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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Oncology

Case Report: Mature tertiary lymphoid structures in a metastatic urothelial carcinoma patient with an exceptional response to sequential immune checkpoint inhibitor and antibody-drug conjugate therapy

Kanta Hori, Takuto Ogasawara, Yuka Mizue, Hiroko Asanuma, Naoki Shijubou, Akihiro Yamashita, Ryo Kato, Jun Furumido, Takashige Abe, Keisuke Sato, Yoshihiko Hirohashi

Background Biomarkers that predict durable benefit from immune checkpoint inhibitors (ICIs) and antibody-drug conjugates (ADCs) in metastatic urothelial carcinoma (mUC) remain limited. Tertiary lymphoid structures (TLS), particularly mature TLS (mTLS) characterized by follicular dendritic cell networks and germinal centers, may reflect a highly compartmentalized antitumor immune niche. Case presentation A 77-year-old man with bladder cancer and lung metastases experienced disease progression after two cycles of gem …

03.09.2026journal-article

Frontiers in Bioengineering and Biotechnology

Plantar-pressure-guided support-plate position control for a walker-assisted lower-limb rehabilitation exoskeleton

Yuhui Yang, Wenyu Zhao, Yuanxiang Guo, Zhijue Huang, Xueshan Gao, Xin Han, Junlin Deng

Introduction Maintaining appropriate foot-ground contact is important for walker-assisted lower-limb exoskeleton training. Excessive plantar loading may increase initial-contact impact and actuator load, whereas excessive unloading may reduce frictional contact and contact stability. Passive spring support can provide impact buffering, but it cannot adjust the support working point according to gait phase or plantar-pressure feedback. Methods This study proposes a multi-zone plantar-pressure-guided position control …

03.09.2026journal-article

Asian Journal of Oncology

Integrating molecular engineering and artificial intelligence to overcome clinical and manufacturing challenges in CAR-T therapy

Lipi Singh, Narendra Singh, Rakesh Kumar Arya, Priya Kiran, Mahrosh Sohail, Parushi Verma, Manish Kumar Arya

Chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable efficacy in addressing hematological malignancies. However, its broader clinical application in other cancer types is still limited by key challenges like antigen escape, on-target/off-tumor toxicity, reduced efficacy for solid malignancies, and large variability in the production process for CAR T-cells. Traditional optimization approaches are increasingly insufficient to address these complex challenges. Notably, current studies do not ful …

03.09.2026journal-article

Frontiers in Public Health

Staff-mediated doll therapy in Chinese residential dementia care: an exploratory pilot and feasibility mixed-methods cluster randomized clinical trial

Zhenti Cui, Rongrong Guan, Tianrui Xue, Yongchang Sun, Maw Pin Tan, Mas Ayu Said, Yingdong Cao

Background Doll therapy is a person-centered intervention for behavioral and psychological symptoms of dementia, but evidence from Chinese nursing homes and information about implementation, medication use, and ethical acceptability remain limited. Methods We conducted an exploratory pilot and feasibility mixed-methods cluster-randomized clinical trial in six nursing homes in Zhengzhou, China. Homes were randomized 1:1 to a staff-mediated doll-therapy care package plus routine care or routine care alone. Residents …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Iparomlimab and Tuvonralimab-based therapy for epithelioid malignant peritoneal mesothelioma: a three-case series

Zhijin Xu, Lehe Zhu, Ying Fang, Yiyan Jiang

Background Epithelioid malignant peritoneal mesothelioma (EMPM) is a rare and aggressive malignancy of serosal origin. Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is generally reserved for carefully selected patients in whom adequate cytoreduction appears feasible, while evidence supporting systemic immunotherapy remains limited for patients with unresectable disease or those unable to tolerate intensive treatment. Iparomlimab and tuvonralimab (QL1706) is a fixed-ratio anti-PD-1/an …

03.09.2026journal-article

European Geriatric Medicine

Improving diabetes management in older adults with cancer: a quality improvement project to enhance monitoring during steroid-based systemic anti-cancer therapy

Evelyne Liuu, Rose Evans, Nathanael Bassas-Letissier, Gitanjali Amaratunga, Sarah Compton, Alexandros Georgiou, Tania Kalsi, Yuk-Fun Liu, James Maguire, Clare Nottage, Hannah L. Rush, Carly Welch

Abstract Purpose Older adults undergoing systemic anti-cancer therapy (SACT) with steroids are at high risk of developing steroid-induced hyperglycaemia (SIH). However, monitoring and management remain inconsistent. This quality improvement project (QIP) involved developing and evaluating the GOLD diabetes enhanced monitoring pathway, a multidisciplinary, age-adapted initiative for older patients at intermediate SIH risk. Methods The pathway was implemented at Guy’s and St Thomas’ NHS Foundation Trust between Febru …

03.09.2026journal-article

Frontiers in Medicine

Work-related distress and professional quality of life in a medical-school workforce: a primary-care occupational-health perspective

Falah Mohammed Almarzooqi, Saif Al-Shamsi, Syed Fahad Javaid, Afaf Alblooshi, Faten AlRadini

Background Work-related distress may present in primary care through nonspecific physical, psychological, or functional complaints. This study assessed professional quality of life in a United Arab Emirates medical-school workforce through primary-care and occupational-health perspectives. Methods A cross-sectional electronic survey was conducted among employees of the College of Medicine and Health Sciences, United Arab Emirates University, between October 2025 and February 2026. The sampling frame comprised 373 e …

03.09.2026journal-article

Frontiers in Rehabilitation Sciences

Let us tell you how to train us! experiences of children and youth with the Wheelchair Skills Training Program and their preferences for training delivery: a descriptive qualitative study

Béatrice Ouellet, Sofia So, Tatiana Dib, Paula W. Rushton, Margaux Hebinck, Sarah A. Moore, Kelly P. Arbour-Nicitopoulos, R. L. Kirby, François Routhier, Krista L. Best

Introduction The Wheelchair Skills Training Program (WSTP) has demonstrated statistical and clinical effectiveness in improving manual wheelchair skills among pediatric manual wheelchair users (PMWUs). However, uptake of this program remains limited in pediatric rehabilitation settings, partly due to clinicians’ uncertainties about its suitability for playful and developmentally appropriate training. Despite children's and youths’ right to engage in discussions regarding their rehabilitation, PMWUs’ lived experienc …

03.09.2026journal-article

Frontiers in Lab on a Chip Technologies

Extracellular vesicle-integrated brain organoid-on-a-chip systems for neuroimmune communication and precision therapy in viral encephalitis

Md. M. N. Azim

Viral encephalitis causes substantial neurological morbidity and mortality through the combined effects of direct viral injury, blood–brain barrier (BBB) dysfunction, and dysregulated communication among neural, vascular, and immune cells. Extracellular vesicles (EVs) are increasingly recognized as mediators of this communication because they transfer proteins, lipids, viral constituents, cytokine-related signals, and regulatory RNAs between neurons, astrocytes, microglia, endothelial cells, and peripheral immune c …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

Selective Internal Radiation Therapy for Hepatocellular Malignancies: Existing Evidence and Advances

Priyanka Yadav, Jaya Shukla

Selective Internal Radiation Therapy (SIRT) is a locoregional treatment for primary and secondary liver neoplasms that spares the surrounding parenchyma while selectively delivering a high radiation dose to the tumour tissue. It functions by injecting radioactive microspheres into the hepatic artery supplying the tumour. SIRT has emerged as a valuable locoregional treatment for liver cancers, including unresectable hepatocellular carcinoma (HCC) and some liver-dominant metastases, such as neuroendocrine tumours and …

03.09.2026journal-article

Haematologica

Pediatric-inspired therapy and blinatumomab consolidation improve outcomes in young adults with Philadelphia-like acute lymphoblastic leukemia

Ibrahim Aldoss, Arthur Li, Diana Knobler, Vaibhav Agrawal, Hoda Pourhassan, Paul Koller, Tamer Othman, Monzr M. Al Malki, Amandeep Salhotra, Karamjeet Sandhu, Haris Ali, Ahmed Aribi, Amanda Blackmon, Brian Ball, Idoroenyi Amanam, Salman Otoukesh, Rick Lin, Julio C. Alvarenga Thiebaud, Sunmin Park, Samer Khaled, Jose Tinajero, Dat Ngo, Zhaohui Gu, Lindsey Murphy, Yazeed Samara, Michelle Afkhami, Andrew Artz, Pamela Becker, Ryotaro Nakamura, Anthony Stein, Stephen Forman, Guido Marcucci, Vinod Pullarkat

Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL associated with poor response to induction chemotherapy, suboptimal measurable residual disease (MRD) clearance, and inferior survival outcomes compared to non-Phlike subtypes. We retrospectively analyzed 140 consecutive adult patients with Ph-like ALL treated at our institution. The median age was 33.5 years, and the majority harbored CRLF2 rearrangements (85%). IKZF1plus deletion and JAK mutations were identified in 26% …

03.09.2026journal-article

Frontiers in Public Health

Construction and application of an occupational health risk grading method based on risk matrix and dynamic weighting: a case study of footwear manufacturing enterprises

Hongying Bian, Xin Wang, Yiwen Dong, Ning Kang, Lin Zhang

Background Occupational hazard factors in the footwear manufacturing industry are complex and encompass benzene series compounds, ketones, esters, dust, noise, and other agents. Existing mainstream occupational health risk assessment methods—including the Singapore semi-quantitative risk assessment method (Ministry of Manpower method, hereafter referred to as the MOM method), the exposure ratio method specified in GBZ/T 298-2017 (hereafter referred to as the exposure ratio method), the United States Environmental P …

03.09.2026journal-article

Annals of Neurosciences

Effectiveness of Cognitive Behavioural Therapy in Reducing Depression and Anxiety Among University Students: An Experimental Study

Bhawna Gurnani, Shubhagata Awasthi

Background Depression and anxiety are among the most prevalent mental health problems affecting university students and are associated with impaired academic performance, emotional distress and reduced quality of life. Cognitive behavioural therapy (CBT) is an evidence-based intervention that has demonstrated effectiveness in reducing symptoms of depression and anxiety; however, intervention-based studies among Indian university students remain limited. Purpose The present study aimed to evaluate the effectiveness …

03.09.2026journal-article

Cardiovascular Drugs and Therapy

Profiling Cardiovascular Disease-Associated Changes in the Composition of High-Density Lipoprotein Particles

Tanith Fester, Carmelita Abrahams, Sandrine Lecour

Abstract Cardiovascular disease remains the leading cause of death worldwide, imposing significant morbidity and healthcare costs. While low serum high-density lipoprotein (HDL)-cholesterol levels have traditionally been linked to cardiovascular risk, most pharmacological interventions aimed at raising HDL-cholesterol levels have not consistently improved cardiovascular outcomes. Epidemiologic and genetic studies further suggest that circulating HDL-cholesterol levels may not directly determine cardiovascular risk, …

03.09.2026journal-article

Frontiers in Drug Delivery

Hyaluronidase-enhanced delivery in gene therapy and regenerative medicine for improved vector, cell, and cargo access

Patrick E. Sewell, Christopher Jensen

Efficient delivery of gene therapy vectors and regenerative cargo to the central nervous system (CNS) is limited by the hyaluronic acid (HA)-rich extracellular matrix (ECM). Adeno-associated virus (AAV) particles, mesenchymal stem cells (MSCs), multilineage-differentiating stress-enduring (MUSE) cells, and small extracellular vesicles (sEVs) must traverse the HA-rich ECM of the nasal submucosa, the perineural and perivascular compartments, and brain parenchyma to reach CNS targets. Dense ECM imposes viscosity, ster …

03.09.2026journal-article

Frontiers in Pediatrics

Clinical utility and tolerability of ketamine as adjunctive rescue therapy for refractory neonatal status epilepticus: a case report of a late preterm infant with multifocal hemorrhagic brain injury

Chiara Gulisano, Alessia Pepe, Elisabetta Amadori, Samuele Caruggi, Daniele Caratozzolo, Lino Nobili, Pasquale Striano, Luca Antonio Ramenghi, Andrea Calandrino

Background Neonatal status epilepticus (NSE) is a life-threatening neurological emergency associated with high mortality and long-term neurodevelopmental morbidity. Although phenobarbital remains the recommended first-line antiseizure medication (ASM), followed by agents such as phenytoin or levetiracetam, seizure control is not always achieved. Ketamine, a non-competitive N methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a potential rescue therapy for refractory status epilepticus because of its uniq …

03.09.2026journal-article

Frontiers in Public Health

Compact metasurface track-side PIS antenna-based occupational electromagnetic exposure research of inspectors in the metro tunnel

Ming-Fei Luo, Jin-Jing Xu, Wen-Ying Zhou, Xin-Hong Li, Mai Lu

Introduction With the advancement of Smart Urban Rail construction, the electromagnetic environment has become increasingly complex inside metro tunnels. Track-side inspectors may experience occupational radio-frequency (RF) exposure when conducting professional inspections in such a closed electromagnetic environment. Methods In order to analyze the occupational electromagnetic exposure dose absorbed by the track-side inspectors,and explore a method to reduce the influence of RF electromagnetic radiation. We propo …

03.09.2026journal-article

Frontiers in Dental Medicine

Curcumin as an adjunct in periodontal therapy: local effects, delivery systems, and clinical perspectives

Ana Carolina Aparecida Rivas, Mario Taba, Paola Gomes Souza

Curcumin, the active polyphenol in turmeric (Curcuma longa), is well-known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it a promising therapeutic agent for a range of diseases, including neuroinflammatory conditions and periodontal disease. Periodontitis, a prevalent oral disease, is associated with chronic inflammation and bacterial infection. Curcumin has demonstrated antibacterial effects against periodontal pathogens such as Aggregatibacter actinomycetemcomitans, Porphyromonas g …

03.09.2026journal-article

Frontiers in Pediatrics

Transcatheter embolization as a rescue therapy for refractory pelvic kaposiform hemangioendothelioma with Kasabachi–Merritt phenomenon: a case report

Yi Xiong, Qi Di, Sanlin Li, Jiajie Cao, Chenghao Chen, Gang Shen

Kasabach–Merritt phenomenon (KMP) is a life-threatening consumptive coagulopathy in children with kaposiform hemangioendothelioma (KHE) or tufted angioma. Until now, there has been no well-accepted treatment regimen in the literature. A pelvic KHE is very rare and its deep anatomical location and invasive growth pattern toward adjacent vital organs pose significant management challenges. Here, we report a 10-month-old girl presenting with KMP secondary to a pelvic KHE. Initial systemic therapy with sirolimus and co …

03.09.2026journal-article

Frontiers in Oncology

Comparison of patient-reported outcomes and healthcare utilization between metastatic colorectal cancer patients receiving systemic therapy with or without concurrent palliative care support: a retrospective cohort study

Xiaoli Liu, Fangtuan Wu, Lunlan Li

Background Patients with metastatic colorectal cancer (mCRC) experience substantial symptom burden, yet evidence on the integration of specialist palliative care (PC) in real-world settings remains limited. We assessed the impact of concurrent PC on patient-reported outcomes and healthcare utilization. Objective To evaluate the impact of integrating professional palliative care (PC) with standard systemic therapy on patient-reported outcomes, medical resource utilization, and overall survival (OS) in metastatic col …

03.09.2026journal-article

Bulletin of the School of Oriental and African Studies

The gate to speech: Smṛtijñānakīrti’s Smra ba’i sgo mtshon cha lta bu /* Vacanamukhāyudhopama and his use of the Abhidharma philosophy of language

Xiaonan Li

Abstract In the early eleventh century, the peripatetic Indian scholar Smṛtijñānakīrti – Dran pa ye shes grags pa in Tibetan – overcame great hardship and many obstacles before ultimately arriving in the central Tibetan region after which he moved on to the Khams area of western Sichuan province. Among a good number of other works, there he authored a profoundly influential grammatical treatise titled Smra ba’i sgo mtshon cha lta bu (* Vacanamukhāyudhopama ), which can be translated as Gate to Speech which is like …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Monoclonal gammopathy associated enteropathy: a potential MGCS related phenotype with response to plasma cell directed therapy

Guo Chen, Li He, Yuan Yuan Chen, Peng Yang, Jing Tan

Background Chronic inflammatory diarrhea with preserved mucosal architecture remains diagnostically challenging when inflammatory bowel disease, autoimmune enteropathy, and infection are excluded. The potential contribution of monoclonal gammopathy in such cases remains poorly defined. Case presentation We report two patients with long-standing, treatment-refractory chronic diarrhea who underwent comprehensive clinical, histopathologic, and hematologic evaluation. Both demonstrated a consistent intestinal pattern c …

03.09.2026journal-article

Frontiers in Oncology

Factors influencing oncologists’ decisions for germline BRCA testing and adjuvant therapy selection in HER2-negative early breast cancer

Qixin Li, M. Janelle Cambron-Mellott, Xiaoqing Xu, Nicole Kashine-Tack, Jennifer F. Hayes, Kathryn Emily Mishkin, Alexandra Gordon, Oliver Will, Lauren A. Howell, Alejandro Noval, Kathleen Beusterien

Introduction With advances in targeted early breast cancer (eBC) treatment, research is needed to understand the factors influencing biomarker testing and respective treatment selection among physicians in routine clinical practice. The purpose of this study was to evaluate factors influencing oncologist decisions for germline BReast Cancer gene (BRCA) mutation (gBRCAm) testing and adjuvant therapy in human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (eBC). Materials and methods US oncol …