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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

American Journal of Physiology-Cell Physiology

Isoform-specific modulation of PI3K/Akt1 signaling by Orai channels in estrogen receptor-positive breast cancer

Alvaro Macías-Díaz, Jose J. Lopez, Manuel Fuentes-Mateos, Tarik Smani, Juan A. Rosado

Orai1 and Orai3 exert opposing effects on the PI3K/Akt1 pathway, revealing a complex regulatory mechanism to coordinate cellular processes, such as survival, in ER+ breast cancer cells. Although Orai3 promotes Akt1 activation via CaMKK to drive tumor progression, Orai1 acts as a modulator on this axis through an AC8/cAMP-dependent mechanism. These findings highlight the functional diversity of Orai proteins and identify them as potential therapeutic targets for modulating Akt1-driven aggressiveness in breast cancer …

01.09.2026journal-article

Clinical Cancer Bulletin

Patient-derived tumor organoid co-culture systems as translational platforms for cancer immunotherapy and precision oncology

Mohamed Gadelkarim, Ahmed Elsayed, Tasneem Abaza, Ahmed Reda Bahr, Yousif Elsayed, Omer Iqbal

Abstract The tumor microenvironment (TME) is a dynamic and immunosuppressive niche that critically governs cancer progression, immune evasion, and therapeutic resistance. Accurately modeling tumor–immune interactions in vitro is therefore essential for advancing our understanding of cancer biology and accelerating the development of effective immunotherapies. Co-culture systems have emerged as powerful platforms for this purpose, enabling the controlled study of cellular crosstalk between tumor cells and immune, st …

01.09.2026journal-article

BMC Cancer

Clinicopathological patterns of colorectal cancer during the Sudan conflict: a regional oncology center experience

Mohammed Eltoum Hamed Azoz, Anas Abdalla Abdelrahman Suleiman, Abdelmoniem M M Makkawi, Moataz Mohamed Al Hasan Ali, Nagi Sulieman Alawad Elimam, Meysaa Abdalazim A Ahmed, Alshareef Mohammed Alshareef, Aimen Elsheikh Khalil Abuelnour, Mohammed Yousof Bakhiet

Abstract Background The current armed conflict in Sudan disrupts the health system and affects the referral pathway. It affected the central oncological lead, leading to dependence on the regional oncological centre. This study aimed to assess the demographic and clinicopathological pattern of colorectal cancer in Sudan during the ongoing health center disruption in the regional oncology White Nile Oncological Center. Methods This retrospective, cross-sectional, hospital-based study analyzed data from all colorecta …

01.09.2026journal-article

INTERNATIONAL JOURNAL OF CARE SCHOLARS

Navigating Complexity Using Framework Analysis in a Case Study on Self-Management in Nasopharyngeal Cancer

Che Azunie Che Abdullah, Sanisah Saidi, Nor Ez-Zatul Hanani Mohamed Rosli, Juliana

Background: Nasopharyngeal cancer presents unique self-management challenges due to its complex treatment regimens, long-term side effects, and cultural influences on patient care. While qualitative approaches are widely used to explore these experiences, there remains limited methodological discussion on how specific analytic frameworks can enhance rigor and transparency in case study designs. Therefore, this paper critically examines the application of framework analysis in a qualitative case study exploring self …

01.09.2026journal-article

Journal of Clinical Oncology

SKYSCRAPER-01: Tiragolumab in Combination With Atezolizumab in Previously Untreated PD-L1–High, Locally Advanced, Unresectable or Metastatic Non–Small Cell Lung Cancer

Solange Peters, Roy Herbst, Hidehito Horinouchi, Luis Paz-Ares, Melissa Johnson, Benjamin J. Solomon, Mahmut Gumus, Mustafa Erman, Igor Bondarenko, Dong-Wan Kim, Enriqueta Felip, Alessandro Morabito, Maciej Bryl, Laszlo Urban, Kaname Nosaki, Martin Reck, Raymond Meng, Chipman Stroud, Palak Kundu, Xiaohui Wen, Namrata S. Patil, Meilin Huang, Sarah Troutman, Christina Matheny, Byoung Chul Cho

PURPOSE Tiragolumab plus atezolizumab has shown encouraging survival outcomes in metastatic non–small cell lung cancer (NSCLC), primarily in patients with PD-L1–high tumors. We further evaluated the combination of tiragolumab plus atezolizumab in the phase III SKYSCRAPER-01 study. METHODS Patients with untreated, locally advanced unresectable/metastatic PD-L1–high (by central laboratory testing) NSCLC were randomly assigned 1:1 to receive either tiragolumab (600 mg) plus atezolizumab (1,200 mg) or placebo plus atez …

1 Zitationen
01.09.2026journal-article

CVIR Oncology

Pulsed Electric Field (PEF) ablation of primary lung cancer: a case series

Logan E. Taylor, Aaron Rohr, Carissa N. Walter, Zachary S. Collins

Abstract PEF (pulsed electric field) ablation uses electric fields to cause irreversible electroporation of cell membranes, which induces apoptosis. Potential advantages include preserved tissue structure around the tumor and reduced local inflammation. Literature on PEF ablation for primary lung cancer is limited. Five patients with lung cancer underwent PEF ablation. Demographic and clinical data were collected on each patient, including pertinent medical history. Of the five patients that underwent PEF ablation, …

01.09.2026journal-article

Frontiers in Immunology

Clinical inflammatory shifts and peripheral flow-cytometry immune modules across benign pulmonary nodules, adenocarcinoma-spectrum nodules, and overt lung cancer

Yunwei Rao, Qianyue Gong, Jiawei Li, Nan Liu, Hongmei Miao, Jinyue Huang, Shuiming Xu

Objective Pulmonary nodules (PN) represent a clinically heterogeneous pathway that includes benign lesions, adenocarcinoma-spectrum lesions, and cases that may differ from clinically overt lung cancer (LC). This study aimed to define a peripheral blood immunophenotyping framework for this pathway by integrating routine inflammatory readouts with transparently defined whole-blood flow-cytometry immune modules. Methods We performed a retrospective analysis of a single-center locked cohort of 217 participants, includi …

01.09.2026journal-article

Frontiers in Psychology

Case Report: Family-mediated prognostic non-disclosure and psychological deterioration in terminal cancer

Pavithra Sankara Subramanian, Shrenik Ostwal

Prognostic non-disclosure is a common practice in Indian palliative care, often driven by family members' intentions to protect patients from emotional distress. However, the psychological consequences of sustained non-disclosure remain insufficiently documented within psycho-oncology literature. This case report, structured according to the CARE guidelines, describes the psychological trajectory of a 34-year-old male police officer with metastatic gastric carcinoma whose terminal prognosis was withheld at his fami …

01.09.2026journal-article

Angewandte Chemie

Sono‐Triggered In Situ Vaccine via a Chlorin‐Based Small Molecule Sensitizer for Systemic Cancer Therapy

Jinrong Li, Kun Shao, Lin Cheng, Guanyi Zhang, Jianlong Su, Yiming Liu, Yang Wang, Chengdong Wang, Zhihao Wu, Xu Wang, Yuxuan Zhang, Bohua Yan, Lei Wang, Guangzhe Li

ABSTRACT Unimolecule‐mediated sonodynamic therapy (SDT) offers a promising approach to combat tumors systemically by enabling synergistic sono‐triggered cytotoxicity and in situ vaccine‐like effects within tumors. Although chlorin‐based sensitizers have achieved clinical success in phototherapy, their translation to SDT has been impeded by inadequate ultrasound (US)‐triggered reactive oxygen species (ROS) generation, leading to suboptimal immunogenic cell death (ICD) and compromised antitumor immunity. To address t …

01.09.2026journal-article

Journal of Clinical Oncology

Reduced/No Dexamethasone With Netupitant/Palonosetron and Olanzapine for Chemotherapy‑Induced Nausea/Vomiting in Highly Emetogenic Chemotherapy: Phase III Noninferiority Trial

Yanchun Meng, Yingying Liu, Mingxi Lin, Lili Wang, Yuxin Mu, Ling Yang, Yiqun Du, Xiaojun Liu, Yong Chen, Shaodong Tian, Qin Zhou, Xiaojie Zhuang, Zikang Li, Jinsong Liu, Shencun Fang, Weifei Fan, Yu Mao, Ling Zhang, Hao Wu, Fei Yan, Jie Weng, Jianhua Zhao, Xiangyu Long, Lianfang Liu, Jianbo Zhou, Jian Zhang

PURPOSE Guideline-recommended 4-day dexamethasone (DEX) for highly emetogenic chemotherapy (HEC) raises toxicity and immunotherapy interference concerns. We tested whether DEX reduction or omission with netupitant/palonosetron (NEPA) plus olanzapine (OLZ) is noninferior to standard DEX. PATIENTS AND METHODS In this open-label, randomized phase III noninferiority trial across 28 Chinese centers, adults receiving HEC received NEPA (day 1) plus OLZ (days 1-4) and were randomly assigned to standard DEX (12 mg day 1, 8 …

1 Zitationen
01.09.2026journal-article

BMC Medical Imaging

Multichannel deep learning using multiregional DCE-MRI to predict axillary pathological complete response after neoadjuvant chemotherapy in breast cancer

Jun Liao, Mengting Xu, Ruimin Li, Shunian Li, Ziwei Cao, Danyang Wang, Yongli Li, Meiyun Wang, Hongna Tan

Abstract Objectives To develop and compare multiregional 2D and 2.5D deep learning models based on DCE-MRI for noninvasive prediction of axillary lymph node (ALN) pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). Methods This retrospective study enrolled 305 patients with invasive breast cancer and ipsilateral ALN metastasis, which were randomly assigned to a training set ( n = 214) and a validation set ( n = 91). The Mann–Whitney U test, Spearman correlation analysis, max-relevance and min …

02.09.2026journal-article

Cancer Informatics

GATES: A Lightweight Tool Automating Pathogenic Variant Discovery From Raw Whole-Exome Sequencing Data

Nicholas E. Bambach, Julio C. Ricarte-Filho, Erin R. Reichenberger, Aime T. Franco

Background Whole-exome sequencing is a widely used technology to identify pathogenic variants in cancer. Although sequencing itself has become increasingly accessible, downstream analysis remains computationally complex, presenting a challenge for many researchers. Existing pipelines lack integrated support for somatic and germline variant detection and still require significant computational resources. Methods We developed GATES (GATK Automated Tool for Exome Sequencing), a lightweight pipeline that automates data …

01.09.2026journal-article

Asian Journal of Andrology

Biochanin A inhibits the activity of androgen receptor mutants to suppress the development of prostate cancer

Yong-Nan Chi, Chen-Yang Wang, Tao Yang, Ying Liu, Deng-Long Wu, Sheng-Song Huang

Androgens and the androgen receptor ( AR ) play a central role in the development and progression of prostate cancer. While biochanin A (BCA) has been reported to suppress androgen synthesis and overcome resistance to abiraterone and enzalutamide, its direct effects on AR , particularly mutant AR , remain unclear. In this study, we systematically investigated the binding affinity and functional impact of BCA on a panel of clinically relevant AR mutations to identify patient subgroups that may benefit from BCA treat …

01.09.2026journal-article

Journal of the American Chemical Society

Large-Mesopore Covalent Organic Framework Nanoparticles for Small Interfering RNA Delivery toward Cancer Immunotherapy

Renzeng Chen, Haiyin Yang, Huiping Zhu, Lihua Wu, Zhitong Guo, Xi Yu, Jie Wang, Yuanbo Wang, Yuanyu Huang, Bo Wang

Abstract Small interfering RNA (siRNA) offers a promising modality for tumor immunotherapy through a precise gene-silencing mechanism, whereas its efficient loading and in vivo delivery rely on specialized carriers because of its polyanionic nature. Porous nanomaterials represent attractive platforms for designing such carriers. However, constructing biocompatible porous organic materials for efficient siRNA loading and in vivo delivery is challenging because structurally stable organic nanoparticles (NPs) with abu …

01.09.2026journal-article

Nano Research

In-situ generation of hyperbaric hydrogen via crystallization-driven β -MgH 2 reservoirs for cancer-specific starvation therapy

Qingqing Guan, Zhou Yang, Wenjiang Ding, Jinyun Tan, Janxin Zou, Jia Pei

Abstract Molecular hydrogen (H2) shows promise for tumor treatment, whereas its therapeutic potential is seriously challenged by inadequate dosing along with unclear biological mechanisms. Herein, spurred on by the first successful report with high-pressure H2 inhalation administration, we develop a locally generated hyperbaric hydrogen platform by fabricating and leveraging crystalline β-phase magnesium hydride (MgH2) as reservoirs of superior hydrogen-releasing capacity for tumor starvation therapy. The as-synthe …

01.09.2026journal-article

Beni-Suef University Journal of Basic and Applied Sciences

Design of novel hydrazide–hydrazone derivatives targeting MGC803 gastric cancer cell line by integrating 3D-QSAR, ADMET, network pharmacology, docking, MD simulations and biological efficacy

Lhoucine Naanaai, Abdellah El Aissouq, Yassine El Allouche, Youssra Ech-Chahdi, Hicham Zaitan, Fouad Khalil

Abstract The MGC803 cell line is a human gastric cancer model frequently used in cancer research. In this context, a combined in silico approach including 3D-QSAR modeling, ADMET analysis, network pharmacology, docking, molecular dynamics and ligand transport evaluations, was applied to design new antiproliferative molecules. A robust 3D-QSAR model with high predictive capacity ( R² and Q² ) was developed and used to design new compounds (PR1–PR4). After an ADMET screening, the putative biological targets of the no …

01.09.2026journal-article

Journal of Clinical Medicine

Baseline and Early On-Treatment Prognostic Nutritional Index in Hormone Receptor–Positive, HER2-Negative Metastatic Breast Cancer Treated with CDK4/6 Inhibitors

Ezgi Çoban, Atilla Eren Kurt, Fırat Akagündüz, Ahmet Demirel, Mustafa Alperen Tunç, Burak Paçacı, Ali Kaan Güren, Erkam Kocaaslan, Pınar Erel, Yeşim Ağyol, Abdussamet Çelebi, Selver Işık, Nazım Can Demircan, Osman Köstek, İbrahim Vedat Bayoğlu, Murat Sarı

Background/Objectives: The prognostic nutritional index (PNI) has been associated with outcome in metastatic breast cancer, but studies in CDK4/6 inhibitor-treated patients have used cohort-derived thresholds and examined only the pretreatment value. We assessed the PNI as a continuous variable, compared it with inflammatory indices, and examined whether repeated measurement added information. Methods: We reviewed 192 consecutive patients with hormone receptor–positive, HER2-negative metastatic breast cancer treate …

01.09.2026journal-article

Molecular Psychiatry

Nutraceuticals and phytoceuticals for the treatment of major depressive disorder: a systematic review and network meta-analysis

Michele Fornaro, Chiara Di Lorenzo, Nicolas Nunez, Alessandro Miola, Raffaella Calati, André Ferrer Carvalho, Luca Steardo, Brendon Stubbs, David Mischoulon, Christoph U. Correll, Marco Solmi

Abstract Background “Nutraceuticals” and “phytoceuticals” may have antidepressant activity, prompting an in-depth network meta-analysis of randomized clinical trials (RCTs). Methods Systematic review and network meta-analysis (PubMed/MEDLINE/EMBASE/Scopus/PsycINFO/CENTRAL/ClinicalTrials.gov (until 01/07/2025) of RCTs vs. placebo or treatment as usual (TAU = antidepressants) testing nutraceuticals/phytoceuticals in major depressive disorder (MDD). Change in depressive symptomatology (standardized-mean-difference = S …

01.09.2026journal-article

Scientific Reports

Microbiome alterations in mismatch-repair deficient metastatic colorectal cancer patients

Gianmarco Piccinno, Paolo Manghi, Luca Lazzari, Chiara Pozzi, Salvatore Siena, Andrea Sartore-Bianchi, Michela Lizier, Carmen Correale, Federica Armanini, Katarina Mladenovic, Michele Palazzo, Alessandra Raimondi, Filippo Pietrantonio, Francesco Asnicar, Federica Marmorino, Chiara Cremolini, Lisa Derosa, Laurence Zitvogel, Alberto Bardelli, Silvia Marsoni, Maria Rescigno, Nicola Segata

Abstract Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Many efforts have been made to stratify CRC cases, from investigating the genomic characteristics of the tumor to – more recently – considering the gut microbiome. Differences in the composition of the gut microbiome occur along CRC stages and according to primary tumor location. The microbiome links with other tumor characteristics remain underinvestigated, including those related to microsatellite instability, that hav …

01.09.2026journal-article

Advanced Healthcare Materials

MYC‐Sensitized Cuproptosis Combined With PTT to Remodel the Immune Microenvironment of Prostate Cancer

Yan Gao, Ji Liu, Jiahui Hu, Chuansheng Xu, Shiyu Mao, Chen Li, Xudong Yao, Shuo Shi

ABSTRACT Prostate cancer (PCa) is the most prevalent malignancy in men, often progressing to a more refractory form castration‐resistant prostate cancer (CRPC) after primary androgen deprivation therapy. Immunotherapy has brought new hope to PCa patients, but the immunosuppressive characteristics of PCa cells limit its efficacy. Cuproptosis, which can affect tumorigenesis, therapeutic resistance, and immune modulation has received significant attention recently. However, it is limited by insufficient copper ion (Cu …

01.09.2026journal-article

Frontiers in Oncology

Leveraging machine learning algorithms to assess the impact of cervical cancer early detection on patients’ survival

Piero Mazimpaka Irakiza, Absolomon Gashaija, Semakula Muhammed, Felix K. Rubuga, Jean Damascene Hagenimana, Emmanuel Christian Nyabyenda, Belson Rugwizangoga

Background Cervical cancer morbidity and mortality remain a significant global health challenge worldwide, with an age-standardized incidence rate (ASR) of 7.3/100,000 in 2022. Low and Middle-Income Countries (LMICs), especially sub-Saharan Africa, have the highest incidence and mortality of cervical cancer, with 70% to 90% of cervical cancer cases and deaths, respectively. Despite Rwanda’s considerable efforts, cervical cancer remained the second most prevalent cancer among Rwandan women in 2023. Although numerous …

01.09.2026journal-article

Frontiers in Oncology

A LASSO-based nomogram for predicting sarcopenia-related nutritional risk in esophageal cancer patients: model development, validation, and an interactive clinical decision tool

Jiwei Zhang, Yayun Cui, Zhen Zong, Wei Zhang

Objective This study aims to construct an interpretable predictive model for esophageal cancer sarcopenia-related nutritional risk based on multidimensional clinical indicators and develop an interactive clinical decision support system. Methods The study cohort comprised 202 patients with a confirmed diagnosis of esophageal cancer who were retrospectively recruited from Taikang Xianlin Drum Tower Hospital. The study period spanned from January 2023 to December 2025. The sample was split into training and validatio …

01.09.2026journal-article

Frontiers in Medicine

Case Report: Blastic plasmacytoid dendritic cell neoplasm mimicking systemic lymphoma: a multidisciplinary diagnostic challenge

Baixue Lv, Qin Rong, Yan Li, Dongdong Zhang

Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy originating from plasmacytoid dendritic cell precursors. While classic cases present with prominent cutaneous nodules and lymphadenopathy, predominant generalized lymphadenopathy can obscure the diagnosis, frequently resulting in a misdiagnosis of systemic lymphoma. Case presentation A 56-year-old male presented with a one-month history of generalized pruritic erythema and multi-regional lymphadenopathy. Initial …

01.09.2026journal-article

Genes, Chromosomes and Cancer

Pleomorphic Liposarcoma: Comprehensive Genomic Analysis of 39 Cases With Comparison to Other Genomically Complex Sarcomas

Mohamed A. Yakoub, Carla Saoud, David Kim, Mark A. Dickson, Aimee M. Crago, Meera Hameed, Narasimhan P. Agaram

ABSTRACT Pleomorphic liposarcoma (PLPS) is an aggressive high‐grade sarcoma that often shows diverse morphological features and can mimic high‐grade undifferentiated pleomorphic sarcoma (UPS)/spindle cell sarcoma or myxofibrosarcoma (MFS), especially when pleomorphic lipoblasts are sparse. The molecular profile of PLPS is distinct from well differentiated/dedifferentiated liposarcoma and myxoid liposarcoma. In this study, we investigate 39 cases of PLPS by comprehensive genomic profiling, occurring in 32 patients w …