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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Public Health

Superior-head automated external defibrillator placement during single-rescuer cardiopulmonary resuscitation: a randomized crossover simulation study and retrospective multicenter cohort

Daojian Xu, Jingchen Zhang, Honghang Lin, Qiqi Cai, Sheng Zhang, Jueyue Yan

Background During single-rescuer cardiopulmonary resuscitation (CPR), one rescuer must sustain chest compressions while operating an automated external defibrillator (AED), yet the optimal physical position of the AED within the rescuer’s working area is uncertain. The study evaluated whether superior-head AED placement improves the single-rescuer defibrillation workflow. Methods The study combined a randomized four-sequence crossover manikin simulation (32 healthcare providers; 128 evaluable trials) comparing four …

03.09.2026journal-article

Frontiers in Public Health

The role of universities in enhancing interprofessional collaboration during COVID-19 in Lebanon: academia as neutral convener in a public-private twinning initiative—a qualitative case study

Kawthar Jaber Fadlallah, Michèle Kosremelli Asmar, Joumana Stephan Yeretzian

Background The Coronavirus Disease 2019 (COVID-19) pandemic underscored the importance of interprofessional collaboration, including partnerships between academic institutions and healthcare organizations. Such collaborations, however, are challenging to initiate and sustain during public health emergencies. This study examines the role and perceived effectiveness of academic involvement within a public–private twinning initiative designed to strengthen COVID-19 response capacities in Lebanon. Methods Using a quali …

03.09.2026journal-article

Nutrients

Unmetabolized Folic Acid: Biology, Epidemiology, and Clinical Consequences: A Systematic Review

Richard E. Frye, Daniel A. Rossignol

Background: Mandatory folic acid (FA) fortification prevents neural tube defects but generates unmetabolized folic acid (UMFA) in blood, because hepatic dihydrofolate reductase (DHFR) reduces FA only slowly. Whether UMFA itself, as distinct from high total folate, carries biological consequences is unresolved. Methods: We systematically searched six databases (January 1995–May 2026; PROSPERO CRD420261407616) and included 65 publications describing 61 unique primary studies, yielding 71 analytic contributions (15 me …

03.09.2026journal-article

Journal of Palliative Medicine

Palliative Surgery to Restore Function and Dignity: A Case of Massive Breast Tumor Debulking in Rural Uganda

Simran Kripalani, Howard Eison, Goretti Nassali, Prossy Nafula, Benjamin Schwarz, Randi Diamond

Background: Palliative surgery plays a critical role in alleviating symptom burden and thus improving quality of life in patients with advanced disease. Case Presentation: This is a case of a 23-year-old female in rural Uganda with an untreated, massive right breast mass present since infancy and progressive abdominal distention of unclear etiology. Over time, the breast mass impaired her mobility, rendering her largely homebound and dependent on others for basic movement. Despite evidence of profound malnutrition, …

03.09.2026journal-article

Frontiers in Endocrinology

Longitudinal clinical trajectories and vascular–inflammatory–neurophysiological associations in diabetic peripheral neuropathy: an exploratory analysis of a TENS-treated cohort

Qian Gao, Liwan Yang, Bin Wang, Lijuan Gao, Qing Yao, Jiangwei Hu

Background Transcutaneous electrical nerve stimulation (TENS) is used as an adjunctive treatment for diabetic peripheral neuropathy (DPN), but long-term clinical trajectories vary among patients. The biological characteristics associated with these different trajectories remain incompletely characterized. This study aimed to identify longitudinal clinical trajectory patterns and examine their associations with vascular, inflammatory, and neurophysiological measures. Methods Prospective 24-month data from 685 patien …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Connective tissue disorders and cardiac arrhythmias: genetic pathways, mechanistic bridges, and clinical implications

Luke Dreher, Hussein Abdul Nabi, Ramzi Ibrahim, Mahmoud Abdelnabi, Omar Baqal, Christopher N. Kanaan, Min Choon Tan, Linnea M. Baudhuin, Fadi E. Shamoun, Hicham Z. El Masry

Background Connective tissue disorders (CTDs) such as Marfan syndrome, Loeys-Dietz syndrome, and Ehlers-Danlos syndromes are traditionally defined by vascular fragility and aortic complications. Increasing evidence, however, demonstrates that CTDs also predispose to atrial and ventricular arrhythmias, often independent of overt cardiomyopathy or severe valvular disease. Content This review integrates emerging data on the arrhythmogenic substrates of CTDs. Four mechanistic bridges are emphasized: (1) diffuse myocard …

03.09.2026journal-article

Frontiers in Pharmacology

The clinical trial landscape of bispecific antibodies in non-small cell lung cancer: mechanistic trends and developmental strategies

Zunyuan Li, Xiyu Wang, Qin Shi, Yuhong Guo, Guirong Dong, Zhidan Liu

Background Non-small cell lung cancer (NSCLC) management remains constrained by acquired resistance to targeted therapies and refractoriness to immune checkpoint inhibitors (ICIs), the latter driven largely by the immunosuppressive tumor microenvironment (TME). Bispecific antibodies (bsAbs) represent a promising modality capable of circumventing these therapeutic hurdles through proximity-driven dual-targeting mechanisms that co-block bypass signaling pathways and reverse immunosuppression. This study systematicall …

03.09.2026journal-article

Ege Tıp Dergisi

Changes in public interest in plastic surgery over time: A comprehensive global perspective using google trends. No job, Yes Aesthetics?

Ecem Esma Yeğin, Mehmet Emre Yeğin

Aim: Google Trends has become an essential resource in health research, providing valuable insights into evolving public interest patterns. Social media platforms significantly influence public interest in cosmetic surgery, with effects observed across age groups. Research shows a clear connection between social media exposure and heightened public interest, serving as a means for surgeons to educate patients and market their services.Material and Methods: This study uses Google Trends data to analyze changes in in …

03.09.2026journal-article

Frontiers in Public Health

Community music activity participation and loneliness among Chinese young adults living alone

Yundi Pian, Yafei Yu

Background Loneliness has become an increasingly salient psychological and social issue among young adults in contemporary urban China. Young adults living alone may be particularly vulnerable because of reduced daily companionship, limited opportunities for sustained social interaction, and relatively weak emotional support networks. As an accessible form of cultural and social participation embedded in community settings, community music activity may be relevant to loneliness among young adults living alone. Howe …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Integrating conformal prediction with machine learning for uncertainty-aware risk stratification in coronary artery disease

Shengnan Lin, Xuyang Hu, Yang Zhang, Qi Zhang, Xiaoning Wang, Yang Yang, Fuzheng Song, Yutong Li, Yushan Liu, Yuanpeng Zhao, Dingjian Zhao, Minghua Nan, Changchuan Bai

Background Predictive models are increasingly used in clinical decision-making in coronary artery disease (CAD). However, most existing models focus on discriminative ability while ignoring individual prediction uncertainty, which is particularly prominent in small-sample contexts, limiting clinical applications. Methods We developed an uncertainty-aware model integrating machine learning and conformal prediction (CP) for CAD prediction in a small-sample setting cohort ( N = 297). Logistic regression (LR) and rando …

03.09.2026journal-article

Frontiers in Dental Medicine

Case Report: Dental treatment under general anesthesia for a child with Ullrich congenital muscular dystrophy

SokIok Cheang, WeiYun Chen, Shuang Wang, XinXin Wang, Kuo Wan, Lin Ma

Background Ullrich congenital muscular dystrophy (UCMD) is a rare inherited myopathy caused by mutations in the COL6 gene and is frequently associated with multisystem complications affecting the respiratory and skeletal systems, which may increase airway and anesthetic risks during dental treatment. Case report This report describes a 4-year-old girl with UCMD who presented with pain in the left lower molar. After a comprehensive multidisciplinary evaluation by the Department of Stomatology, Anesthesiology, and Pe …

03.09.2026journal-article

Frontiers in Public Health

High-magnification inpatient cases under DIP payment reform: prevalence, cost burden, and risk factors in an NHC-administered hospital in China

Jianjun Lu, Zhuochen Lin, Ziyi Xin, Junfeng Liu, Yuting Gu, Ying Xiong, Wujun Zhang

Background The nationwide rollout of Diagnosis-Intervention Packet (DIP) payment reform in China aims to enhance inpatient cost efficiency, yet high-magnification cases impose escalating financial burdens on tertiary hospitals. This study characterized the cost profiles and independent determinants of high-magnification cases under DIP to inform precision cost governance and medical insurance policy optimization. Methods This retrospective observational study included 191,490 consecutive inpatient admissions from a …

03.09.2026journal-article

Frontiers in Clinical Diabetes and Healthcare

Moisturizer formulations for diabetic foot xerosis: a systematic review and meta-analysis of randomized controlled trials

Karin Borgström, Sebastian Björklund, Petri Gudmundsson, Anna Ericsson, Stefan Acosta

Background Foot xerosis in people with diabetes increases the risk of skin fissuring, ulceration and complications like amputation, sepsis and death. Preventive skin care is therefore important, yet evidence-based guidance on the most effective formulations remains limited. This systematic review aimed to identify effective ingredients and formulations to treat diabetic foot xerosis. Methods A literature search was conducted in Medline, Cinahl, Embase, CENTRAL and Scopus. Randomized controlled trials (RCTs) involvi …

03.09.2026journal-article

International Journal of Gynecology & Obstetrics

Maternal and neonatal outcomes associated with expanded antibiotic therapy in preterm prelabor rupture of membranes

Juan Manuel Burgos‐Luna, Laura Soto Giraldo, Maria Alejandra Suarez‐Revelo, Juan Sebastián Galindo‐Sánchez, Isabella Mejia Rodriguez, Mariana Cordoba Munoz, Albaro Jose Nieto‐Calvache

Abstract Objective To compare maternal and neonatal outcomes in women with preterm prelabor rupture of membranes (PPROM) managed expectantly with either ampicillin–erythromycin or an institutional alternative regimen combining ampicillin, ceftriaxone, and clarithromycin. Methods This was a retrospective historical cohort study at a tertiary referral center in Cali, Colombia, including women with singleton pregnancies and confirmed PPROM between 24 +0 and 34 +6 weeks (January 2019–December 2024). Ampicillin–erythrom …

03.09.2026journal-article

Journal of Cybersecurity and Privacy

QKD-Assisted Secure Transport Framework for Federated Healthcare Systems: A Software Prototype and Baseline Evaluation

Fardin Muttaki, Aqeel Sahi, Shahab Abdulla

Decentralised machine learning requires authenticated transport to secure exchanged model updates. To this end, this study presents a healthcare-focused proof of concept integrating a quantum key distribution (QKD) simulation with HKDF-SHA-256, AES-256-GCM, role-based access control, replay detection, and sample-weighted federated averaging (FedAvg), and evaluates it on 42,989 medical records across 1107 synthetic patients. A trusted server decrypted authorised updates before plaintext aggregation. Centralised logi …

03.09.2026journal-article

Geriatrics

A Patient- and Function-Centric Model/Approach for Hypoglycemia Management in Older Adults

Kannayiram Alagiakrishnan, Laurie Mereu, Gulelala Rahim, Mahua Ghosh, Albert Vu

Diabetes-related hypoglycemia contributes substantially to increased morbidity, mortality, health-care utilization, and reduced quality of life. Older adults with diabetes represent a heterogeneous group of patients who need individualized blood glucose targets to avoid hypoglycemia. Since the elderly present with varying degrees of functional and cognitive status and individualized health needs, their management varies among individuals. Complicating this, the hypoglycemia risk in older adults treated with insulin …

03.09.2026journal-article

Journal of Clinical Medicine

Sex Disparities in Outcomes After Minimally Invasive Direct CABG for Single-Vessel Disease: A Propensity Score-Matched Analysis

Lukman Amanov, Arian Arjomandi Rad, Sadeq Ali-Hasan-Al-Saegh, Jawad Salman, Fabio Ius, Abdullah Tahir, Thanos Athanasiou, Saeed Torabi, Stefan Rümke, Bastian Schmack, Arjang Ruhparwar, Alina Zubarevich, Alexander Weymann

Background: Female sex is widely regarded as an independent risk factor for adverse outcomes after conventional coronary artery bypass grafting (CABG) and is incorporated as a risk variable in EuroSCORE II. Whether this disadvantage persists in the setting of minimally invasive direct coronary artery bypass (MIDCAB), in which sternotomy and cardiopulmonary bypass are avoided, remains insufficiently characterised. We assessed sex-specific short- and long-term outcomes after MIDCAB in a single-centre cohort with exte …

03.09.2026journal-article

British Journal of Nursing

Colostomy formation for neurogenic bowel dysfunction after spinal cord injury: a national survey

Michelle Boucher

Background: Neurogenic bowel dysfunction significantly affects those living with spinal cord injury (SCI). Guidelines position colostomy as a last resort, but this is not reflected in current practice. Pathways and professional attitudes are inconsistent. Aim: Explore the attitudes of health professionals towards colostomy as an option for people living with SCI. Methods: Online questionnaire for health professionals; descriptive statistics and thematic analysis. Results: 122 responses. Indications for colostomy: i …

03.09.2026journal-article

El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam

The Effect of Service Quality, Trust, Hospital Image and Facilities on Patient Satisfaction in Outpatient Pharmacy Services

Jaka Arifin Budiyana, Istiatin Istiatin, Oong Ridhoi

This research aims to test and analyze the influence of service quality, trust, hospital image and facilities on patient satisfaction in outpatient pharmacy services at Dr. RM. Soedjarwadi Mental Hospital. The research method used is quantitative. The number of samples used was 100 respondents with instrument testing in the form of validity and reliability tests. Furthermore, the research data was analyzed using Multiple Linear Regression, F-Test, t-test, and Coefficient of Determination. The results of the study i …

03.09.2026journal-article

Humanities and Social Sciences Communications

Psychosocial predictors and justification patterns of traditional and alternative medicine in Peru

Angelo Fasce, Jose Rosales-Trabuco, Javier Rodriguez-Ferreiro, Itxaso Barberia, Elvis Pinedo-Yzaguirre, Juan Manuel Espinoza Nunez, Wilson Marcos Ortiz-Treviños, Christian David Pizarro-Moncada, Mario Reyes-Bossio, Carlos Carbajal-León, Ezequiel Lopez-Lopez

Abstract This mixed-methods study investigates the prevalence, attitudes, psychological predictors, and reasons for perceived effectiveness of traditional and alternative medicine in Peru. A representative national sample ( N = 805) reported their experiences with 16 unconventional medical techniques, alongside psychometric measures of pseudoscientific beliefs, ideological traditionalism, and trust in the medical profession. Traditional medicine was more widely used, while alternative medicine elicited more favorab …

03.09.2026journal-article

BMC Public Health

Awareness level of cancer risk factors and warning signs among adults in Mansoura District, Egypt

Ahmed M. Eid, Abeer M. Kamal, Asmaa Elsayed, Rahma M. Almetwaly, Basma Kamel, Naira A. Shoman, Aya M. Abdelmohsin, Sara H. Elhendawy, Yasmeen A. State, C. A. collaboration team, Abdallah Gamal, Menna S. Sellow, Nourhan R. Elbatal, Mohamed A. Abdelaziz, Ahmad M. Gewili, Mariam B. Elbialy, Nouran K. Mashaly, Rania S. Omar, Abdelrahman M. Darweesh, Abdelsmad Elhalwaty, Hager S. Elhebeshy, Moustafa Y. Nassar, Hanin Fadl, Ahmed H. Maarouf, Omar M. Eid, Sama Mahmoud Abo Younis, Ashraf Alaziz, Mokhtar M. Elkerdawey, Ahmed Mohamed Zayed, Abdel-Hady El-Gilany

Abstract Background Cancer remains a leading cause of mortality worldwide, with prevention and early detection dependent on the public awareness of its risk factors and warning signs. However, knowledge of cancer-related symptoms and modifiable risk factors remains limited in many populations, particularly in low- and middle-income countries. Limited research exists examining general cancer awareness in Egypt's general population. Objective To assess public knowledge of cancer's early warning signs, risk factors, a …

03.09.2026journal-article

Frontiers in Medicine

Development and validation of an automatic machine learning-based myocardial contusion prediction model in rib fracture patients: a retrospective multicenter cohort study

Yan Yang, Ping Liu, Ni Jia, Yisha Xu, Peng Wu, Zhigang Zhang, Tingyong Han, Yan Jiang, Xianpeng Huang, Long Li

Objective This study aims to construct an automatic machine learning-based prediction model to accurately identify the risk of myocardial contusion in traumatic rib fracture patients, addressing the core limitations of insufficient sensitivity in traditional diagnostic methods and difficulties in clinical translation of existing prediction models. Methods A multicenter retrospective study design was adopted, including 1,038 rib fracture patients from 8 hospitals (training set: 808 cases; testing set: 230 cases) fro …

03.09.2026journal-article

Frontiers in Public Health

Declining trends but persistent disparities in cervical cancer mortality in the United States, 1999–2023

Jie Liu, Yonglin Liu, Yanjiao Jiang, Xuefeng Wang, Xianwei Zhou

Background Cervical cancer is largely preventable through effective screening and human papillomavirus (HPV) vaccination; however, mortality disparities remain a persistent public health challenge in the United States. This study aimed to examine long-term trends and socio-demographic and geographic inequalities in cervical cancer mortality. Methods We conducted a population-based study of cervical cancer mortality among U.S. women aged ≥25 years from 1999 to 2023 using national mortality data from the CDC WONDER d …

03.09.2026journal-article

Frontiers in Nutrition

The effects of maternal dietary fiber and short-chain fatty acids on the health of offspring: a mini review

Shaozhi Liu, Senling Feng, Zhongwen Yuan, Zhengrong Mei, Jinjin Yin, Lei Chen, Yongxia Zhang

Maternal nutrition during pregnancy is a critical determinant of offspring long-term health. Dietary fiber has emerged as a key modifiable factor. Through gut microbial fermentation, fiber is converted into short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate. This mini review synthesizes current evidence from molecular, animal, and human studies on the role of maternal SCFAs in programming offspring metabolic and immune health. Mechanistically, SCFAs act via two complementary pathways: acti …