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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

The Journal of Knee Surgery

Pulsed Electrical Stimulation for Knee Osteoarthritis: Reappraisal of a 21-Year Clinical Development Program

Michael A. Mont, Chase W. Smitterberg, Javad Parvizi, Thomas Zizic

Abstract Knee osteoarthritis (OA) remains a leading cause of pain and disability, yet few nonoperative therapies have demonstrated durable clinical benefit or potential effects on structural disease progression. Pulsed electrical stimulation (PES) was investigated extensively over two decades, but this evidence has received little attention in the contemporary era of disease-modifying OA research. A structured evidence synthesis was performed of five principal prospective clinical investigations evaluating capaciti …

02.09.2026journal-article

Experimental & Molecular Medicine

Oxygen-dependent subcellular redistribution of PHD3 links the hypoxic microenvironment to mitochondrial metabolic reprogramming in ccRCC

Jaelim Sim, Soyeon Lim, Changjun Lee, Hani Jieun Kim, Wonseok Lee, Hyeonki Kim, Hojun Lee, Kimyeong Kim, Mahesh Kumar Teli, Kyeong Beom Jo, Jacob Wright, Jee Soo Park, Myung Eun Lee, Minsun Jung, Minsoo Noh, Dae-Kyum Kim, Mi-Hyun Kim, Dong Wook Choi, Tae Su Choi, Won Sik Ham, Hunsang Lee, Haejin Yoon

Abstract Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic dysregulation, with both prolyl hydroxylase domain protein 3 (PHD3) and pyruvate carboxylase (PC) independently implicated in disease progression. Although each influences patient outcomes, a direct mechanistic interplay between these two regulators has remained elusive. Here, we uncover a novel regulatory axis involving PHD3 and PC by identifying an unexpected subcellular behavior of PHD3, namely, its dual localization to the c …

02.09.2026journal-article

Advanced Healthcare Materials

A Modular Prussian Blue Nanozyme‐Based Microneedle Platform With Flexible Therapeutic Formulations for Localized Treatment of Traumatic Brain Injury

Xiang Wang, Ge Gao, Jinhua Li, Yilong Wang

ABSTRACT Secondary injury after traumatic brain injury (TBI) is characterized by excessive reactive oxygen species (ROS) production and persistent neuroinflammation, which remain difficult to control using a single therapeutic agent. Herein, a dissolvable microneedle platform based on Prussian blue (PB) nanoparticles was developed to locally deliver curcumin (Cur) or edaravone (EDA) into injured brain tissue through a transiently disrupted blood–brain barrier. The microneedles were fabricated from hyaluronic acid/c …

02.09.2026journal-article

Hepatology

Drug-Induced Liver Injury (DILI) in clinical trials: Views and practical updates from DILI specialists at FDA

Paul H. Hayashi, Mark I. Avigan

Drug induced liver injury (DILI) continues to be a significant challenge in drug development. Just one or two cases of severe hepatotoxicity in a clinical trial can be enough to raise drug approvability concerns. Though great strides were made in DILI risk assessment and mitigation in clinical trials during the early 2000s, drugs continue to fail in development due to DILI, while severe cases still occur in late phase clinical trials and post-market. Also, changes in drug development will challenge the US Food and …

02.09.2026journal-article

Diagnosis

Methods to measure clinicians’ diagnostic calibration: an appraisal for real world application

Andrea Bradford, Umber Shahid, Rosann Cholankeril, Gopi Astik, Andrew P.J. Olson, Hardeep Singh, Ashley N.D. Meyer

Abstract Objectives Many, if not most, diagnostic errors go unrecognized by clinicians unless they cause significant patient harm. Reducing the gap between clinicians’ perceived and actual diagnostic performance (i.e., improving calibration) may improve patient outcomes. However, existing approaches to measuring calibration were developed for use in experimental settings rather than realistic practice environments. We reviewed the scientific literature and solicited expert field input to improve approaches for asse …

02.09.2026journal-article

Konya Journal of Engineering Sciences

HYBRID DEEP LEARNING WITH PCA-OPTIMIZED FEATURE SELECTION IN EARLY-STAGE PAPAYA LEAF DISEASE DIAGNOSIS

Ebru Ergün

Early detection of leaf diseases is essential to maintain crop health and improve agricultural yield. This study proposes an advanced system that uses artificial intelligence (AI) and principal component analysis (PCA) for efficient feature selection in papaya leaf disease classification. The system uses a combination of deep learning models, including VGGNet, ResNet and GoogLeNet, to extract critical features from a comprehensive dataset of healthy and diseased papaya leaf images. PCA is applied to reduce the dime …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

APPLICATION OF HIGH-FREQUENCY CAPACITIVE PLASMA OF LOW PRESSURE TO INCREASE THE EFFICIENCY OF SEPARATION OF OIL-WATER EMULSIONS BY POLYMER MEMBRANES

V.O. Dryakhlov

In recent decades, the use of polymer membranes has attracted considerable interest due to their high performance and energy efficiency. However, the main limitation to the widespread adoption of such membranes is their susceptibility to oiling and subsequent contamination by petroleum components. To address this issue, surface modification methods are being actively developed, and one of the most promising approaches is environmentally friendly treatment with low-pressure high-frequency plasma. This treatment allo …

02.09.2026journal-article

Frontiers in Cardiovascular Medicine

PROMBot-HSM-AF: protocol for a feasibility study of a chatbot-based platform to collect patient-reported outcomes after atrial fibrillation ablation

Sérgio Laranjo, Pedro Silva Cunha, Federico Guede-Fernández, Eduarda Oliosi, Rita Contins, Pedro Dias, Catarina Silva, Ana Clara Félix, Mário Martins Oliveira, Ana Rita Londral

Introduction Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with catheter ablation increasingly recommended as first-line therapy. Despite its effectiveness, 15% to 20% of patients require reassessment within the first month post-procedure. Standard follow-up relies on scheduled consultations and intermittent monitoring, which may delay recognition of recurrence or complications. Remote patient monitoring through conversational agents may address these gaps, yet evidence on feasibility an …

02.09.2026journal-article

Critical Care

Thiamine-deficiency in the ICU-patient - When the plug is out

Wilfred Druml, Thomas Staudinger, Gunnar Elke

Abstract There is a notorious difficulty in judging micronutrient stores and requirements in critically ill patients and deficiency states will be rarely associated with clinical symptoms. A fundamental exception is vitamin B1, thiamine, a micronutrient of crucial importance in mitochondrial energy production. With thiamine deficiency ”the energy plug is out”, resulting in multiple organ dysfunctions, such as of brain, heart, kidney or respiratory system, lactate formation is increased, lactate clearance reduced, a …

02.09.2026journal-article

IECCMEXICO

Cutaneous-Ocular Manifestations in Systemic Inflammatory Diseases: Clinical Patterns, Early Recognition, and Multidisciplinary Management

Ana Patricia Torres Barrios, Sandra Carolina Méndez Sosa, Luis Felipe Espinal Pérez, Cruz Vargas Katherine Gisela, José Arnulfo Pérez Carrillo, Madelayne Lourdes Mejía Concha, Katherine Guissela Garza Córdova, Diego Alejandro Rojas López

Systemic inflammatory diseases may simultaneously affect the skin and ocular structures, generating clinical patterns that can contribute to earlier recognition of underlying immune-mediated disorders. This review analyzed the relationship between cutaneous and ocular manifestations in systemic lupus erythematosus, Sjögren’s syndrome, Behçet’s syndrome, sarcoidosis, dermatomyositis, granulomatosis with polyangiitis, systemic sclerosis, and psoriasis, with emphasis on early diagnosis and comprehensive management. An …

02.09.2026journal-article

European Journal of Clinical Nutrition

From mother’s plate to newborn’s health: dietary patterns and pregnancy outcomes—a cohort study

Tahnee Zacher, Rebecca Opel, Carolin Sobek, Peggy Ober, Wieland Kiess, Mandy Vogel

Abstract Background Maternal nutrition during pregnancy significantly influences both maternal and neonatal health outcomes, yet distinct dietary patterns and their impacts remain underexplored. The objective of this study was to identify dietary patterns during pregnancy and to investigate associations between these patterns and pregnancy outcomes. Methods We analyzed data from 1404 pregnant women in the LIFE Child cohort (Germany, 2011–2025) who completed a Food Frequency Questionnaire. To identify food groups an …

02.09.2026journal-article

Aesthetic Surgery Journal

Long-term Clinical Outcomes of Autologous Non-activated Platelet-rich Plasma (A-PRP) Delivered Through Mechanical and Controlled Infiltration in Male and Female Androgenetic Alopecia: A 10-year Prospective Randomized Evaluator-blinded Study

Pietro Gentile

Abstract Background Androgenetic alopecia (AGA) is the most common cause of progressive hair loss in men and women and is associated with significant psychosocial distress. Platelet-rich plasma (PRP) is a regenerative therapy that stimulates follicular activity, angiogenesis, and dermal papilla activation through growth factor release. Objectives This prospective randomized evaluator-blinded clinical trial evaluated the long-term efficacy and safety of autologous non-activated PRP (A-PRP) delivered through a standa …

02.09.2026journal-article

Children

Talk to Me, Not Just My Parent: Teen and Caregiver Perspectives on Implementing Screening, Brief Intervention, and Referral to Treatment Equitably in Pediatric Inpatient Settings for Teens with Chronic Illness

Faith Summersett Williams, Sarah Welch, Ella Kuffour, Emily Lynott, Sheridan Grettenberger, Kennedy Curtis, Yiyang Liu, Ruth Debono, Maria H. Rahmandar, Sara Becker

Background/Objectives: While screening, brief intervention, and referral to treatment (SBIRT) is a widely recommended evidence-based approach for early detection and intervention for alcohol and other drug (AOD) use, limited guidance exists for implementing SBIRT among hospitalized adolescents with chronic medical conditions (A-CMCs). This exploratory qualitative study examined A-CMC and caregiver perspectives on factors that may shape the acceptability, feasibility, and equitable implementation of a proposed inpat …

02.09.2026journal-article

Journal of the American Veterinary Medical Association

Comparing compressed 2-dose and 3-dose melarsomine protocols in the era of adjunctive therapy: a randomized clinical trial of 168 dogs with heartworm disease

Linda S. Jacobson, Jessie L. Dyer, Adrienne Van Vlake, Brian A. DiGangi, Mirah A. Horowitz, Julie K. Levy

Abstract Objective To test the hypothesis that, when used with doxycycline, moxidectin, and prednisone, 2-dose melarsomine would be as safe and effective as 3-dose melarsomine. Methods A randomized clinical trial was conducted from April 2024 to December 2025, comparing compressed 2-dose and 3-dose melarsomine protocols. Dogs with Class 1 or 2 heartworm disease received sustained-release moxidectin, doxycycline, prednisone, and 2 or 3 injections of melarsomine. Melarsomine was administered on days 14 and 15 (2-dose …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Changing Species Dynamics and Species-Specific Associations Observed between Anopheles and Plasmodium Genera in Diebougou Health District, Southwest Burkina Faso

Paula Lado, Lyndsey I. Gray, Emmanuel Sougué, Ashley L. Knight, Madeleine R. Sorensen, Anna-Sophia Leon, Molly E. Ring, Greg Pugh, Jenna C. Randall, Kathryn L. Coffin, Zane Wilson, Claire Stewart, Elizabeth Hemming-Schroeder, Justin Goodwin, Martina Wade, Hannah Sproch, Cheick Oumar W. Ouédraogo, Sié Rodrigue Dah, A. Fabrice Somé, Roch K. Dabiré, Sunil Parikh, Brian D. Foy

ABSTRACT. The prevalence of malaria parasite species in parts of Africa is rapidly changing and influenced by detection methods. These trends could be influenced by differential vector competence/capacity of anophelines for Plasmodium species, but these factors have been well described only for P. falciparum ( Pf ) and are unclear in the context of mixed and non- falciparum infections. During two clinical trials testing ivermectin for malaria control in the same region of Burkina Faso in 2015 and 2019–2020, we samp …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

In Vitro Efficacy of Quinolones and Carbapenems against Nonfermenting Gram-Negative Bacteria Isolated from Clinical Specimens in a Nepalese Tertiary Care Hospital

Shila Shrestha, Aakash Parajuli, Shiba Kumar Rai

ABSTRACT. Nonfermenting Gram-negative bacteria (NFGNB) pose a significant public health threat due to multidrug resistance (MDR) mediated by biofilms, efflux pumps, and carbapenemases. This cross-sectional study evaluated the minimum inhibitory concentrations (MICs) of quinolones and carbapenems against the Acinetobacter calcoaceticus–baumannii (ACB) complex and Pseudomonas aeruginosa isolated from clinical specimens at the Nepal Armed Police Force Hospital, Balambu, Kathmandu, Nepal. These NFGNB were isolated and …

02.09.2026journal-article

Academy for Practical Oncology

The significance of power doppler imaging and ultrasound tomography for the early diagnosis of endometrial and ovarian cancer

S. V. Ivashina, L. A. Ashrafyan, N. A. Babaeva, O. I. Aleshikova

AIM : To evaluate the possibilities of energy Doppler ultrasonography and ultrasound tomography in the early diagnosis of endometrial cancer and ovarian cancer. To evaluate the intraendometrial blood flow of endometrial polyps and endometrial cancer, as well as the intraovarian blood flow of benign and malignant ovarian tumors using high-tech ultrasound methods Introduction: Early diagnosis of endometrial cancer and ovarian cancer continues to be a complex and relevant problem. The use of energy Doppler ultrasonogr …

02.09.2026journal-article

Toxins

Dystonia 3×3: A Training Guideline for Beginners in Botulinum Neurotoxin Treatment of Cervical Dystonia

Sebastian Paus, Andreas Funke, Jürgen Hamacher, Bernhard Haslinger, Jan Heckelmann, Chi Wang Ip, Wolfgang H. Jost, Anatol Kivi, Stephan Klebe, John-Ih Lee, Ebba Lohmann, Frederic Mack, Axel Schramm, Andrea Stenner, Pawel Tacik, Uwe Walter, David T. Weise

Cervical dystonia (CD) is a hyperkinetic movement disorder characterized by involuntary muscle contractions leading to abnormal postures of the head and neck. The injection of botulinum neurotoxin type A (BoNT-A) into the muscles involved is the treatment of choice for CD. BoNT-A therapy of CD requires appropriate training, which has not been standardized in Germany. To address the key challenges in BoNT-A education, an expert panel developed a simplified step-by-step treatment guideline for beginners, adapted from …

02.09.2026journal-article

Human Resources for Health

Physician workforce imbalances in Japan: how structural incentives shape hospital-based acute-care capacity

George Kujo

Abstract Japan's physician workforce problem in hospital-based high-intensity care is better understood as an interaction between distribution and retention than as a simple question of national physician headcount. This Comment examines three pathways that can reduce hospital service capacity: working conditions that impede entry and career continuity in high-intensity specialties; early movement from initial residency into cosmetic medicine, known as choku-bi; and later movement from hospital employment to clinic …

02.09.2026journal-article

Current Opinion in Clinical Nutrition & Metabolic Care

Micronutrients in adult critically ill patients: lessons learned and the path toward precision

Christian Stoppe, Kursat Gundogan, Stefano Marelli

Purpose of review Despite strong biological plausibility, empiric high-dose micronutrient supplementation has failed to improve outcomes in critically ill patients. This review synthesizes evidence from the past 18 months and outlines the necessary transition toward biomarker-guided precision nutrition. Recent findings Recent evidence has further challenged routine high-dose micronutrient therapy. High-dose intravenous vitamin C failed to improve outcomes and was associated with potential harm in patients with seps …

02.09.2026journal-article

Current Opinion in Rheumatology

Partners in discovery: building equal and proactive patient engagement in inflammatory myopathies

Karen Cheng, Valérie Leclair

Purpose of review Patient engagement in research has evolved from passive participation and inclusion toward active partnership and co-leadership. This review examines the current landscape of patient involvement in myositis research, highlights existing initiatives and frameworks, and identifies persistent gaps and overlaps. Recent findings In myositis, or inflammatory myopathies, early onboarding and integration of patients as research partners in preclinical and clinical studies offer invaluable opportunities to …

02.09.2026journal-article

Annals of Surgery

A Randomized Controlled Trial Evaluating Negative Pressure Therapy (NPT) to Reduce Wound Complications Following Major Lower Extremity Amputation

Paul J. DiMuzio, Cara M. Staley, Federico Biscetti, Dawn M. Salvatore, Babak Abai, Michael J. Nooromid, Roberto G. Aru, Scott Keith, Romeo B. Mateo, Nii-Kabu Kabutey, Ellen D. Dillavou

Objective: This study hypothesizes that negative pressure therapy (NPT) reduces wound-healing complications following major amputation. Background: Major lower extremity amputation carries a high incidence of incisional complications. NPT reduces these complications in other areas of the body, suggesting a benefit following amputation. Methods: Patients undergoing above- or below-knee amputation (AKA, BKA) were randomized in this multi-institution study into receiving NPT versus standard dressing. The primary endpo …

02.09.2026journal-article

EMBO Molecular Medicine

New thinking for the next generation of antimalarials

Hannah Asiki, Jason Hlozek, Kathryn J Wicht, John G Woodland, Kelly Chibale

Abstract Despite decades of intensive research and substantial clinical gains, malaria remains a major global health challenge exacerbated by the continued emergence of drug-resistant strains of the causative agent, Plasmodium parasites. Encouragingly, recent advances in functional genomics, chemical biology and computational science are reshaping antimalarial drug discovery. In this review, we examine the discovery and development of next-generation antimalarials, including advances in phenotypic and target-based …

02.09.2026journal-article

Clinical Rheumatology

The incidence of clinically diagnosed chronic obstructive pulmonary disease in patients with spondyloarthritis compared to matched population-based references: a register-based study

Sofia Exarchou, Ankita Sharma, Petros Zamout, Carl Turesson

Abstract Introduction/Objective To estimate and compare the incidence of chronic obstructive pulmonary disease (COPD) in patients with spondyloarthritis (SpA) to matched population-based references. Methods Patients with ≥ 1 SpA-diagnosis from an outpatient department of rheumatology/internal medicine (≥ 17 years at diagnosis) between January 1, 2000, and June 30, 2005, were identified in a regional healthcare register. From the same register, five controls without SpA-diagnosis were matched to each SpA-case on age …