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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Immunology

Overall survival with immune checkpoint inhibitors across treatment settings and clinical and PD-L1-defined subgroups in advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis of randomized trials

Bing Wang, Xiaoyu Han, Zengli Shen

Introduction To quantify overall-survival effects of immune-checkpoint-inhibitor (ICI)-containing regimens by treatment line and to evaluate whether clinical characteristics or PD-L1 definitions modify relative treatment benefit in advanced esophageal squamous cell carcinoma (ESCC). Methods PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science were searched from inception through 1 August 2026. Two reviewers independently screened records, assessed full texts, extracted data, and ev …

03.09.2026journal-article

Frontiers in Public Health

E-health literacy status and its influencing factors among college students majoring in sports

Yue Yin, Jing Chen, Wenqing Zhao, Linwang Hu, Hang Cai, Liang Gao

Objective To understand the level of e-health literacy among sports majors and its influencing factors, providing reference for developing measures to improve e-health literacy in this population. Methods An online survey was conducted among college students from 6 universities in Jiangsu Province using an e-health literacy questionnaire. SPSS 26.0 statistical software was used for χ 2 test. t -test, one-way ANOVA, and multiple linear regression analysis were employed to explore the influencing factors of e-health …

03.09.2026journal-article

Ege Tıp Dergisi

Evaluating GPT-4.1 Mini and GPT-5 in Postmastectomy Lymphedema Patient Education: A Comparative Study of Usefulness and Reliability

Benil Nesli Ata, Ece Cinar, Sibel Eyigör

Aim: To compare the reliability and usefulness of GPT-4.1 mini and GPT-5 in postmastectomy lymphedema patient education.Materials and Methods: Twenty patient-centered questions were developed from reputable sources. Responses from both models were independently rated by three blinded physiatrists using 7-point Likert scales for reliability and usefulness.Results: GPT-5 demonstrated higher usefulness and reliability scores compared to GPT-4.1 mini (p = 0.005 and p = 0.021, respectively).Conclusions: Both models prod …

03.09.2026journal-article

Frontiers in Medicine

Necroptosis–senescence crosstalk in tubulointerstitial fibrosis: the mtDNA–cGAS–STING–PFKFB3 axis as a metabolic bridge

Donghui Wang, Hongxiang Zheng, Xinyue Zhang, Chenghua Zhang, Dandan Zhao, Shuqi Min, Shenju Wang

Background Chronic kidney disease progresses irreversibly toward tubulointerstitial fibrosis. Although renin-angiotensin system inhibitors and sodium-glucose cotransporter 2 inhibitors slow progression, they cannot block or reverse fibrosis. Recent work shows that necroptosis and cellular senescence in tubular epithelial cells are not independent events; they form a dynamically evolving continuum through the mitochondrial DNA-cyclic GMP-AMP synthase-stimulator of interferon genes-interferon regulatory factor 3-6-ph …

03.09.2026journal-article

Hospital Pediatrics

Prevalence and Characteristics of Mental Health Interventions Following Pediatric Hospitalization

Mariah L. DeSerisy, Julia A. Heneghan, Matt Hall, Daniel H. Choi, Leslie A. Dervan, Daniel Garros, Denise M. Goodman, Jason M. Kane, Joseph G. Kohne, Colin M. Rogerson, Nadia Roumeliotis, Vanessa Toomey, Adam C. Dziorny

BACKGROUND AND OBJECTIVES As survival after pediatric critical illness improves, attention has shifted to post–intensive care syndrome and the long-term mental health of pediatric intensive care unit (PICU) survivors, who have high rates of posttraumatic stress, anxiety, and depression. The objective of this study is to examine the rates of new mental health follow-up and psychopharmacology use among publicly insured children following PICU hospitalization, compared with those hospitalized on acute care wards. METH …

03.09.2026journal-article

Livers

Early Versus Late Biliary Leakage After Hepatic Resection: Incidence, Risk Profiles, and Clinical Impact of Diagnostic Timing

Giacomo Paolini, Luca Tirloni, Ilenia Bartolini, Matteo Risaliti, Nicola Nocchi, Alessio Morandi, Maria Novella Ringressi, Antonio Taddei, Gian Luca Grazi

Background/Objectives: Post-hepatectomy biliary leakage (BL) remains a major source of postoperative morbidity. While traditional risk models treat BL as a single clinical entity, its chronological presentation follows distinct patterns that raise the hypothesis of distinct underlying pathophysiological mechanisms. This study aimed to stratify post-hepatectomy biliary fistulas into early and late onset to identify unique independent risk factors and clarify their separate risk profiles. Methods: This retrospective …

03.09.2026journal-article

Journal of Biology and Nature

Effect of Spirulina (Spirulina platensis) Administered in Drinking Water on Growth Performance and Health of the Rabbit (Oryctolagus cuniculus) in the Post-weaning Period

Sangaré Sidiki, Ouattara Adidjatou, Silué Fatogoma Etienne, Kimsé Moussa, Konan André Brou, Alassane Méité

Background: Spirulina (Spirulina platensis) is a nutrient-rich microalga that has been investigated as a feed supplement for improving animal growth and health. However, evidence regarding the effects of low doses of spirulina administered specifically through drinking water to rabbits during the post-weaning period remains limited, particularly for growth performance and health-related outcomes. Aims: To evaluate the effect of three doses of spirulina (Spirulina platensis) administered in drinking water on growth …

03.09.2026journal-article

Sports Health: A Multidisciplinary Approach

Sport-Specific Virtual Reality Tasks Reveal Distinct Patterns of Biomechanical Adaptation Compared With the Drop Vertical Jump

Jennifer A. Hogg, Scott Bonnette, Christopher D. Riehm, Staci Thomas, Manish Anand, Christopher A. DiCesare, Kim D. Barber Foss, Jed A. Diekfuss, Katie Beasley, Andrew Schille, Dustin van der Haar, Dustin R. Grooms, Janet Simon, Sophia Ulman, Richard Danilkowicz, Gregory D. Myer, Michael A. Riley

Background: Neuromuscular training (NMT) improves biomechanical risk factors associated with anterior cruciate ligament (ACL) injury yet has failed to abate increasing ACL injury rates at scale. This study assessed sport-specific sensorimotor adaptations resulting from a NMT protocol with additive real-time sensorimotor augmented biofeedback (augmented NMT [aNMT] or sham aNMT) in a standardized drop vertical jump (DVJ) task and in ecologically valid sport-specific tasks performed in a simulated virtual reality (VR) …

03.09.2026journal-article

Criminal Behaviour and Mental Health

Assault‐on‐Law‐Enforcement: The Complications of Charges for Individuals on Mental Health Court Dockets

Steven Keener, Audrey Morrison

ABSTRACT Background Mental health courts divert individuals with serious mental illness away from imprisonment into community‐based treatment and supervision. Early research indicates that such treatment contracts can reduce recidivism and provide various other benefits. Aspects of eligibility for this diversion option are still under‐researched. Aims To explore the nature of alleged offences against people accepted into mental health courts (on mental health court dockets), and their demographic and mental health …

03.09.2026journal-article

Revista Psicologia, Diversidade e Saúde

Vínculos psicossociais e saúde mental de adolescentes: contribuições do psicodrama em interface com o existencialismo no contexto escolar

Gilmar Antoniassi Junior, Díone Gomes Silva

INTRODUCTION: Adolescence is a period of intense biopsychosocial transformations, in which emotional and social challenges may impact mental health, and school represents a strategic space for the promotion of well-being. OBJECTIVE: To analyze the mental health condition of adolescents, highlighting the influence of psychosocial bonds on their reasons for living, and to discuss the contributions of psychodrama in interface with existentialism in the school context. METHODS: This is a descriptive and exploratory stu …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Factors Influencing the Uptake of Health Care Services Among Undergraduate Students of Kwara State University, Malete, Kwara State

Okunade O. Oluwole

Background: Healthcare services are the activity undertaken by individuals who perceive to have a health problem or to be ill for the purpose of finding an appropriate remedy. Traditional herbal medicines have been used to treat malaria for thousands of years and are the source of the two main groups (artemisinin and quinine derivatives) of modern antimalarial drugs. With the problems of increasing levels of drug resistance and difficulties in poor areas of being able to afford and access effective antimalarial dru …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Influence of Ethanol, Methanol and N-Hexane Extracts of Kigelia Africana Leaves and Fruits on Oxidative and Biochemical Properties in Induced Diabetic Rats

Erienu Obruche Kennedy

Diabetes mellitus is a common metabolic disorder characterized by sustained hyperglycemia, oxidative stress, and disrupted biochemical parameters. This study investigated the effects of ethanol, methanol, and n-hexane extracts from the leaves and fruits of Kigelia africana on oxidative and biochemical markers in alloxan-induced diabetic rats. The plant materials were extracted using maceration and solvent evaporation methods. Diabetes was induced by a single intraperitoneal dose of alloxan monohydrate. Experimental …

03.09.2026journal-article

LATAM Revista Latinoamericana de Ciencias Sociales y Humanidades

Alfabetización en Salud Renal en adultos jóvenes: una estrategia de enfermería para prevenir la enfermedad renal crónica en atención primaria. Búsqueda narrativa

Maria Fernanda Cruz Hernandez, Yaneth Martinez Hernandez, José Arias Rico, Esther Ramírez Moreno, Aldo Pelcastre Neri

La insuficiencia renal crónica (IRC) se define como la pérdida progresiva, permanente e irreversible de la tasa de filtración glomerular a lo largo de un tiempo variable, a veces incluso de años, expresada por una reducción del aclaramiento de creatinina estimado < 60 ml/min/1,73 m2 (1). La enfermedad renal crónica (ERC) constituye un importante problema de salud pública debido a su creciente incidencia, elevada carga económica y repercusiones sobre la calidad de vida. Aunque tradicionalmente se asocia con adultos …

03.09.2026journal-article

Borneo Nursing Journal (BNJ)

Perbedaan Pengaruh Brisk Walking Dan Mindfulness Walking Terhadap Peningkatan Kualitas Hidup Pada Lansia Di Panti Jompo

Maria Yosefina Reinit, Abdillah Choirul Chisholi, Suci Muqodimatul Jannah

Penurunan kualitas hidup pada lansia merupakan konsekuensi dari proses penuaan yang menyebabkan penurunan fungsi fisik, psikologis, dan sosial. Aktivitas fisik menjadi salah satu intervensi yang direkomendasikan untuk menjaga kesehatan serta meningkatkan kualitas hidup pada kelompok lanjut usia. Brisk Walking Exercise dan Mindfulness Walking Exercise merupakan dua bentuk latihan berjalan dengan mekanisme yang berbeda dalam meningkatkan kondisi fisik maupun psikologis lansia. Penelitian ini bertujuan untuk menganali …

03.09.2026journal-article

Saudi Journal of Medicine and Public Health

Abdominal Tuberculosis: An Interdisciplinary Approach to Diagnosis, Treatment, and Patient Care-An Updated Review

Majd Abdulrhman Almutiri, Eman Mohammad S. Al Dawood, Ashwag Saleem Almuzaini, Thekra Bandar Khalid Albahuoth, Hussam Hussain Abdullah Ashawi, Omar Muteb S. Alhammadi, Musaad Eid Saeed Aldosari, Abdullah Yahya H. Oagde, Awatef Rabah Almamoni

Background: Abdominal tuberculosis is an important extrapulmonary manifestation of Mycobacterium tuberculosis infection and remains a diagnostic challenge because of its variable, nonspecific, and often indolent presentation. Its clinical and pathological similarities with other gastrointestinal diseases may result in delayed or inappropriate diagnosis. Aim: To provide a comprehensive overview of the etiology, epidemiology, pathophysiology, histopathology, clinical presentation, diagnostic evaluation, differential …

03.09.2026journal-article

Journal of Public and Nonprofit Affairs

Association between Organizational Performance and Job Satisfaction:How Sectoral Identity Moderates the Relationship

Minjung Kim

Job satisfaction is a key element of human resource management, yet the association between organizational performance and employee job satisfaction remains theoretically underdeveloped, particularly regarding the direction of influence and how institutional context shapes this relationship. Drawing on organizational climate theory and social identity theory, this study examines how organizational performance is associated with job satisfaction and whether sectoral identity moderates this relationship. Using a pane …

03.09.2026journal-article

Technology and Health Care

Accuracy improvement for heart rate monitoring from bed-based ballistocardiography signals with motion artifacts

Zeya Wang, Zhumu Fu, Hua Wang, Xiutao Cui, Yeping Zheng, Qin Yu, Xin Chen, Qiqi Shao, Bin Feng

Abstract Background Ballistocardiography (BCG)-based heart rate (HR) monitoring faces accuracy degradation due to motion artifacts, limiting its practical deployment. Objective This study aims to enhance HR estimation reliability under motion-contaminated conditions while ensuring real-time performance. Methods A hybrid system integrating adaptive filtering and enhanced continuous wavelet transform (CWT) is developed. The framework localizes motion segments (95.1% accuracy) and employs spectral reconstruction via m …

03.09.2026journal-article

Global Spine Journal

Testosterone Replacement Therapy is Associated With Increased Risk of Pseudarthrosis After Single-Level Anterior Cervical Discectomy and Fusion: A Propensity Matched Analysis

William Han, Kyle Stump, Karim Gubara, Prabhat Gottipati, Stephan Aynaszyan, Theresa Pazionis

Objective To evaluate whether preoperative testosterone replacement therapy (TRT) use is associated with increased risks of pseudarthrosis and reoperation following single-level anterior cervical discectomy and fusion (ACDF). Methods The TriNetX Research Network was queried to identify adult males aged 18 to 89 years who underwent single-level ACDF. Patients were separated into a TRT exposure group within 1 year before initial ACDF procedure as well as comparator cohort without TRT exposure that was matched 1:1 usi …

03.09.2026journal-article

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

<b>EXERCÍCIO FÍSICO, IRISINA E CÂNCER: REVISÃO NARRATIVA DOS MECANISMOS MOLECULARES E DAS EVIDÊNCIAS EXPERIMENTAIS E CLÍNICAS</b>

Elias Campos Martins Bonilha

A irisina é uma mioquina liberada predominantemente pelo músculo esquelético durante a prática de exercícios físicos e participa da comunicação entre o tecido muscular e diferentes órgãos. Nos últimos anos, essa molécula tem despertado interesse na oncologia devido ao seu possível envolvimento nos benefícios do exercício sobre o desenvolvimento e a progressão tumoral. Objetivo: Reunir e discutir, por meio de revisão narrativa, as evidências sobre a atuação da irisina produzida pelo exercício físico no câncer, com ê …

03.09.2026journal-article

Nutrition and Health

Antioxidant status and dehydroepiandrosterone sulfate in aging: Evidence from MIDUS 3 biomarkers cohort

Laith Ashour, Leen Altiti, Rand Khawaldeh, Batool Abuqudaira, Rakan Hani Wadi, Mera Jaber, Basae'r Najadat, Shaima Jaber, Rand Ibrahim Awwad, Tuqa Waleed Smadi, Sara Jamal Mohammad

Background Dehydroepiandrosterone sulfate (DHEAS) has been consistently linked to cardiovascular and skeletal health; however, the relationship between circulating antioxidant concentrations, including vitamins, and DHEAS levels in older adults has been insufficiently examined. Aim To assess associations between serum DHEAS and five antioxidants: β-cryptoxanthin, total lycopene, α-tocopherol, γ-tocopherol, and retinol. Methods Data from the Midlife in the United States (MIDUS3) Biomarker Project (2017–2022) were an …

03.09.2026journal-article

International Journal of Adolescent Medicine and Health

The dual impact of digital integration and peer influence on smartphone addiction and psychological distress among Indonesian adolescents

Marthoenis Marthoenis, Julianti Jauhari

Abstract Adolescents in higher health professional education experience heightened academic and clinical pressures, increasing their vulnerability to mental health problems. This study examined the prevalence of depression, anxiety, and stress, and identified key psychosocial predictors among Indonesian adolescents. A cross-sectional survey was conducted among 1,886 health polytechnic adolescents from multiple campuses of an Indonesian Health Polytechnic. Participants completed an online questionnaire including the …

03.09.2026journal-article

Pediatric Blood & Cancer

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich

ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA protocol for vessel thrombosis and mechanical valve obstruction in infants and children, and to characterize D‐dimer kinetics by indication. Methods This retrospecti …

03.09.2026journal-article

Revista Portuguesa de Doenças Infecciosas (RPDI)

Protocolo de utilização de soluções de bloqueio com antibiótico em cateter venoso central

Luisa Graça, Betânia Abreu Faria, Joana Laranjinha, Charlene Viana, Catarina Silva, Marcelo Costa, Sandra Teixeira, Susana Ribeiro, Diana Gaspar, Joana Alves, Ana Cláudia Carvalho

Introdução: Perante uma infeção associada a cateter venoso central, a remoção do cateter é a opção privilegiada para o controlo do foco. Quando tal não é possível, o uso de soluções de bloqueio de altas concentrações de antibiótico (ou lock) associa-se a uma melhor resposta do que a antibioterapia sistémica isoladamente. A eficácia desta técnica está dependente do agente de infeção e das soluções utilizadas. Objetivos: Uniformizar a prescrição e aplicação da solução de bloqueio com antibiótico e, assim, maximizar a …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Effects of a neo-functional psychotherapeutic approach on post-traumatic stress disorder following spontaneous coronary artery dissection: a case report

Emilia Solinas, Filippo Luca Gurgoglione, Andrea Denegri, Giorgio Benatti, Rossella Giacalone, Manjola Noni, Giulia Magnani, Luigi Vignali, Giampaolo Niccoli, Caterina Viaro, Enrica Pedrelli, Rita Pinetti, Roberta Rosin, Luciano Sabella, Giuseppe Rizzi, Luciano Rispoli

Background Post-traumatic stress disorder (PTSD) is increasingly recognized after acute coronary syndromes, including spontaneous coronary artery dissection (SCAD), a condition predominantly affecting women. PTSD symptoms may negatively influence autonomic regulation, adherence to therapy, and cardiovascular outcomes. Evidence regarding structured psychotherapeutic interventions targeting SCAD-related PTSD is limited. Case presentation A 58-year-old woman was admitted with non–ST-elevation myocardial infarction due …