scazzone, Giulia Bivona, Valentina Calò, Marco Pio La Manna, Nadia Caccamo, Francesco Dieli, Sergio Siragusa, Serena Meraviglia

Minimal residual disease (MRD) assessment has emerged as a key prognostic marker in multiple myeloma (MM), with MRD negativity (undetectable MRD, uMRD) correlating with improved progression-free and overall survival. The International Myeloma Working Group recommends standardized protocols for MRD detection, including the EuroFlow-based next-generation flow cytometry (NGF), although its implementation in routine care remains challenging. We evaluated the feasibility and clinical utility of two CE-IVD-approved EuroF …

03.09.2026journal-article

Pacing and Clinical Electrophysiology

Association Between Global Longitudinal Strain and Pacing‐Induced Cardiomyopathy: A Systematic Review and Meta‐Analysis

David T. Zhang, Rachel M. Suen, Sakshum Chadha, Kenney Abraham, Matthew Pelletier, Noelle N. Mann, Michael Tao

ABSTRACT Background High right ventricular pacing burden is a well‐established risk factor for the development of left ventricular dysfunction and pacing‐induced cardiomyopathy (PICM). However, identification of post‐implant patients at risk for PICM remains challenging. This meta‐analysis evaluated the association between global longitudinal strain (GLS) by speckle tracking echocardiography (STE) and the risk of subsequent development of PICM in patients who undergo pacemaker implantation. Methods We searched the …

03.09.2026journal-article

Journal of Educational Evaluation for Health Professions

Development and initial validation of an instrument measuring the perceived importance of core competencies for clinical nurse educators in Korea: a methodological study

Heui-Kyeong Kwon, Junmoo Ahn, Kyungsan Seo, Seung-Hee Lee, Eunhee Jung, Yoonjung Lee

Purpose: This study aimed to develop an instrument to assess the perceived importance of core competencies for clinical nurse educators (CNEs) in Korea, defined here as hospital-based nurse educators under the Korean Nursing Act, and to provide initial evidence of its content validity, internal structure, and reliability.Methods: A preliminary 44-item pool, developed from international nurse educator frameworks and the literature, was refined by 8 experts through a 2-round modified Delphi process. A nationwide samp …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Soft endoscopic treatment of Herlyn–Werner–Wunderlich syndrome: an innovative clinical procedure for hymen preservation

Yonghua Tian, Wei Fu, Yan Geng

Background Herlyn–Werner–Wunderlich syndrome (HWWS) management typically requires hymenotomy. We describe the fully endoscopic, hymen-sparing septotomy in a patient with no history of sexual intercourse. Case presentation A 20-year-old patient with no prior sexual intercourse and progressive dysmenorrhea was diagnosed by MRI with HWWS, presenting as uterus didelphys, obstructed right hemivagina, and left renal agenesis. A 9-mm flexible gastroscope and endoscopic submucosal dissection (ESD) knives were introduced th …

03.09.2026journal-article

Frontiers in Neurology

Pediatric stroke in inborn errors of metabolism: clinical characteristics, neuroimaging features, and short-term outcomes

Javeria Raza Alvi, Areeba Wasim, Saher Gul Ahdi, Tipu Sultan, Muhammad Zia-ur-Rehman, Khalid Al-Thihli, Fathiya Al Murshedi, Amna Al Futaisi

Introduction Pediatric stroke has a broad etiological spectrum, with inborn errors of metabolism (IEM) increasingly recognized as an important and potentially treatable cause. This study aimed to characterize the clinical, radiological, and electroencephalographic features of IEM-related pediatric stroke and to evaluate short-term functional outcomes. Methods This prospective cohort study was conducted at The Children’s Hospital Lahore, Pakistan, and Sultan Qaboos University Hospital, Muscat, Oman (January 2024–Dec …

03.09.2026journal-article

Frontiers in Immunology

Thirty years in, regulatory T cells are ready for medicine

Ryoji Kawakami, Ayush Jain

Regulatory T (Treg) cells are a specialized subset of CD4 + T cells indispensable for the establishment and maintenance of immunological tolerance. Treg cells employ diverse mechanisms of immune regulation mediated by a broad repertoire of immunosuppressive molecules under the control of the lineage-specifying transcription factor FoxP3. Functional defects in Treg cells disrupt immune homeostasis and are implicated in the pathogenesis of autoimmune diseases, chronic inflammatory disorders, and cancer. In this artic …

03.09.2026journal-article

Asian Journal of Oncology

Integrating molecular engineering and artificial intelligence to overcome clinical and manufacturing challenges in CAR-T therapy

Lipi Singh, Narendra Singh, Rakesh Kumar Arya, Priya Kiran, Mahrosh Sohail, Parushi Verma, Manish Kumar Arya

Chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable efficacy in addressing hematological malignancies. However, its broader clinical application in other cancer types is still limited by key challenges like antigen escape, on-target/off-tumor toxicity, reduced efficacy for solid malignancies, and large variability in the production process for CAR T-cells. Traditional optimization approaches are increasingly insufficient to address these complex challenges. Notably, current studies do not ful …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Sex differences in the associations of multidomain risk factor profiles with incident major adverse cardiovascular events

Yuhui Yang, Xi Chen, Yuhao Hu, Xiaochen Wang, Huili Wang, Youquan Wei, Feilong Zhang, Zhen Dong, Ronghui Yu

Background Major adverse cardiovascular events (MACE) exhibit sex-specific disparities, but comprehensive analyses of combined genetic and clinical risk factor profiles across sexes remain limited. Methods This prospective cohort study included 397,806 UK Biobank participants (55.1% female) without baseline MACE. Five weighted risk scores [social-demographic, lifestyle, metabolic, clinical comorbidity, polygenic risk score (PRS)] were evaluated for associations with incident MACE via sex-stratified Cox proportional …

03.09.2026journal-article

Frontiers in Public Health

Staff-mediated doll therapy in Chinese residential dementia care: an exploratory pilot and feasibility mixed-methods cluster randomized clinical trial

Zhenti Cui, Rongrong Guan, Tianrui Xue, Yongchang Sun, Maw Pin Tan, Mas Ayu Said, Yingdong Cao

Background Doll therapy is a person-centered intervention for behavioral and psychological symptoms of dementia, but evidence from Chinese nursing homes and information about implementation, medication use, and ethical acceptability remain limited. Methods We conducted an exploratory pilot and feasibility mixed-methods cluster-randomized clinical trial in six nursing homes in Zhengzhou, China. Homes were randomized 1:1 to a staff-mediated doll-therapy care package plus routine care or routine care alone. Residents …

03.09.2026journal-article

Frontiers in Medicine

Clinical efficacy of the Galdakao-modified supine Valdivia position vs. the lithotomy position in FANS-UAS-assisted IPC-RIRS for renal calculi

Qiuhua Zhu, Yunxia Cai, An Wang, Jiansheng Xiao, Leming Song, Tairong Liu, Hua Chen

Objective To evaluate the clinical efficacy and safety of a modified Galdakao-modified supine Valdivia (GMSV) position combined with a flexible and navigable suction ureteral access sheath (FANS-UAS) in intelligent pressure-controlled retrograde intrarenal surgery (IPC-RIRS) for the treatment of renal calculi. Methods This single-center retrospective cohort study included 158 patients with renal calculi who underwent FANS-UAS-assisted IPC-RIRS between June 2023 and June 2025. Patients were categorized into the GMSV …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Novel predictors of late recurrence after catheter ablation for atrial fibrillation: from biomarkers to artificial intelligence models

Chiyu Chen

Atrial fibrillation (AF) is the most common sustained arrhythmia, and catheter ablation is an established rhythm-control strategy. However, late atrial arrhythmia recurrence remains common, limiting long-term procedural benefits. This review provides a structured and critical overview of current evidence on the predictors of late recurrence after AF catheter ablation across four domains: circulating biomarkers, imaging and electrophysiological substrate markers, genetic susceptibility, and artificial intelligence a …

03.09.2026journal-article

Frontiers in Oncology

The expression and clinical significance of SIRT5, H2A and TOP2A in cervical cancer

Fenghu Li, Xue Tian, Fan Mei, Yanjun Du, Lili Hu, Jiehui Li, Shengfa Su, Bing Lu

Objective To analyze the correlation between the expression of lysine deacetylase 5 (SIRT5), histone H2A and topoisomerase IIα (TOP2A) protein with clinical stage and survival in cervical cancer. Methods The expression levels of SIRT5, H2A and TOP2A proteins were detected by immunohistochemical two-step method in paraffin-embedded tissue blocks from 65 patients with cervical cancer (21 cases of stage IB, 9 cases of stage IIA and 35 cases of stage IIIC1p). The expression distribution and positive rate of SIRT5, H2A …

03.09.2026journal-article

Emergency Medicine Australasia

Criteria for Safe Hospital Discharge in Bronchiolitis: A Systematic Review

Meredith L. Borland, Kate Loveys, Franz E. Babl, Elizabeth Cotterell, Libby Haskell, Sharon O'Brien, Ed Oakley, Emma J. Tavender, Catherine L. Wilson, Stuart R. Dalziel, the Paediatric Research in Emergency Departments International Collaborative (PREDICT) Network

ABSTRACT Bronchiolitis is the leading cause of hospital presentation and admission for infants in Australasia. We aimed to synthesise current evidence on the effect of discharge criteria for infants (aged < 12 months) who are presenting to or are admitted to hospital with bronchiolitis, to inform a binational guideline recommendation update. Systematic searches were conducted on MEDLINE, EMBASE, PubMed, Cochrane Library and CINAHL (last search 19 February 2025) for non‐randomised studies evaluating hospital dischar …

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice

Luisa Agnello, Andrea Pilotto, Lorenzo Gaetani, Giovanni Bellomo, Valentina Bessi, Marco Bozzali, Annachiara Cagnin, Angelo Labate, Federico Massa, Fabio Moda, Roberto Monastero, Giulia Musso, Tommaso Piccoli, Giulia Sancesario, Lucilla Parnetti, Alessandro Padovani, Marcello Ciaccio

Abstract Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, therapeutic decision-making, and longitudinal disease monitoring. To effectively support clinical decision-making, biomarker measurements must be communicated in a standardized, transparent, and clinically interpretable manner. Despite internati …

03.09.2026journal-article

European Geriatric Medicine

Improving diabetes management in older adults with cancer: a quality improvement project to enhance monitoring during steroid-based systemic anti-cancer therapy

Evelyne Liuu, Rose Evans, Nathanael Bassas-Letissier, Gitanjali Amaratunga, Sarah Compton, Alexandros Georgiou, Tania Kalsi, Yuk-Fun Liu, James Maguire, Clare Nottage, Hannah L. Rush, Carly Welch

Abstract Purpose Older adults undergoing systemic anti-cancer therapy (SACT) with steroids are at high risk of developing steroid-induced hyperglycaemia (SIH). However, monitoring and management remain inconsistent. This quality improvement project (QIP) involved developing and evaluating the GOLD diabetes enhanced monitoring pathway, a multidisciplinary, age-adapted initiative for older patients at intermediate SIH risk. Methods The pathway was implemented at Guy’s and St Thomas’ NHS Foundation Trust between Febru …

03.09.2026journal-article

Clinical and Experimental Dermatology

Uncommon benign tumour of the scalp

Peter Robinson, Sam Cook, Stephanie Ball, Fraser Charlton, Neil Rajan

A 37-year-old male (Fitzpatrick skin type III) presented with a 10-month history of an enlarging nodule on the right parietal scalp. There was a paternal history of melanoma, but no family history of similar skin lesions. Physical examination revealed an ill-defined, pink, round, non-tender, mobile nodule measuring 15 x 15 mm. A second similar papule measuring 6 x 5 mm was found at the right scalp apex.