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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Academic Bulletin of Mental Health

Disulfiram-Induced Catatonia Following a Disulfiram–Alcohol Reaction: A Case Report

Satyasmita Jena, Rakesh Kumar Jangde, Rachana Chandekar, Priyansh Dubey

Disulfiram is commonly used in the management of alcohol dependence. Although generally safe, it may rarely lead to neuropsychiatric adverse effects such as catatonia. We report a case of a 32-year-old male with alcohol dependence who developed acute catatonic symptoms following a disulfiram–alcohol reaction after unsupervised use of disulfiram. Such cases, though previously reported, remain uncommon in clinical practice, particularly in settings like Chhattisgarh where unsupervised disulfiram use and limited aware …

03.09.2026journal-article

European Journal of Clinical Microbiology & Infectious Diseases

Diagnosis of pneumococcal pneumonia using quantitative PCR targeting lytA and piaB in adult patients with community-acquired pneumonia

Nienke Paternotte, Willem R. Miellet, Tessa Nieuwenhuijsen, Rob Mariman, Wil A. van der Reijden, Wouter Rozemeijer, Elisabeth A.M. Sanders, Dominic Snijders, Cornelis H. van Werkhoven, Marc J.M. Bonten, Krzysztof Trzciński, Wim G. Boersma

Abstract Purpose Accurate diagnosis of pneumococcal pneumonia remains challenging due to suboptimal sensitivity of conventional microbiological methods. Molecular techniques may improve Streptococcus pneumoniae detection, but their clinical utility remains uncertain. Methods In this prospective observational study, we compared conventional diagnostics with qPCR-based detection of lytA and piaB genes in nasopharyngeal, oropharyngeal, saliva, and sputum samples collected from adults with community-acquired pneumonia …

03.09.2026journal-article

BMC Oral Health

Effects of post drill specification, preparation depth and adjacent tooth status on the scanning trueness of post space: an in vitro study

Ke Huang, Jun-bin Zou, Yue-ran Guo, Hui-cong Zhu, Xiao Li

Abstract Background The indication for direct intraoral scanning of post spaces should be guided by the post drill. This study evaluated the influence of drill specifications, preparation depth, and the presence or absence of bilateral adjacent teeth on the scanning trueness of post spaces using two intraoral scanners (IOSs) in vitro. Methods A standard maxillary denture model was scanned for virtual post spaces preparation of the right maxillary central incisor. There were two groups of models, 8 models per group: …

03.09.2026journal-article

Demidov Law Journal

Заведомость как обязательный признак преступлений, связанных с публичным распространением ложной информации: актуальные проблемы применения статей 207.1-207.3 УК РФ

Nikhad V. Dunyamalyev

This article is devoted to a comprehensive study of the element of «deliberateness» in crimes related to the public dissemination of false information (Articles 207.1-207.3 of the Russian Criminal Code). An analysis of various doctrinal approaches to the legal nature of deliberateness is conducted, examining it as a special technique of legislative drafting. Particular attention is paid to the analysis of current judicial practice, which reveals significant heterogeneity in the methodological approaches of judicial …

03.09.2026journal-article

Journal of Clinical Medicine

Association Between DLCO and Echocardiographic Right Ventricular–Pulmonary Arterial Coupling in Idiopathic Pulmonary Fibrosis

Francesca Coppi, Susan Darroudi, Giulia Renda, Alessandra Lodeserto, Arianna Maini, Damiano De Cesare, Youssef Othman, Martina Mercati, Dalia Caleffi, Filippo Gozzi, Francesco Marangi, Dario Andrisani, Federica Andolfi, Alessio Baccarani, Daniela Aschieri, Anna Vittoria Mattioli, Francesco Fedele, Enrico Clini, Stefania Cerri, Gianluca Pagnoni

Background: Idiopathic pulmonary fibrosis (IPF) is frequently complicated by pulmonary vascular involvement and right ventricular (RV) dysfunction, both of which adversely affect prognosis. The relationship between impaired gas exchange and echocardiographic indices of RV function, particularly the TAPSE/PAPs (tricuspid annular plane systolic excursion/systolic pulmonary artery pressure) ratio as a marker of RV–pulmonary arterial (RV–PA) coupling, has not been fully characterized. Methods: We retrospectively evalua …

03.09.2026journal-article

Journal of Clinical Medicine

The Association of SARIFA with Poor Prognosis and Aggressive Tumor Phenotypes in Cancers: A Meta-Analysis

Jiaqi Lao, Guangwei Tian, Lin Guan

Background: SARIFA (Stroma Areactive Invasion Front Areas) is an emerging histopathological biomarker defined by direct tumor–adipocyte contact at the invasive front. Preliminary studies suggest its association with poor prognosis, but evidence remains fragmented across cancer types. This meta-analysis aims to systematically evaluate the prognostic value of SARIFA for overall survival (OS) and its correlation with aggressive tumor phenotypes. Methods: Following PRISMA guidelines, we searched PubMed, Embase, Web of …

03.09.2026journal-article

British Journal of Nursing

Innate limitations and deprivation of liberty

Richard Griffith

Richard Griffith , Senior Lecturer in Health Law at Swansea University, discusses limitations that restrict the right to liberty, potentially exposing the vulnerable to disproportionate restrictions and undignified care

03.09.2026journal-article

Indian Journal of Radiology and Imaging

Digital Twins in Oncology: From Multimodal Data Integration to Precision Clinical Practice

Annamalai Vairavan, Rupsa Bhattacharjee, Bagyam Raghavan

Oncology digital twins are patient-specific computational models that are built by combining electronic health records, multiomics genomic data, and diagnostic imaging to simulate individual tumor biology and predict multiple treatment-related outcomes. Conceptually originated from aerospace engineering, it has matured clinically through convergent advances in radiomics, mechanistic tumor modeling, pharmacokinetic- pharmacodynamic systems, federated machine learning, and, most recently, large language model (LLM)-b …

03.09.2026journal-article

Clinical Spine Surgery

Comparative Study of Sagittal Spinopelvic Parameters and Clinical Outcomes After Minimally Invasive Versus Open Fusion in Mild Isthmic Lumbar Spondylolisthesis

Zhongzheng Sun, Qiquan Hao, Kai Sun, Janlei Hou

Study Design: Retrospective comparative study. Objective: This study evaluated the radiologic and clinical outcomes of minimally invasive versus open fusion surgery using a computer-assisted image analysis tool. Background: Lumbar spondylolisthesis, isthmic in nature, tends to interfere with sagittal balance and results in chronic back pain and disability. Operationally, the primary aim is to correct sagittal imbalance and restore functional stability. Methods: Patients with single-level mild isthmic lumbar spondyl …

03.09.2026journal-article

Foresight and STI Governance

The Digital Transformation of Public Governance: A Foresight Study for the Water Sector

Majdi Argoubi, Khaled Mili

The digital transformation of public administration requires more complex approaches than previously thought. There are no one-size-fits-all solutions, as each country has a unique resource base, natural conditions, historical context, and capacity to adopt technologies and accelerate development. A key role is also played by a multidimensional analysis of the national governance system’s potential for profound and systemic transformation, an ambidextrous approach to current and strategic tasks, and the search for …

03.09.2026journal-article

Clinical Microbiology Reviews

Human vascular pythiosis: pathogenesis, diagnosis, and evidence-informed management

Nitipong Permpalung, Sadeep Medhasi, Pattama Torvorapanit, Rongpong Plongla, Navaporn Worasilchai

SUMMARY Human vascular pythiosis is a rare, life-threatening angioinvasive infection caused predominantly by the oomycete Pythium insidiosum . Unlike ocular or cutaneous pythiosis, the vascular form is defined by arterial wall invasion, long-segment thrombosis, limb ischemia, aneurysmal complications, and high risks of amputation and death. Although P. insidiosum is broadly distributed in freshwater environments, reported human vascular disease remains concentrated in Thailand, indicating that exposure alone is ins …

03.09.2026journal-article

Physics in Medicine & Biology

S2V-DREME: a time-resolved slice-to-volume MR image reconstruction framework with dynamic reconstruction and motion estimation

Xiaoxue Qian, Hua-Chieh Shao, Jie Deng, Yan Dai, You Zhang

Abstract Objective. Existing volumetric magnetic resonance imaging (MRI) techniques are constrained by the trade-off between acquisition time and image quality, limiting accuracy in motion-impacted sites such as the liver. To enable fast, better-quality volumetric imaging with sufficient spatiotemporal resolution, we developed a time-resolved volumetric MRI technique that recovers 3D volumes from acquired 2D MR slices for real-time 3D anatomy and motion tracking. Approach. 2D MR slices dynamically acquired in time …

03.09.2026journal-article

American Journal of Audiology

Health-Related Quality-of-Life Profiles in Adults With Tinnitus

Preeti Pandey, Hansapani Rodrigo, Megan Kruger, Eldre Beukes, De Wet Swanepoel, Anu Sharma, Gerhard Andersson, Vinaya Manchaiah

Purpose: The study aimed to characterize the multidimensional burden of tinnitus on health-related quality of life (HRQoL) using the EuroQol 5-Dimension 5-Level (EQ-5D-5L) dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) moving beyond symptom severity alone. Method: A cross-sectional analysis was conducted using baseline data ( N = 428, M age = 54.9 years, 51.9% female) from several clinical trials examining the efficacy of internet-based cognitive behavioral therapy for t …

03.09.2026journal-article

Clinical Anatomy

Accuracy of Freehand Versus Navigated External Ventricular Drainage and Comparison of Insertion Trajectories: A Systematic Review and Meta Analysis

Adam Sedlák, Martin Černý, Adam Koza, David Kachlík, David Netuka, Lea Mladá, Miroslav Žáček, Martin Májovský

ABSTRACT The external ventricular drainage is a routine neurosurgical procedure, most often performed by cannulating the frontal horn of the lateral ventricle. Various entry points and insertion trajectory definitions have been proposed; nevertheless, it remains unclear which approach yields the highest success rate. Furthermore, in contemporary clinical practice, generally more efficient navigated ventriculostomies are available. This study aims to compare success rates between freehand and navigated procedures an …

03.09.2026journal-article

Clinical Research in Cardiology

Gaps in lipid management among high-risk patients without prior MI or stroke: the VESALIUS-REAL global study

Queenie Chan, Jaimini Cegla, Ulrich Laufs, Jan H. Cornel, Gaetano M. De Ferrari, Emil Hagström, Huei-Kai Huang, José Lopez-Miranda, Suna Avcil, Corinne Brooks, Thomas Cars, Adrienne Y. L. Chan, Celine S. L. Chui, Michael Duxbury, Edward Chia-Cheng Lai, David Neasham, Andreas Ochs, James O’Kelly, Gabriel Paiva da Silva Lima, Naomi Reimes, Swati Sakhuja, Shih-Chieh Shao, Ju-Young Shin, Mahendra Sibartie, Ilona Verburg, Matthew J. Budoff, Kyung Woo Park, Kenichi Tsujita, Kai Hang Yiu, Nafeesa Dhalwani, Ian C. K. Wong

Abstract Background Real-world evidence on lipid-lowering therapy (LLT) use and low-density lipoprotein cholesterol (LDL-C) control in patients at high cardiovascular (CV) risk without prior myocardial infarction (MI) or stroke remains limited. We evaluated LLT use, treatment intensification, LDL-C monitoring, and LDL-C goal attainment across North America, Europe, and Asia-Pacific. Methods VESALIUS-REAL is a retrospective observational study using a common protocol across 11 databases between 2017 and 2022. Eligib …

03.09.2026journal-article

Liaquat National Journal of Primary Care

Neuroprotective Properties of Lactobacillus plantarum: Bridging Gut Health and Cognition

Deepali Deepali, Pavan Kumar Chikkavalli Muddanna, Dhanush Hulikere Koppalu Devaraju, Dhanya Kellur Nagaraja, Mahendra Kumar Betur Jayappa

A growing body of research demonstrates that the composition of the gut microbiome influences central nervous system function through the gut-brain axis, an essential link in neurophysiological processes. Lactobacillus plantarum, a widely studied probiotic, exhibits multiple neuroprotective mechanisms that support its potential as a psychobiotic. This review synthesizes current preclinical and clinical evidence regarding the effects of L. plantarum on cognitive function, neuroinflammation, oxidative stress, and neu …

03.09.2026journal-article

Frontiers in Medicine

Analytical validation of capillary blood Krebs von den Lungen-6 measurement using a high- sensitivity chemiluminescent immunoassay in pediatric patients

Chengyuan Zhao, Lingyun Shi, Dan Cao, Xianwei Zhang, Tong Cao

Objective This study evaluates the analytical validity of capillary blood for Krebs von den Lungen-6 (KL-6) detection using a high-sensitivity chemiluminescent immunoassay (CLIA) on the C5000 analyser and assesses agreement between capillary plasma and venous plasma measurements, with emphasis on methodological feasibility rather than clinical diagnostic performance. Methods Analytical performance was assessed in terms of repeatability, accuracy and method comparison. Precision was evaluated using pediatric venous …

03.09.2026journal-article

Journal of Risk and Financial Management

Professional Judgment and AI Disclosure Governance in Audit and Sustainability Assurance: Public Evidence from the UK Big Four

Radosveta Krasteva-Hristova

Artificial intelligence (AI) is entering audit workflows while sustainability reporting expands the evidence subject to professional evaluation. This exploratory study examines how the UK Big Four publicly describe safeguards that keep AI-assisted work human-led, reviewable and accountable. The complete 2024 transparency-report cross-section was coded against seven pre-specified dimensions and summarized in an AI–Judgment Governance Disclosure Index (AI-JGDI). The index measures AI disclosure governance—the complet …

03.09.2026journal-article

Annals of Human Resource Management Research

The Adaptive Turn in Public HRM: Managing Generational Diversity for Productivity in Nias Regency

Fatolosa Hulu, Yamolala Zega, Odaligoziduhu Halawa

Purpose: This study investigates adaptive leadership strategies for managing generational diversity (Generation X, Millennials, and Generation Z) within the context of local public bureaucracy, using a mixed-methods case study of the Department of Population and Civil Registration in Nias Regency. It examines how leadership practices respond to different values, communication styles, and work expectations across generations in public institutions. Research Methodology: A mixed-methods approach with an exploratory s …

03.09.2026journal-article

Journal of Clinical Medicine

Recorded Early Imaging Responses After Transarterial Chemoembolization Plus Lenvatinib Versus Transarterial Chemoembolization Without Documented Lenvatinib for Unresectable Hepatocellular Carcinoma: A Vietnamese Cohort Study

Vu Le Minh, Nguyen Van Hung, Pham The Anh, Pham Tuan Anh, Pham Minh Thong

Background/Objectives: Vietnamese evidence on transarterial chemoembolization (TACE) plus lenvatinib for unresectable hepatocellular carcinoma (HCC) remains limited. We examined recorded early imaging responses and uncertainty from missing outcomes, exposure classification, and confounding. Methods: This single-center secondary cohort included all eligible available records during a shared post-approval period (21 February 2024–19 August 2025). The endpoint was a documented complete or partial response according to …

03.09.2026journal-article

Cancer

Long‐term outcomes and patterns of failure in patients with thymic malignancies treated with surgery and radiation therapy

Oded Icht, Inbar Nardi‐Agmon, Paaladinesh Thavendiranathan, Shaf Keshavjee, Amiya Agrawal, John‐Michael Miro, Omar Badran, Geoffrey Liu, Xiang Y. Ye, B. C. John Cho, Andrea Bezjak, Andrew Hope

Abstract Background The role of peri‐operative radiation therapy in thymic epithelial tumors remains controversial, and randomized data are lacking. The authors evaluated recurrence patterns, pathologic predictors of recurrence, and long‐term survival among patients who underwent surgery and received peri‐operative radiation at a high‐volume tertiary center. Methods The authors conducted a retrospective cohort study of patients who had thymic malignancies treated surgically between 2004 and 2021. Clinical, patholog …

03.09.2026journal-article

Journal of Global Social Transformation

Analysis of Health-Related Quality of Life among School-Going Children: A Cross-Sectional Study from Tehsil Faisalabad

Neha, Muhammad Khushnood Ashraf, Muhammad Abubker Zia

Health-Related Quality of Life (HRQoL) is a multidimensional construct which represents children's physical, psychological and overall health. Analyzing HRQoL during childhood is important because health-related experiences can influence children's daily functioning, participation, learning, and emotional development. The current study was meant to evaluate the Health-Related Quality of Life (HRQoL) of school going children conducted by a cross sectional survey design at Tehsil Faisalabad. The number of mothers par …

03.09.2026journal-article

Journal of Embedded Systems, Security and Intelligent Systems

Internet of Things-Based Decision Support System for Toddler Health Using Mamdani Fuzzy Logic

I Gede Wiryawan, Yogiswara, Beni Widiawan, Lalitya Nindita Sahenda, Nanda Raditya Akbar

Purpose – This study develops and evaluates an Internet of Things-based decision support system using Mamdani fuzzy logic for the early identification of febrile seizure risk in toddlers. The system integrates continuous body-temperature and heart-rate monitoring to provide automated risk classification and real-time warning information. Design/methods/approach – The prototype combines an Arduino Uno, a GY-906 non-contact temperature sensor, a pulse sensor, an ESP8266 communication module, and a web-based monitorin …