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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

The Oncologist

31 Racial Demographic Reporting in Clinical Trials Informing NCCN Kidney Cancer Guidelines

Suhail Sapkota, Niket Shah, Asish Nepal, Maha Bayya, Nadeen Saad, Shreya Motkur, Jason Law, Sai Sushrutha Vemula, James Hosner, Ling Wang, Daniel Isaac

Abstract Background Racial and ethnic disparities persist in kidney cancer incidence and outcomes, yet the evidence-based guiding treatment may not reflect the populations most affected. The American Cancer Society reports a higher burden among African American, American Indian, and Alaska Native populations. The National Comprehensive Cancer Network (NCCN) guidelines define standard-of-care management, but the representativeness of the clinical trials informing these recommendations remains unclear. We evaluated r …

01.09.2026journal-article

TAJ: Journal of Teachers Association

Evaluation of Oxidative Stress in Benign Prostatic Hyperplasia Patients Before and After Treatment with Tamsulosin

Mst Sufia Sultana, Md Tafiqul Islam, Md Abdur Rahim, Md Jahangir Hossain

Background: Benign prostatic hyperplasia (BPH) is a common health problem in aging males, characterized by increased prostate tissue mass leading to urinary outflow obstruction and significant morbidity. Plasma markers of oxidative stress are elevated in men with BPH. This study aimed to assess oxidative stress by measuring serum malondialdehyde (MDA) levels in BPH patients before and after tamsulosin treatment. Methods: This quasi-experimental study was conducted on 60 newly diagnosed BPH patients from January 201 …

02.09.2026journal-article

Clinical Case Reports

Sintilimab Combined With Albumin‐Bound Paclitaxel and SOX Regimen as Conversion Therapy for Unresectable Advanced Gastric Cancer Achieving Complete Remission: A Case Report and Literature Review

Yufan Tang, Boquan Zhou, Bingbing Wen, Ke Yu, Jiajia Jia, Ying Sha, Jixiang Liu, Luyao Li, Ruifang Fan

ABSTRACT For carefully selected patients with unresectable advanced gastric cancer, immunochemotherapy combining PD‐1 inhibitor with albumin‐bound paclitaxel and S‐1/oxaliplatin may achieve deep remission and enable successful R0 resection. Our findings suggest that this multimodal conversion approach could be considered in selected cases with favorable performance status and MDT‐supported indications, as pathological complete remission appears to be attainable in this context.

02.09.2026journal-article

Journal of Cellular and Molecular Medicine

Comparative Efficacy of BTK Inhibitors in Treatment‐Naïve and Relapsed/Refractory Mantle Cell Lymphoma: A Systematic Review and Meta‐Analysis

Fangfei Xu, Xiuping Zou, Yulin Yang, Kuangguo Zhou, Wei Huang

ABSTRACT Bruton tyrosine kinase inhibitors (BTKis) have been employed in the treatment of mantle cell lymphoma (MCL). However, direct comparisons of ibrutinib, zanubrutinib, and acalabrutinib across treatment‐naïve (TN) and relapsed/refractory (R/R) MCL remain limited. This meta‐analysis was intended to evaluate their efficacy, addressing critical gaps in clinical decision‐making. We systematically searched PubMed, Embase, and Cochrane up to January 2025 for studies (RCT/single‐arm) assessing the efficacy of BTKis …

01.09.2026journal-article

British Journal of Ophthalmology

Modular multi-task deep learning framework for prediction of treatment initiation in neovascular age-related macular degeneration modular AI for NVAMD treatment initiation study-MANTIS

Qitong Gao, David Kuo, Joshua Amason, Terry Lee, Jay K Rathinavelu, Miroslav Pajic, Majda Hadziahmetovic

Purpose The purpose of this study is to develop a fully automated system for determining the optimal time to begin anti-vascular endothelial growth factor (anti-VEGF) treatment, based on retinal changes observed in optical coherence tomography (OCT) images and visual acuity (VA) scores. Methods This retrospective study included two cohorts: patients with intermediate dry age-related macular degeneration (AMD) who did not progress to neovascular AMD (NVAMD) and those who progressed and received anti-VEGF treatment. …

01.09.2026journal-article

Journal of Veterinary Internal Medicine

Effect of trilostane treatment on proteinuria secondary to spontaneous hypercortisolism in dogs

Filippo Tagliasacchi, Federico Fracassi, Maddalena Poli, Laura Dalla Tomba, Stefania Golinelli, Antonio Maria Tardo, Francesca Del Baldo

Abstract Background Proteinuria is reported in 68%-71% of dogs with spontaneous hypercortisolism (HC). The long-term effect of trilostane on HC-associated proteinuria remains poorly documented. Hypothesis/Objectives To evaluate the efficacy of trilostane on proteinuria in dogs with HC and identify potential clinical, anamnestic, and analytical differences between responders and nonresponders. Methods Retrospective longitudinal cohort study including dogs with proteinuric HC treated exclusively with trilostane. Clin …

01.09.2026journal-article

Borneo Nursing Journal (BNJ)

Hubungan Cervical Cancer Awareness Terhadap Keikutsertaan Dalam Melakukan Imunisasi HPV Pada Siswi Di SMP Negeri 5 Malang

Valin Novita Putri, Endah Kamila Mas'udah

Kanker serviks merupakan salah satu masalah kesehatan reproduksi utama pada perempuan yangsebagian besar disebabkan oleh infeksi Human Papillomavirus (HPV). Upaya pencegahan primermelalui imunisasi HPV telah direkomendasikan pada remaja putri, namun tingkat keikutsertaan masihbervariasi dan diduga dipengaruhi oleh tingkat cervical cancer awareness. Penelitian ini bertujuanuntuk mengetahui hubungan cervical cancer awareness dengan keikutsertaan dalam melakukanimunisasi HPV pada siswi di SMP Negeri 5 Malang. Peneliti …

02.09.2026journal-article

BMJ Open

Effects of electronic patient-reported outcome monitoring on symptom burden and health-related quality of life in patients with metastatic breast cancer: a systematic review and meta-analysis protocol

Huanhuan Xiong, Qijing Luan, Wei Li, Pingping Tian, Jie Ning, Zhihao Han

Introduction Metastatic breast cancer is increasingly managed as a long-term condition, yet symptom burden and health-related quality of life (HRQoL) remain major patient-centred concerns. Electronic patient-reported outcome (ePRO) monitoring has shown promise in improving symptom surveillance and supporting more responsive care in oncology; however, evidence specifically relating to metastatic breast cancer remains fragmented and has not yet been systematically synthesised. This review, therefore, aims to evaluate …

01.09.2026journal-article

Nano Research

Metabolically glycoengineered vesicular nanovaccine for direct antigen presentation and robust cancer immunotherapy

Xiaoyuan Fan, Fengxiang Liu, Xiwei Jiang, Lili Du, Zhonggui He, Shujun Wang, Jin Sun, Kaiyuan Wang

Abstract Dendritic cell (DC) vaccines have made substantial progress in cancer immunotherapy; however, their efficacy is still limited by the transient in vivo fate of mature DCs and suboptimal lymphatic transport. Here, we report a metabolically glycoengineered, nanovesicle-based and personalized nanovaccine (GSNVs) that displays upregulated C-C chemokine receptor 7 (CCR7) and major histocompatibility (MHC)-I complexes to promote lymph node homing and effectively presents tumor antigens to CD8+ T cells, ultimately …

01.09.2026journal-article

American Journal of Physiology-Cell Physiology

Isoform-specific modulation of PI3K/Akt1 signaling by Orai channels in estrogen receptor-positive breast cancer

Alvaro Macías-Díaz, Jose J. Lopez, Manuel Fuentes-Mateos, Tarik Smani, Juan A. Rosado

Orai1 and Orai3 exert opposing effects on the PI3K/Akt1 pathway, revealing a complex regulatory mechanism to coordinate cellular processes, such as survival, in ER+ breast cancer cells. Although Orai3 promotes Akt1 activation via CaMKK to drive tumor progression, Orai1 acts as a modulator on this axis through an AC8/cAMP-dependent mechanism. These findings highlight the functional diversity of Orai proteins and identify them as potential therapeutic targets for modulating Akt1-driven aggressiveness in breast cancer …

01.09.2026journal-article

Clinical Cancer Bulletin

Patient-derived tumor organoid co-culture systems as translational platforms for cancer immunotherapy and precision oncology

Mohamed Gadelkarim, Ahmed Elsayed, Tasneem Abaza, Ahmed Reda Bahr, Yousif Elsayed, Omer Iqbal

Abstract The tumor microenvironment (TME) is a dynamic and immunosuppressive niche that critically governs cancer progression, immune evasion, and therapeutic resistance. Accurately modeling tumor–immune interactions in vitro is therefore essential for advancing our understanding of cancer biology and accelerating the development of effective immunotherapies. Co-culture systems have emerged as powerful platforms for this purpose, enabling the controlled study of cellular crosstalk between tumor cells and immune, st …

01.09.2026journal-article

BMC Cancer

Clinicopathological patterns of colorectal cancer during the Sudan conflict: a regional oncology center experience

Mohammed Eltoum Hamed Azoz, Anas Abdalla Abdelrahman Suleiman, Abdelmoniem M M Makkawi, Moataz Mohamed Al Hasan Ali, Nagi Sulieman Alawad Elimam, Meysaa Abdalazim A Ahmed, Alshareef Mohammed Alshareef, Aimen Elsheikh Khalil Abuelnour, Mohammed Yousof Bakhiet

Abstract Background The current armed conflict in Sudan disrupts the health system and affects the referral pathway. It affected the central oncological lead, leading to dependence on the regional oncological centre. This study aimed to assess the demographic and clinicopathological pattern of colorectal cancer in Sudan during the ongoing health center disruption in the regional oncology White Nile Oncological Center. Methods This retrospective, cross-sectional, hospital-based study analyzed data from all colorecta …

01.09.2026journal-article

INTERNATIONAL JOURNAL OF CARE SCHOLARS

Navigating Complexity Using Framework Analysis in a Case Study on Self-Management in Nasopharyngeal Cancer

Che Azunie Che Abdullah, Sanisah Saidi, Nor Ez-Zatul Hanani Mohamed Rosli, Juliana

Background: Nasopharyngeal cancer presents unique self-management challenges due to its complex treatment regimens, long-term side effects, and cultural influences on patient care. While qualitative approaches are widely used to explore these experiences, there remains limited methodological discussion on how specific analytic frameworks can enhance rigor and transparency in case study designs. Therefore, this paper critically examines the application of framework analysis in a qualitative case study exploring self …

01.09.2026journal-article

Journal of Clinical Oncology

SKYSCRAPER-01: Tiragolumab in Combination With Atezolizumab in Previously Untreated PD-L1–High, Locally Advanced, Unresectable or Metastatic Non–Small Cell Lung Cancer

Solange Peters, Roy Herbst, Hidehito Horinouchi, Luis Paz-Ares, Melissa Johnson, Benjamin J. Solomon, Mahmut Gumus, Mustafa Erman, Igor Bondarenko, Dong-Wan Kim, Enriqueta Felip, Alessandro Morabito, Maciej Bryl, Laszlo Urban, Kaname Nosaki, Martin Reck, Raymond Meng, Chipman Stroud, Palak Kundu, Xiaohui Wen, Namrata S. Patil, Meilin Huang, Sarah Troutman, Christina Matheny, Byoung Chul Cho

PURPOSE Tiragolumab plus atezolizumab has shown encouraging survival outcomes in metastatic non–small cell lung cancer (NSCLC), primarily in patients with PD-L1–high tumors. We further evaluated the combination of tiragolumab plus atezolizumab in the phase III SKYSCRAPER-01 study. METHODS Patients with untreated, locally advanced unresectable/metastatic PD-L1–high (by central laboratory testing) NSCLC were randomly assigned 1:1 to receive either tiragolumab (600 mg) plus atezolizumab (1,200 mg) or placebo plus atez …

1 Zitationen
01.09.2026journal-article

CVIR Oncology

Pulsed Electric Field (PEF) ablation of primary lung cancer: a case series

Logan E. Taylor, Aaron Rohr, Carissa N. Walter, Zachary S. Collins

Abstract PEF (pulsed electric field) ablation uses electric fields to cause irreversible electroporation of cell membranes, which induces apoptosis. Potential advantages include preserved tissue structure around the tumor and reduced local inflammation. Literature on PEF ablation for primary lung cancer is limited. Five patients with lung cancer underwent PEF ablation. Demographic and clinical data were collected on each patient, including pertinent medical history. Of the five patients that underwent PEF ablation, …

01.09.2026journal-article

Frontiers in Immunology

Clinical inflammatory shifts and peripheral flow-cytometry immune modules across benign pulmonary nodules, adenocarcinoma-spectrum nodules, and overt lung cancer

Yunwei Rao, Qianyue Gong, Jiawei Li, Nan Liu, Hongmei Miao, Jinyue Huang, Shuiming Xu

Objective Pulmonary nodules (PN) represent a clinically heterogeneous pathway that includes benign lesions, adenocarcinoma-spectrum lesions, and cases that may differ from clinically overt lung cancer (LC). This study aimed to define a peripheral blood immunophenotyping framework for this pathway by integrating routine inflammatory readouts with transparently defined whole-blood flow-cytometry immune modules. Methods We performed a retrospective analysis of a single-center locked cohort of 217 participants, includi …

01.09.2026journal-article

Frontiers in Psychology

Case Report: Family-mediated prognostic non-disclosure and psychological deterioration in terminal cancer

Pavithra Sankara Subramanian, Shrenik Ostwal

Prognostic non-disclosure is a common practice in Indian palliative care, often driven by family members' intentions to protect patients from emotional distress. However, the psychological consequences of sustained non-disclosure remain insufficiently documented within psycho-oncology literature. This case report, structured according to the CARE guidelines, describes the psychological trajectory of a 34-year-old male police officer with metastatic gastric carcinoma whose terminal prognosis was withheld at his fami …

01.09.2026journal-article

Angewandte Chemie

Sono‐Triggered In Situ Vaccine via a Chlorin‐Based Small Molecule Sensitizer for Systemic Cancer Therapy

Jinrong Li, Kun Shao, Lin Cheng, Guanyi Zhang, Jianlong Su, Yiming Liu, Yang Wang, Chengdong Wang, Zhihao Wu, Xu Wang, Yuxuan Zhang, Bohua Yan, Lei Wang, Guangzhe Li

ABSTRACT Unimolecule‐mediated sonodynamic therapy (SDT) offers a promising approach to combat tumors systemically by enabling synergistic sono‐triggered cytotoxicity and in situ vaccine‐like effects within tumors. Although chlorin‐based sensitizers have achieved clinical success in phototherapy, their translation to SDT has been impeded by inadequate ultrasound (US)‐triggered reactive oxygen species (ROS) generation, leading to suboptimal immunogenic cell death (ICD) and compromised antitumor immunity. To address t …

01.09.2026journal-article

Journal of Clinical Oncology

Reduced/No Dexamethasone With Netupitant/Palonosetron and Olanzapine for Chemotherapy‑Induced Nausea/Vomiting in Highly Emetogenic Chemotherapy: Phase III Noninferiority Trial

Yanchun Meng, Yingying Liu, Mingxi Lin, Lili Wang, Yuxin Mu, Ling Yang, Yiqun Du, Xiaojun Liu, Yong Chen, Shaodong Tian, Qin Zhou, Xiaojie Zhuang, Zikang Li, Jinsong Liu, Shencun Fang, Weifei Fan, Yu Mao, Ling Zhang, Hao Wu, Fei Yan, Jie Weng, Jianhua Zhao, Xiangyu Long, Lianfang Liu, Jianbo Zhou, Jian Zhang

PURPOSE Guideline-recommended 4-day dexamethasone (DEX) for highly emetogenic chemotherapy (HEC) raises toxicity and immunotherapy interference concerns. We tested whether DEX reduction or omission with netupitant/palonosetron (NEPA) plus olanzapine (OLZ) is noninferior to standard DEX. PATIENTS AND METHODS In this open-label, randomized phase III noninferiority trial across 28 Chinese centers, adults receiving HEC received NEPA (day 1) plus OLZ (days 1-4) and were randomly assigned to standard DEX (12 mg day 1, 8 …

1 Zitationen
01.09.2026journal-article

BMC Medical Imaging

Multichannel deep learning using multiregional DCE-MRI to predict axillary pathological complete response after neoadjuvant chemotherapy in breast cancer

Jun Liao, Mengting Xu, Ruimin Li, Shunian Li, Ziwei Cao, Danyang Wang, Yongli Li, Meiyun Wang, Hongna Tan

Abstract Objectives To develop and compare multiregional 2D and 2.5D deep learning models based on DCE-MRI for noninvasive prediction of axillary lymph node (ALN) pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). Methods This retrospective study enrolled 305 patients with invasive breast cancer and ipsilateral ALN metastasis, which were randomly assigned to a training set ( n = 214) and a validation set ( n = 91). The Mann–Whitney U test, Spearman correlation analysis, max-relevance and min …

02.09.2026journal-article

Cancer Informatics

GATES: A Lightweight Tool Automating Pathogenic Variant Discovery From Raw Whole-Exome Sequencing Data

Nicholas E. Bambach, Julio C. Ricarte-Filho, Erin R. Reichenberger, Aime T. Franco

Background Whole-exome sequencing is a widely used technology to identify pathogenic variants in cancer. Although sequencing itself has become increasingly accessible, downstream analysis remains computationally complex, presenting a challenge for many researchers. Existing pipelines lack integrated support for somatic and germline variant detection and still require significant computational resources. Methods We developed GATES (GATK Automated Tool for Exome Sequencing), a lightweight pipeline that automates data …

01.09.2026journal-article

Asian Journal of Andrology

Biochanin A inhibits the activity of androgen receptor mutants to suppress the development of prostate cancer

Yong-Nan Chi, Chen-Yang Wang, Tao Yang, Ying Liu, Deng-Long Wu, Sheng-Song Huang

Androgens and the androgen receptor ( AR ) play a central role in the development and progression of prostate cancer. While biochanin A (BCA) has been reported to suppress androgen synthesis and overcome resistance to abiraterone and enzalutamide, its direct effects on AR , particularly mutant AR , remain unclear. In this study, we systematically investigated the binding affinity and functional impact of BCA on a panel of clinically relevant AR mutations to identify patient subgroups that may benefit from BCA treat …

01.09.2026journal-article

Journal of the American Chemical Society

Large-Mesopore Covalent Organic Framework Nanoparticles for Small Interfering RNA Delivery toward Cancer Immunotherapy

Renzeng Chen, Haiyin Yang, Huiping Zhu, Lihua Wu, Zhitong Guo, Xi Yu, Jie Wang, Yuanbo Wang, Yuanyu Huang, Bo Wang

Abstract Small interfering RNA (siRNA) offers a promising modality for tumor immunotherapy through a precise gene-silencing mechanism, whereas its efficient loading and in vivo delivery rely on specialized carriers because of its polyanionic nature. Porous nanomaterials represent attractive platforms for designing such carriers. However, constructing biocompatible porous organic materials for efficient siRNA loading and in vivo delivery is challenging because structurally stable organic nanoparticles (NPs) with abu …

01.09.2026journal-article

Nano Research

In-situ generation of hyperbaric hydrogen via crystallization-driven β -MgH 2 reservoirs for cancer-specific starvation therapy

Qingqing Guan, Zhou Yang, Wenjiang Ding, Jinyun Tan, Janxin Zou, Jia Pei

Abstract Molecular hydrogen (H2) shows promise for tumor treatment, whereas its therapeutic potential is seriously challenged by inadequate dosing along with unclear biological mechanisms. Herein, spurred on by the first successful report with high-pressure H2 inhalation administration, we develop a locally generated hyperbaric hydrogen platform by fabricating and leveraging crystalline β-phase magnesium hydride (MgH2) as reservoirs of superior hydrogen-releasing capacity for tumor starvation therapy. The as-synthe …