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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Medicine

Isolated gastrointestinal hereditary angioedema associated with a pathogenic SERPING1 variant arising de novo: a case report

Ziyu Yuan, Weipeng Lin, Yue Zheng, Xizi Yuan, Ming Luo, Lingyu Fu, Haiyan Zhang

Hereditary angioedema (HAE) is a rare genetic disorder typically characterized by cutaneous and submucosal edema. Cases presenting exclusively with gastrointestinal symptoms, devoid of concurrent or historical cutaneous or upper airway manifestations, are uncommon. This atypical presentation poses a considerable diagnostic challenge and often leads to a marked delay in diagnosis, particularly in patients without a family history. We report the case of a 28-year-old female with an over 6-year history of recurrent, s …

03.09.2026journal-article

El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam

Analysis of Non-Menopatic Patient Loyalty at Dr. Rm. Soedjarwadi Regional Mental Hospital, Central Java Province

Asril Aziz Rahmatullah, Sudarwati Sudarwati, Oong Ridhoi

This study aims to analyze the influence of service quality, facilities, rates, location, and hospital image on the loyalty of non-mental patients at Dr. RM. Soedjarwadi Mental Hospital, Central Java Province. This study used a quantitative method with a survey approach. The study population was all non-mental patients who had received services at Dr. RM. Soedjarwadi Mental Hospital, Central Java Province, with the criteria of having received treatment at least twice. Data were collected using a questionnaire compi …

03.09.2026journal-article

South African Journal of Information Management

Implementing mobile health applications in disaster zones: A systematic literature review

Sinothando Bacela, Olutoyin Olaitan

Background: Mobile health (mHealth) applications have emerged as powerful tools in healthcare delivery, particularly in disaster zones where infrastructure is compromised and conventional health systems are disrupted. Their ability to provide remote access, real-time communication and data-driven decision support makes them especially valuable in resource-constrained settings. Objectives: This systematic review analyses the current landscape of mHealth applications deployed in disaster settings, focusing on their c …

03.09.2026journal-article

Biomedical Engineering / Biomedizinische Technik

Federated learning for multi-institutional AI in healthcare via digital pathology

Ramin Soleimani, Mohammadreza Azimi, Nazanin Talebi

Abstract The integration of artificial intelligence (AI) in digital pathology has shown significant promise in advancing cancer diagnostics, grading, and treatment response prediction. However, widespread development and deployment of robust AI models face critical challenges due to data silos, privacy concerns, and the need for large-scale multi-institutional datasets. Federated Learning (FL) presents a transformative approach by enabling collaborative model training across hospitals without direct data sharing. I …

03.09.2026journal-article

Frontiers in Pediatrics

Clinical utility and tolerability of ketamine as adjunctive rescue therapy for refractory neonatal status epilepticus: a case report of a late preterm infant with multifocal hemorrhagic brain injury

Chiara Gulisano, Alessia Pepe, Elisabetta Amadori, Samuele Caruggi, Daniele Caratozzolo, Lino Nobili, Pasquale Striano, Luca Antonio Ramenghi, Andrea Calandrino

Background Neonatal status epilepticus (NSE) is a life-threatening neurological emergency associated with high mortality and long-term neurodevelopmental morbidity. Although phenobarbital remains the recommended first-line antiseizure medication (ASM), followed by agents such as phenytoin or levetiracetam, seizure control is not always achieved. Ketamine, a non-competitive N methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a potential rescue therapy for refractory status epilepticus because of its uniq …

03.09.2026journal-article

Frontiers in Public Health

Understanding support needs for family-participatory prehabilitation before hepatectomy: a qualitative study on Chinese patients and family caregivers

Chuan You, Huan Li, Norshafarina Shari, Jingdong Li

Background/objectives Prehabilitation can improve patients’ physical and psychological reserve before hepatectomy, but its value depends on implementation in daily life. Because prehabilitation mainly takes place at home, family caregivers may strongly influence whether patients can follow the program. It remains unclear how family caregivers can be involved effectively. This study explored the support needs, barriers, and facilitators experienced by patients awaiting hepatectomy and their family caregivers, with t …

03.09.2026journal-article

Frontiers in Pediatrics

Physical activity and health-related quality of life among Chinese adolescents: a cross-sectional statistical path model involving sleep disturbance and depressive symptoms

Mengxuan Liu

Objective Physical activity (PA) is positively associated with health-related quality of life (HRQoL) in adolescents, while sleep disturbance and depressive symptoms are also closely related to both PA and HRQoL. However, relatively few studies have examined these factors simultaneously, particularly among Chinese adolescents. This study examined the association between PA and HRQoL and assessed the separate and serial indirect associations involving sleep disturbance and depressive symptoms. Methods A cross-sectio …

03.09.2026journal-article

Frontiers in Public Health

Compact metasurface track-side PIS antenna-based occupational electromagnetic exposure research of inspectors in the metro tunnel

Ming-Fei Luo, Jin-Jing Xu, Wen-Ying Zhou, Xin-Hong Li, Mai Lu

Introduction With the advancement of Smart Urban Rail construction, the electromagnetic environment has become increasingly complex inside metro tunnels. Track-side inspectors may experience occupational radio-frequency (RF) exposure when conducting professional inspections in such a closed electromagnetic environment. Methods In order to analyze the occupational electromagnetic exposure dose absorbed by the track-side inspectors,and explore a method to reduce the influence of RF electromagnetic radiation. We propo …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

From particle count to residence time: a kinetic framework for atherogenic risk

Esteban Larronde

Two sequential advances have narrowed the gap between lipid measurement and atherogenic mechanism. Mendelian randomization established that coronary risk tracks apolipoprotein B (ApoB) particle count, not cholesterol content: when natural discordance exists between low-density lipoprotein cholesterol (LDL-C) and ApoB, risk follows ApoB reduction independently of LDL-C. The 2026 ACC/AHA dyslipidemia guideline formalized this advance, placing ApoB above LDL-C as a risk measure in discordance contexts. That particle-c …

03.09.2026journal-article

Frontiers in Oncology

Exploring traditional Chinese medicine to enhance the efficacy and reduce toxicity of immunotherapy for non-small cell lung cancer from the perspective of “spleen deficiency”: a trial protocol for mechanism and clinical evidence

Cunya Li, Xiaonan Zhang, Shujuan Fu, Pantong Wu, Zhiying Wang, Zhixian Zhong, Yi Zhong

Introduction Although immune checkpoint inhibitors (ICIs) have changed the treatment landscape of advanced non-small cell lung cancer (NSCLC), their low response rates and immune-related adverse reactions (irAEs) remain serious challenges. Traditional Chinese medicine believes that “spleen deficiency” is the core pathogenesis of advanced lung cancer, and its corresponding immune suppression and metabolic disorders may be related to the efficacy of ICIs. This paper aims to explore the clinical application status and …

03.09.2026journal-article

Exploration of Medicine

A computational pathology-based AI framework for predicting PD-L1 expression and prognosis in HNSCC

Yingying Cui, Chuanyang Ding, Long Li, Xinjia Cai

Aim: To investigate interobserver variability in programmed cell death ligand 1 (PD-L1) combined positive score (CPS) assessment in head and neck squamous cell carcinoma (HNSCC) and to develop an artificial intelligence (AI)-based model for predicting PD-L1 expression and patient prognosis from hematoxylin and eosin (H&E)-stained slides. Methods: Fifty HNSCC specimens were independently evaluated for PD-L1 by pathologists with different experience levels. Agreement was assessed using Fleiss’ and Cohen’s κ. Whole-sl …

03.09.2026journal-article

Frontiers in Adolescent Medicine

Testicular adrenal rests tumours in congenital adrenal hyperplasia: unraveling prevalence, risk factors and new therapeutic horizons in adolescents

Irene Tizianel, Giulia Bovo, Pierluigi Mazzeo, Filippo Ceccato, Mattia Barbot

Testicular adrenal rest tumours (TARTs) are benign intratesticular lesions occurring in males with classic congenital adrenal hyperplasia (CAH), with a prevalence ranging from 0% to 94% depending on age, disease severity and screening method. Although TARTs are non-malignant, their characteristic location can lead to compression of seminiferous tubules causing infertility. Adolescence represents a critical and particularly vulnerable window for TART development and progression. Besides ACTH chronic stimulation, whi …

03.09.2026journal-article

The FASEB Journal

PEBP1 Regulates Ferroptosis in Acute Glaucoma: Targeted Therapy Using Engineered Exosomes

Yijia Huang, Di Gong, Junhong Guo, Wei Huang, Tingyu Hu, Shengbin Tang, Li Li, Bingkai Feng, Kuanrong Dang, Simin Deng, Yong Liu, Chunyan Tan, Fei Yao, Jiantao Wang

ABSTRACT Glaucoma is the leading cause of irreversible blindness worldwide, primarily driven by the progressive loss of retinal ganglion cells (RGCs) under pathological high intraocular pressure (ph‐IOP). Despite the established role of ferroptosis in RGC degeneration, specific molecular targets that can be used for clinical intervention still need to be optimized, and the slow onset of conventional gene therapy vectors is incompatible with the acute clinical course of glaucoma. Here, we integrate single‐cell RNA s …

03.09.2026journal-article

L'Endocrinologo

Biomarcatori nell’orbitopatia basedowiana: nuove prospettive per diagnosi, prognosi e terapia personalizzata

Silvia Corrias, Marina Porcu, Francesco Boi, Filippo Lixi, Giuseppe Giannaccare, Giulia Lanzolla

Sommario L’identificazione di biomarcatori rappresenta una delle principali sfide irrisolte nell’orbitopatia basedowiana (OB). In assenza di indicatori biologici validati, la valutazione della malattia rimane essenzialmente clinica. Le crescenti evidenze relative a biomarcatori sierologici, lacrimali e tissutali delineano nuove prospettive per la diagnosi precoce, la stratificazione dei pazienti, il monitoraggio terapeutico e l’implementazione di approcci personalizzati.

03.09.2026journal-article

Municipal service: legal issues

Municipal Control over the Observance of Patients' Rights: The State and Development Trends of Legal Regulation in the Context of the Healthcare System Reform

Levan T. Chikhladze, Ashot V. Kamalyan

The article examines the legal nature and content of municipal control over the observance of patients’ rights in the context of healthcare system reform in the Russian Federation. The study analyzes constitutional, municipal and healthcare legislation defining the scope and limits of local self-government bodies’ participation in ensuring patients’ rights. The paper identifies key regulatory and institutional challenges of municipal control and substantiates the main directions of its development within a risk-bas …

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Translating analytical performance into clinical misclassification risk: a probabilistic framework for HbA 1c interpretation

Lorenza Fagnani, Rita Tennina, Pierangelo Bellio, Patrizia Frascaria, Marco Rossi, Sabrina Viggioni, Moira Tucceri Cimini, Consuelo Scimia, Alessandra Piccirilli, Mariagrazia Perilli, Fabio Antonelli, Giuseppe Celenza

Abstract Objectives Using HbA 1c for diabetes diagnosis directly links analytical uncertainty to patient classification. Since traditional performance metrics provide limited insight into these clinical implications, we developed a probabilistic framework to translate HbA 1c concentrations and components of analytical uncertainty into clinically interpretable diagnostic risk. Methods The framework was applied to 100,472 HbA 1c results obtained from a real-world Laboratory Information System. Analytical bias, analyt …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Perimenopause as a potential window of cardiometabolic remodeling in heart failure with preserved ejection fraction: a missed opportunity for prevention

Faith Adedayo Adejumo, Oluwayimika Oluwatobi Obielodan, Fiyinfoluwa Adetoye, Nicholas Aderinto

Heart failure with preserved ejection fraction (HFpEF) disproportionately affects women and has emerged as one of the most prevalent forms of heart failure worldwide. Although the marked increase in HFpEF incidence after menopause is well recognized, the biological events that initiate disease development remain poorly defined. Most mechanistic and clinical investigations have focused on postmenopausal women or established HFpEF, leaving the menopausal transition comparatively underexplored despite growing evidence …

03.09.2026journal-article

Frontiers in Organizational Psychology

The factors associated with workforce attrition and intention-to-leave among healthcare workers in New Zealand: a systematic literature review and meta-synthesis of qualitative research

Mia Clarke, Ben Stephen, Mike Frecklington, Irene Zeng, Matthew R Carroll, Richard J Siegert, Sarah Stewart

Despite growing concern about the stability of New Zealand's (NZ) health workforce, no prior synthesis has examined qualitative evidence on factors associated with attrition or intention-to-leave. This systematic review and meta-synthesis included 20 studies and followed the ENTREQ checklist to guide a content analysis of the literature. Seven themes were generated spanning organizational, professional, and personal levels: high workloads, unsupportive organizational culture, limited opportunities for career advanc …

03.09.2026journal-article

Frontiers in Health Services

Patient misidentification and data integrity risks in ultrasound imaging: a case report using multi-framework incident analysis

Benedicta Osei-Donkor, Abdallah Hassoun, Md Shafiqur Rahman Jabin

Background Digital imaging workflows depend on accurate scheduling, patient identity reconciliation, and reliable metadata continuity to ensure safe image storage and retrieval. Disruptions in these processes may not directly affect image acquisition but can delay access to imaging information and pose significant patient safety risks. Objective To examine a recurrent ultrasound workflow failure that compromised downstream image availability and to identify practical strategies for preventing recurrence. Methods A …

03.09.2026journal-article

Frontiers in Medicine

Global trends and thematic clusters in healthcare professional education, medical errors, and patient safety: a bibliometric analysis, 2000–2026

Birgit Hladschik-Kermer, Olena Litvinova, Michel-Edwar Mickael, Maima Matin, Ahmed Fatimi, Anass Belbachir, Mairim Russo Serafini, Maria Kletecka-Pulker, Atanas G. Atanasov, Thomas Wochele-Thoma

Background In the context of the active implementation of the World Health Organization’s Global Patient Safety Action Plan, there is a growing need for a comprehensive synthesis of scientific evidence reflecting the development of research in the field of healthcare professional education. Objective This study aims to conduct a bibliometric analysis of scientific publications addressing the relationship between healthcare professional education, medical errors, and patient safety over the period 2000–2026, based o …

03.09.2026journal-article

Frontiers in Dental Medicine

Curcumin as an adjunct in periodontal therapy: local effects, delivery systems, and clinical perspectives

Ana Carolina Aparecida Rivas, Mario Taba, Paola Gomes Souza

Curcumin, the active polyphenol in turmeric (Curcuma longa), is well-known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it a promising therapeutic agent for a range of diseases, including neuroinflammatory conditions and periodontal disease. Periodontitis, a prevalent oral disease, is associated with chronic inflammation and bacterial infection. Curcumin has demonstrated antibacterial effects against periodontal pathogens such as Aggregatibacter actinomycetemcomitans, Porphyromonas g …

03.09.2026journal-article

Frontiers in Medicine

Time-Series modeling for predicting mortality risk in intensive care unit patients with pulmonary inflammation

Yihai Zhai, Ruixin Xu, Haisu Lu, Siying Lv, Liqin Mo

Objective This study aims to evaluate dynamic changes in pneumonia-related mortality risk among ICU patients using time-series models and develop interpretable predictive models for early mortality assessment. Methods Data were obtained from the MIMIC-IV and eICU Collaborative Research Database. The MIMIC-IV cohort was split into training and testing sets (7:3 ratio), with external validation conducted using the eICU cohort. Missing data were handled using forward filling and multiple imputation. LSTM was used to e …

03.09.2026journal-article

Frontiers in Medicine

Design, implementation, and evaluation of a programmatic assessment model in an emergency medicine residency: a mixed-methods study

İbrahim Ulaş Özturan, Dilek Kitapcioglu, Prattama Santoso Utomo, Cansu Alyesil Ozturan, Nurettin Özgür Doğan, Elif Yaka, Serkan Yılmaz, Murat Pekdemir, Levent Altıntaş

Background Programmatic assessment (PA) is widely endorsed in postgraduate medical education, but empirical accounts of real-world implementation in emergency medicine (EM) remain limited and are concentrated in North American settings. We piloted and evaluated the design, implementation, and outcomes of a PA model in an EM residency at a high-volume tertiary care center in Türkiye. Methods A mixed-methods study was conducted over an eight-month pilot (November 2024–June 2025). Program design and evaluation followe …

03.09.2026journal-article

Frontiers in Oncology

Analysis of clinical features and outcomes in a Chinese cohort with ALK fusion across pan-cancer: a retrospective study

Meng Zhang, Yi Feng, Xue Du, Changda Qu, Meizhu Meng, Meiying Ye, Min Liang, Ziran Yang, Wenjuan Gong, Xingyu Ma, Jialiang Guo, Wenmei Li, Shuqin Jia

Background ALK fusions are validated oncogenic drivers, yet their molecular heterogeneity and therapeutic implications remain poorly characterized. This study defined the landscape of ALK fusion partners, EML4-ALK variants, and co-mutations and their impact on treatment responses in a large Chinese pan-cancer cohort. Methods We retrospectively analyzed 16,335 consecutive pan-cancer patients via next-generation sequencing to identify ALK fusions. Clinical characteristics, fusion partners, co-mutations, and treatment …