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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Nutrition

Development of a three-item short form of the EAT-10 for screening suspected dysphagia in hospitalized older adults: findings from a multicentre study

María Trinidad Castillo-García, Irene Llagostera-Reverter, Joaquín Moncho-Vasallo, Víctor M. González-Chordá, Cristina Carretero-Randez, María Isabel Orts-Cortés, NUTRIFAG Group

Aim To develop a three-item short form of the EAT-10 by identifying the smallest subset of items that preserves the screening performance of the full questionnaire in hospitalized older adults. Design Multicentre cross-sectional observational study. Methods The study was conducted in nine public hospitals in Spain within the NUTRIFAG project. Hospitalized patients aged ≥65 years with a length of stay ≥48 h were included. Patients receiving enteral or parenteral nutrition at admission, those in terminal condition, o …

03.09.2026journal-article

Frontiers in Aging Neuroscience

Multidimensional iron dysmetabolism and gut-brain axis interactions in restless legs syndrome: from peripheral deficiency to central dysregulation

Ziyang Liu, Yunsong Zhang, Yating Li, Ting Li, Jianbo Jia, Tao Cai

Restless Legs Syndrome (RLS) is a sensorimotor neurological disorder characterized by an irresistible urge to move the lower limbs. Although traditional paradigms attribute its pathogenesis to peripheral iron deficiency, many clinically diagnosed patients present with normal peripheral iron indicators yet exhibit central iron homeostatic dysregulation. This discrepancy highlights a distinct decoupling between peripheral iron stores and central iron availability. The RLS-associated iron metabolic impairment is inher …

03.09.2026journal-article

Working with Older People

Healthy ageing among older LGBTQIA+ adults: a conceptual framework for promoting inclusive ageing systems

Afsara Khanam Mehter, V.V. Ravi Kumar, Mrigakshi Mehta

Purpose This study aims to synthesise the existing literature on healthy ageing among older LGBTQIA + adults to develop a conceptual framework and discuss ways of creating inclusive ageing systems. Design/methodology/approach An integrative literature review was conducted using peer-reviewed articles retrieved from the Scopus and Web of Science databases. Following the removal of duplicate and non-relevant records, 82 studies were included in the review. A thematic synthesis was undertaken to identify key themes re …

03.09.2026journal-article

Frontiers in Public Health

Staff-mediated doll therapy in Chinese residential dementia care: an exploratory pilot and feasibility mixed-methods cluster randomized clinical trial

Zhenti Cui, Rongrong Guan, Tianrui Xue, Yongchang Sun, Maw Pin Tan, Mas Ayu Said, Yingdong Cao

Background Doll therapy is a person-centered intervention for behavioral and psychological symptoms of dementia, but evidence from Chinese nursing homes and information about implementation, medication use, and ethical acceptability remain limited. Methods We conducted an exploratory pilot and feasibility mixed-methods cluster-randomized clinical trial in six nursing homes in Zhengzhou, China. Homes were randomized 1:1 to a staff-mediated doll-therapy care package plus routine care or routine care alone. Residents …

03.09.2026journal-article

European Geriatric Medicine

Improving diabetes management in older adults with cancer: a quality improvement project to enhance monitoring during steroid-based systemic anti-cancer therapy

Evelyne Liuu, Rose Evans, Nathanael Bassas-Letissier, Gitanjali Amaratunga, Sarah Compton, Alexandros Georgiou, Tania Kalsi, Yuk-Fun Liu, James Maguire, Clare Nottage, Hannah L. Rush, Carly Welch

Abstract Purpose Older adults undergoing systemic anti-cancer therapy (SACT) with steroids are at high risk of developing steroid-induced hyperglycaemia (SIH). However, monitoring and management remain inconsistent. This quality improvement project (QIP) involved developing and evaluating the GOLD diabetes enhanced monitoring pathway, a multidisciplinary, age-adapted initiative for older patients at intermediate SIH risk. Methods The pathway was implemented at Guy’s and St Thomas’ NHS Foundation Trust between Febru …

03.09.2026journal-article

Clinical Oral Investigations

Oral health and functioning in older adults in Switzerland from 1970 to 2025 - a systematic review and meta-analysis

Roberta Borg-Bartolo, Maurus Jaeggi, Martin Schimmel, Hendrik Meyer-Lueckel

Abstract Objectives This systematic review analysed the oral health status, chewing function, and quality of life among individuals aged ≥ 65 years in Switzerland using studies published from 1970 onwards. Materials and methods The electronic databases Embase, MEDLINE via PubMed, Swiss data repositories, and manual searches were screened. Risk of bias was assessed using the Joanna Briggs Institute tools. Meta-analyses were performed using the random-effects models with 95% confidence intervals to assess the prevale …

03.09.2026journal-article

Frontiers in Sports and Active Living

Physical exercise and circulating α-Klotho in humans: a systematic review and meta-analysis with emphasis on older adults

Aigul A. Abduldayeva, Saule A. Iskakova, Gulnur N. Doszhanova, Nikolay A. Safonov, Aliya M. Tuliyeva

Introduction Global aging and the growing burden of age-related disease have intensified interest in modifiable biomarkers of biological age. α -Klotho, the product of the KL gene, is a pleiotropic anti-aging protein whose circulating (soluble, s-Klotho) form declines with age and is independently associated with all-cause mortality, sarcopenia, cognitive deficit, and cardiovascular events. We conducted a systematic review and meta-analysis of publications from 2015 to 2025 evaluating the effect of exercise trainin …

03.09.2026journal-article

The Journal of Infectious Diseases

Factors Associated with Persistently Increased IL-6 Levels in People with HIV

Victoria S Kjærgaard, Bruno Ledergerber, Wendy Bannister, Ricardo Cortez Cardoso Penha, Jason V Baker, Simon Collins, H Clifford Lane, Gail V Matthews, Sarah L Pett, Cavan Reilly, Amy Weintrob, Maja Milojevic, Jens Lundgren

Abstract Background Individuals with HIV remain at higher risk of non-communicable diseases associated with interleukin-6-specific (IL-6) inflammation compared to the background population. Despite antiretroviral therapy, some individuals exhibit persistent hyperinflammation. We characterise these understudied longitudinal profiles and distinguish the predictors of chronic versus acute inflammation. Methods A subset from the Strategic Timing of Antiretroviral Treatment (START) trial with up to seven years of biomar …

03.09.2026journal-article

Frontiers in Public Health

Future care preparation profiles and self-support ability among rural Chinese older adults: a cross-sectional study

Fangyuan Wang, Xianhong Li, Jiajia Han, Yinghui Guan, Jiaqi Tian, Le Xu, Bing Huang, Jianhui Xie

Background Population aging is accelerating worldwide, and rural older adults may face particular challenges because of limited access to formal care resources. Preparation for future care (PFC) is a multidimensional process involving awareness, avoidance, decision-making, and concrete planning. This study identified latent PFC profiles among rural older adults in China and examined their association with self-support ability. Methods A cross-sectional survey was conducted among 851 older adults from 16 rural villa …

03.09.2026journal-article

Frontiers in Sociology

Forced displacement and gendered violence in conflict zones in the southern Philippines: the experiences of internally displaced people from Zamboanga and Marawi

Diana Therese Montejo Veloso

Migration is not always by choice, but rather, influenced by circumstance. Displacement due to human-made disasters, such as armed conflict, constitutes forced migration, also known as involuntary migration. This paper examines the experience of forced displacement due to armed conflict and the risk of gender-based violence (GBV) in conflict zones in the southern Philippines, focusing on the survivors of the 2013 Zamboanga Siege and the 2017 Marawi Siege. The researcher examines the dynamics of violence during arme …

03.09.2026journal-article

Ege Tıp Dergisi

Computed tomography-derived muscle metrics and functional outcomes after proximal femoral nailing in older women with intertrochanteric fractures

Fatih Erdem, Mustafa Çeltik

Aim: To examine whether computed tomography (CT)-derived cross-sectional area (CSA) and radiodensity (Hounsfield units, HU) of the psoas, gluteus maximus, and gluteus medius-minimus are associated with postoperative function in women aged ≥65 years treated with a proximal femoral nail (PFN) for intertrochanteric fracture.Materials and Methods: Sixty-three women aged ≥65 years undergoing PFN fixation for intertrochanteric fracture were analyzed retrospectively. Muscle measurements were obtained on standardized axial …

03.09.2026journal-article

CIVIL SOCIETY IN RUSSIA AND ABROAD

The Rule of the People as the Fundamental Principle of Constitutional Order

Sergey S. Zenin

The article is devoted to the study of the place and role of direct democracy in the system of foundations of the constitutional system of the Russian Federation. The author conducts a critical analysis of the functional and institutional approaches to understanding the constitutional system that have developed in the Russian doctrine and comes to the conclusion that none of them reveals its starting point. The position is substantiated, according to which such a primary basis is popular sovereignty, implemented in …

03.09.2026journal-article

Frontiers in Aging Neuroscience

Joint network analysis of non-motor symptoms and quality of life in patients with Parkinson’s disease

CaiNi Wu, XueYing Wang, JiaJia Li, ShaoHua Yang, Xue Cong, Yi Jin

Background Non-motor symptoms (NMS) are highly prevalent in Parkinson’s disease (PD) and are major determinants of declining quality of life (QoL), yet traditional statistical approaches are insufficient to capture the complex interactions between NMS and QoL. Network analysis offers a promising alternative for exploring these interactions. Objective To construct a joint network of non-motor symptoms (NMS) and quality of life (QoL) in patients with Parkinson’s disease (PD), identify core and bridge nodes, and infor …

03.09.2026journal-article

AIDS

Circulating markers of organ damage associate with COPD in people with HIV: an exploratory proteomic analysis

Lennart Riemann, Lena Böger, Carina Dahl, Timo Gemoll, Sandra Steffens, Charisis Totsikas, Metodi V. Stankov, Alexandra Dopfer-Jablonka, Christine Happle, Georg M.N. Behrens

Background: People with HIV (PWH) develop chronic obstructive pulmonary disease (COPD) more frequently and at younger ages than the general population, yet the circulating proteomic correlates of COPD in PWH remain poorly characterized. Methods: We applied a targeted 92-plex organ damage proteomics panel (Olink Organ Damage) to compare serum protein profiles between 38 PWH with established COPD and 49 PWH without COPD, enrolled in a prospective observational cohort. Results: Differential abundance analysis adjusted …

03.09.2026journal-article

Frontiers in Human Neuroscience

The association between nonverbal fluency and anomia treatment outcomes in people with post-stroke aphasia

Deena Schwen Blackett, Victoria A. Diedrichs, Alexandra Zezinka Durfee, Courtney C. Jewell, Stacy M. Harnish

Introduction Many people with aphasia experience concomitant executive functioning deficits, and the literature supports a role of executive functioning in treatment response. However, the optimal executive functioning assessment for measuring this impact is unclear, as is the extent to which outcomes (e.g., acquisition, generalization) may be impacted differently. The present retrospective study aimed to determine the degree to which nonverbal fluency, one measure of executive functioning with minimal language dem …

03.09.2026journal-article

Frontiers in Aging Neuroscience

Inflammation and delirium in critically Ill patients: a review

Liang Li, Xiaoli Wang, Jialin Liu

The high prevalence and adverse impact of delirium in critically ill patients necessitate a deeper understanding of its mechanisms. This review explores the pivotal interplay between systemic inflammation and delirium, examining how insults like age, pain and surgery orchestrate neuroinflammation and delirium through microglial activation and blood-brain barrier disruption. Our synthesis identifies a spectrum of inflammatory and neuronal injury biomarkers with prognostic value and evaluates the burgeoning field of …

03.09.2026journal-article

Frontiers in Dementia

Mapping intersectionality in dementia care research: a decadal scoping review

Martina Roes, Franziska Laporte Uribe, Simone Anna Felding, Georgina Charlesworth, Nicole Müller, Saloua Berdai, Jem Bhatt, Kuebra Altinok, Viktoria Peters-Nehrenheim

Background In the past decade, an increasing number of studies have addressed health care disparities and the complex determinants of care for diverse populations. At the same time, it remains unclear how social categories (e.g. gender, ethnicity, migration status, socioeconomic position) intersect with health care disparities for people living with dementia and may lead to experiences of inequity and inequality. Aim This scoping review analyzes the use of intersectionality frameworks and intersection analyses in d …

03.09.2026journal-article

BMC Health Services Research

Associations between physical activity in adulthood and utilisation of municipal home and long-term healthcare services in older age: the HUNT study

Aslaug Angelsen, Sigrid Nakrem, Bjørn Heine Strand, Linn Beate Strand

Abstract Background Physical activity is a key component in public health frameworks to maintain functional ability through ageing. In Norway, healthcare services such as home health nursing and long-term institutional stays for older adults account for a significant amount of healthcare expenditures, but little is known about the association between physical activity levels through adulthood and utilisation of these services later in life. To this end, we wanted to explore an association between physical activity …

03.09.2026journal-article

Frontiers in Psychiatry

Potentially inappropriate medications in older outpatients with depression: a cross-sectional study comparing the Beers criteria and the Chinese criteria

Hong Jiang, Xiaojuan Zhou, Pinpin Feng, Zhongni Xia, Wenjuan Yang, Bing Han, Meiling Zhang, Qinqin Zhao

Objective To determine the prevalence of PIMs and identify associated factors in older Chinese outpatients with depression, using a combined evaluation based on the 2023 Beers criteria and the 2017 Chinese criteria. Methods A cross-sectional study was conducted at a provincial tertiary psychiatric hospital in China, enrolling older outpatients (≥ 65 years) diagnosed with depression. PIM status was identified according to the 2023 Beers criteria and the 2017 Chinese criteria. Logistic regression analyses were perfor …

03.09.2026journal-article

Frontiers in Systems Biology

Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum

Andrea Angarita-Rodríguez, Johan H. Largo-González, Julián Pérez-Mejía, Daniel Balcazar, Viviana Vargas-López, Jason A. Papin, Andrés Pinzón, Janneth González

Introduction Mild cognitive impairment (MCI) represents a prodromal stage of Alzheimer’s disease (AD), but the metabolic mechanisms underlying early neuronal dysfunction remain incompletely understood. GABAergic neurons, which maintain excitatory–inhibitory balance and network stability, exhibit early vulnerability during neurodegeneration, although the metabolic alterations associated with their dysfunction remain poorly characterized. Methods We developed a context-specific genome-scale metabolic model (GEM) of h …

03.09.2026journal-article

International Journal of STD & AIDS

Anti–IL-17 therapy in people living with HIV who have cutaneous psoriasis: A four-patient case series

Melike Merve Güçlü, Fatma Aslı Hapa, Fatma Elif Yıldırım

Aim To describe the clinical, immunological, virological and safety outcomes observed during anti–IL-17 therapy in patients living with HIV who had cutaneous psoriasis. Method Four patients living with HIV who had cutaneous psoriasis and were treated with anti–IL-17 agents were included in this case series. Psoriasis Area Severity Index (PASI) scores, CD4 cell counts, HIV RNA levels, treatment duration and adverse events were obtained from medical records. Results Three patients received secukinumab and one receive …

03.09.2026journal-article

Psicologia: Reflexão e Crítica

Spanish version of the personal experience of aging scale: psychometric analyses from classical and network psychometrics approaches in a Chilean sample

Oscar Terán-Mendoza, Vicente Cancino

Abstract Background How people experience aging is linked to health, well-being, and engagement in later life, but Spanish-language measures for capture self-perceptions of aging in Latin America remain limited. Objective To adapt the Personal Experience of Aging Scale (PEAS) into Spanish and evaluate its psychometric properties in Chilean adults aged 50 and older. Methods The instrument was translated into Spanish, and content validity was examined by expert judges. Two independent community samples from Chile (ex …

03.09.2026journal-article

Frontiers in Psychiatry

Clinical characteristics and neuropsychiatric profiles of young-onset dementia: a retrospective cross-sectional study at a tertiary care center in Northern Thailand

Sirivipa Jekpoo, Kittithatch Booncharoen, Supisara Prompila, Tinakon Wongpakaran, Huali Wang, Nahathai Wongpakaran

Background Data on young-onset dementia (YOD) in Thailand remain limited. We aimed to describe clinical presentation, general cognitive performance, neuropsychiatric symptoms, neuroimaging features, and selected laboratory findings across YOD subtypes in a tertiary-care cohort in Northern Thailand. Methods We conducted a retrospective cross-sectional study of 295 individuals with YOD (symptom onset < 65 years) treated at Chiang Mai University Hospital (2010–2025). Data extracted included demographics, presenting …

03.09.2026journal-article

Frontiers in Psychiatry

Prevalence, role impairment, and mental health service utilization of depressive disorders among community-dwelling older adults in China

Dandan Wang, Xiaofei Hou, Zhaorui Liu, Yueqin Huang, Shuiyuan Xiao, Lingjiang Li, Tingting Zhang, Jie Yan, Yaqin Yu, Xiufeng Xu, Zhizhong Wang, Yifeng Xu, Tao Li, Xiangdong Xu, Limin Wang, Yongping Yan, Minghui Li, Guangming Xu, Huifang Yin

Background Depressive disorders pose a significant public health burden, particularly among older adults. However, their prevalence, associated factors, role impairment, and mental health service utilization patterns among community-dwelling older ay -30dults in China remain understudied. Methods The data for this study were obtained from the China Mental Health Survey (CMHS) among participants aged 60 years and older. The World Health Organization Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) …