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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

ARACÊ

DESENVOLVIMENTO, CARACTERIZAÇÃO FÍSICO-QUÍMICA E ESTABILIDADE DE BATOM LABIAL ANIDRO CONTENDO ACICLOVIR E MELISSA OFFICINALIS L. PARA O TRATAMENTO DO HERPES LABIAL

Andressa Cardoso De Melo, Maria Eduarda Schile, Thaila Fernanda Oliveira Da Silva

O herpes labial é uma infecção viral frequente, cujo tratamento tópico convencional pode apresentar limitações relacionadas à praticidade, à permanência da formulação nos lábios e à adesão ao tratamento. Nesse contexto, o desenvolvimento de uma forma farmacêutica inovadora contendo aciclovir associado à Melissa officinalis apresenta-se como uma alternativa de interesse farmacêutico. Objetivou-se desenvolver e avaliar uma formulação de batom labial anidro contendo aciclovir e Melissa officinalis, visando obter uma a …

04.09.2026journal-article

Cancer Research Communications

Neighborhood Factors and Treatment Outcomes in Pediatric Acute Lymphoblastic Leukemia: A REDIAL Consortium Report

Rutu A. Rathod, Amy E. Hughes, Pagna Sok, Karen R. Rabin, Sandi L. Pruitt, Philip J. Lupo, Michael E. Scheurer, Jeremy M. Schraw, the REDIAL Consortium

Abstract Acute lymphoblastic leukemia (ALL) shows persistent outcome disparities among socioeconomically disadvantaged and Hispanic children. Neighborhood socioeconomic status (nSES) and residence in Hispanic enclaves may contribute to these disparities, yet their impact on pediatric ALL is unclear. We examined associations of nSES and Hispanic enclave residence with ALL treatment outcomes. We analyzed children (0–24 years) diagnosed with ALL between 2005 and 2017 and treated at REducing Disparities In Acute Leukem …

04.09.2026journal-article

Therapeutic Advances in Medical Oncology

Adjuvant FOLFIRINOX versus S-1 monotherapy for resected PDAC: retrospective real-world data

Hui Tang, Zhengxia Li, Tingting You, Jinrong Ying, Yuejuan Cheng, Chunmei Bai, Yingyi Wang

Background: Although modified FOLFIRINOX (mFOLFIRINOX) has improved survival in patients with resected pancreatic ductal adenocarcinoma (PDAC) in clinical studies, S-1 is also a treatment option with desirable efficacy and limited toxicity. We aimed to compare the efficacy and safety of adjuvant mFOLFIRINOX with those of S-1 monotherapy for PDAC. Objectives: This study aimed to compare the efficacy and safety of adjuvant mFOLFIRINOX versus S-1 monotherapy in resected PDAC. Design: A retrospective real-world study. …

01.09.2026journal-article

JAIDS Journal of Acquired Immune Deficiency Syndromes

Proviral HIV-1 DNA Below Detection in Early Treated Adolescents After Previous Treatment Interruption

Kavidha Reddy, Louise Kuhn, Shaun Barnabas, Chantal Molechan, Kennedy Otwombe, Thidarat Jupimai, Diana A. Rutebarika, Tacilta Nhampossa, Maria G. Lain, Moherndran Archary, Almoustapha I. Maiga, Avy Violari, Moira Spyer, Ana Barrios-Tascon, Gbenankpon M. Houvessou, Holly L. Peay, Savita Pahwa, Paolo Palma, Mathias Lichterfeld, Mark F. Cotton, Thumbi Ndung'u, CARMA-Global Study Team of the EPIICAL Consortium

Background: Low and undetectable HIV-1 DNA levels are associated with greater likelihood of ART-free viral control and may help select candidates for analytic treatment interruption. We investigated predictors of HIV-1 DNA levels in older children and adolescents with perinatally acquired HIV who started ART early in life. Methods: Children older than 7 years and adolescents on ART and virally suppressed (

01.09.2026journal-article

JAIDS Journal of Acquired Immune Deficiency Syndromes

Incidence and Prevalence of Human Papillomavirus Infection to Predict Outcomes from HPV-Based Cervical Cancer Screening in Women and People with a Cervix Living with HIV

Sofia Nicolls, Elisabeth McClymont, Marette Lee, François Coutlée, Sylvie Trottier, Fiona Smaill, Mona Loutfy, Mark H. Yudin, Marina B. Klein, Marianne Harris, Sarah Stone, Jorge Martinez-Cajas, Sharon Walmsley, Deborah Money, HPV in HIV Study Team

Background: Human papillomavirus (HPV) testing has been implemented in many organized cervix screening programs; however, understanding how this screening methodology affects rates of colposcopy and further follow-up procedures remains underexplored, especially among women with HIV. In the absence of HPV screening program data in British Columbia (BC), Canada, we sought to determine HPV prevalence and estimates for colposcopies among a cohort of women with HIV using the BC Cervix Screening algorithm. Setting: HPV d …

01.09.2026journal-article

American Journal of Physiology-Cell Physiology

Deciphering LonP1’s role in glioblastoma: an alternative mechanism of treatment resistance

Shashi Jain, Dahlia A. Ordaz, Javier Lepe, Naomi Lomeli, James Pham, Bhaskar Das, Daniela A. Bota

Temozolomide (TMZ) is the standard therapy for glioblastoma, but resistance is common and often linked to MGMT-mediated DNA repair. We found that LonP1, a mitochondrial protease, also drives MGMT-independent resistance by maintaining oxidative phosphorylation. Cells chronically exposed to TMZ upregulate LonP1, increase mitochondrial mass, and adopt a more oxidative phosphorylation (OXPHOS)-dependent metabolic phenotype accompanied by altered extracellular acidification. Targeting LonP1 reverses this adaptation and …

01.09.2026journal-article

Journal of Clinical Oncology

Five-Year Outcomes of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy for Locally Advanced Rectal Cancer: Updated Results of the STELLAR Trial

Yuan Tang, Hai-Tao Zhou, Tong-Zhen Xu, Ning Li, Li-Ming Jiang, Jun Jiang, Ning-Ning Lu, Shuai Li, Si-Lin Chen, Hui-Ying Ma, Yong Cai, Yong-Heng Li, Yuan Zhu, Ming-Yuan He, Xin Wang, Ke Liu, Hong-Yan Zhang, Jun Wang, Ting Zhao, Gao-Feng Li, Jia-Lin Yang, Kuan Zhang, Wen-Ling Wang, Wei-Wei Xiao, Yihebali Chi, Lin Yang, Ai-Ping Zhou, Shuang-Mei Zou, Hui Fang, Shu-Lian Wang, Hai-Zeng Zhang, Xi-Shan Wang, Li-Chun Wei, Shi-Xin Liu, Yuan-Hong Gao, Ye-Xiong Li, Chen Hu, Jing Jin

This updated analysis of the STELLAR trial reports 5-year outcomes comparing short-course radiotherapy followed by chemotherapy (SCRT-based total neoadjuvant therapy [TNT]) with standard long-course chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). Patients with distal or middle-third LARC were randomly assigned to receive either SCRT-based TNT or CRT. At a median follow-up of 68.7 months, the 5-year disease-free survival (DFS) was 62.0% in the TNT group and 58.7% in the CRT group, wit …

01.09.2026journal-article

RETINAL Cases & Brief Reports

TREATMENT OF CHOROIDAL MELANOMA-ASSOCIATED EXUDATIVE RETINAL DETACHMENTS WITH A DEXAMETHASONE INTRAVITREAL IMPLANT BEFORE PROTON BEAM RADIATION

Anne M. Lane, Evangelos S. Gragoudas, Ivana K. Kim

Purpose: To evaluate the safety and potential efficacy of a dexamethasone implant (Ozurdex) administered before proton radiation in patients with tumor-associated exudative retinal detachments. Methods: This was an investigator-initiated pilot study. Patients diagnosed with choroidal melanomas ≤10 mm thick, detachments spanning >2 clock hours, and visual acuity of 20/100 or better were randomized 1:1 to receive the dexamethasone implant or no treatment before proton radiation. Patients, masked to treatment complete …

01.09.2026journal-article

Current Nanomedicine

Revolutionizing Disease Prevention: The Rise of mRNA Vaccines and Nanotechnology for the Treatment of Cancer and Infectious Diseases

Diksha Shankar, Deepak Mishra, Astha Singh, Neha Pathak, Neha Minocha, Parijat Pandey, Pankaj Malhotra

Introduction: mRNA is a single-stranded RNA molecule. It conveys all the genetic information that is found in DNA and is complementary to it. mRNA was discovered in the early 1960s, and further studies were conducted in the 1970s. Yet, the greatest issue was that mRNA would be taken up by the body and rapidly destroyed. The crisis condition developed during the COVID-19 pandemic made the evolution of mRNA vaccines very swift. The main aim of this review article is to explain the development of different types of mR …

01.09.2026journal-article

Frontiers in Oncology

Myxoid glioneuronal tumor of the septum pellucidum with concurrent dual PDGFRA and FGFR3 gene mutations: a case report and literature review

Meng Wang, Lingyan Wang, Lili Zhang, Jianwei Zhang, Yonghui Yang, Li Zhang

Myxoid glioneuronal tumor (MGNT), a rare neuroepithelial neoplasm newly recognized in the 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (5th edition), is associated with platelet‐derived growth factor receptor α ( PDGFRA) gene alterations. While MGNT typically exhibits indolent histopathological features and a favorable clinical course, rare cases of intraventricular dissemination and leptomeningeal metastasis have been documented. We report a case of a 10-year-old fema …

01.09.2026journal-article

Journal of Experimental & Clinical Cancer Research

Gliamimic: a longitudinal, multimodal in vitro platform for evaluating glioblastoma treatment response and post-treatment tumor progression in patient-derived organoids or spheroids

Selina Camenisch, Luisa Bell, Nadine Stokar-Regenscheit, Natalia Vélez Char, Wolfram Jochum, Simon Heinze, Anna Maria Zeitlberger, Thomas Hundsberger, Marian Neidert, Peter Wick, Vanesa Ayala-Nunez

Abstract Treatment resistance and recurrence continue to define the clinical landscape of glioblastoma (GBM), yet their study is limited by traditional in vitro frameworks that fail to capture long-term treatment dynamics and tumor evolution. Here we present GliaMimic, a longitudinal in vitro platform incorporating irradiation and multi-dose temozolomide (TMZ). Using patient-derived organoids (PDOs) and cell line-derived spheroids, tumor progression and treatment response were monitored non-invasively over four wee …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Preoperative Magnetic Resonance Imaging Findings of the Transition Zone Predict Incidental Prostate Cancer in HoLEP

TOSHIKI ITO, YUSAKU HISAMATSU, SHUHEI MIZUTANI, TAKASHI KODAMA, SHINYA WATANABE, HIROYUKI AMANO, TERUO INAMOTO

Background/Aim: To assess the effectiveness of magnetic resonance imaging (MRI) of the transition zone (TZ) for predicting incidental prostate cancer (iPCa) detected after holmium laser enucleation of the prostate by comparing cases with and without iPCa. Patients and Methods: We retrospectively evaluated 136 patients who underwent holmium laser enucleation for benign prostatic hyperplasia (BPH) between June 2022 and April 2025. After excluding seven patients with biopsy-confirmed prostate cancer, data from 114 pat …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Jejunal Mixed Adenoneuroendocrine Carcinoma (MANEC) With a Novel PTPRK-RSPO3 Fusion Initially Presenting as a Large Ovarian Mass: Diagnostic Challenges and Poor Prognosis

RAN WANG, JINPING LAI

Background/Aim: Jejunal mixed adenoneuroendocrine carcinomas (MANECs) are rare but aggressive tumors. We report such a case initially present as a large ovarian mass with a novel gene fusion. Case Report: A 51-year-old female presented with multiple episodes of abdominal pain. Computed tomography (CT) scan showed a 16.1 cm right ovarian mass. Surgery was performed and intraoperative frozen sections of the ovarian mass showed adenocarcinoma. Further histopathologic evaluation of the ovarian tumor demonstrated intest …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Immune Checkpoint Inhibitor Resistance in Rectal Adenocarcinoma Containing a Mismatch Repair Deficiency Component: A Case Report

KOHEI OKURA, HARUKA TAKENAKA, HIROSHI FUJITA, NORIHISA HANADA, YOSHIHIRO KOMOHARA

Background/Aim: Immune checkpoint inhibitors (ICIs) are important therapeutic options for metastatic colorectal cancer showing microsatellite instability-high (MSI-H)/mismatch repair deficiency (dMMR). We report a case of rectal adenocarcinoma with liver metastases diagnosed as dMMR cancer that was resistant to ICI therapy, leading us to conduct an additional pathological analysis to uncover the reasons underlying ICI resistance. Case Report: A 53-year-old woman had a tumor in the lower rectum. Biopsy revealed coex …

01.09.2026journal-article

Cancer Discovery

Translational Challenges and Opportunities in mRNA Cancer Vaccines

Seong Dong Jeong, Benjamin R. Schrank, James J. Mancuso, Betty Y.S. Kim, Wen Jiang, Padmanee Sharma

Abstract Messenger RNA (mRNA) cancer vaccines have progressed rapidly, with personalized platforms such as mRNA-4157 and BNT122 demonstrating feasibility, safety, and durable immune activity but limited scalability. Off-the-shelf constructs, including BNT111 and BNT113, enable faster, broader deployment, yet they risk reduced precision or immune tolerance. These complementary approaches reveal key translational dualities: personalization versus shared antigen (off-the-shelf), potency versus safety, and speed versus …

01.09.2026journal-article

Cancer Discovery

Mitochondrial Complex I at the Crossroads of NK cell Dysfunction in Glioblastoma

Silvia Tiberti, Katayoun Rezvani, May Daher

Summary: Zhou and colleagues identify mitochondrial complex I activity, mediated through NDUFA9, as a critical determinant of natural killer (NK) cell metabolic fitness and antitumor function in glioblastoma. Their study links impaired oxidative phosphorylation to glutamine dependence, epigenetic repression of effector programs, and loss of NK cell activity, highlighting mitochondrial fitness as an actionable axis for improving cellular immunotherapy in solid tumors. See related article by Zhou et al., p. 1924

01.09.2026journal-article

University of Bisha Journal for Basic and Applied Sciences

Prevalence, Awareness, Treatment, and Control of Hypertension Among Saudi Adults: A Secondary Analysis of National Health Survey Data Aligned With WHO Global Hearts Initiative Targets

Ahmed A. Almohammadi

Background: Hypertension is the leading modifiable risk factor for cardiovascular disease and premature mortality globally. Despite its high prevalence in Saudi Arabia, the national hypertension care cascade—spanning awareness, treatment, and blood pressure control—remains insufficiently characterized across demographic and geographic strata.Objectives: To characterize the prevalence, awareness, treatment, and control of hypertension among Saudi adults, analyze temporal trends from 2013 to 2022, evaluate demographi …

03.09.2026journal-article

Journal of Clinical Neuromuscular Disease

Chronic Inflammatory Demyelinating Polyneuropathy: Update on Diagnosis and Treatment

Jin Jun Luo, Xiaohong Si

Abstract Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated neuropathy characterized by progressive or relapsing weakness and sensory loss because of demyelination of peripheral nerves. CIDP has a higher prevalence in men and older adults. Immunopathogenesis involves both cellular and humoral mechanisms, including autoreactive T cells and macrophage-mediated demyelination. Typical CIDP presents with symmetric sensorimotor deficits, whereas atypical variants such as distal acquir …

02.09.2026journal-article

The Oncologist

31 Racial Demographic Reporting in Clinical Trials Informing NCCN Kidney Cancer Guidelines

Suhail Sapkota, Niket Shah, Asish Nepal, Maha Bayya, Nadeen Saad, Shreya Motkur, Jason Law, Sai Sushrutha Vemula, James Hosner, Ling Wang, Daniel Isaac

Abstract Background Racial and ethnic disparities persist in kidney cancer incidence and outcomes, yet the evidence-based guiding treatment may not reflect the populations most affected. The American Cancer Society reports a higher burden among African American, American Indian, and Alaska Native populations. The National Comprehensive Cancer Network (NCCN) guidelines define standard-of-care management, but the representativeness of the clinical trials informing these recommendations remains unclear. We evaluated r …

01.09.2026journal-article

TAJ: Journal of Teachers Association

Evaluation of Oxidative Stress in Benign Prostatic Hyperplasia Patients Before and After Treatment with Tamsulosin

Mst Sufia Sultana, Md Tafiqul Islam, Md Abdur Rahim, Md Jahangir Hossain

Background: Benign prostatic hyperplasia (BPH) is a common health problem in aging males, characterized by increased prostate tissue mass leading to urinary outflow obstruction and significant morbidity. Plasma markers of oxidative stress are elevated in men with BPH. This study aimed to assess oxidative stress by measuring serum malondialdehyde (MDA) levels in BPH patients before and after tamsulosin treatment. Methods: This quasi-experimental study was conducted on 60 newly diagnosed BPH patients from January 201 …

02.09.2026journal-article

Clinical Case Reports

Sintilimab Combined With Albumin‐Bound Paclitaxel and SOX Regimen as Conversion Therapy for Unresectable Advanced Gastric Cancer Achieving Complete Remission: A Case Report and Literature Review

Yufan Tang, Boquan Zhou, Bingbing Wen, Ke Yu, Jiajia Jia, Ying Sha, Jixiang Liu, Luyao Li, Ruifang Fan

ABSTRACT For carefully selected patients with unresectable advanced gastric cancer, immunochemotherapy combining PD‐1 inhibitor with albumin‐bound paclitaxel and S‐1/oxaliplatin may achieve deep remission and enable successful R0 resection. Our findings suggest that this multimodal conversion approach could be considered in selected cases with favorable performance status and MDT‐supported indications, as pathological complete remission appears to be attainable in this context.

02.09.2026journal-article

Journal of Cellular and Molecular Medicine

Comparative Efficacy of BTK Inhibitors in Treatment‐Naïve and Relapsed/Refractory Mantle Cell Lymphoma: A Systematic Review and Meta‐Analysis

Fangfei Xu, Xiuping Zou, Yulin Yang, Kuangguo Zhou, Wei Huang

ABSTRACT Bruton tyrosine kinase inhibitors (BTKis) have been employed in the treatment of mantle cell lymphoma (MCL). However, direct comparisons of ibrutinib, zanubrutinib, and acalabrutinib across treatment‐naïve (TN) and relapsed/refractory (R/R) MCL remain limited. This meta‐analysis was intended to evaluate their efficacy, addressing critical gaps in clinical decision‐making. We systematically searched PubMed, Embase, and Cochrane up to January 2025 for studies (RCT/single‐arm) assessing the efficacy of BTKis …

01.09.2026journal-article

British Journal of Ophthalmology

Modular multi-task deep learning framework for prediction of treatment initiation in neovascular age-related macular degeneration modular AI for NVAMD treatment initiation study-MANTIS

Qitong Gao, David Kuo, Joshua Amason, Terry Lee, Jay K Rathinavelu, Miroslav Pajic, Majda Hadziahmetovic

Purpose The purpose of this study is to develop a fully automated system for determining the optimal time to begin anti-vascular endothelial growth factor (anti-VEGF) treatment, based on retinal changes observed in optical coherence tomography (OCT) images and visual acuity (VA) scores. Methods This retrospective study included two cohorts: patients with intermediate dry age-related macular degeneration (AMD) who did not progress to neovascular AMD (NVAMD) and those who progressed and received anti-VEGF treatment. …

01.09.2026journal-article

Journal of Veterinary Internal Medicine

Effect of trilostane treatment on proteinuria secondary to spontaneous hypercortisolism in dogs

Filippo Tagliasacchi, Federico Fracassi, Maddalena Poli, Laura Dalla Tomba, Stefania Golinelli, Antonio Maria Tardo, Francesca Del Baldo

Abstract Background Proteinuria is reported in 68%-71% of dogs with spontaneous hypercortisolism (HC). The long-term effect of trilostane on HC-associated proteinuria remains poorly documented. Hypothesis/Objectives To evaluate the efficacy of trilostane on proteinuria in dogs with HC and identify potential clinical, anamnestic, and analytical differences between responders and nonresponders. Methods Retrospective longitudinal cohort study including dogs with proteinuric HC treated exclusively with trilostane. Clin …