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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Association between genomic classifier scores and initial management of localized prostate cancer in the United States

Michael S Leapman, Rong Wang, Preston C Sprenkle, Isaac Y Kim, Stacy Loeb, Tyler M Seibert, Matthew R Cooperberg, Peter H Gann, Kevin Ginsburg, William J Catalona, Michaela A Dinan, Cary P Gross, Xiaomei Ma

Abstract Background Tissue-based gene expression assays provide prognostic information in prostate cancer, but their influence on decisions regarding immediate treatment vs conservative management, including active surveillance (AS) and watchful waiting (WW), remains uncertain. Methods Using a linkage with the Surveillance, Epidemiology, and End Results program, we evaluated the association between a 22-gene genomic classifier (GC) and initial management among patients with low or intermediate clinical-risk prostat …

31.08.2026journal-article

Indian Journal of Medical and Paediatric Oncology

Liquid Biopsy in Precision Oncology: Clinical Applications of Circulating Tumor DNA and Circulating Tumor Cells

Prabhat Ganju

Abstract The advent of “liquid biopsy” as a tool for the detection of molecular abnormalities has paved the way for its use not only in diagnosis but also in screening, monitoring of therapeutic response, and surveillance. Detection of circulating tumor deoxyribonucleic acid and circulating tumor cells are among the commonly employed liquid biopsy targets that are changing the diagnostic and treatment landscape. By offering a minimally invasive method for disease monitoring and aiding treatment decision-making, liq …

31.08.2026journal-article

Neuro-Oncology

Cancer-intrinsic SIRPα Signaling Triggers Mitochondrial Fission and Immune Tolerance to Promote TNBC Breast-to-Brain Metastasis

Yu-Ting Tsai, Jessica D Mackert, Adam Wilson, Mitra Kooshki, Valerie Payne, Jamie J Sagastume, Ashley Szymonski, Brian Westwood, Lance D Miller, Pierre L Triozzi, Dawen Zhao, Linda Metheny-Barlow, Masaki Terabe, Katherine L Cook, Glenn J Lesser, David R Soto-Pantoja

Lay Summary Although the development of advanced treatment including immunotherapy has dramatically increased Triple-negative breast cancer (TNBC) patients’ survival, the treatment efficacy on patients who developed brain metastasis is still poor. 35% of TNBC patients will develop brain metastasis and therapeutic options are limited. Herein, we showed that targeting SIRPα on TNBC cancer cells has the potential to increases the brain metastasis free survival by reducing cancer metastasis potential and reversing the …

31.08.2026journal-article

Pakistan Journal of Health Sciences

Aprepitant, When Used with Chemotherapy, Reduces the Risk of Recurrence, Metastasis, And Mortality in Patients with Breast Cancer

Miguel Munoz

The study included a large number of women (n=13,811) who had been treated with chemotherapy and antiemetics for early-stage breast cancer (2008-2020), with follow-up for metastasis and death until 2021. Compared with any other class of antiemetic, researchers determined that the neurokinin-1 receptor (NK-1R) antagonist aprepitant (125 mg on day 1, 80 mg daily on days 2 and 3) proved to significantly improve survival and decreased the risk of metastasis when used in combination with chemotherapy. Triple-negative br …

31.08.2026journal-article

Kapadokya Üniversitesi

Adult Patients Perceptions and Preferences Toward Accelerated Orthodontic Treatment Perceptions of Accelerated Orthodontic Treatment

Hanan Miftah Ashour, Göksu Trakyalı

Statement of the Problem: Prolonged orthodontic treatment may discourage adults from initia-ting or continuing orthodontic care. Several approaches have been proposed to accelerate orthodontic treatment, but their acceptance by patients may vary according to invasiveness and cost. Purpose: This study aimed to evaluate adult patients’ perceptions of orthodontic treatment dura-tion, their acceptance and preferences regarding invasive and non-invasive approaches to accelerate tre-atment, and their willingness to pay a …

31.08.2026journal-article

BMC Cancer

Uptake and associated factors of family-specific variant genetic testing among at-risk relatives of hereditary gynecological cancer probands

Xia Wang, Hui Wang, Huiyuan Cai, Jing You, Yuejiao Zhao, Xiaomin Chen, Yan Ding

Abstract Background Family-specific variant genetic testing is crucial for cancer risk management among at-risk relatives of individuals with hereditary gynecological cancer. However, the uptake of such testing remains suboptimal, and the factors influencing uptake have not been fully elucidated. This study aimed to investigate the uptake of family-specific variant genetic testing among at-risk relatives of probands with hereditary gynecological cancers and to identify factors associated with testing uptake. Method …

31.08.2026journal-article

Journal of Religion & Society Supplement Series

A Bridge between Oncology Medicine and Eastern Orthodoxy

Cristina Pop

In this article, I draw from ethnographic research in an enclosed suspended bridge/passageway connecting a Romanian oncology hospital to an adjacent Eastern Orthodox church. I examine the space of the bridge as a “heterotopia of deviation,” that is, a real site where individuals are isolated, regulated, or contained. Even though it connects the oncology hospital and the church, the bridge itself is neither hospital nor church. First, the bridge functions temporarily as a place of festivity, especially during Sunday …

31.08.2026journal-article

Cancers

Longitudinal Improvements in Treatment Delivery Efficiency for MR-Guided Radiation Therapy: An 8-Year Single-Institution Experience

Robert A. Herrera, Sirikorn Unsri, Kathryn E. Mittauer, Rupesh Kotecha, Adeel Kaiser, Matthew D. Hall, Yongsook C. Lee, Yonatan Weiss, Tatiana Bejarano, Eyub Y. Akdemir, Mattison J. Flakus, Nikolai Strusberg-Fernandez, Ranjini Tolakanahalli, Nema Bassiri, Maria Ayala, Noah S. Kalman, Diane Alvarez, Tino Romaguera, Minesh P. Mehta, Alonso N. Gutierrez, Michael D. Chuong

Purpose: While magnetic resonance-guided radiation therapy (MRgRT) may provide significant clinical advantages, delivery times tend to be longer than other radiation therapy (RT) modalities and published data on these times are limited. We evaluated longitudinal treatment times across our 8-year institutional MRgRT experience. Methods/Materials: A retrospective analysis of patients treated at our institution on a 0.35-Tesla MR-Linac between April 2018 and April 2026 was performed. All fractions were delivered with …

31.08.2026journal-article

Scientific Reports

Clinicopathologic and molecular characteristics of colorectal cancer patients with brain metastases: a multicenter cohort study

Fatih Kemik, Bahadır Köylü, Cevat İlteriş Kıkılı, Nazan Demir, Jamshid Hamdard, Ali Kaan Güren, Sezin Yıldızhan, Arda Ulaş Mutlu, Çiğdem Yıldırım, Nargiz Majidova, Nülifer Kılıç Durankuş, Uğur Selek, Rıza Umar Gürsu, Leyla Özer, Burak Şakar, Senem Karabulut, Osman Köstek, Ahmet Bilici, Nil Molinas Mandel, Fatih Selçukbiricik, Şahin Laçin

Abstract Brain metastases (BM) from colorectal cancer (CRC) are uncommon but clinically consequential. We characterized clinicomolecular features of CRC patients with BM and evaluated the prognostic impact of BM timing. We screened CRC patients treated/followed between 2015 and 2024 and included those with radiologically confirmed BM. Primary tumor location was classified as rectum, left-sided colon or right-sided colon. BM timing was defined as de novo (≤ 90 days from CRC diagnosis) versus interval (> 90 days). Bi …

31.08.2026journal-article

International Journal of Innovative Science and Research Technology

NEUROCALIB: Design, Implementation and Internal Evaluation of a Calibrated, Explainable and Selective Bimodular Framework for Brain Tumor Classification and Segmentation on MRI

Hervé Kinkete Mfumabi, Matangila Gradi, Nsiala Ndona Clémence, Kavugho Kahasa Thérèse, Kalema Manzambie Jordanie, Kema Mulumba Joël, Madio Motemona Godard, Ilolo Nana

High aggregate performance does not guarantee reliable individual predictions or clinical transportability. This study designed, implemented, and internally evaluated NEUROCALIB, a selective bimodular research framework comprising independently assessed classification and segmentation pipelines, and audited their integration into the NeuroVision web prototype. EfficientNetB0 was evaluated on 6,683 public brain MRI images across four classes; MobileNetV2–U-Net was evaluated on 4,048 image-mask pairs after removal of …

31.08.2026journal-article

Materials

The Effect of Three Kinds of Surface Treatment Methods on the Corrosion and Wear Resistance of AM60B Magnesium Alloy with La, Ce Addition

Shusen Wang, Zhongyu Qiu, Naibao Huang, Chenghao Liang, Wenning Jiang

Three kinds of surface treatments, including permanganate, molybdate, and phytic acid conversion films, were fabricated on La-Ce mischmetal containing AM60B magnesium alloy. Their effects on the corrosion and tribological behaviors of the alloy in 3.5 wt% NaCl solution were systematically investigated via Mott–Schottky analysis, electrochemical measurements, and friction–wear tests. The results show three surface treatments shift the flat band potential in the negative direction, reduce the corrosion current densit …

31.08.2026journal-article

International Journal of Advanced Research

DIFFUSE-TYPE TENOSYNOVIAL GIANT CELL TUMOR (PIGMENTED VILLONODULAR SYNOVITIS) OF THE KNEE: A CASE REPORT

Zajli Driss, Lahlou Hamza, Abaydi Anass, Khardi Moad, SRadi Jihad, Lahrach Kamal, Marzouki Amine, Boutayeb Fawzi

Background:Tenosynovial giant cell tumor (TGCT), formerly known as pigmented villonodular synovitis (PVNS), is a rare, benign but locally aggressive proliferative disorder of the synovial membrane. Its diffuse type is more aggressive than the localized type and carries a substantially higher risk of recurrence. Case presentation: We report the case of a 25-year-old man with no relevant medical history who presented with mechanical pain of the right knee evolving over 4 years. Clinical examination found a mildly swo …

31.08.2026journal-article

South African Journal of Oncology

A retrospective study on the incidence and outcomes of hepatoblastoma in relation to prognostic indicators at Universitas Academic Hospital, Bloemfontein, South Africa (2000–2022)

Helen Okafor, Jan du Plessis

Background: Hepatoblastoma (HB) is the most common solid liver cancer in childhood. Globally, survival has significantly improved with advanced treatment modalities. However, survival is poor in low-middle-income countries (LMICs) due to advanced-stage presentation. Aim: The aim was to evaluate the incidence and outcomes of children diagnosed with HB in relation to prognostic indicators which included age, sex, PRE-Treatment EXTent (PRETEXT) staging, metastasis and surgical intervention. Outcomes included survival …

31.08.2026journal-article

Frontiers in Oncology

Interpretable machine-learning risk stratification at the time of diagnosis for 3-year mortality in de novo metastatic prostate cancer: development and temporal validation in SEER

Xin Wang, Guanglei Yao, Heqian Liu, Wei Ding

Men with de novo metastatic prostate cancer (mPCa) face a poor but heterogeneous prognosis, yet interpretable, transparently reported diagnostic-time tools remain limited. Using the Surveillance, Epidemiology, and End Results (SEER) 17-registry database (2010–2020), we developed and temporally validated machine-learning models to predict fixed 3-year cancer-specific mortality (CSM) and overall mortality (OM) in newly diagnosed mPCa. From 42,691 exported cases, we defined a cohort of 41,057 (survival ≥1 month) and s …

31.08.2026journal-article

Journal of Surgical Oncology

How Does the Surgical Margin Status Affect the Association Between Mesorectal Excision Quality and Overall Survival in Patients With Locally Advanced Rectal Cancer? A Contemporary Analysis From the NCDB

Sameh Hany Emile, Nir Horesh, Maher Al Khaldi, Zubair Bayat, Noam Kahana, Michal Perets, David Maron, Marylise Boutros

ABSTRACT Background The quality of mesorectal excision completeness is a key determinant of oncologic outcomes in rectal cancer; however, it is unclear how surgical margin status influences the survival impact of mesorectal excision quality. The present study aimed to assess the survival outcomes of incomplete total mesorectal excision (TME) in patients with locally advanced rectal cancer, according to surgical margin status. Methods Using a contemporary (2022–2023) cohort from the US National Cancer Database, adul …

31.08.2026journal-article

International Journal of Bioinformatics and Intelligent Computing

State-of-the-Art Approaches in Lung Cancer: Advancing Diagnosis, Treatment and Drug Discovery Through AI

Danish Mushtaq, Harshita Bisht, Anam Beg, Ashok Sharma, Rashmi Gupta

Lung Cancer (LC) is one of the most common causes of cancer-related mortality worldwide, including India, with rising incidence attributed to smoking, air pollution and occupational exposures. It is broadly classified into Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC), with very distinct pathological and therapeutic approaches. New developments and recent advances in diagnostic technologies, particularly AI tools are enhancing early diagnosis by allowing for faster assessments of radiological …

31.08.2026journal-article

Cancer Epidemiology, Biomarkers & Prevention

The KPROCS Study: A Real-World and Research Resource to Investigate Multilevel Determinants of Ovarian Cancer Treatment and Survival

Elisa V. Bandera, Jennifer A. Doherty, Valerie S. Lee, Lindsay J. Collin, Juraj Kavecansky, Farzin Khosrow-Khavar, Jia Li, Lisa M. Moy, Ekaterina Chirikova, Pushkar P. Inamdar, Salma Shariff-Marco, Laurie Grieshober, Martin Köbel, Scarlett Lin Gomez, Lawrence H. Kushi

Abstract Background: Compared with non-Hispanic White (NHW) women, Black women with epithelial ovarian cancer (EOC) experience poorer survival, partly due to differences in treatment and access to care. However, these factors do not fully explain survival disparities, and outcomes among other groups remain understudied. Emerging evidence also suggests racial differences in molecular subtypes. The Kaiser Permanente Northern California (KPNC) Research on Ovarian Cancer Survival (KPROCS) Study was established to evalu …

31.08.2026journal-article

Cancers

The Association of FIT-Based Colorectal Cancer Screening with Earlier Disease Detection: The Romanian Experience

Catalin-Andrei Dutei, Gabriel Richiteanu, Florin Andrei Grama, Gabriel Becheanu, Bogdan Cotruta, Teodora-Ecaterina Manuc, Andreea-Elena Chifulescu, Mircea Manuc

Background/Objectives: Given the increasing burden of colorectal cancer (CRC), effective screening strategies are essential for early disease detection. As a primary endpoint, this study aimed for the assessment and comparison of two different diagnostic pathways in the Romanian population: population-based screening using the fecal immunochemical test (FIT) and opportunistic, symptom-driven, colonoscopy. Methods: A retrospective observational study was conducted in two groups comprising a total of 236 patients fro …

31.08.2026journal-article

Neuro-Cell Molecular Research

Reconsidering Cancer Through a Systemic Metabolic Perspective: A Holistic Approach to Tumor Metabolism and Clinical Evidence

Berrin Ustundag

Cancer has traditionally been viewed as a genetic disease driven by accumulated mutations; however, growing evidence indicates that metabolic dysregulation also plays an important role in tumor initiation and progression. This review aims to evaluate the evidence supporting a systemic metabolic perspective of cancer by integrating molecular, cellular, and clinical findings related to tumor metabolism. Key metabolic alterations such as aerobic glycolysis (Warburg effect), mitochondrial dysfunction, altered lipid and …

31.08.2026journal-article

Journal of Translational Medicine

Deciphering the dual role of γδ T cells in the non-small cell lung cancer microenvironment: mechanistic insights and therapeutic frontiers

Yige Wang, Qiang Xiao

Abstract Background Lung cancer is the leading cause of cancer-related death worldwide, and non-small cell lung cancer accounts for approximately 85% of all cases. Although immune checkpoint inhibitors have transformed the therapeutic landscape, downregulation of the major histocompatibility complex and chronic immunosuppression in the tumor microenvironment frequently limit the efficacy of conventional T cell immunotherapy. Gamma delta T cells, unconventional lymphocytes enriched in pulmonary mucosa, provide surve …

31.08.2026journal-article

Astana Medical Journal

An integrated diagnostic algorithm for the detection of HPV-associated precancerous lesions of the cervix for the prevention of cervical cancer

Talshyn Ukybassova, Nazira Kamzayeva, Kuralay Kongrtay, Gulzhanat Aimagambetova, Sanimkul Makhambetova, Makhabbat Galym

Introduction. Cervical cancer is still one of the pressing problems in medicine and public health in Kazakhstan. Infection with high-risk human papillomavirus (HPV) is a key cause of precancerous changes development, which suggests the need to find new ways of diagnosing and assessing risk factors. Aim. To develop an integrated algorithm for evaluation and diagnosis of the risk of precancerous cervical changes caused by HPV, considering the features of modern diagnostic methods and the healthcare system of Kazakhst …

31.08.2026journal-article

Sains Malaysiana

Emerging Immunohistochemical Biomarkers Beyond Prostate Specific Antigen in Prostate Cancer

Huma Afzal, Nosheen Aslam, Ghulam Mustafa, Shazia Anwer Bukhari

Prostate cancer remains a significant health concern, particularly among the older male population. Proper differentiation between malignant adenocarcinoma and benign prostatic diseases is critical for successful diagnosis. This study aimed to determine the dependability of immunohistochemistry (IHC) markers specifically AMACR, p63, and Cytokeratin as a means of diagnosing cancer. The diagnostic value of HOXB13 gene variants and MYC mRNA expression in tissues with benign prostatic hyperplasia (BPH) was also evaluat …

31.08.2026journal-article

Journal of the Korean Society of Cosmetology

The Relationship between Lookism and Appearance Satisfaction of Female Consumers with Eyelash Treatment Experience

Ga-Hyun Kim, Eun-Jun Park

The purpose of this study is to analyze the relationship between lookism and appearance satisfaction of female consumers who have experienced eyelash procedures. To this end, a survey was conducted on female consumers who have experienced eyelash procedures in Seoul and the metropolitan area from April 21 to May 25, 2025, and 546 out of a total of 580 copies were used for the final analysis. Frequency analysis, factor analysis, reliability analysis, and regression analysis were conducted using SPSS 22.0 for the col …

31.08.2026journal-article

Frontiers in Oncology

Precision-guided therapy in dialysis-dependent classic hairy cell leukemia: a case report

Sindhusha Veeraballi, Madhu Bhargavi Chandra, Eric J. Vick

Background Classic hairy cell leukemia (HCL) is a rare, indolent B-cell lymphoproliferative disorder characterized by bone marrow fibrosis causing pancytopenia, splenomegaly, and a near-universal BRAF V600E mutation. Purine nucleoside analogs (PNAs) are the standard first-line therapy but are contraindicated in patients with significantly advanced chronic kidney disease (CKD) or end-stage renal disease (ESRD) due to renal excretion and risk of prolonged myelosuppression. Data on the use of targeted therapies, such …