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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Frontiers in Pharmacology

Preclinical pharmacokinetic modeling and clinical translation of SIG001, a novel anti-cancer therapeutic antibody targeting on cancer-derived sialylated IgG

Qingyu Yao, Chen Liu, Shenghua Zhang, Yaou Liu, Ying Zhou, Xiaoyan Qiu

Introduction Sialylated immunoglobulin G (SIA-IgG) has emerged as a novel therapeutic target selectively overexpressed in epithelial-derived malignancies. The humanized monoclonal antibody SIG001 binds specifically to tumor-associated SIA-IgG and is regarded as a promising first-in-class candidate for the broad-spectrum treatment of epithelial cancers. Methods The pharmacokinetic (PK) behavior of SIG001 was evaluated in both cynomolgus monkeys and mice following intravenous administration. Utilizing modeling approa …

01.09.2026journal-article

Maxillofacial Plastic and Reconstructive Surgery

Contralateral facial artery-based chimeric flap for reconstruction of large oral cavity defects in elderly pre-frail patients: a two-case report

Jingxin Ma, Ieoktong U., Ye Li, Linling Chen, Le Yang, Dikan Wang, Huanzi Lu, Yujie Liang, Sien Zhang, Guiqing Liao

Abstract Background Large oral cavity defects after oncologic ablation require reliable reconstruction to restore oral function and aesthetics. Although free flap reconstruction remains a standard option, it may be unsuitable for elderly pre-frail patients with multiple comorbidities. This report describes a contralateral facial artery-based chimeric flap combining a nasolabial island flap and a submental artery island flap for reconstruction of large oral cavity defects. Case presentation Two elderly pre-frail pat …

01.09.2026journal-article

Frontiers in Surgery

Arthroscopic-assisted uniportal spinal surgery for the treatment of rare T10/T11 thoracic disc herniation: a case report

De Meng, GuoFang Meng, ShenRong Jiang, Yuan Zhong

Background Thoracic disc herniation (TDH) is rare, with an estimated incidence of 1 per 1,000,000 individuals. Surgical treatment is indicated for those suffering from myelopathy and/or intractable neurological deficit. Open surgical approaches including transthoracic and retropleural access carry substantial perioperative risks. Contemporary minimally invasive endoscopic techniques reduce tissue dissection and manipulation of the thecal sac, yet they are associated with a steep learning curve and limited intraoper …

01.09.2026journal-article

Frontiers in Pediatrics

The global landscape of pediatric monoclonal antibody (mAb) clinical trials: an analysis of ClinicalTrials.gov

Agrata Sharma, Sanjana Mukherjee, Sharonann Lynch

Introduction Monoclonal antibodies (mAbs) are a growing class of biologics used to address many diseases, including cancers, autoimmune diseases, and infectious diseases, with several mAbs specifically approved for use in children for various indications. However, developing and using mAbs in pediatric populations is particularly challenging due to limited clinical trial data in children, which stems from recruitment difficulties, ethical considerations, and other issues. Furthermore, inconsistent access to clinica …

01.09.2026journal-article

Frontiers in Pediatrics

Case Report: Selumetinib as a neoadjuvant treatment for the removal of a PN

Ciavarelli Patricia, Mezmezian Mónica Beatriz, Daniel Yedlin, Paloma Amarillo

Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that presents with benign tumors of the peripheral nerve sheath, named plexiform neurofibromas. Progressive tumor growth may cause pain, physical disfigurement, and compression of adjacent structures, potentially impairing normal development during childhood. We report the case of a 13-year-old patient with a plexiform neurofibroma in the right foot, which had been growing since the first months of life and compromised the talocalcaneal joint, …

01.09.2026journal-article

Journal of Orthopaedic & Sports Physical Therapy

CFT+ With a Subsequent Interdisciplinary Pain Management Program (IPMP) If Needed Versus IPMP Alone for Patients With Severe Disabling Chronic LBP: Pragmatic Patient-Blinded RCT With Economic Analysis

Henrik Bjarke Vaegter, Anne Smith, Jannick Vaaben Johansen, Irene Stegemejer, Kira Søndberg Fuglsang, Jesper Fredslund Pedersen, Liza Sopina, Rob Schutze, Peter O’Sullivan, Peter Kent, Gitte Handberg, Francis Fatoye, Kasper Ussing, Jonas Bloch Thorlund

OBJECTIVES: We aimed to determine whether, for patients with severely disabling chronic low back pain (cLBP), initiating care with cognitive functional therapy combined with psychologist support (CFT+) improved disability and pain, and was cost-effective compared with an interdisciplinary pain management program (IPMP) at 12 months. METHODS: We conducted a randomized controlled trial (NCT04399772) with concealed allocation, blinded patients, and intention-to-treat analysis. One hundred thirty-three adults with seve …

01.09.2026journal-article

IOASD Journal of Medical and Pharmaceutical Sciences

Clinical Significance of Lipoprotein and Ceruloplasmin Variation in Preeclampsia

Nnodim Johnkennedy, Katherine A. Emenikeh, Nwaokoro Joakin Chidozie

Preeclampsia is a multisystem illness of pregnancy characterised by new-onset hypertension after 20 weeks of gestation and end-organ failure of varied severity. Placental dysfunction, maternal endothelial injury, inflammation, oxidative stress, and aberrant lipid metabolism are identified as significant features of the disease process, however the detailed pathophysiology is still not fully understood. Preeclamptic women have shown changes in circulating lipoproteins, including an increase in triglycerides, total c …

01.09.2026journal-article

Journal of Korean Medicine

Factors Associated with Korean Medicine Utilization during the COVID-19 Pandemic Period (2019–2023): A Panel Analysis of the Korea Health Panel

Changyon Han

Objectives: This study investigates factors associated with Korean Medicine (KM) outpatient utilization in 2019–2023, a period that includes the COVID-19 pandemic, using the Andersen behavioral model. It analyzes individual-level panel data to distinguish factors associated with entry (whether KM is used) from those associated with intensity (how much is used), across three dimensions.Methods: This study estimated three outcomes using household-member random-effects panel models in accordance with Andersen’s behavi …

01.09.2026journal-article

Journal of Korean Medicine

Changes in Autonomic Nervous System Indices Assessed by Heart Rate Variability After Mugwort Moxibustion

Jin Suk Koo

Objectives: This study aimed to investigate changes in autonomic nervous system–related indices assessed by heart rate variability (HRV) following mugwort (Artemisia vulgaris) moxibustion.Methods: This quasi-randomized controlled trial enrolled 44 adult outpatients who visited a Korean medicine clinic in Andong, Republic of Korea, with non-specific health complaints such as stress, fatigue, or sleep disturbance. Participants were systematically assigned to either the moxibustion group or the control group based on …

01.09.2026journal-article

Journal of Arthroscopy and Joint Surgery

Intraoperative and Early Postoperative Complications of Hip Arthroscopy

V. R. K. V. Prasad Gourineni, Sitaram Chopperla, Vishnu Senthil, Durga Prasad Valleri, S. Ravi Kumar, Susmith Koneru

Abstract Background: Hip arthroscopy is widely used for treating various hip pathologies and is considered a safe joint preservation procedure. However, reported complication rate varies considerably, likely reflecting differences in the technique, traction protocols, and patient-related factors. Subjects and Methods: A retrospective review of 1000 consecutive hip arthroscopy surgical procedures was performed to evaluate intraoperative and early complications occurring within 2 weeks postoperatively. Procedures wer …

01.09.2026journal-article

Energy & Fuels

Evolution of Pore-Fracture Structure and Coupled Damage–Seepage Characteristics of Coal Induced by LCO2 Phase-Transition Treatment: A 3D Digital Core Study

Xianke Wang, Yonggang Qiao, Nan Fan, Danping Yuan, Shida Zhang, Yongliang Mu

Abstract This study combines micro-CT scanning with Avizo-based three-dimensional reconstruction technology to quantitatively characterize the evolution of pore-fracture structures in coal during LCO2 phase-transition treatment and systematically investigates the coupled response of damage evolution and seepage behavior under different stress conditions based on digital coal core models. Results show that LCO2 phase-transition treatment significantly reconstructs the coal pore-fracture network, promoting the develo …

02.09.2026journal-article

Clinical Case Reports

Persistent Gingival Bleeding After Scaling: A Diagnostic Clue to von Willebrand Disease

Huihui Zhang, Nan Qiu, Zhengguo Cao, Shuhuan Shang

ABSTRACT Von Willebrand disease (VWD) is not a rare inherited bleeding disorder. However, it is frequently underdiagnosed because early mucocutaneous bleeding manifestations are often attributed to local factors such as inflammation or anatomical abnormalities, leading to delayed recognition of the underlying systemic disease. A 31‐year‐old Han Chinese female presented with persistent gingival bleeding after routine dental scaling. Her medical history was notable for lifelong recurrent epistaxis and severe intraope …

01.09.2026journal-article

Plastic and Reconstructive Surgery - Global Open

Financing a Private Practice: A Practical Framework for Plastic Surgeons

Nicholas Mosca, Ferris Zeitouni, Madeline Tierney, Ellen C. Via, Peter J. Wirth, Pradeep K. Attaluri, Venkat K. Rao

Summary: Many plastic surgery trainees enter private or group practice, yet there is little guidance on financing strategies when starting or joining a practice. The aim of this article is to provide physicians starting or joining a private practice with a clear, evidence-based resource on financing options. Common funding avenues are described, ranging from traditional bank and Small Business Administration loans to equipment leasing, hospital joint ventures, and equity-based investments. Comparisons are made to c …

01.09.2026journal-article

Advances in Respiratory Medicine

Precision Medicine in Overlap Syndrome (COPD–Obstructive Sleep Apnea): From Phenotypes and Endotypes to Treatable Traits

Carina Adina Afloarei, Andreea Zabara Antal, David Toma, Adriana Loredana Pintilie, Georgiana Pitusac, Raluca Tiron, Tudor Birladeanu, Teodor Zaharia, Radu Crisan Dabija

Introduction: COPD-OSA overlap syndrome (OVS) is defined by the coexistence of chronic obstructive pulmonary disease and obstructive sleep apnea syndrome in the same patient; it affects 28.3% of patients evaluated for either condition and is associated with significantly higher mortality compared to either pathology in isolation. Current therapeutic approaches, involving PAP therapy and bronchodilation, treat this syndrome as a homogeneous entity and ignore the biological heterogeneity of this patient population. O …

01.09.2026journal-article

ACS Nano

Injectable Biodegradable Non-Hermitian Biotelemetric System Enabling Early Diagnosis of Acute Compartment Syndrome

Jie Li, Jinfeng Zhou, Jianhui Wu, Kaihang Zhang, Yifan Wu, Congying Shen, Xinyu Cai, Jiaqi Lu, Jiafeng Ni, Liangquan Xu, Rui Wan, Chuanrui Chen, Fengling Zhuo, Dinku Hazarika, Weipeng Xuan, Jinkai Chen, Yiying Qi, Gang Feng, Jinjin Cao, Minye Yang, Zhen Cao, Hao Jin, Shurong Dong, Jikui Luo

Abstract Acute compartment syndrome (ACS) requires timely diagnosis, delayed diagnosis can cause irreversible neuromuscular injury, limb loss, and even death, whereas current diagnosis still relies on subjective examination and intermittent invasive pressure measurements. Here, we report an injectable, biodegradable biotelemetric implant for accurate, continuous wireless monitoring of intracompartmental pressure (IcP), and further establish a predictive model that converts pressure-duration signals into quantitativ …

01.09.2026journal-article

Annals of Clinical and Analytical Medicine

Surgical management of incidental asymptomatic contralateral inguinal hernias: a retrospective cohort study

Yahya Almarhabi

Aim The management of asymptomatic contralateral inguinal hernias incidentally detected on preoperative imaging remains debated. This research evaluates surgical strategies and outcomes for individuals with incidental findings versus those with clinically symptomatic hernias. Methods A retrospective cohort study of 244 patients undergoing inguinal hernia repair from January 2022 to April 2025 at a tertiary care center was conducted. Patients were grouped into those with a symptomatic unilateral hernia and an incide …

01.09.2026journal-article

Annals of Clinical and Analytical Medicine

A multidimensional approach to home accidents in children aged 0-6: a community-based study

Feza Demir, Ramazan Azim Okyay, Ayşegül Erdoğan

Aim Home accidents are a significant cause of injury and death among children aged 0–6 due to their limited motor and cognitive abilities. This study aimed to investigate the prevalence, characteristics, and associated risk factors of home accidents in this age group. Methods A cross-sectional study was conducted between March and May 2024, including 652 mothers of 1,003 children aged 0–6 attending Family Health Centers in a southeastern province (blinded country). Data were collected through face-to-face questionn …

01.09.2026journal-article

Annals of Clinical and Analytical Medicine

Systemic inflammatory indices in the first trimester: emerging tools for early prediction of preeclampsia

Ramazan Bülbül, Hüseyin Erdal, Ahmet Burak Gürpınar

Aim To investigate the association between first-trimester systemic inflammatory indices and the subsequent development of preeclampsia and to evaluate their predictive performance as early screening markers. Methods This retrospective case-control study included 123 women who subsequently developed preeclampsia and 121 healthy pregnant controls. Inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation r …

01.09.2026journal-article

Journal of Child Neurology

Clinical Response and Tolerability of Brivaracetam in Pediatric Epilepsy: A Systematic Review and Meta-analysis

Uneeb Ullah Khan, Mohammad Saboor Kamran, Muhammad Ansab, Ali Irtiza Talpur, Ayman Shakeel Ahmed, Ghadeer Mohammed Abbas, Syeda Zahra Hasan, Phan Huu Hung, Syed Hashim Ali Inam, Jabez David John, S.M Washaqul Arfin

This systematic review and meta-analysis aims to synthesize evidence on the safety and efficacy of brivaracetam (BRV) usage in pediatric epilepsy. The primary outcome of our study was to assess the endurability of BRV in a population of children (age ≤18 years) with epilepsy, which was measured by the retention rate. The responder rate, rate of seizure freedom, rate of adverse effects, and rate of withdrawal from the study were all taken as secondary outcomes, with a total number of 12 citations included in our met …

03.09.2026journal-article

Veterinary Medicine and Science

Genetic Diversity and Population Structure of Zambian Indigenous Cattle

Ellison Musimuko, King Shimumbo Nalubamba, Victor Chisha Zulu, Idowu Kolawole Odubote, Walter Muleya

ABSTRACT A study was conducted to determine the genetic diversity of Zambian indigenous cattle using microsatellites. In Zambia, cattle provide draft power, food, manure and generate income. DNA extraction followed the Qiagen protocol, and Arlequin V3.0 was used for data analysis. 72 unrelated animals from three regions, Eastern (Angoni), Southern (Tonga) and Western (Barotse), were sampled. 315 alleles observed were higher in TGLA 263 (106 bp) with 0.861, 0.824 and 0.753, BMS650 (160 bp) with 0.710 and SPS 115 (24 …

01.09.2026journal-article

Epilepsy Currents

Cause, Consequence, or Compass? The Thalamus in Temporal Lobe Epilepsy Surgery

John D. Rolston

Thalamic organization differentially contributes to clinical conditions in epilepsy. Communications Medicine in press Zhang Q, Javidi SS, Ankeeta A, Sperling MR, Zhang Z, Tracy JI. Communications Medicine in press. Background: The thalamus plays an important role in key clinical conditions of focal temporal lobe epilepsy (TLE), but no investigation has examined whether the same thalamic local and connectome properties shape a patient's status across these different conditions. Methods: This retrospective longitudin …

04.09.2026journal-article

Obstetrical & Gynecological Survey

Comment on “Natural Ovulation Versus Programmed Regimens Before Frozen Embryo Transfer in Ovulatory Women: Multicentre, Randomized Clinical Trial”

David L. Keefe

Frozen embryo transfer in in vitro fertilization (IVF) treatments has now surpassed fresh embryo transfer in the annual number of cycles due to increases in the use of preimplantation genetic testing and the freeze-all strategy. In frozen transfer cycles, the endometrium requires preparation to receive the embryo, and the most common regimens are a natural ovulation regimen and a programmed regimen using exogenous estrogen and progesterone. Great controversy surrounds the issue of which regimen provides better safe …

01.09.2026journal-article

ACR Open Rheumatology

Fracture Risk Associated With Long‐Term Discontinuation of Postmenopausal Osteoporosis Treatment: A French Population‐Based Study Using National Claims Data (Système National des Données de Santé)

Audrey Lajoinie, Meriem Benmerad, Magali Laborey, Pascale Samama, Gaëlle Désaméricq, Leila Chelbani, Karine Briot

Objective This retrospective cohort study evaluated the long‐term discontinuation (LTD) of osteoporosis treatments in postmenopausal women in France and associated fracture risk and economic burden. Methods From the national French health care database (Système National des Données de Santé), we included postmenopausal women aged ≥60 years initiating oral bisphosphonates, intravenous bisphosphonates, or denosumab between 2012 and 2015 with three or more (bisphosphonates) or two or more (denosumab) years of continuo …

01.09.2026journal-article

The International Journal of Comprehensive Health, Medicine, & Dentistry

Knowledge, Attitudes, and Practices Regarding Antibiotic Use and Resistance Among Medical Students in Pakistan: A Cross-Sectional Study

Muhammad Nouman, Samman Malik, Arshia Arshad, Fatima Riaz, Zunaira Shahzad, Laeeba Iqbal

Background: Antibiotic resistance is a major global public health challenge, fueled in part by the inappropriate use of antibiotics among healthcare professionals and medical students. As future prescribers, medical students constitute a key target for educational interventions because their knowledge, attitudes, and prescribing practices are developed during undergraduate medical education. Objectives: To evaluate the knowledge, attitudes, and practices (KAP) related to antibiotic use and antimicrobial resistance …