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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Lipoprotein(a) measurement: challenges and opportunities

John H. Contois

Abstract Lipoprotein(a) [Lp(a)] is a causal, independent risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. New guidelines recommend testing everyone at least once in a lifetime, and with new drugs specifically targeting Lp(a) on the horizon, accurate measurement remains vitally important. Yet, its measurement has for decades been challenging because of apolipoprotein(a) size heterogeneity, imperfect calibration strategies, and mixed use of mass (mg/dL) vs. molar (nmol/L) uni …

03.09.2026journal-article

Clinical and Translational Oncology

Prognostic modeling of overall survival in metastatic pancreatic cancer: an inflammation-based tool validated in PANTHEIA-SEOM cohort

Vilma Pacheco-Barcia, Axel Mariño-Mendez, María Ángeles Vicente Conesa, María de Toro Carmena, Paula Cerdà Serdà, Carmen Guillen-Ponce, Mónica Benavente Lucas, Raquel Hernández San Gil, Ángela Lamarca, Javier Gallego, Maria Luisa Soriano Tabares de Nava, Jorge Hernando, Elena Brozos-Vazquez, Ana López-Alfonso, Jorge Adeva, Ismael Ghanem, Sandra Soriano, Javier Soto-Alsar, Andrés Muñoz, Paula Jimenez-Fonseca, Alberto Carmona-Bayonas

Abstract Purpose To develop and internally validate the PANTHEIA-SIRI prognostic model, which integrates log-transformed systemic inflammation response index (SIRI) with clinical predictors, to estimate overall survival (OS) in metastatic pancreatic ductal adenocarcinoma (mPDAC) treated with first-line chemotherapy. Methods We used data from the multicenter PANTHEIA-SEOM registry. OS was defined from chemotherapy start. The model was fitted as a Weibull accelerated failure time model in the survival-analysis popula …

03.09.2026journal-article

Frontiers in Public Health

Use behavior and spatial characteristics of National Fitness Routes in China: an in situ observational study

Yunxi Tian, Baoquan Zhu, Mengwei Zhao, Zhengyang Yao, Qisheng Han, Kai Wang

Background The installation of outdoor gyms (OGs), also known as the National Fitness Route (NFR) program in China, is increasing in popularity as a government-funded solution to declining population physical activity (PA) levels. However, evidence regarding how these facilities are used and whether they effectively support PA remains limited. Methods Systematic in situ observations were conducted across four representative NFRs in Yangling District, Shaanxi Province, China, during three seasons. Demographic charac …

03.09.2026journal-article

Prävention und Gesundheitsförderung

Ethische Reflexionskompetenz in der Gesundheitsförderung: Herausforderungen und Ansätze für die Aus‑, Fort- und Weiterbildung

Karin Nordström, Petra Plunger, Dagmar Starke, Verena Biehl, Birgit Ulrika Keller, Katja Podzeit

Zusammenfassung Hintergrund und Fragestellung Vierzig Jahre nach der Ottawa-Charta bilden Chancengerechtigkeit, Empowerment und Partizipation weiterhin die normativen Grundlagen der Gesundheitsförderung (GF). Gleichzeitig führen gesellschaftliche Entwicklungen wie Digitalisierung, Klimawandel und demographischer Wandel zu neuen ethischen Herausforderungen, insbesondere hinsichtlich wachsender Ungleichheiten. Ethische Reflexionskompetenz gewinnt dadurch für Fachpersonen der GF zunehmend an Bedeutung. Ziel des Beitra …

03.09.2026journal-article

Frontiers in Immunology

Exploring type 2 inflammation and disease complexity: perspectives of a clinical immunologist

Yuval Tal, Limor Rubin, Ariel Munitz, Irit Adini

Type 2 inflammatory diseases are often grouped together as a single immunological entity, driven by shared cytokines and overlapping pathways. This framework has led to the development of biologic therapies targeting upstream epithelial-derived “alarmins”, including thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and interleukin (IL)-25. These mediators promote downstream cytokine responses, most notably IL-4, IL-5, and IL-13, which orchestrate type 2 inflammation across multiple tissues. Despite these sh …

03.09.2026journal-article

Frontiers in Public Health

H5N1 clade 2.3.2.1e lineage transition in Lao PDR during 2023–2024 associated with regional spread and human infection risk-associated receptor-binding features

Duc Duong Than, Boyoon Chang, Eun Lee, Watthana Theppangna, Seon-Ju Yeo, Hyun Park

Highly pathogenic avian influenza (HPAI) H5N1 viruses clade 2.3.2.1e has re-emerged in the Indochinese Peninsula, raising concerns about regional spread and zoonotic risk. We characterized eight H5N1 viruses isolated from 32 environmental and poultry-derived samples collected in Lao People’s Democratic Republic (Lao PDR) live bird markets during 2023–2024. Whole-genome and phylogenetic analyses showed that all isolates belonged to clade 2.3.2.1e and were distinct from the previously dominant Lao clade 2.3.2.1c, ind …

03.09.2026journal-article

ShodhAI: Journal of Artificial Intelligence

EXAMINING LEGAL ACCOUNTABILITY FRAMEWORKS FOR AI IN HEALTHCARE

Lakshmi Walia, Namrata Yadav

From AI-powered diagnostic tools in hospitals to autonomous drones in military operations, Artificial Intelligence is rapidly shaping decisions that affect millions of lives every day. Imagine a medical AI misdiagnosing a patient due to faulty training data, or a semi-autonomous weapon acting unpredictably on the battlefield — who is held accountable when such high-risk technologies fail?This paper explores how India, the European Union (EU), and the United States (US) address the legal accountability of AI systems …

03.09.2026journal-article

Environmental Health Perspectives

Associations of Green Space and Air Pollution Mixture with Heterogeneous Biological Aging Patterns

Guoqiang Ma, Jing Xu, Yishu Li, Yuefei Wu, Qian Li, Xuan Cao, Zitong Zhao, Jingyan Gao, Lijun Gao, Lina Yan, Xiaolin Zhang

Abstract Evidence on associations between green space, air pollution mixture, and heterogeneous biological aging patterns remains limited. We investigated the opposing effects of green space and air pollution mixture on biological aging patterns using an accelerated longitudinal design based on repeated-measures data from 11,760 adults (aged 20–65 years) in a high-pollution Chinese city. Biological age acceleration (BAA) was derived via the Klemera-Doubal method. Group-based trajectory modeling identified three sta …

03.09.2026journal-article

Turkish Journal of Gastroenterology

Lumen-Apposing Metal Stent in the Treatment of Persistent Dysphagia due to Cervical Radiation Therapy

Eren Yilmaz, Mucahit Ergul, Oguz Ozturk, Kadir Can Acun, Emir Tuğrul Keskin, Orhan Coskun, Ilhami Yuksel

Cite this article as: Yilmaz E, Ergul M, Ozturk O, et al. Lumen-apposing metal stent in the treatment of persistent dysphagia due to cervical radiation therapy. Turk J Gastroenterol. Published online September 3, 2026. doi: 10.5152/tjg.2026.26290.

03.09.2026journal-article

Food, Nutrition and Health

Effect of malted iron-rich beans flour inclusion on nutritional and sensory properties of broken rice-based complementary food: a community-based experimental study

Christopher Atibo, Sunday Mark Oyet, Christopher Muggaga, Basil Mugonola

Abstract Background Iron and zinc deficiencies are a major public health concern among children aged 6-24 months in Northern Uganda, particularly in the Acholi sub-region. These deficiencies are largely linked to complementary foods prepared from inadequately processed local ingredients with high anti-nutritional factors, which impair micronutrient absorption. This study investigated the effect of malting on broken rice-iron-rich beans composite flour, focusing on sensory properties, nutrient composition, bioavaila …

03.09.2026journal-article

Clinical Pharmacology & Therapeutics

AI Cautionary Guide: Pitfalls and Strategies for the Use of Machine Learning in Medical Research

Qi Liu, Ruihao Huang, Hanrui Zhang, Thomas F. Osborne

Machine learning ( ML ) is increasingly utilized in medical research. However, underrecognized methodological pitfalls can result in misleading conclusions, which if acted upon can result in patient mismanagement and harm. As a result, we have provided a compilation of common pitfalls and practical safeguard considerations for ML ‐enabled medical research. Examples emphasize the importance of integrating clinical/biologic knowledge and statistical/epidemiologic principles, illustrated with key case examples. Topics …

03.09.2026journal-article

Journal of Clinical Medicine

Neurological Severity and Systemic Biochemical Markers in Relation to Transition to Oral Feeding in Chronic Post-Stroke Dysphagia

Timur Orhanoglu, Merve Savaş, Senanur Kahraman Beğen, Abdulhalim Senyigit, Hafize Uzun

Background: Post-stroke dysphagia is associated with aspiration pneumonia, malnutrition, and poor functional outcomes. Although systemic biochemical abnormalities are common after stroke, their contribution to swallowing recovery and transition to oral feeding remains unclear. This study investigated the association of systemic biochemical markers with oral feeding transition and swallowing-related functional improvement in patients with chronic post-stroke dysphagia. Methods: This retrospective single-center study …

03.09.2026journal-article

Head & Neck

Trismus and Health‐Related Quality of Life in HNC Patients up to 10 Years Post‐Radiotherapy Completion

Therese Karlsson, Lisa Tuomi, Caterina Finizia

ABSTRACT Background This prospective study investigates trismus prevalence, quality of life (QOL), and trismus‐related symptoms in HNC patients up to 10 years post‐radiotherapy (RT). Methods A total of 211 patients with HNC receiving RT were followed pretreatment, 12, 60, and 120 months post‐RT. Primary outcome was trismus defined as a maximum interincisal opening (MIO) ≤ 35 mm. Secondary outcomes included the European Organization for Treatment of Cancer Quality‐of‐Life Questionnaire Core‐30 (EORTC QLQ‐C30), Head …

03.09.2026journal-article

Frontiers in Psychiatry

Design and evaluation of a group-based integrative expressive art therapy intervention for mental health among pregnant women in China: a pilot pre-post study

Xue Feng, Quanlun Li, Ling Huang, Hongting Yan, Chunmei Lan, Yu Ling, Ruimin Ling, Yini Li, Hua Yu

Background Pregnant women in China face various emotional difficulties during pregnancy but lack adequate mental health support. This study aimed to design and evaluate a group-based integrative expressive art therapy intervention for addressing emotional and psychological concerns in this population. Methods A quasi-experimental design with pre- and post-intervention assessments were delivered from July to December 2025. We developed a five-session expressive art therapy intervention employing multiple art modalit …

03.09.2026journal-article

npj Systems Biology and Applications

Network analysis and drug repurposing reveal targets for combination therapy in drug resistant breast cancer

Najmeh Fattahi, Changiz Eslahchi, Fahimeh Ghasemi, Paria Alipour, Razieh Heidari, Morteza Karimipoor, Seyed Abbas Mirzaei, Soroush Sardari

Abstract Multidrug resistance remains a major obstacle in cancer therapy and is driven by hyperactive efflux transporters and dysregulated signaling pathways. In this study, text mining and network analyses were performed to identify key genes associated with breast cancer drug resistance. Critical regulatory nodes were identified using the Boykov-Kolmogorov algorithm applied to a directed protein–protein interaction network. Molecular docking and molecular dynamics simulations were subsequently conducted to screen …

03.09.2026journal-article

Frontiers in Medicine

Exploring the qualities and adaptive professional capabilities required of physicians for disaster response through perspective transformation among physicians in Fukushima, Japan

Megumi Yasuda, Rintaro Imafuku, Kaho Hayakawa, Maham Stanyon, Takuya Saiki

Background The Great East Japan Earthquake and the Fukushima Daiichi Nuclear Power Plant accident confronted health care professionals with profound uncertainty and ethical dilemmas. However, it remains unclear how physicians made sense of these extreme experiences, reconsidered their assumptions, values and professional roles, and came to recognize and embody the qualities and adaptive professional capabilities required for disaster response. Aim Through the narratives of physicians in Fukushima, Japan, this study …

03.09.2026journal-article

Law of Succession

THE PUBLIC LAW STATUS OF A NOTARY AS THE BASIS FOR THE PRESUMPTION OF AUTHENTICITY OF A NOTARIZED WILL

Lilia V. Ovsepyan

The article examines the issues surrounding challenges to notarized wills on the grounds of an alleged defect of the testator's will. Particular attention is paid to the evidentiary value of a notarized will. The paper substantiates the necessity of establishing, within judicial and law enforcement practice, a presumption of reliability of notarized expressions of intent. Special emphasis is placed on the public-law status of the notary as a person ensuring the recording and protection of the testator's last will a …

03.09.2026journal-article

BMC Oral Health

Clinical performance of a giomer-based pit and fissure sealant with and without air-abrasion pretreatment: a 12-month randomized clinical trial

Yomna Sayed Khallaf, Olfat Elsayed Hassanein, Aya Mohamed Adly, Dina Kamal

Abstract Background Pit and fissure sealants are widely used for caries prevention; however, their long-term success depends largely on retention. Giomer-based sealants containing surface pre-reacted glass ionomer fillers offer bioactive properties, yet concerns remain regarding their bonding durability when applied with mild self-etch primers. This randomized clinical trial evaluated the effect of bioactive glass air-abrasion pretreatment on the retention and caries preventive efficacy of a giomer-based sealant in …

03.09.2026journal-article

Frontiers in Imaging

Artificial intelligence in breast cancer imaging: a systematic review of detection, segmentation, explainability, and clinical translation

Iqra Iqbal Khan, Syed Adil Hussain Shah, Alexandra Tsipourakis, Marta Malavolta, Aleesha Aleesha, Syed Baqir Hussain Shah, Mozhdeh Hajiani, Andrea Buccoliero, Konstantinos Panagiotopoulos, Syed Taimoor Hussain Shah, Marco Agostino Deriu

Introduction Breast cancer remains the most commonly diagnosed malignancy in women worldwide, with approximately 2.3 million new cases and 670,000 deaths in 2022. Artificial intelligence (AI) is increasingly being applied across breast imaging for detection, characterization, segmentation, risk stratification, explainability, and clinical translation. Methods This systematic review synthesized 284 eligible peer-reviewed publications published between 2015 and 2025, identified through a PRISMA 2020-compliant search …

03.09.2026journal-article

Healthcare

Nocturnal Pain in Patients with Knee Osteoarthritis: A Single-Center Cross-Sectional Study

Köksal Sarıhan, Erdem Özkaya, Cemil Güner, Ali Yazıcı, Osman Topçu, Ceyhun Yurtsever, Erhan Özdemir

Objectives: The aim of this study was to determine the differences between groups with and without nocturnal pain (NP) in patients with knee osteoarthritis (KOA) in terms of radiographic stage, disease severity, neuropathic pain, central sensitivity, sleep quality, physical activity level, and number of hospital visits. Methods: The study included 150 patients with KOA (101 women, 49 men; mean age 64 years (IQR: 9; range: 40–81)). Kellgren–Lawrence (KL) grading was used for radiographic staging, the Western Ontario …

03.09.2026journal-article

Jurnal Ekonomi Bisnis dan Akuntansi

Analisis Implementasi New Public Management dalam Meningkatkan Kualitas Layanan Metro Jabar Trans

Hasna Septiani, Sri Mulyani

Public transport service quality is an important indicator of the successful implementation of New Public Management (NPM) in the public transport sector. Metro Jabar Trans (MJT), a Bus Rapid Transit (BRT) system managed by the West Java Provincial Government through a Buy The Service (BTS) partnership scheme, faces operational challenges such as low load factors, longer-than-standard bus headways, and limited bus stop infrastructure despite significant government subsidies. This study aims to analyze the implement …

03.09.2026journal-article

Health Affairs Scholar

Cross-Country Differences in Household Healthcare Spending

Irene Papanicolas, Jonathan Cylus, Maecey Niksch, Luca Lorenzoni

Abstract Introduction Health systems face financial pressures as populations age and economic growth slows, with implications for who pays for health care and for what drives expenditure growth. Methods We examined changes in outpatient and pharmaceutical care financing across OECD countries from 2000 to 2023. Results While overall health spending growth slowed across countries after the Great Recession, household spending grew modestly everywhere, averaging about half a percentage point growth annually. The United …

03.09.2026journal-article

ISPRS International Journal of Geo-Information

Scale-Dependent Spatial Clustering of Hospital Operational Performance and Patient Safety Outcomes in East Java, Indonesia: A Spatial Autocorrelation Analysis

Muhammad Kamran, Inge Dhamanti, Shumaila Ismail

Understanding variations in hospital performance and patient safety is critical for improving health system efficiency, particularly in decentralized healthcare systems such as that of Indonesia. While geographic disparities in health outcomes are often emphasized in research, the relative contribution of spatial patterns remains underexplored. The aim of this study was to identify and visualize spatial clustering of hospital performance and mortality-oriented patient safety. Data from 428 hospitals in East Java, I …

03.09.2026journal-article

Rambam Maimonides Medical Journal

Fetal Pain: Neurobiology, Clinical Practice, and Compassionate Care—A Narrative Review

Omri Dominsky, Ido Solt

Background: Whether a fetus can experience pain remains scientifically and clinically contested, particularly as invasive fetal procedures become more common. Objectives: To review fetal nociceptive development, the evidence and uncertainties relevant to pain perception, and the clinical rationale for fetal analgesia during invasive procedures. Methods: We performed a targeted narrative search of PubMed/MEDLINE, Google Scholar, the Cochrane Library, reference lists, and professional society websites. The final synt …