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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Journal of Educational Evaluation for Health Professions

Refusal-aware evaluation of frontier AI models available in June 2026 using the Japanese National License Examination for Pharmacists: a comparative study

Hiroyasu Sato, Katsuhiko Ogasawara, Hidehiko Sakurai

Purpose: Conventional single-run accuracy may be insufficient for evaluating frontier generative artificial intelligence (AI) models when safety-related refusals occur. This 4-model benchmark examined the need for repeated, refusal-aware evaluation using the Japanese National License Examination for Pharmacists (JNLEP).Methods: ChatGPT GPT-5.5, Gemini 3.5 Flash, Claude Opus 4.8, and Claude Fable 5 were evaluated using all 345 questions from the 107th JNLEP. The original Japanese questions, including image-containin …

03.09.2026journal-article

Frontiers in Pharmacology

Vietnamese pharmacogenomic variation in global context: a systematic review and meta-analysis for clinical implementation

Van Thi Bich Hoang, Anh Van Tran, Tham Thi Bui, Quynh Thi Vu, Mai Thi Quynh Ngo, Khai Van Nguyen, Phuong Thi Thu Nguyen

Background Population-frequency evidence is indispensable for planning pharmacogenomic services, but broad ancestry categories do not reliably capture the distribution of clinically important alleles, haplotypes, and structural variants. We undertook a systematic synthesis of pharmacogenetic variation reported in Vietnamese populations and evaluated its relevance to clinical implementation. Methods Following a prospectively registered protocol and PRISMA 2020, we searched international and Vietnamese sources throug …

03.09.2026journal-article

Frontiers in Public Health

A community-focused rural academic health department model in North Carolina: elevating community engagement, rural public health practice and research

Carmen D. Samuel-Hodge, Lisa Macon Harrison, Wendy Smith, Karl T. Johnson, Anna Feng, Devon Noonan

Introduction In decentralized public health systems, rural public health departments have fewer economic resources and higher needs for public health programs and services. This case study describes the evolution of a rural district health department’s community and academic partnerships across three phases. Throughout this process, partnerships grounded in community engagement informed the local public health workforce, translated research into practice, and supported the design, implementation, and evaluation of …

03.09.2026journal-article

Experimental & Molecular Medicine

Bone marrow stromal cells promote chemoresistance in acute myeloid leukaemia through P2RX7-mediated antioxidant defence

Ruolan You, Xiaoting Wang, Xiaoming Zheng, Wenqi Fang, Cen Jiang, Jingru Liu, Xiaolin Xu, Maoqing Tan, Danni Cai, Diyu Hou, Jing Zheng, Xinjian Lin, Huifang Huang

Abstract Acute myeloid leukaemia (AML) remains a therapeutically challenging malignancy owing to its high relapse rates and chemoresistance, often linked to elevated antioxidant defences. Here, we demonstrate that bone marrow stromal cells (BMSCs) confer chemoresistance in AML by upregulating the purinergic receptor P2RX7. Blocking P2RX7 restored chemosensitivity of AML cells. Mechanistically, BMSC-mediated P2RX7 overexpression induces calcium influx and mitochondrial calcium overload, triggering mitochondrial stre …

03.09.2026journal-article

British Journal of Nursing

Addressing sexual harassment within acute care nursing

Samantha Hagan, Claire Dosdale

Sexual harassment within health care, particularly in the NHS, has become an increasingly urgent concern following high-profile investigations and surveys exposing unacceptable workplace behaviours. Acute care settings such as theatres and critical care units appear to carry a higher risk for sexually inappropriate conduct, with many staff reporting unwanted sexual behaviours from colleagues, patients and the public. This article explores the prevalence of sexual harassment among acute care nursing teams in the NHS …

03.09.2026journal-article

Frontiers in Endocrinology

In utero and lactational exposure to tenofovir disoproxil fumarate and bone health outcomes: a scoping review of 31 studies

Xia Ji, Yuanzhong Wang, Zefan Zhang, Kok-Lun Pang, Xiong Khee Cheong, Norliza Muhammad, Kok-Yong Chin

Introduction Tenofovir disoproxil fumarate (TDF) is a key antiretroviral agent for preventing mother-to-child transmission of human immunodeficiency virus (HIV) and treating chronic hepatitis B (HBV) during pregnancy. However, concerns persist regarding its potential effects on bone metabolism during foetal development and postpartum recovery. Objective This scoping review synthesised evidence on the impact of in utero and lactational TDF exposure on bone health in offspring and mothers. Methods A systematic search …

03.09.2026journal-article

Frontiers in Medicine

Identifying systemic vulnerability phenotypes associated with programmed regimens in frozen embryo transfer: a secondary analysis of a multicentre randomized clinical trial

Junfeng Chen, Hu Li, Mengfei Wang, Bailian Cai, Junjie Qu, Yiran Li

Background Programmed endometrial preparation is widely used for frozen embryo transfer (FET) because it allows flexible scheduling. Recent randomized evidence has shown that programmed regimens increase the risk of hypertensive disorders of pregnancy, particularly pre-eclampsia, compared with natural ovulation regimens. However, it remains unclear whether this risk is distributed uniformly across patients or concentrated in women with specific baseline characteristics. Objective This study aimed to evaluate the he …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

A case report of cardiogenic shock with transcranial color-coded ultrasound monitoring under ECMO

Yuyi Chen, Jingyi Wu, Huiying Chen, Jiefeng Xie, Yuping Liao, Qianwei Zheng, Yu Gan

Background Cardiogenic shock (CS) during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support carries high mortality, often due to neurological injury. Precise matching of ECMO flow to cerebral perfusion is critical. Transcranial color-coded sonography (TCCS) offers real-time, non-invasive hemodynamic assessment to guide flow titration, though its clinical integration remains limited. Case presentation This study reports a 58-year-old male firefighter who suffered out-of-hospital cardiac arrest due to …

03.09.2026journal-article

Frontiers in Neurology

The clinical features of anti-CNTN1 antibodies associated autoimmune nodopathies with nephropathy: a case series

Jinping Wan, Tiegen Xiong, Jianian Hu, Shaojun Liu, Jie Lin, Chongbo Zhao, Chong Sun, Hai Xiao

Objective The concurrence of anti-contactin-1 (CNTN1) antibody-associated autoimmune nodopathies (AN) and nephropathy has been sporadically reported, though the underlying relationship remains unclear. This case series study aimed to investigate the clinical characteristics and renal pathology of anti-CNTN1 antibody-associated AN with nephropathy. Methods A retrospective case series was conducted including 69 patients diagnosed with AN, among whom 11 patients tested positive for anti-CNTN1 antibodies. Clinical mani …

03.09.2026journal-article

Frontiers in Oncology

Lattice SFRT in a geriatric patient with an initially inoperable leg bulky sarcoma: case report and literature review

Francesco Di Siervi, Bruno Curcio, Renato Cuocolo, Silvio Maffei, Carolina Mainardi, Immacolata A.M. Pilotti, Davide Di Gennaro

Background Management of inoperable bulky soft tissue sarcomas mostly in geriatric patients presents a significant clinical challenge due to high and hypoxia-induced radioresistance, proximity to dose-limiting Organs at Risk (OARs), and the need to minimize systemic toxicity. Spatially Fractionated Radiation Therapy (SFRT), specifically 3D Lattice Radiation Therapy (LRT), offers a novel approach to safely escalate dose within the tumor volume. Case presentation 85-year-old female presenting a massive (20.7 x 9.8 cm …

03.09.2026journal-article

Journal of Health Research

From readiness to transformation: the mediating role of digital maturity in linking ai readiness to organizational change in hospitals

Muhammad Ryan Adi Putra, Giovanni Reynaldo, Dewi Sri Surya Wuisan

Background: Organizational readiness is essential for AI-enabled digital transformation as healthcare organizations increasingly integrate artificial intelligence (AI). However, empirical evidence regarding the relationship between AI readiness and organizational change, the mediating role of digital maturity, remains limited in healthcare settings. This study investigated the mediating role of digital maturity in the relationship between AI readiness and organizational change. Methods: This cross-sectional study i …

03.09.2026journal-article

Primary Health Care Practice Journal

Psychological distress and preserved academic functioning among medical trainees in Kenya: a convergent mixed-methods cross-sectional study

Collins Moses Owuor, Augustine Mwangi Gatotoh, Ruth Mumo Omungo, Grace Achieng Otieno

Introduction: psychological distress is highly prevalent among health professional trainees, yet academic decline may inadequately identify psychologically vulnerable students. This study examined the association between psychological distress and academic functioning among medical trainees in Kenya. Methods: a convergent mixed-methods cross-sectional study was conducted among 266 medical trainees at Kenya Medical Training College, Kisumu Campus, selected through stratified random sampling. Psychological distress w …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Effects of Improper Disposal of Expired and Unused Pharmaceutical Products on Man and the Environment

Yinka Akinade

The improper disposal of expired and unused pharmaceutical products has become something of great public health and environmental concern worldwide. This study examines the pathways through which pharmaceuticals enter the environment, including household waste, sewage systems, and landfill leachates, and assess their effects on human health and ecological systems. Pharmaceuticals such as antibiotics, hormones, analgesics and cytotoxic drugs are continually found in soil and water bodies as a result of inadequate wa …

03.09.2026journal-article

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Impact of Erythropoietin Therapy on Inflammatory Biomarkers in Chronic Kidney Disease: A Comparative Study

Riyam Naji Al_Alwani, Jahanbakhsh Asadi, Zainab Mohammadi

Background: Chronic kidney disease (CKD) is a progressive disorder frequently complicated by anemia and a persistent inflammatory state, both of which significantly contribute to morbidity and mortality. Reduced renal production of erythropoietin (EPO) is the primary cause of anemia in CKD. Emerging evidence suggests that EPO may exert anti-inflammatory and metabolic effects beyond its hematopoietic role. This study aimed to compare serum EPO levels and inflammatory biomarkers in CKD patients treated with EPO versu …

03.09.2026journal-article

Journal of Health Psychology

Examining the predictive role of multidimensional trust in healthcare systems on health-seeking behavior and healthcare demand procrastination behavior

Gizem Zevde Aydin, Bilge Büyükşirin, Özlem Özer

This study aimed to investigate whether multidimensional trust in healthcare systems predicts health-seeking behavior and healthcare demand procrastination behavior. The study was conducted with individuals aged 18 and over residing in Samsun, Türkiye, and data were collected from 544 participants. Descriptive analyses indicated that the mean scores were 3.25 ± 0.90 for the multidimensional trust in healthcare systems scale, 3.55 ± 1.01 for the health-seeking behavior scale, and 2.41 ± 1.11 for the healthcare deman …

03.09.2026journal-article

Public International and Private International Law

Judgements of the International Court of Justice as a Source of Law

Ekaterina S. Lutsenko

The article analyzes scientific theories regarding the legal nature of decisions of the International Court of Justice. Its role in identifying and specifying the norms of international law and developing the system of international law, ensuring the consistency and predictability of international judicial practice, and implementing the principle of the rule of law is noted.

03.09.2026journal-article

Public International and Private International Law

The Real Statute: The Status and Possible Development Ways

Nikita Yu. Chaplin

In the theory and practice of contemporary private international law, questions regarding the legal classification of property statutes remain unresolved, with debates surrounding the relationship between property and obligatory statutes. In the context of unprecedented economic and technological growth, the need to modernize property statutes arises. The classification of elements of property statutes remains controversial. In this article, the author not only outlines this issue but also proposes approaches to ad …

03.09.2026journal-article

European Journal of Trauma and Emergency Surgery

Long-term patient-reported outcomes and quality of life after tibiofemoral knee dislocations in patients with open growth plates: a retrospective case series from a Level 1 trauma center

Pierre Hepp, Yasmin Youssef, Ralf Henkelmann

Abstract Background Tibiofemoral dislocations in children and adolescents are rare, and treatment guidelines are primarily based on adult data and algorithms. This case series of four pediatric and adolescent patients aims to add to the limited literature and highlights key aspects of diagnosis, treatment, and patient-reported outcomes. Methods We conducted a retrospective-prospective single-center case series of pediatric and adolescent patients (

03.09.2026journal-article

Frontiers in Health Services

Development of targeted strategies to enhance linkage and retention in HIV care among people living with HIV/AIDS in Mpumalanga province

Thuso Charity Mafhungo, Mygirl Lowane, Linda Skaal

Background Despite significant progress in HIV services, significant patient loss occurs at every stage of the HIV care continuum. While efforts made by the NDoH aim to combat the HIV epidemic and achieve the 95-95-95 targets, these targets cannot be reached unless PLHIV are effectively linked to and retained in care. This study aims to develop targeted strategies to improve linkage to and retention in HIV care among PLHIV in the Msukaligwa Sub-district, Mpumalanga Province. Methods A convergent parallel mixed-meth …

03.09.2026journal-article

Frontiers in Reproductive Health

The “puberty deadline”: cultural constructions of maturity, anticipated shame, and child marriage as a perceived risk-mitigation strategy in rural Niger

Jean Christophe Fotso, Aichatou Hamadou, Ferdinard Ngong, Paul Bukuluki

Introduction In rural Niger, child marriage remains highly prevalent, often functioning as a mechanism of risk mitigation. This qualitative study explores the cultural and bio-social drivers of child marriage, focusing on the intersection of physical maturation, anticipatory shame, and economic vulnerability. Methods The study drew on 53 in-depth interviews, six body mapping focus group discussions (FGDs), and 9 social norms mapping FGDs with adolescents, parents, and community leaders (n = 165) in the Maradi regio …

03.09.2026journal-article

Frontiers in Medicine

The role of Advanced Practice Providers in improving primary care capacity: practice perspectives on challenges and opportunities

Marie Shoen, Ben Webel, Jacqueline Britz, Hailee Hoffman, Jennifer Gilbert, Alex H. Krist, E. Marshall Brooks

Background In Virginia and across the United States, primary care workforce shortages limit access to care and exacerbate adverse health outcomes. We conducted a statewide survey of primary care practices in 2022 and found that 42% of practices reported losing a physician or Advanced Practice Provider (APP), including Nurse Practitioners (NPs) and Physician Assistants (PAs), in the past year. Adding APPs to primary care teams is one strategy practices are using to mitigate the shrinking availability of primary care …

03.09.2026journal-article

Frontiers in Public Health

Associations of work-related extended availability with overweight and obesity among Chinese workers

Huiying Wang, Xin Li

Objective Work-related extended availability (WREA) has become an increasingly salient feature of the contemporary labor market and may be associated with workers' health outcomes. Nevertheless, the associations of WREA with overweight and obesity remain insufficiently explored. This study aimed to examine the associations of WREA with overweight and obesity among Chinese workers. Methods Using data from the 2020 and 2022 waves of the China Family Panel Studies, we constructed an analytical sample of 16,969 observa …

03.09.2026journal-article

Frontiers in Ecology and Evolution

Spatiotemporal evolution and associated factors of coupling coordination between socio-economic development and ecological health: county-level evidence from the Central Yunnan Urban Agglomeration, China

Ying Li, Lede Niu, Anlin Li, Yan Zhou

Understanding how socio-economic development aligns with ecological health is essential for the sustainable governance of mountainous urban agglomerations. This study investigates 49 county-level units in the Central Yunnan Urban Agglomeration, China, from 2010 to 2023. Socio-economic development and ecological health were evaluated using a pooled entropy-weighted TOPSIS framework. A baseline coupling coordination degree (CCD-B) and a reconstructed non-overlapping measure (CCD-R) were developed to reduce mechanical …

03.09.2026journal-article

Physics in Medicine & Biology

Rapid whole-brain susceptibility source separation using sub-minute three-dimensional multiple overlapping-echo detachment acquisition

Longkun Chen, Qinqin Yang, Shiwei Huang, Nuowei Ge, Zejun Wu, Jianjun Zhou, Jianfeng Bao, Lijun Bao, Yuanhao Cheng, Jianfa Chen, Shuhui Cai, Zhong Chen, Liuhong Zhu, Congbo Cai

Abstract Objective. Magnetic susceptibility source separation provides profound insights into tissue pathophysiology by disentangling the underlying paramagnetic and diamagnetic sources within the human brain. However, the highly time-consuming nature of existing acquisition techniques creates a critical need for rapid and reliable separation methodologies to facilitate routine clinical applications. Approach. A highly accelerated framework for whole-brain magnetic susceptibility source separation was proposed by u …