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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Biology

Application of an Index Based on Aquatic Insect Biotic Integrity for River Ecosystem Health Assessment in Haihe River Basin, China

Fanqing Kong, Zhilin Li, Yue Shen, Yanchu Zhao, Yin Hou, Zihang Hu, Shaowei Bian

As critical biological components of freshwater ecosystems, aquatic insects are highly sensitive to cumulative anthropogenic disturbances and can effectively reflect long-term variations in river ecological quality, serving as ideal bioindicators for aquatic ecological monitoring and assessment. However, most existing benthic biotic integrity indices integrate diverse macroinvertebrate groups, which dilute the unique indicative value of aquatic insect communities, and few targeted evaluation systems have been indep …

03.09.2026journal-article

Acta Neurochirurgica

Clinical course of traumatic cerebral venous sinus thrombosis: Insights from a UK major trauma centre

Sheikh Muktadir Bin Momin, Faheem Anwar, Georgina Shallard, Azam Ali Baig, Yousra Rasool, Anam Fatima, Andrew R. Stevens, Philip Ho, Anne Preece, David James Davies, Antonio Belli, Ramesh Chelvarajah, Philip J. O’Halloran

Abstract Background Traumatic venous sinus thrombosis (tCVST) is a recognised complication of traumatic brain injury (TBI), usually secondary to adjacent skull fractures or intracranial haemorrhage. The optimal timing of diagnostic CT venography (CTV) and anticoagulation initiation remains uncertain. Methods A retrospective cohort study was performed at Queen Elizabeth Hospital Birmingham, a UK Major Trauma Centre, including patients aged > 16 years with radiologically-confirmed tCVST between January 2020-December …

03.09.2026journal-article

Journal of Imaging Informatics in Medicine

Multi-centre Validation of Automated Outer-to-Outer Wall Segmentation of Infrarenal Abdominal Aortic Aneurysms Using a nnU-Net Based Model

Cas H. F. Hendricks, Willemina A. van Veldhuizen, Amin Ranem, Bram Fioole, Rogier H. J. Kropman, Jelmer M. Wolterink, Jean-Paul P. M. de Vries

Abstract Accurate outer-to-outer wall aortic segmentation is essential for abdominal aortic aneurysm (AAA) assessment and endovascular aneurysm repair (EVAR) planning, yet manual segmentation is time-consuming and impractical for routine use. This study aimed to validate a pre-trained open-source nnU-Net–based model for fully automated outer-to-outer wall segmentation of the abdominal aorta in AAA patients. In this retrospective multicentre observational validation study, 75 consecutive AAA patients (25 per centre) …

03.09.2026journal-article

Acupuncture & Electro-Therapeutics Research: International Journal of Integrated Medicine

Acupuncture Improves Poststroke Cognitive Impairment by Regulating the miR-18a-5p

Tianshi Li, Li Wan, Hongyan Chen

Background Poststroke cognitive impairment (PSCI) severely impacts patients’ lives. Acupuncture shows potential in improving PSCI, yet the molecular mechanism remains unclear. Aims This study aimed to investigate the potential efficacy of acupuncture in alleviating PSCI symptoms by regulating miR-18a-5p. Methods The study assessed mental status and self-care capacity in 107 PSCI cases and 102 healthy participants through the Mini-Mental State Examination, Revised Hasegawa’s Dementia Scale, and activities of daily l …

03.09.2026journal-article

Technology and Health Care

Smartphone based clinical decision support system for early detection of neonatal jaundice using artificial intelligence with temporal convolutional network

Mahmoud Ragab, Iyad Katib, Mohammed K. Al-Hanawi, Sanaa A. Sharaf, Mohamed Alqurashi, Abdullah AL-Malaise AL-Ghamdi

Abstract Physiological jaundice is present in the initial week of life in neonates owing to the rise in level of bilirubin thereby resulting in yellowish coloring of sclera and skin. Severe jaundice and lethal bilirubin levels may result from brain damage as bilirubin is located in the central nervous system. Present diagnostic techniques consist of time-consuming and a painful invasive blood test and non-invasive tests using expensive transcutaneous bilirubin meters. Then regular monitoring is important, numerous …

03.09.2026journal-article

Journal of Intensive Care Medicine

HbA1c Stratification Identifies High-Risk ICU Patients: Mortality and Complications in a Retrospective Critical Care Cohort

Paul Karim, Isaac Huang, Jiahui Chen, Marco Sanvitti, Robert Canelli, Federico Bilotta

Introduction Glycemic variability is common in critical illness and can obscure the prognostic significance of premorbid glycemic status. Hemoglobin A1c (HbA1c) reflects chronic glycemia and may improve risk stratification beyond acute glucose measurements. We examined whether HbA1c-defined glycemic phenotypes were associated with in-hospital complications and mortality among critically ill adults. Methods We conducted a retrospective cohort study using MIMIC-IV (v3.1), a de-identified database of ICU admissions at …

03.09.2026journal-article

Journal of Endovascular Therapy

Safety and Efficacy Evaluation of a Novel High-Frequency Automated-Pullback Peripheral Intravascular Ultrasound System in a Porcine Model

Lei Zhang, Rui Li, Pengcheng Guo, Lin Li, Tao Xu, Zhenchang Wang, Chang Shu, Xin Li

Objective: To evaluate the efficacy and safety of a novel single-use peripheral intravascular ultrasound (IVUS) system in a porcine model. Methods: Six healthy white pigs were randomized into 2 groups. The Efficacy Valuation Group (group A, self-controlled, n = 3) underwent imaging before and after stent implantation with both the test device (automated pullback) and a control IVUS system (manual pullback). The Safety Evaluation Group (group B, n = 3) was imaged with the test device only for safety and pathological …

03.09.2026journal-article

Eastern Mediterranean Health Journal

Challenges of implementing health technology assessment in the Iranian pharmaceutical industry

Meysam Behzadifar, Saeed Shahabi, Ahad Bakhtiari, Samad Azari, Mohammad Yarahmadi, Aidin Aryankhesal, Banafsheh Darvishi Teli, Masoud Behzadifar

Background: Health technology assessment remains underdeveloped in the Islamic Republic of Iran, with limited systematic application in the pharmaceutical sector. Aim: To identify the challenges facing the development and implementation of health technology assessment in the Iranian pharmaceutical industry. Methods: Between August and November 2024 we conducted in-depth interviews with 15 experts who have experience in implementing health technology assessment, on the development and implementation of health techno …

03.09.2026journal-article

Allergies

Biologic Therapies for Severe Pediatric Asthma: Current Evidence, Clinical Indications, and Future Directions

Dafni Moriki, Michalis Kalogiannis, Maria Tsouprou, Vasilis Grammeniatis, Konstantinos Douros, Despoina Koumpagioti

Severe pediatric asthma remains a significant clinical challenge despite advances in conventional therapy. Some children continue to experience persistent symptoms, recurrent exacerbations, and substantial morbidity despite optimized treatment with inhaled corticosteroids and long-acting bronchodilators. Advances in the understanding of asthma immunopathology, particularly type 2 (T2) inflammation, have led to the development of targeted biologics that modulate key inflammatory pathways. Several monoclonal antibodi …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

Sentinel Lymph Node Imaging, Biopsy in Head/Neck and Breast Cancers: A Comprehensive Review

Palaniswamy Shanmuga Sundaram, Padma Subramanyam

Sentinel lymph node imaging and biopsy (SLNI and SLNB) have become key components in the management of many solid tumours, especially Head / Neck cancer (HNCa) and breast cancer (BC), offering an accurate and minimally invasive lymph nodal staging. The rationale being that the sentinel lymph node (SLN) is the first draining node from the primary tumour site and, therefore, is the most likely site for early lymphatic dissemination of metastatic tumour cells. SLN identification is conventionally performed using minut …

03.09.2026journal-article

Frontiers in Endocrinology

In utero and lactational exposure to tenofovir disoproxil fumarate and bone health outcomes: a scoping review of 31 studies

Xia Ji, Yuanzhong Wang, Zefan Zhang, Kok-Lun Pang, Xiong Khee Cheong, Norliza Muhammad, Kok-Yong Chin

Introduction Tenofovir disoproxil fumarate (TDF) is a key antiretroviral agent for preventing mother-to-child transmission of human immunodeficiency virus (HIV) and treating chronic hepatitis B (HBV) during pregnancy. However, concerns persist regarding its potential effects on bone metabolism during foetal development and postpartum recovery. Objective This scoping review synthesised evidence on the impact of in utero and lactational TDF exposure on bone health in offspring and mothers. Methods A systematic search …

03.09.2026journal-article

Frontiers in Medicine

Identifying systemic vulnerability phenotypes associated with programmed regimens in frozen embryo transfer: a secondary analysis of a multicentre randomized clinical trial

Junfeng Chen, Hu Li, Mengfei Wang, Bailian Cai, Junjie Qu, Yiran Li

Background Programmed endometrial preparation is widely used for frozen embryo transfer (FET) because it allows flexible scheduling. Recent randomized evidence has shown that programmed regimens increase the risk of hypertensive disorders of pregnancy, particularly pre-eclampsia, compared with natural ovulation regimens. However, it remains unclear whether this risk is distributed uniformly across patients or concentrated in women with specific baseline characteristics. Objective This study aimed to evaluate the he …

03.09.2026journal-article

Haematologica

Efficacy and safety of bridging therapy prior to CAR T-cell therapy in relapsed or refractory multiple myeloma

Marie Christine Wesener, Uta Margareta Demel, Thomas Pabst, Raphael Teipel, Anca-Maria Albici, Bastian Von Tresckow, Marcel Teichert, Amelie Boquoi, Tobias Holderried, Friederike Schmitz, Fabian Müller, Friedrich-Linus Rößiger, Michele Hoffmann, Natalie Schub, Natalia Tovar, Aina Oliver-Caldes, Nicolaus Kröger, Ben-Niklas Baermann, Stephan Bohl, David Fandrei, Vladan Vucinic, Irene Strassl, Friedrich Stölzel, Carlos Fernández De Larrea, Ulrich Keller, Antonia Busse, Maximilian Merz, Nico Gagelmann

Disease burden at the time of BCMA-directed chimeric antigen receptor (CAR) T-cell infusion is a key determinant of outcome in relapsed or refractory multiple myeloma (RRMM). Bridging therapy is frequently administered between leukapheresis and infusion to prevent disease progression, yet its clinical impact remains unclear. We conducted a multicenter real-world cohort study of 399 patients with RRMM treated with BCMA-directed CAR T-cell therapy, including 348 (87%) who received bridging therapy. Bridging therapy r …

03.09.2026journal-article

Experimental & Molecular Medicine

Bone marrow stromal cells promote chemoresistance in acute myeloid leukaemia through P2RX7-mediated antioxidant defence

Ruolan You, Xiaoting Wang, Xiaoming Zheng, Wenqi Fang, Cen Jiang, Jingru Liu, Xiaolin Xu, Maoqing Tan, Danni Cai, Diyu Hou, Jing Zheng, Xinjian Lin, Huifang Huang

Abstract Acute myeloid leukaemia (AML) remains a therapeutically challenging malignancy owing to its high relapse rates and chemoresistance, often linked to elevated antioxidant defences. Here, we demonstrate that bone marrow stromal cells (BMSCs) confer chemoresistance in AML by upregulating the purinergic receptor P2RX7. Blocking P2RX7 restored chemosensitivity of AML cells. Mechanistically, BMSC-mediated P2RX7 overexpression induces calcium influx and mitochondrial calcium overload, triggering mitochondrial stre …

03.09.2026journal-article

Communications Medicine

Comparison of surgical techniques for myopia correction: a systematic review and comprehensive network meta-analysis of refractive procedures

Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan

Abstract Background Myopia is increasingly prevalent worldwide, and several refractive surgical options are available, including photorefractive keratectomy (PRK), laser-assisted in situ keratomileusis (LASIK), femtosecond laser-assisted LASIK (FS-LASIK), small-incision lenticule extraction (SMILE), laser-assisted subepithelial keratectomy (LASEK), and phakic intraocular lens (PIOL) implantation. This network meta-analysis compared their visual, refractive, and corneal outcomes. Methods PubMed, Embase, Web of Scien …

03.09.2026journal-article

British Journal of Nursing

Addressing sexual harassment within acute care nursing

Samantha Hagan, Claire Dosdale

Sexual harassment within health care, particularly in the NHS, has become an increasingly urgent concern following high-profile investigations and surveys exposing unacceptable workplace behaviours. Acute care settings such as theatres and critical care units appear to carry a higher risk for sexually inappropriate conduct, with many staff reporting unwanted sexual behaviours from colleagues, patients and the public. This article explores the prevalence of sexual harassment among acute care nursing teams in the NHS …

03.09.2026journal-article

Community Dentistry and Oral Epidemiology

Meaningful Community Engagement—The Foundations of Global Oral Health Research

Richard G. Watt, Mirai Chatterjee, Michelle Stennett, Regina Mutave, Paulo Sávio Angeiras de Goes, Manu Mathur, Abhishek Mehta, Luis‐Alberto Sánchez‐Alfaro, Maria‐Kamila Navarro Ramirez, Starry John D'Cruz, Susan Thomas, Rajeev Basapathy Rudrappa, Alastair Ross, David I. Conway, Teddy Kyalo Kitili, Carolina Thaiza Costa Pazos, Carol C. Guarnizo‐Herreño

ABSTRACT The global burden of oral diseases and shocking inequalities highlight the failure of current oral health systems and policies. One of the limitations with existing approaches is that they rely almost exclusively on professional perspectives with minimal input from communities, and in particular disadvantaged populations. As a consequence, interventions often fail to achieve sustained improvements and have limited impact in reducing inequalities. Within global health, there is growing recognition of the im …

03.09.2026journal-article

Primary Health Care Practice Journal

Psychological distress and preserved academic functioning among medical trainees in Kenya: a convergent mixed-methods cross-sectional study

Collins Moses Owuor, Augustine Mwangi Gatotoh, Ruth Mumo Omungo, Grace Achieng Otieno

Introduction: psychological distress is highly prevalent among health professional trainees, yet academic decline may inadequately identify psychologically vulnerable students. This study examined the association between psychological distress and academic functioning among medical trainees in Kenya. Methods: a convergent mixed-methods cross-sectional study was conducted among 266 medical trainees at Kenya Medical Training College, Kisumu Campus, selected through stratified random sampling. Psychological distress w …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

A case report of cardiogenic shock with transcranial color-coded ultrasound monitoring under ECMO

Yuyi Chen, Jingyi Wu, Huiying Chen, Jiefeng Xie, Yuping Liao, Qianwei Zheng, Yu Gan

Background Cardiogenic shock (CS) during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support carries high mortality, often due to neurological injury. Precise matching of ECMO flow to cerebral perfusion is critical. Transcranial color-coded sonography (TCCS) offers real-time, non-invasive hemodynamic assessment to guide flow titration, though its clinical integration remains limited. Case presentation This study reports a 58-year-old male firefighter who suffered out-of-hospital cardiac arrest due to …

03.09.2026journal-article

Frontiers in Neurology

The clinical features of anti-CNTN1 antibodies associated autoimmune nodopathies with nephropathy: a case series

Jinping Wan, Tiegen Xiong, Jianian Hu, Shaojun Liu, Jie Lin, Chongbo Zhao, Chong Sun, Hai Xiao

Objective The concurrence of anti-contactin-1 (CNTN1) antibody-associated autoimmune nodopathies (AN) and nephropathy has been sporadically reported, though the underlying relationship remains unclear. This case series study aimed to investigate the clinical characteristics and renal pathology of anti-CNTN1 antibody-associated AN with nephropathy. Methods A retrospective case series was conducted including 69 patients diagnosed with AN, among whom 11 patients tested positive for anti-CNTN1 antibodies. Clinical mani …

03.09.2026journal-article

Frontiers in Oncology

Lattice SFRT in a geriatric patient with an initially inoperable leg bulky sarcoma: case report and literature review

Francesco Di Siervi, Bruno Curcio, Renato Cuocolo, Silvio Maffei, Carolina Mainardi, Immacolata A.M. Pilotti, Davide Di Gennaro

Background Management of inoperable bulky soft tissue sarcomas mostly in geriatric patients presents a significant clinical challenge due to high and hypoxia-induced radioresistance, proximity to dose-limiting Organs at Risk (OARs), and the need to minimize systemic toxicity. Spatially Fractionated Radiation Therapy (SFRT), specifically 3D Lattice Radiation Therapy (LRT), offers a novel approach to safely escalate dose within the tumor volume. Case presentation 85-year-old female presenting a massive (20.7 x 9.8 cm …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Effects of Improper Disposal of Expired and Unused Pharmaceutical Products on Man and the Environment

Yinka Akinade

The improper disposal of expired and unused pharmaceutical products has become something of great public health and environmental concern worldwide. This study examines the pathways through which pharmaceuticals enter the environment, including household waste, sewage systems, and landfill leachates, and assess their effects on human health and ecological systems. Pharmaceuticals such as antibiotics, hormones, analgesics and cytotoxic drugs are continually found in soil and water bodies as a result of inadequate wa …

03.09.2026journal-article

Frontiers in Pharmacology

Vietnamese pharmacogenomic variation in global context: a systematic review and meta-analysis for clinical implementation

Van Thi Bich Hoang, Anh Van Tran, Tham Thi Bui, Quynh Thi Vu, Mai Thi Quynh Ngo, Khai Van Nguyen, Phuong Thi Thu Nguyen

Background Population-frequency evidence is indispensable for planning pharmacogenomic services, but broad ancestry categories do not reliably capture the distribution of clinically important alleles, haplotypes, and structural variants. We undertook a systematic synthesis of pharmacogenetic variation reported in Vietnamese populations and evaluated its relevance to clinical implementation. Methods Following a prospectively registered protocol and PRISMA 2020, we searched international and Vietnamese sources throug …

03.09.2026journal-article

Frontiers in Public Health

A community-focused rural academic health department model in North Carolina: elevating community engagement, rural public health practice and research

Carmen D. Samuel-Hodge, Lisa Macon Harrison, Wendy Smith, Karl T. Johnson, Anna Feng, Devon Noonan

Introduction In decentralized public health systems, rural public health departments have fewer economic resources and higher needs for public health programs and services. This case study describes the evolution of a rural district health department’s community and academic partnerships across three phases. Throughout this process, partnerships grounded in community engagement informed the local public health workforce, translated research into practice, and supported the design, implementation, and evaluation of …