Effect of Topical HealFast Silver Ointment on Pain and Early Wound-Healing Parameters After Caesarean Section: A Randomized Placebo-Controlled Clinical Trial

Vollständiger Abstract

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Background: Caesarean section is associated with postoperative pain and wound-related morbidity. Topical agents that promote early wound healing may enhance postoperative recovery. This randomized, placebo-controlled clinical trial evaluated the effect of HealFast Silver Ointment on pain and early wound-healing parameters after Caesarean section. Methods: Two hundred women who underwent Caesarean section were randomly allocated into two groups: a placebo group and a HealFast Silver Ointment group, each consisting of 100 women. The intervention was applied topically three times daily for three weeks. Outcomes were assessed at baseline, week 1, and week 3, and included pain intensity using the Visual Analogue Scale, transepidermal water loss, tissue oxygenation assessment, and wound surface morphology using Visioscan. Results: Baseline characteristics were comparable between groups. At week 3, the Visual Analogue Scale score decreased from 8.13 ± 0.93 to 1.33 ± 0.71 in the treated group, compared with 8.15 ± 1.47 to 7.03 ± 1.95 in the placebo group. Transepidermal water loss decreased from 34.13 ± 6.89 to 6.84 ± 3.99 in the treated group, compared with 32.70 ± 6.67 to 30.77 ± 6.69 in the placebo group. O2C increased from 40.08 ± 6.36 to 57.48 ± 7.19 in the treated group, compared with 40.80 ± 6.70 to 45.00 ± 6.84 in the placebo group. Significant time × group interactions were observed for the main clinical and physiological outcomes. Conclusions: HealFast Silver Ointment was associated with reduced postoperative pain, improved epidermal barrier recovery, increased tissue oxygenation, and improved wound surface morphology during the first three weeks after Caesarean section. Larger registered multicenter trials with longer follow-ups are needed to confirm these findings.