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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

BMC Cancer

Towards a universal ovarian cancer biomarker model: clinical validation of Trx1 and CA125 dual strategy

Mi A Park, Songhak Kim, Xiaoguang Yang, Jong Am Song, Geon Woo Lee, Heon Jong Yoo, Soyoung Kim, Kyoung Hoon Suh, Young Bok Ko

Abstract Background Ovarian cancer is the fifth leading cause of cancer-related mortality in women, with early detection being critical for improving patient outcomes. Current diagnostic biomarkers, including Cancer antigen 125 (CA125), human epididymis protein 4 (HE4), and their combined Risk of Ovarian Malignancy Algorithm (ROMA), exhibit limited sensitivity and specificity, particularly in early-stage disease and premenopausal women. Thioredoxin-1 (Trx1) has emerged as a potential complementary biomarker. This e …

03.09.2026journal-article

Bioengineering

Patient-Reported Knee Function Versus Star Excursion Balance Performance as Correlates of Psychological Return-to-Sport Readiness After Anterior Cruciate Ligament Reconstruction

Ryan T. Halvorson, Aidan Foley, Hayden Sampson, Cameron Nosrat, Drew A. Lansdown, Brian T. Feeley, Jeannie F. Bailey

Background: Psychological readiness, quantified by the Anterior Cruciate Ligament Return to Sport after Injury (ACL-RSI) scale, is one of the most consistent correlates of return-to-sport success following ACL reconstruction. Whether psychological readiness reflects an independent construct or is related to measured functional performance is not known. Purpose: To evaluate the associations between patient-perceived knee function and objective performance on a functional task, as quantified by traditional scoring, k …

03.09.2026journal-article

Frontiers in Pediatrics

Transcatheter embolization as a rescue therapy for refractory pelvic kaposiform hemangioendothelioma with Kasabachi–Merritt phenomenon: a case report

Yi Xiong, Qi Di, Sanlin Li, Jiajie Cao, Chenghao Chen, Gang Shen

Kasabach–Merritt phenomenon (KMP) is a life-threatening consumptive coagulopathy in children with kaposiform hemangioendothelioma (KHE) or tufted angioma. Until now, there has been no well-accepted treatment regimen in the literature. A pelvic KHE is very rare and its deep anatomical location and invasive growth pattern toward adjacent vital organs pose significant management challenges. Here, we report a 10-month-old girl presenting with KMP secondary to a pelvic KHE. Initial systemic therapy with sirolimus and co …

03.09.2026journal-article

Current Opinion in Otolaryngology & Head & Neck Surgery

A translational framework for early-phase inner-ear gene therapy: clinical trial design, regulatory strategy, and ethical considerations

Emma C. Dunn, Spencer H. Short, Ravi N. Samy

Purpose of review Hereditary hearing loss has historically been approached as a diagnostic category rather than a therapeutically modifiable disease. Recent advances in molecular genetics, cochlear gene delivery, and first-in-human clinical trials are changing that. This review summarizes contemporary progress in the genetics of hearing loss, with emphasis on emerging gene-based therapies, clinical trial design, regulatory and ethical considerations, and practical implications for otolaryngologists as biologic trea …

03.09.2026journal-article

Frontiers in Public Health

Psychosocial determinants of exercise behavior in Parkinson’s disease: a mini-review

Guanyu Zhang

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by progressive motor and non-motor symptoms that profoundly impact quality of life. Physical exercise has emerged as a promising non-pharmacological intervention with neuroprotective potential, yet adherence rates remain suboptimal. This mini-review synthesizes current evidence on psychosocial determinants influencing exercise behavior in PD patients. Accumulating evidence suggests that psychosocial factors play an importan …

03.09.2026journal-article

Frontiers in Medicine

Water awareness and bioethical perspectives among medical students at Mersin University Faculty of Medicine: an analytical cross-sectional study comparing academic-stage groups

Selda Okuyaz, Oya Ögenler

Background The escalating environmental crisis underscores water as a vital bioethical responsibility and public health determinant. Accordingly, water consumption, sustainability, and related ethical responsibilities are relevant topics in medical education. Objective This study aimed to compare water-consumption behaviours, awareness, knowledge, and attitudes toward water use and water-related ethics between Year 3 and Year 6 medical students. Methods This analytical cross-sectional study was conducted at Mersin …

03.09.2026journal-article

Frontiers in Dental Medicine

A novel image-based algorithm to support future remote assessment of chewing function

Dawn Branley-Bell, Richard Brown, Elias Obreque-Sepúlveda, Claire McGrogan, Helen Cartner, Elhassan Mohamed, Chee Siang Ang, Robert Pellegrino

Background Chewing difficulty is associated with poorer physical and mental health. Objective measurement of chewing function is currently limited to methods that require specialist lab equipment (for example lab-based manipulation or comminution tests). A remote method for estimating chewing-related metrics would support the development of accessible and scalable means of detecting and monitoring chewing-related health issues. Method This paper details initial work on developing a novel smartphone-based, image-ana …

03.09.2026journal-article

Frontiers in Neuroscience

Multimodal neuroimaging fusion in presurgical evaluation of drug-resistant epilepsy: current evidence, clinical integration, and future directions

Yuying Zhao, Mingli Wang, Bo Shen, Wei Luo

Approximately 30% of patients with epilepsy are drug-resistant, and for many of them surgical resection of the epileptogenic zone (EZ) offers the best chance of seizure freedom. Because the EZ cannot be measured directly by any single test, it must be inferred from the convergence of complementary imaging markers, and multimodal neuroimaging fusion has therefore become central to modern presurgical evaluation. This critical narrative review examines what each modality—structural MRI, [18F]FDG-PET, ictal SPECT/SISCO …

03.09.2026journal-article

Frontiers in Public Health

Latent class analysis of sleep-related worry and its influencing factors among shift work nurses: a cross-sectional study

Shuangli Zhang, Zhilin Cheng, Jianhong Qiao

Objective To identify the distinct profiles of sleep-related worry among shift-work nurses and explore their influencing factors, thereby providing a basis for developing targeted interventions for nursing management. Methods A convenience sampling method was used to select 653 shift nurses from three tertiary grade A hospitals in Shandong Province from March to July 2025 as the study participants. Data were collected using a general information questionnaire, the Anxiety and Preoccupation about Sleep Questionnaire …

03.09.2026journal-article

Frontiers in Endocrinology

Artificial intelligence in obesity management: clinical evidence, translational gaps, and implementation priorities—a structured narrative review

Wenneng Liu, Jian Zhao, Dan Zhang, Chun Dang, Yaoheng Lu, Xiao Du

Obesity is a chronic, relapsing disease that requires long-term lifestyle treatment, pharmacotherapy, and metabolic and bariatric surgery. Artificial intelligence (AI) is increasingly being studied across these pathways, but its clinical readiness varies substantially. This Scale for the Assessment of Narrative Review Articles (SANRA)-informed structured narrative review searched PubMed/MEDLINE, Embase, Scopus, ScienceDirect, and Google Scholar through 1 June 2026, primarily for literature published since 2015, wit …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Diagnostic accuracy of recombinase polymerase amplification-based assays for mosquito-borne virus detection in clinical samples: a systematic review and meta-analysis

Yonghui Gao, Jihong Chen

Background Mosquito-borne viral diseases pose an important public health threat due to their frequent outbreaks, similar early clinical manifestations, and potential for rapid transmission. Conventional diagnostic methods, such as virus isolation, serological assays and RT-qPCR, are reliable but may be limited by long turnaround time, cross-reactivity, laboratory equipment requirements and trained operators. Recombinase polymerase amplification (RPA)-based methods have emerged as promising tools for rapid detection …

03.09.2026journal-article

Frontiers in Dental Medicine

Making periodontal risk visible: the role of artificial intelligence in recall adherence

Prajakta Karkare

Supportive periodontal care is essential for maintaining periodontal stability after active therapy, yet adherence to periodontal maintenance remains difficult. Once bleeding, halitosis or other presenting concerns improve, some patients may interpret the disease as resolved and the maintenance visit as “just a clean.” This Perspective uses the intention–behaviour gap to examine behavioural, financial and health-literacy barriers to continued supportive care. It then considers a narrower, testable hypothesis: artif …

03.09.2026journal-article

Frontiers in Public Health

The role of universities in enhancing interprofessional collaboration during COVID-19 in Lebanon: academia as neutral convener in a public-private twinning initiative—a qualitative case study

Kawthar Jaber Fadlallah, Michèle Kosremelli Asmar, Joumana Stephan Yeretzian

Background The Coronavirus Disease 2019 (COVID-19) pandemic underscored the importance of interprofessional collaboration, including partnerships between academic institutions and healthcare organizations. Such collaborations, however, are challenging to initiate and sustain during public health emergencies. This study examines the role and perceived effectiveness of academic involvement within a public–private twinning initiative designed to strengthen COVID-19 response capacities in Lebanon. Methods Using a quali …

03.09.2026journal-article

Frontiers in Public Health

Early interventions in mental health services: a rapid review of systematic review

Rosina Anna Adu, Medard Kofi Adu, Belinda Agyapong, Vincent I. O. Agyapong

Background Mental health disorders account for a substantial global burden of disease, with many individuals experiencing significant delays in receiving appropriate care. Early intervention has emerged as a key strategy to improve clinical, functional, and economic outcomes across the mental health continuum. Although evidence surrounding early intervention is well established, a broader synthesis of early intervention models across diagnoses, age groups, and service settings has been lacking. Objectives This Rapi …

03.09.2026journal-article

Frontiers in Nutrition

Patients’ and healthcare professionals’ experiences of malnutrition risk management in heart failure: a qualitative study

Mengdie Liu, Zhiteng Xiong, Yanjuan Xu, Qihui Shen, Xinglan Sun, Si Liu, Xi Chen, Xiaoyun Xiong

Background Malnutrition risk is common among patients with heart failure (HF) and is associated with disease progression and adverse clinical outcomes. However, patients and healthcare professionals (HCPs) differ in their understanding of and responses to nutritional issues in HF, and early identification and ongoing management remain insufficient in clinical practice. Objective To explore the current perceptions and needs of patients with HF and HCPs regarding malnutrition risk management, thereby supporting the i …

03.09.2026journal-article

Frontiers in Medicine

PD-1/PD-L1 inhibitors combined with chemotherapy as first-line treatment for advanced biliary tract cancer: a systematic review and meta-analysis

Hongye Geng, Chengyuan Lu, Shuling Wang, Lijuan Tian

Objective To systematically evaluate the efficacy and safety of PD-1/PD-L1 inhibitors plus chemotherapy as first-line treatment for advanced biliary tract cancer (BTC). Methods PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases were searched for RCTs and retrospective studies. Meta-analysis was performed using R 4.6.1 software with the meta (v8.5–0) and metafor (v5.0–1) packages. The full R code and datasets are provided in the supplementary material to ensure reproducibility. Result …

03.09.2026journal-article

Frontiers in Oncology

Comparison of patient-reported outcomes and healthcare utilization between metastatic colorectal cancer patients receiving systemic therapy with or without concurrent palliative care support: a retrospective cohort study

Xiaoli Liu, Fangtuan Wu, Lunlan Li

Background Patients with metastatic colorectal cancer (mCRC) experience substantial symptom burden, yet evidence on the integration of specialist palliative care (PC) in real-world settings remains limited. We assessed the impact of concurrent PC on patient-reported outcomes and healthcare utilization. Objective To evaluate the impact of integrating professional palliative care (PC) with standard systemic therapy on patient-reported outcomes, medical resource utilization, and overall survival (OS) in metastatic col …

03.09.2026journal-article

Frontiers in Public Health

Superior-head automated external defibrillator placement during single-rescuer cardiopulmonary resuscitation: a randomized crossover simulation study and retrospective multicenter cohort

Daojian Xu, Jingchen Zhang, Honghang Lin, Qiqi Cai, Sheng Zhang, Jueyue Yan

Background During single-rescuer cardiopulmonary resuscitation (CPR), one rescuer must sustain chest compressions while operating an automated external defibrillator (AED), yet the optimal physical position of the AED within the rescuer’s working area is uncertain. The study evaluated whether superior-head AED placement improves the single-rescuer defibrillation workflow. Methods The study combined a randomized four-sequence crossover manikin simulation (32 healthcare providers; 128 evaluable trials) comparing four …

03.09.2026journal-article

Frontiers in Immunology

Traditional Chinese medicine remodels the immune microenvironment of colorectal cancer: mechanisms and therapeutic perspectives

Zeanbang Shi, Jie Mei, Qinchang Zhang, Liu Li, Haibo Cheng

Colorectal cancer (CRC) is a common malignancy of the digestive tract, and its initiation and progression are closely associated with dysregulation of the tumor immune microenvironment. The CRC immune microenvironment consists of effector immune cells, immunosuppressive cells, inflammatory mediators, immune checkpoint pathways, stromal cells, the extracellular matrix, the gut microbiota, and microbial metabolites. Its pathological features include impaired immune recognition and effector immunity, enhanced immunosu …

03.09.2026journal-article

International Journal of Legal Medicine

A technical note on the preparation and staining of unfixed, undecalcified and unembedded fresh and taphonomically altered human bone with five common stains and dyes

Simona A. Dinu, Iris Sluis, Wilma Duijst, Tristan Krap

Abstract Anthropological and forensic investigations often rely on skeletonized human remains as the only piece of evidence for lifestyle, age and post-mortem interval predictions. Recent studies have demonstrated that histological staining has the potential to extend or improve the knowledge that can be extracted from the microstructure of bone. However, histological staining has only been scarcely applied and investigated on (taphonomically altered) human bones, leading to a lack of available methodology. In this …

03.09.2026journal-article

Frontiers in Immunology

Complete and durable remission in a patient with brain metastasis from gastric cancer treated with SRS followed by RC48 plus camrelizumab after progression on chemo-immunotherapy: a case report and literature review

Xiao Liu, Baozhen Ma, Mengjiao Yang, Lingdi Zhao

Background Brain metastasis from gastric cancer carries a dismal prognosis, with median overall survival of only 3–6 months. Patients who progress on immune checkpoint inhibitor (ICI)-containing regimens have limited salvage options. HER2-low expression (IHC 1+ or IHC 2+/FISH-negative), historically excluded from anti-HER2 therapy, has now emerged as a novel therapeutic target for antibody-drug conjugates (ADCs) such as RC48 (disitamab vedotin). Case summary A 52-year-old male with HER2-low (IHC 2+/FISH-negative), …

03.09.2026journal-article

F1000Research

Artificial Intelligence-Assisted Community Eye Screening in Primary Healthcare: A Prospective Multicentre Diagnostic Accuracy and Implementation Study

Debapriya Mukhopadhyay, Ankit Varshney, Rajib Mandal, Shoubhik Chakraborty, SK Jahir, Anik Dingal, Apurbayan Biswas, Vishakh Nair, Hlabje Carel Masemola, Swati Mukhopadhyay, Shreyasi Mukherjee, Harinath Mukherjee

Background Artificial intelligence (AI)-assisted retinal screening may extend access to eye care in primary healthcare, but prospective evidence on diagnostic performance and implementation under routine community conditions remains limited. Methods We conducted a prospective multicentre diagnostic accuracy and implementation study across 12 urban and rural community eye-screening centres in India from 1 January to 30 June 2025. Adults aged ≥18 years underwent AI-assisted retinal-image analysis followed by masked c …

03.09.2026journal-article

Journal of Community Health Provision

Association of Lipid Profile, Glycated Hemoglobin (HbA1c), and Hypertension History with Coronary Artery Disease among Adult Patients: A Cross-Sectional Study

Witi Karwiti, Nasrazuhdy Nasrazuhdy, Wuni Sri Lestari, Nurhayati Nurhayati, Yusneli Yusneli, Asrori Asrori

Coronary artery disease (CAD) remains a major cause of cardiovascular morbidity and mortality worldwide. This study aimed to examine the association of lipid profile, glycated hemoglobin (HbA1c), and hypertension history with CAD among adult patients. A cross-sectional analytical study was conducted among 40 adult patients undergoing cardiovascular evaluation at Abdul Manap Regional General Hospital, Jambi, Indonesia, including 20 patients with CAD and 20 participants without CAD. Demographic characteristics, lipid …