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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Adolescent Medicine

Testicular adrenal rests tumours in congenital adrenal hyperplasia: unraveling prevalence, risk factors and new therapeutic horizons in adolescents

Irene Tizianel, Giulia Bovo, Pierluigi Mazzeo, Filippo Ceccato, Mattia Barbot

Testicular adrenal rest tumours (TARTs) are benign intratesticular lesions occurring in males with classic congenital adrenal hyperplasia (CAH), with a prevalence ranging from 0% to 94% depending on age, disease severity and screening method. Although TARTs are non-malignant, their characteristic location can lead to compression of seminiferous tubules causing infertility. Adolescence represents a critical and particularly vulnerable window for TART development and progression. Besides ACTH chronic stimulation, whi …

03.09.2026journal-article

Frontiers in Pediatrics

Clinical utility and tolerability of ketamine as adjunctive rescue therapy for refractory neonatal status epilepticus: a case report of a late preterm infant with multifocal hemorrhagic brain injury

Chiara Gulisano, Alessia Pepe, Elisabetta Amadori, Samuele Caruggi, Daniele Caratozzolo, Lino Nobili, Pasquale Striano, Luca Antonio Ramenghi, Andrea Calandrino

Background Neonatal status epilepticus (NSE) is a life-threatening neurological emergency associated with high mortality and long-term neurodevelopmental morbidity. Although phenobarbital remains the recommended first-line antiseizure medication (ASM), followed by agents such as phenytoin or levetiracetam, seizure control is not always achieved. Ketamine, a non-competitive N methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a potential rescue therapy for refractory status epilepticus because of its uniq …

03.09.2026journal-article

Frontiers in Pediatrics

Physical activity and health-related quality of life among Chinese adolescents: a cross-sectional statistical path model involving sleep disturbance and depressive symptoms

Mengxuan Liu

Objective Physical activity (PA) is positively associated with health-related quality of life (HRQoL) in adolescents, while sleep disturbance and depressive symptoms are also closely related to both PA and HRQoL. However, relatively few studies have examined these factors simultaneously, particularly among Chinese adolescents. This study examined the association between PA and HRQoL and assessed the separate and serial indirect associations involving sleep disturbance and depressive symptoms. Methods A cross-sectio …

03.09.2026journal-article

Frontiers in Public Health

Compact metasurface track-side PIS antenna-based occupational electromagnetic exposure research of inspectors in the metro tunnel

Ming-Fei Luo, Jin-Jing Xu, Wen-Ying Zhou, Xin-Hong Li, Mai Lu

Introduction With the advancement of Smart Urban Rail construction, the electromagnetic environment has become increasingly complex inside metro tunnels. Track-side inspectors may experience occupational radio-frequency (RF) exposure when conducting professional inspections in such a closed electromagnetic environment. Methods In order to analyze the occupational electromagnetic exposure dose absorbed by the track-side inspectors,and explore a method to reduce the influence of RF electromagnetic radiation. We propo …

03.09.2026journal-article

Frontiers in Public Health

Understanding support needs for family-participatory prehabilitation before hepatectomy: a qualitative study on Chinese patients and family caregivers

Chuan You, Huan Li, Norshafarina Shari, Jingdong Li

Background/objectives Prehabilitation can improve patients’ physical and psychological reserve before hepatectomy, but its value depends on implementation in daily life. Because prehabilitation mainly takes place at home, family caregivers may strongly influence whether patients can follow the program. It remains unclear how family caregivers can be involved effectively. This study explored the support needs, barriers, and facilitators experienced by patients awaiting hepatectomy and their family caregivers, with t …

03.09.2026journal-article

Municipal service: legal issues

Municipal Control over the Observance of Patients' Rights: The State and Development Trends of Legal Regulation in the Context of the Healthcare System Reform

Levan T. Chikhladze, Ashot V. Kamalyan

The article examines the legal nature and content of municipal control over the observance of patients’ rights in the context of healthcare system reform in the Russian Federation. The study analyzes constitutional, municipal and healthcare legislation defining the scope and limits of local self-government bodies’ participation in ensuring patients’ rights. The paper identifies key regulatory and institutional challenges of municipal control and substantiates the main directions of its development within a risk-bas …

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Translating analytical performance into clinical misclassification risk: a probabilistic framework for HbA 1c interpretation

Lorenza Fagnani, Rita Tennina, Pierangelo Bellio, Patrizia Frascaria, Marco Rossi, Sabrina Viggioni, Moira Tucceri Cimini, Consuelo Scimia, Alessandra Piccirilli, Mariagrazia Perilli, Fabio Antonelli, Giuseppe Celenza

Abstract Objectives Using HbA 1c for diabetes diagnosis directly links analytical uncertainty to patient classification. Since traditional performance metrics provide limited insight into these clinical implications, we developed a probabilistic framework to translate HbA 1c concentrations and components of analytical uncertainty into clinically interpretable diagnostic risk. Methods The framework was applied to 100,472 HbA 1c results obtained from a real-world Laboratory Information System. Analytical bias, analyt …

03.09.2026journal-article

Frontiers in Organizational Psychology

The factors associated with workforce attrition and intention-to-leave among healthcare workers in New Zealand: a systematic literature review and meta-synthesis of qualitative research

Mia Clarke, Ben Stephen, Mike Frecklington, Irene Zeng, Matthew R Carroll, Richard J Siegert, Sarah Stewart

Despite growing concern about the stability of New Zealand's (NZ) health workforce, no prior synthesis has examined qualitative evidence on factors associated with attrition or intention-to-leave. This systematic review and meta-synthesis included 20 studies and followed the ENTREQ checklist to guide a content analysis of the literature. Seven themes were generated spanning organizational, professional, and personal levels: high workloads, unsupportive organizational culture, limited opportunities for career advanc …

03.09.2026journal-article

Sage Sphere International Journal

Cirugía laparoscópica versus cirugía robótica en la resección de tumores hepáticos: resultados y beneficios clínicos

Joel Sebastian Chango Yosa, Kelvin Alejandro Torres Quezada, Mario Gabriel Salas Martínez, Dana Isabel Morales Figueroa, Alonso Patricio Espinoza Ayala

Introducción: La resección hepática constituye el tratamiento principal de diversos tumores hepáticos. Los abordajes laparoscópico y robótico han ampliado las posibilidades de cirugía mínimamente invasiva, especialmente en procedimientos técnicamente complejos. Objetivo: Sintetizar la evidencia científica sobre los resultados y beneficios clínicos de la cirugía laparoscópica versus robótica en la resección de tumores hepáticos. Metodología: Se realizó una revisión bibliográfica narrativa mediante búsquedas en PubMe …

03.09.2026journal-article

Frontiers in Dental Medicine

Curcumin as an adjunct in periodontal therapy: local effects, delivery systems, and clinical perspectives

Ana Carolina Aparecida Rivas, Mario Taba, Paola Gomes Souza

Curcumin, the active polyphenol in turmeric (Curcuma longa), is well-known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it a promising therapeutic agent for a range of diseases, including neuroinflammatory conditions and periodontal disease. Periodontitis, a prevalent oral disease, is associated with chronic inflammation and bacterial infection. Curcumin has demonstrated antibacterial effects against periodontal pathogens such as Aggregatibacter actinomycetemcomitans, Porphyromonas g …

03.09.2026journal-article

Frontiers in Medicine

Time-Series modeling for predicting mortality risk in intensive care unit patients with pulmonary inflammation

Yihai Zhai, Ruixin Xu, Haisu Lu, Siying Lv, Liqin Mo

Objective This study aims to evaluate dynamic changes in pneumonia-related mortality risk among ICU patients using time-series models and develop interpretable predictive models for early mortality assessment. Methods Data were obtained from the MIMIC-IV and eICU Collaborative Research Database. The MIMIC-IV cohort was split into training and testing sets (7:3 ratio), with external validation conducted using the eICU cohort. Missing data were handled using forward filling and multiple imputation. LSTM was used to e …

03.09.2026journal-article

Frontiers in Medicine

Design, implementation, and evaluation of a programmatic assessment model in an emergency medicine residency: a mixed-methods study

İbrahim Ulaş Özturan, Dilek Kitapcioglu, Prattama Santoso Utomo, Cansu Alyesil Ozturan, Nurettin Özgür Doğan, Elif Yaka, Serkan Yılmaz, Murat Pekdemir, Levent Altıntaş

Background Programmatic assessment (PA) is widely endorsed in postgraduate medical education, but empirical accounts of real-world implementation in emergency medicine (EM) remain limited and are concentrated in North American settings. We piloted and evaluated the design, implementation, and outcomes of a PA model in an EM residency at a high-volume tertiary care center in Türkiye. Methods A mixed-methods study was conducted over an eight-month pilot (November 2024–June 2025). Program design and evaluation followe …

03.09.2026journal-article

Frontiers in Oncology

Analysis of clinical features and outcomes in a Chinese cohort with ALK fusion across pan-cancer: a retrospective study

Meng Zhang, Yi Feng, Xue Du, Changda Qu, Meizhu Meng, Meiying Ye, Min Liang, Ziran Yang, Wenjuan Gong, Xingyu Ma, Jialiang Guo, Wenmei Li, Shuqin Jia

Background ALK fusions are validated oncogenic drivers, yet their molecular heterogeneity and therapeutic implications remain poorly characterized. This study defined the landscape of ALK fusion partners, EML4-ALK variants, and co-mutations and their impact on treatment responses in a large Chinese pan-cancer cohort. Methods We retrospectively analyzed 16,335 consecutive pan-cancer patients via next-generation sequencing to identify ALK fusions. Clinical characteristics, fusion partners, co-mutations, and treatment …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Perimenopause as a potential window of cardiometabolic remodeling in heart failure with preserved ejection fraction: a missed opportunity for prevention

Faith Adedayo Adejumo, Oluwayimika Oluwatobi Obielodan, Fiyinfoluwa Adetoye, Nicholas Aderinto

Heart failure with preserved ejection fraction (HFpEF) disproportionately affects women and has emerged as one of the most prevalent forms of heart failure worldwide. Although the marked increase in HFpEF incidence after menopause is well recognized, the biological events that initiate disease development remain poorly defined. Most mechanistic and clinical investigations have focused on postmenopausal women or established HFpEF, leaving the menopausal transition comparatively underexplored despite growing evidence …

03.09.2026journal-article

Frontiers in Health Services

Patient misidentification and data integrity risks in ultrasound imaging: a case report using multi-framework incident analysis

Benedicta Osei-Donkor, Abdallah Hassoun, Md Shafiqur Rahman Jabin

Background Digital imaging workflows depend on accurate scheduling, patient identity reconciliation, and reliable metadata continuity to ensure safe image storage and retrieval. Disruptions in these processes may not directly affect image acquisition but can delay access to imaging information and pose significant patient safety risks. Objective To examine a recurrent ultrasound workflow failure that compromised downstream image availability and to identify practical strategies for preventing recurrence. Methods A …

03.09.2026journal-article

Frontiers in Medicine

Global trends and thematic clusters in healthcare professional education, medical errors, and patient safety: a bibliometric analysis, 2000–2026

Birgit Hladschik-Kermer, Olena Litvinova, Michel-Edwar Mickael, Maima Matin, Ahmed Fatimi, Anass Belbachir, Mairim Russo Serafini, Maria Kletecka-Pulker, Atanas G. Atanasov, Thomas Wochele-Thoma

Background In the context of the active implementation of the World Health Organization’s Global Patient Safety Action Plan, there is a growing need for a comprehensive synthesis of scientific evidence reflecting the development of research in the field of healthcare professional education. Objective This study aims to conduct a bibliometric analysis of scientific publications addressing the relationship between healthcare professional education, medical errors, and patient safety over the period 2000–2026, based o …

03.09.2026journal-article

International Journal of Computer Science and Mathematical Theory

Mathematical Modelling of Epidemiological Infectious Disease Transmission Dynamics: Public Health Intervention Strategies

Christiana Nkuturum

This study explores the epidemiological infectious disease transmission dynamics with public health intervention strategies using nonlinear ordinary differential equations with four compartments in a mathematical modeling approach. The study identified two major public intervention strategies as preventive and treatment measures. The findings of this study are that the region D of the subset is a positively-invariant set mathematically and epidemiologically from the model equation (1) as a result of the two interve …

03.09.2026journal-article

Healthcare

Association of Aspirin Use with In-Hospital Mortality in Patients with Radiation-Associated Acute Pneumonitis: Insights from the National Inpatient Sample Database

Akash Sharma, Shalini, Sowntappan Balasubramanian, Hamza Yousaf, Ankit Agrawal, Vrinda Vyas

Introduction: This study investigates the relationship between long-term aspirin use and mortality in patients experiencing acute radiation-induced pulmonary complications. Methods: We conducted a secondary analysis from the National Inpatient Sample from 2016 to 2020. Our cohort comprised patients diagnosed with acute pneumonitis secondary to chest radiation. We adhered strictly to the STROBE checklist, extracting various patient characteristics for analysis. Categorical variables were compared using Pearson’s chi …

03.09.2026journal-article

CIVIL SOCIETY IN RUSSIA AND ABROAD

Public Participation in Law Enforcement: Forms and Areas of Implementation

Ivan V. Teplyashin

The development of democratic institutions in the modern national legal system ensures the broad participation of public structures in legal activities, the determination of their status and scope of legal opportunities, their real place in constitutional and legal relations. Special attention should be paid to the possibility of participation of citizens and their associations in law enforcement activities as one of the conditions for strengthening citizens' trust in public authorities and the formation of high-qu …

03.09.2026journal-article

Mental Health and Social Inclusion

Patriarchal career constraints and mental well-being among rural young women: a scoping review of gendered barriers and psychological distress

Shreya Rana, Sunita Dhenwal

Purpose This paper aims to examine the relationship between patriarchal career constraints and mental well-being among rural young women. It explores how gendered barriers related to family authority, restricted mobility, educational discontinuity, marriage expectations and limited employment exposure contribute to psychological distress and social exclusion. Design/methodology/approach This paper adopts a scoping review approach to map and synthesise literature on patriarchy, rural young women, career barriers, ps …

03.09.2026journal-article

Scientific Reports

Genomic and epidemiological comparative analysis of clinical Campylobacter isolates from public and private healthcare centers in Santiago, Chile

Dona Benadof, Mirta I. Acuña-Ávila, Mireya Ahumada, Lorena Porte, Thomas Weitzel, Alfonso Fernández, Gabriel Cavada, Christopher Grim, Narjol González-Escalona, Carlos J Blondel, Assaf Katz, Verónica Bravo

Abstract Campylobacteriosis remains underestimated in Latin America due to limited surveillance and diagnostic capacity. In this context, a comparison was made of clinical Campylobacter strains from two distinct healthcare settings in Santiago, Chile: a public pediatric hospital and a private tertiary clinic. Through genomic analysis, host-source attribution was observed to vary across socioeconomic profiles: poultry-associated lineages (such as ST-353 and ST-443 complexes) were, as expected, frequently identified …

03.09.2026journal-article

BMC Cancer

Towards a universal ovarian cancer biomarker model: clinical validation of Trx1 and CA125 dual strategy

Mi A Park, Songhak Kim, Xiaoguang Yang, Jong Am Song, Geon Woo Lee, Heon Jong Yoo, Soyoung Kim, Kyoung Hoon Suh, Young Bok Ko

Abstract Background Ovarian cancer is the fifth leading cause of cancer-related mortality in women, with early detection being critical for improving patient outcomes. Current diagnostic biomarkers, including Cancer antigen 125 (CA125), human epididymis protein 4 (HE4), and their combined Risk of Ovarian Malignancy Algorithm (ROMA), exhibit limited sensitivity and specificity, particularly in early-stage disease and premenopausal women. Thioredoxin-1 (Trx1) has emerged as a potential complementary biomarker. This e …

03.09.2026journal-article

Journal of Community Health Provision

Association of Lipid Profile, Glycated Hemoglobin (HbA1c), and Hypertension History with Coronary Artery Disease among Adult Patients: A Cross-Sectional Study

Witi Karwiti, Nasrazuhdy Nasrazuhdy, Wuni Sri Lestari, Nurhayati Nurhayati, Yusneli Yusneli, Asrori Asrori

Coronary artery disease (CAD) remains a major cause of cardiovascular morbidity and mortality worldwide. This study aimed to examine the association of lipid profile, glycated hemoglobin (HbA1c), and hypertension history with CAD among adult patients. A cross-sectional analytical study was conducted among 40 adult patients undergoing cardiovascular evaluation at Abdul Manap Regional General Hospital, Jambi, Indonesia, including 20 patients with CAD and 20 participants without CAD. Demographic characteristics, lipid …