Vollständiger Abstract
Worum geht es in dieser Arbeit?
Orai1 and Orai3 exert opposing effects on the PI3K/Akt1 pathway, revealing a complex regulatory mechanism to coordinate cellular processes, such as survival, in ER+ breast cancer cells. Although Orai3 promotes Akt1 activation via CaMKK to drive tumor progression, Orai1 acts as a modulator on this axis through an AC8/cAMP-dependent mechanism. These findings highlight the functional diversity of Orai proteins and identify them as potential therapeutic targets for modulating Akt1-driven aggressiveness in breast cancer.
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Alvaro Macías-Díaz, Jose J. Lopez, Manuel Fuentes-Mateos, Tarik Smani, Juan A. Rosado
- Quelle
- American Journal of Physiology-Cell Physiology
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 0363-6143, 1522-1563
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Zitierfähiger Nachweis
Alvaro Macías-Díaz, Jose J. Lopez, Manuel Fuentes-Mateos, Tarik Smani, Juan A. Rosado (2026). Isoform-specific modulation of PI3K/Akt1 signaling by Orai channels in estrogen receptor-positive breast cancer. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00333.2026