Alle Themen: neue Gesundheitspublikationen – Seite 162

08.09.2026journal-article

Environmental Health

Associations between prenatal air pollution exposure and adverse birth outcomes: a siblings-matched case-control study

Fengxiang Qin, Xuemei Xu, Liangqin Mao, Xuanqian Huang, Gangjie Wei, Peini Lu, Chong Chen, Yingrong Chen, Dan Luo, Boyang Wang, Xiaomin Wang, Guanghui Dong, Wu Jiang, Shun Liu

Abstract Background Previous studies linking prenatal air pollution to adverse birth outcomes may be confounded by unmeasured familial factors, potentially leading to biased effect estimates and misleading public health recommendations. Methods This sibling-matched case-control study re-examined associations between six criteria air pollutants and preterm birth (PTB), low birth weight (LBW), and small-for-gestational-age (SGA). Associations were assessed using both a sibling-matched generalized linear mixed model ( …

08.09.2026journal-article

Cancer Cytopathology

Economic value and clinical role of minimally invasive, biopsy‐based diagnostics in non‐small cell lung cancer

Jiayuan Guo, Bo Franzén, Rolf Lewensohn, Martin Hysek, Linus Jönsson

Abstract Background Precision oncology requires diagnostic sampling that delivers molecularly actionable material quickly and safely. In non‐small cell lung cancer (NSCLC), core‐needle biopsy (CNB) remains common. Yet fine‐needle aspiration (FNA) has re‐emerged with rapid on‐site evaluation (ROSE), optimized cell blocks, and next‐generation sequencing. The objective of this study was to compare the economic costs of FNA versus CNB with respect to an FNA‐first with predefined CNB escalation strategy for NSCLC clinic …

08.09.2026journal-article

Environment and Planning C: Politics and Space

Municipal governance, jurisdiction, and punitive local responses to health and social crises in a small British Columbia city

Trevor Wideman, Sharon Karsten, The Walk With Me team

The Province of British Columbia (BC), Canada, is experiencing acute and overlapping health and social crises that have spread from the largest cities into smaller municipalities, where limited resources and supports are increasingly strained by visible poverty, homelessness, and substance use on local streets. While some smaller municipalities have responded by seeking additional supports for affected populations, others have pursued more punitive measures, such as dismantling tent encampments, opposing harm reduc …

08.09.2026journal-article

Journal of Clinical Technology and Theory

HPV integration landscape in precancerous lesion of cervical cancer

Yuancheng Chen, Wei Chen, Yaping Li, Wei Wang

Persistent high-risk Human Papillomavirus (HPV) infection is the major cause of cervical cancer. The integration of HPV DNA into human genome is key event during cervical carcinogenesis. However, the viral integration profiles in precancerous lesion samples remain incompletely characterized. Here, this study identified HPV-human genome integration breakpoints in cervical precancerous lesion through high-risk HPV genome capture sequencing of 500 Thinprep Cytologic Test (TCT) samples. After sequencing reads alignment …

08.09.2026journal-article

Journal of Neurology

Autoantibodies targeting G protein-coupled receptors and clinical outcome after ischemic stroke (PROSCIS-B)

Anna-Sophia Miesenberger, Friederike A. Arlt, Leif Koschützke, Pimrapat Gebert, Harald Heidecke, Kai Schulze-Forster, Rusan Ali Catar, Guido Moll, Christoph Harms, Anna Kufner, Thomas Liman, Harald Prüss, Matthias Endres, Pia S. Sperber

Abstract Background G protein-coupled receptor (GPCR) directed regulatory autoantibodies (RABs) have previously been linked to poor functional outcome after ischemic stroke. We investigated the impact of anti-α1/α2/β1/β2 receptor, endothelin B receptor, angiotensin II receptor type 2, and CXCR3 receptor directed RABs on functional outcome and recurrent events after ischemic stroke. Methods Data were derived from the Prospective Cohort with Incident Stroke Berlin (PROSCIS-B; NCT01363856). RABs were measured by ELISA …

08.09.2026journal-article

Journal of the American Medical Informatics Association

Evaluating retrieval-augmented generation versus long-context input for clinical reasoning over electronic health records

Skatje Myers, Dmitriy Dligach, Timothy A Miller, Samantha Barr, James Landefeld, Yanjun Gao, Matthew M Churpek, Anoop Mayampurath, Majid Afshar

Abstract Objective To evaluate whether retrieval-augmented generation (RAG) can serve as an efficient alternative to long-context prompting for clinical reasoning over electronic health records (EHRs). Materials and Methods We defined 3 EHR-based tasks that are replicable across health systems and vary in reasoning complexity: (1) extracting imaging procedures (modality, date, and anatomic site), (2) generating timelines of therapeutic antibiotic use, and (3) identifying the key diagnoses for a hospitalization. Usi …

08.09.2026journal-article

Advanced Healthcare Materials

Engineering a Multifunctional Sprayable Curcumin‐Modified Polyitaconate‐Based Hydrogel to Accelerate Methicillin‐Resistant Staphylococcus aureus ‐Infected Wound Healing

Min Wang, Guoqiang Wang, Sihua Li, Jiachen Wang, Jing Tian, Yanzi Zhao, Hao Yang

ABSTRACT Hydrogel dressings that can simultaneously curb infection and dampen inflammation are particularly attractive for accelerating multidrug‐resistant bacteria‐infected wound healing. However, clinical translation of many reported hydrogels is often constrained by multi‐component formulations, complicated preparation procedures, and insufficient sprayability, which limit conformal coverage on irregular wound beds. Polyitaconate possesses intrinsic antibacterial and anti‐inflammatory activities, yet its weak an …

08.09.2026journal-article

European Journal of Haematology

Translational Insights From the Molecular Landscape to Precision Therapy in Peripheral T‐Cell Lymphoma: Integrating Multi‐Omics and Artificial Intelligence

Qiuyu Zhang, Wei Fang, Yanyan Liu

ABSTRACT Peripheral T‐cell lymphoma (PTCL) is a heterogeneous group of aggressive malignancies with poor prognosis and limited response to standard chemotherapy. Although recent advances in molecular and biological characterization have refined PTCL classification, profound molecular heterogeneity continues to result in highly variable treatment outcomes. Emerging targeted and immunotherapeutic agents show activity in specific subtypes, yet responses remain difficult to predict amid their biological complexity. Thi …

08.09.2026journal-article

Nursing Philosophy

When Nurses Witness Discrimination: Epistemological Silence and the Nursing Justice Reflexivity Framework

Kamel Abdi, Aram Karimian

ABSTRACT Discrimination in healthcare is conventionally framed as a matter of patient experience or individual clinician bias. What is notably absent from the theoretical and empirical landscape of nursing is a systematic engagement with nurses' own witnessing of discrimination—not as neutral observers, but as professionals embedded within organisational structures that impose, encourage, or normalise discriminatory practices. This article argues that this absence is not a mere oversight but an epistemological patt …

08.09.2026journal-article

Research in Nursing & Health

Effects of Interprofessional Collaborative Practice in Older Adults’ Hip Fractures Care: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Santo Imanuel Tonapa, I‐Chin Huang, Bih‐O Lee, Wendy Chaboyer

ABSTRACT This study aimed to evaluate the effectiveness of interprofessional collaborative practice interventions in improving activities of daily living, quality of life, length of stay, and in reducing mortality among older adults with hip fractures. Systematic review and meta‐analysis of randomized controlled trials. Eight databases including AgeLine, PubMed, Embase, CINAHL Ultimate, Scopus, MEDLINE Ultimate, Web of Science, and the Cochrane Library were searched from inception to November 2025. Two reviewers in …

08.09.2026journal-article

Clinical Practice and Cases in Emergency Medicine

Medicolegal Pitfalls in Management of Shoulder Dislocations: A Case Series

Clara Billings, Aaron Thomas, Abigail Bardwell, Rachel Lindor

Introduction: Shoulder dislocations comprise approximately half of all major joint dislocations evaluated in the emergency department. Despite often being considered a simple injury, diagnosing a dislocation can be difficult, especially when accompanied by a fracture associated with unusual mechanism, or when the physical examination is limited. Missed and delayed diagnoses can result in poor patient outcomes and legal risks for clinicians, necessitating a high level of vigilance. Case Series: We review three medic …

08.09.2026journal-article

Current Addiction Reports

Medetomidine as a Fentanyl Adulterant: Pharmacology, Detection, Clinical Presentation, and Management

Kory S. London, Philip Durney, Brendan Hart, Ashish Thakrar, Dennis Goodstein, Alex J. Krotulski, Daniel Teixeira da Silva, Joseph D’Orazio, Lara Carson Weinstein, Jeanmarie Perrone, Michael J. Lynch

Abstract Purpose of Review Medetomidine is a veterinary α2-adrenergic agonist that has been an adulterant of illicitly manufactured opioids since 2022. We review its pharmacology, detection, intoxication, withdrawal, and management, and assess why severe withdrawal has emerged in some regions but not others. Recent Findings Medetomidine has spread through North American drug markets yet evades most toxicology testing. Roughly two hundred times more potent than xylazine, with greater α2 selectivity and imidazoline-1 …

08.09.2026journal-article

PLOS One

A study on the efficiency and spatial correlation of health resource allocation in Chinese hospitals

Yan Zhao, Guang Song, Weilong Zhao, Ting Min, Yaxing Nan

Background This study quantitatively evaluated the efficiency of hospital healthcare resource allocation across 31 provinces in China from 2019 to 2023, with the aim of providing evidence-based decision support for improving resource utilization efficiency and promoting the sustainable development of medical institutions. Methods A three-stage Data Envelopment Analysis (DEA)–Malmquist model was employed to estimate both static and dynamic efficiency in hospital healthcare resource allocation. Spatial autocorrelatio …

08.09.2026journal-article

Current Drug Therapy

Exploring Fabaceae Medicinal Plants as Therapeutic Candidates for Arthritis: Molecular Insights and Mechanisms

Sukanya Vijayan, Thirumal Margesan

Abstract: Rheumatoid arthritis (RA) is a complex autoimmune disease characterised by chronic joint inflammation that necessitates effective management strategies. In recent years, medicinal plants of the Fabaceae family have gained considerable attention for their potential therapeutic roles in managing inflammatory disorders, including RA. This review examines the anti-arthritic potential of Fabaceae plants and elucidates their underlying mechanisms of action. A comprehensive literature search was conducted across …

08.09.2026journal-article

Journal of Clinical Periodontology

Alveolar Bone Regeneration Using 3D‐Printed, Patient‐Specific, Resorbable PCL Scaffold: Prospective Cohort Study

Jamil Alayan, Reuben Staples, Sašo Ivanovski

ABSTRACT Aim To evaluate clinical feasibility of 3D‐printed, patient‐specific, polycaprolactone (PCL) resorbable scaffolds for staged alveolar ridge augmentation. Materials and Methods Ten patients requiring staged bone augmentation underwent digital planning to virtually reconstruct the defect to its original contour. Patient‐specific medical‐grade PCL scaffolds were then fabricated using 3D printing and sterilised using γ irradiation. Following surgical access of the defect site, the scaffolds were loaded with a …

08.09.2026journal-article

ARACÊ

ANÁLISE DE CONHECIMENTO DOS DISCENTES, DO CURSO DE ODONTOLOGIA DE UMA UNIVERSIDADE DA REGIÃO DO ABC, ACERCA DO GERENCIAMENTO DE RESÍDUOS DE SERVIÇOS DE SAÚDE

Isabella Barauna, Arthur Colin Cruz, Gabriel Freitas Da Silva, Paulo Roxo Barja, Airton Viriato

O gerenciamento adequado dos Resíduos de Serviços de Saúde (RSS) na Odontologia é crítico devido ao elevado potencial infeccioso, químico e perfurocortante dos materiais gerados, demandando conformidade com as normas sanitárias (RDC Anvisa nº 222/2018 e Resolução CONAMA nº 358/2005) para mitigar riscos ambientais e de infecção cruzada. Com o objetivo de analisar o nível de conhecimento técnico, prático e a autopercepção dos discentes do curso de Odontologia de uma universidade da região do ABC Paulista acerca do ge …

08.09.2026journal-article

Artificial Intelligence in Health

Improving mpox identification under imbalanced data using geometric transformation and color augmentation with graph neural networks

Mohammad Reza Faisal, Luu Duc Ngo, Radityo Adi Nugroho, Fatma Indriani, Muhammad Rafi

Mpox lesion identification from skin images remains challenging because lesion appearances often overlap with other dermatological diseases and available data are commonly imbalanced. This study proposes a graph-based multi-class classification framework that combines class-balancing augmentation, convolutional neural network (CNN)-based feature extraction, and graph neural classification. Experiments were conducted on the Mpox Skin Lesion Dataset Version 2.0 using three data configurations: (i) the original imbala …

08.09.2026journal-article

Journal of Gastroenterology and Hepatology

Clinical Spectrum of Esophageal Motility Disorders in Nonobstructive Dysphagia: A Multicenter, Multiethnic Study

Jun Xin Lim, Ram Prasad, Nabilah Izham, Wah Loong Chan, Naveen Ramasami, Wei Jin Wong, Sanjiv Mahadeva, Yeong Yeh Lee, Kee Huat Chuah

ABSTRACT Background and Aims Nonobstructive dysphagia (NOD) is a frequently encountered condition. The spectrum of underlying esophageal motility disorders remains incompletely characterized in Asian populations. We aimed to define the manometric spectrum of NOD, identify predictors of achalasia, and evaluate the diagnostic value of provocative testing. Methods This retrospective multicenter study included adults who underwent high‐resolution manometry (HRM) for NOD at two tertiary hospitals in Malaysia from 2014 t …

08.09.2026journal-article

Journal of Endovascular Therapy

The Leak-Loop Technique for In Situ Fenestrated Thoracic Endovascular Arch Repair in Extensive Aortic Intramural Haematoma With Zone 0 Involvement: A Case Report

Ye Tian, Kristine J. S. Kwan, Jin Li, Zai-Ying Yeerbao, Min Mu, Xin-Xi Li, Jing-Dong Tang

Purpose: To report the first application of the Leak-Loop Technique (LLT) that combines controlled endoleak and dual guidewire loop stabilization to address cerebral perfusion maintenance and endograft malpositioning during in situ fenestrated thoracic endovascular arch repair (fTEVAR) under urgent resource-limited setting. Case Report: A 52-year-old man presented with acute progressive chest pain. Computed tomographic angiography identified an extensive subacute intramural haematoma (IMH) with penetrating atherosc …

08.09.2026journal-article

Journal of Asian Pacific Society of Cardiology

Environmental Impact on Cardiovascular Health: A Narrative Review

Sean WY Lee, Paul Dendale

Cardiovascular disease remains the leading cause of death globally. While traditional risk factors, such as smoking, obesity, diet and physical inactivity, remain major contributors to cardiovascular mortality, environmental factors are often underrecognised and insufficiently addressed in research and clinical practice. Asia is experiencing the fastest rates of urbanisation and second-fastest population growth globally, yet there remains a lack of epidemiological evidence and in-depth understanding of the detrimen …

08.09.2026journal-article

Nuclear Medicine Communications

Fluorine-18 fluorodeoxyglucose PET/computed tomography-based radiomics for predicting risk groups, tumor stage, and capsular and fat tissue invasion in thymomas

Ebru Tatci, Büşra Bozca, Kayacan Dizdar, Tuba İnal Cengiz, Nesrin Gürcay, Leyla Nesrin Acar, Ülkü Yilmaz, Özlem Özmen, Pinar Tari, Nur Aydinbelge Dizdar

Purpose This study aimed to investigate the predictive value of fluorine-18 fluorodeoxyglucose PET/computed tomography (CT) based radiomics in patients with thymoma for risk stratification and tumor staging, including capsular and fat tissue invasion. Methods A total of 67 (50 for training and 17 for validation) patients with thymoma were analyzed. Thymomas were categorized as low risk (types A, AB, and B1) or high risk (types B2 and B3) and as early stage (I–II) or advanced stage (III–IV). PET- and CT-derived radi …

08.09.2026journal-article

Advanced Science

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang

ABSTRACT Sepsis remains a leading cause of mortality because current therapies fail to address its dynamically evolving pathophysiology, in which infection, oxidative stress, and immune dysfunction emerge sequentially and interdependently. Here, we present a pH‐adaptive nanozyme platform (MICP@HG) that orchestrates stage‐specific antibacterial and immunomodulatory activities throughout sepsis progression. The platform integrates near‐infrared imaging, catalytic therapy, and immune regulation into a single construct …

08.09.2026journal-article

Australian and New Zealand Journal of Obstetrics and Gynaecology

Clinical Pregnancy and Live Birth Outcomes From 445 Vitrified Oocyte Cycles in Australia

Anna Dalton, Alicia Filby, Luk Rombauts, Kelton Tremellen, Ross Turner, Michael Costello, Deirdre Zander‐Fox, Leanne Pacella‐Ince, Juliette Koch

ABSTRACT Aim To describe the outcomes for women in Australia who proceed with vitrified oocyte‐thaw (VOT) cycles to achieve pregnancy. Method Our descriptive retrospective cohort study of 445 medical and personal VOT cycles over 12 years (2009–2021) at 11 Australian IVF clinics assessed outcomes in oocyte survival, ICSI fertilisation rate, embryo utilisation rate, clinical pregnancy rate (CPR) and live birth rate (LBR), using age‐stratified data (≤ 35, 35–39 and ≥ 40 years). Results Women were on average 36.8 years …

08.09.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

USO INDISCRIMINADO DE ESTEROIDES ANABOLIZANTES E SUAS REPERCUSSÕES SOBRE A SAÚDE CARDIOVASCULAR EM ADULTOS JOVENS

Gabrielle Ramos de Carvalho, Emanuelle Oliveira da Silva, Bianca da Silva Cardoso Porto, Matheus Ramos de Carvalho, Ramon Fraga de Souza Lima

A saúde cardiovascular constitui um pilar fundamental para a manutenção do bem-estar metabólico, físico e mental. Embora as doenças cardiovasculares sejam tradicionalmente associadas ao envelhecimento, observa-se um aumento progressivo de sua incidência entre indivíduos mais jovens, impulsionado principalmente por fatores relacionados ao estilo de vida e pelo uso não terapêutico de substâncias exógenas, como os esteroides anabolizantes. O uso desses hormônios está vinculado à busca por padrões estéticos, com o obje …

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Aktuelle Forschung nach Fachgebiet

Associations between prenatal air pollution exposure and adverse birth outcomes: a siblings-matched case-control study

Economic value and clinical role of minimally invasive, biopsy‐based diagnostics in non‐small cell lung cancer

Municipal governance, jurisdiction, and punitive local responses to health and social crises in a small British Columbia city

HPV integration landscape in precancerous lesion of cervical cancer

Autoantibodies targeting G protein-coupled receptors and clinical outcome after ischemic stroke (PROSCIS-B)

Evaluating retrieval-augmented generation versus long-context input for clinical reasoning over electronic health records

Engineering a Multifunctional Sprayable Curcumin‐Modified Polyitaconate‐Based Hydrogel to Accelerate Methicillin‐Resistant Staphylococcus aureus ‐Infected Wound Healing

Translational Insights From the Molecular Landscape to Precision Therapy in Peripheral T‐Cell Lymphoma: Integrating Multi‐Omics and Artificial Intelligence

When Nurses Witness Discrimination: Epistemological Silence and the Nursing Justice Reflexivity Framework

Effects of Interprofessional Collaborative Practice in Older Adults’ Hip Fractures Care: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Medicolegal Pitfalls in Management of Shoulder Dislocations: A Case Series

Medetomidine as a Fentanyl Adulterant: Pharmacology, Detection, Clinical Presentation, and Management

A study on the efficiency and spatial correlation of health resource allocation in Chinese hospitals

Exploring Fabaceae Medicinal Plants as Therapeutic Candidates for Arthritis: Molecular Insights and Mechanisms

Alveolar Bone Regeneration Using 3D‐Printed, Patient‐Specific, Resorbable PCL Scaffold: Prospective Cohort Study

ANÁLISE DE CONHECIMENTO DOS DISCENTES, DO CURSO DE ODONTOLOGIA DE UMA UNIVERSIDADE DA REGIÃO DO ABC, ACERCA DO GERENCIAMENTO DE RESÍDUOS DE SERVIÇOS DE SAÚDE

Improving mpox identification under imbalanced data using geometric transformation and color augmentation with graph neural networks

Clinical Spectrum of Esophageal Motility Disorders in Nonobstructive Dysphagia: A Multicenter, Multiethnic Study

The Leak-Loop Technique for In Situ Fenestrated Thoracic Endovascular Arch Repair in Extensive Aortic Intramural Haematoma With Zone 0 Involvement: A Case Report

Environmental Impact on Cardiovascular Health: A Narrative Review

Fluorine-18 fluorodeoxyglucose PET/computed tomography-based radiomics for predicting risk groups, tumor stage, and capsular and fat tissue invasion in thymomas

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Clinical Pregnancy and Live Birth Outcomes From 445 Vitrified Oocyte Cycles in Australia

USO INDISCRIMINADO DE ESTEROIDES ANABOLIZANTES E SUAS REPERCUSSÕES SOBRE A SAÚDE CARDIOVASCULAR EM ADULTOS JOVENS