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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

THE SINGULAR THERAPEUTIC PROJECT AND CARE MANAGEMENT FOR PEOPLE WITH DISABILITIES IN RONDÔNIA: IS THE PATIENT AT THE CENTER OF CARE?

Rodrigo Moreira Campos, Samantha de Freitas Campos

The consolidation of the Care Network for People with Disabilities within the Brazilian Unified Health System has been accompanied by the expansion of approaches grounded in the biopsychosocial model and person-centered care. In this context, the training of health managers and professionals may contribute to incorporating these principles into everyday service delivery. This article presents an experience report on a multiprofessional training initiative aimed at implementing the Singular Therapeutic Project, prom …

03.09.2026journal-article

Public International and Private International Law

The Role of Ethics in the Implementation of Anti-Corruption Standards for Civil Servants in Russia and China

Yury V. Truntsevsky, Vyacheslav V. Sevalnev, Sergey N. Matulis

Corruption is a structural pathology of public administration that destroys public trust in government institutions. In the context of globalization and digitalization, combating it requires not only institutional reforms, but also a profound restructuring of the ethical grounds of public service. Russia and China, two major countries with different political systems, have chosen fundamentally different paths to integrating ethics into anti-corruption architecture. A comparative analysis of these models allows us t …

03.09.2026journal-article

LABOR LAW IN RUSSIA AND ABROAD

Implementation of ILO Convention No. 187 "Concerning the Promotional Framework for Occupational Safety and Health" (2006) into Russian Legislation: Problems of a Systemic Approach to Occupational Safety Management

Mikhail A. Afanasyev

The article presents a comparative legal analysis of the provisions of ILO Convention No. 187 "Concerning the Promotional Framework for Occupational Safety and Health" (2006) and the norms of Russian legislation regulating occupational safety. The author examines the basic principles and requirements of the Convention and identifies existing problems and gaps in the legal framework that impede the full implementation of international standards. The focus is on the systemic approach to occupational safety management …

03.09.2026journal-article

Health Education

Process evaluation of a school-based sexual health intervention targeting 13–14-year-olds in Finland

Hanna Putkonen, Jari Kylmä, Tiina Rissanen, Marjorita Sormunen

Purpose A systematic approach to conducting process evaluations is essential for understanding the implementation of health interventions and their mechanisms of impact. This study aims to describe the process evaluation of a school-based, social-marketing-principles-utilising sexual health intervention targeting adolescents aged 13–14 in Finland. The content and delivery methods of the intervention, along with adolescents' engagement, learning, and functionality, were evaluated. Design/methodology/approach The Med …

03.09.2026journal-article

Journal of Clinical Pathology

Anaplastic lymphoma kinase immunohistochemical positivity in high-grade pulmonary neuroendocrine carcinoma: an actionable signal or merely a shadow?

Ullas Batra, Sabeena Choudhary, Ritwika Choudhury, Alka Yadav, Mansi Sharma, Abhinav Dewan, Sunil Pasricha, Anurag Mehta, Priyanka Venkataraman

Aims Anaplastic lymphoma kinase (ALK) rearrangements are actionable drivers in non-small cell lung carcinoma (NSCLC), but the biological significance of ALK-immunohistochemistry (IHC) positivity in high-grade pulmonary neuroendocrine carcinoma (NEC) remains unclear. This study evaluated the diagnostic and therapeutic implications of discordant ALK IHC and genomic findings and the role of multimodal molecular testing in resolving them. Methods We retrospectively analysed eight South Asian patients (Indian and Nepali …

03.09.2026journal-article

Clinical Spine Surgery

Assessing Global Upper Extremity Function Before and After Decompressive Surgery in Patients With Degenerative Cervical Myelopathy (DCM)

Angie Zhang Lung, John Hong, Vicky Chan, Maya N. Hatch, Jay J. Han, Yu-Po Lee, Nitin N. Bhatia, Michael Oh

Study Design: A total of 20 patients with degenerative cervical myelopathy (DCM) and a plan for surgical decompression were recruited in this pilot study to assess a new outcome measure. Patients were evaluated preoperatively and 3 months, 6 months, and 1 year postoperatively using a 3-dimensional motion-tracking application (reachable workspace) to calculate an upper extremity (UE) relative surface area (RSA) and standard measurements [modified Japanese Orthopedic Association (mJOA), 12-Item Short Form Health Surv …

03.09.2026journal-article

Journal of Clinical Investigation

Enhancing Gemcitabine Uptake by Promoting Dimerization of the ENT1 Transporter Improves Sarcoma Patient Response Rate

Aditya Ganju, Shyam Rao, Mark A. Dickson, Robert A. Lefkowitz, Chris Thompson, Jin Cheng, Katia Manova, Adriana Haimovitz-Friedman, Gary Schwartz, Zhigang Zhang, Zvi Fuks, William D. Tap, Richard Kolesnick

Transport of nucleoside chemotherapeutic drugs into tumor cells is primarily accomplished through Equilibrative Nucleoside Transporter 1 (ENT1), considered to be constitutively-active, redistributing drugs across lipid bilayers via facilitated diffusion. Here we discover that ENT1 is not constitutively-active but rather requires activation of acid sphingomyelinase (ASMase) by gemcitabine, generating ceramide-rich platforms (CRPs) on external plasma membranes of endothelial and tumor cells into which ENT1 inserts, d …

03.09.2026journal-article

The Family Journal

Elderly Family Members’ Health Status in Pakistan's Plural Healthcare System: A Qualitative Study of Medical Practitioners’ Perspectives

Hafiz Saad Bin Tahir, Sana Rehman, Memona Habib

The health status of elderly family members is shaped by complex biological, psychological, and social factors; however, the role of healthcare practitioner behavior and system-level practices within family-oriented and plural healthcare contexts remains under-explored, particularly in low- and middle-income countries. This study examined how medical practitioners conceptualize determinants of elderly family members’ health outcomes in Pakistan's plural healthcare system. Using a qualitative exploratory design, 22 …

03.09.2026journal-article

Clinical Anatomy

Integrating Professional‐Values‐Oriented Education Into PBL Teaching: Practice Based on Case Discussions in Anatomy Curriculum

Liu He, Yunwen Hu, Chengjun Hu

ABSTRACT This study, conducted among first‐year undergraduates, investigates the feasibility of integrating professional‐values‐oriented education into the discussion‐based human anatomy teaching module via the problem‐based learning (PBL) model. Over a three‐year reform period, PBL cases combining clinical scenarios with professional‐values‐oriented elements were designed and implemented specifically for this human anatomy module; the effectiveness of this approach was subsequently evaluated through a systematic a …

03.09.2026journal-article

Military Medicine

Military Medical Training for Role 1 and Role 2 Combat Casualty Care Skills: A Narrative Review

Jennifer L Patton, Kiffin R Smallegan, Emily R Latimer, Anna R Prendergast, Gary J Jimenez Pena, Angela K Phillips

Abstract Introduction Military medics are often tasked to train other medics. While there is ample content of what to train, there exists a lack of trainer education or emphasis on how to train others effectively. Current military medical training is highly variable, often relying on anecdotal methods, with limited evaluation of training effectiveness. Although the importance of readiness training is well recognized, little attention has been devoted to identifying evidence-based approaches for training military me …

03.09.2026journal-article

Nutrition and Health

Influence of a culturally adapted pre-Ramadan nutrition education intervention on diabetes-related knowledge and self-management practices among Egyptian adults with type 2 diabetes: A single-group pretest–posttest study

Naqaa Alomari, Dalia Tayel, Doaa Tawfik

Background Managing type 2 diabetes becomes more difficult during fasting Ramadan. Alterations in meal timing, food choices, and medication schedules can increase the risk of glycemic complications. Although pre-Ramadan education is strongly recommended, there are still few culturally tailored interventions. Aim This study assessed the impact of a culturally appropriate pre-Ramadan nutritional education program on diabetes-related knowledge and practices for self-management. Methods A one-group, pretest–posttest qu …

03.09.2026journal-article

Pedagogy in Health Promotion

Positive Deviance Shines at the Bright Spots Mini-Lab

Grace Armon, Zobeida Bonilla, Jamie Stang, Katherine R. Hendel, Sara Benning, Lauren Roach, Charlotte Stow

Qualitative research and evaluation methods are critical in public health practice. However, the public health workforce often has little training in such methods. The Bright Spots Qualitative Mini-Lab at the University of Minnesota–Twin Cities School of Public Health was developed to address this qualitative training gap. Since its inception, the Mini-Lab has evolved to offer training sessions on a diverse range of qualitative research topics such as conducting focus groups, leading community-driven studies, and v …

03.09.2026journal-article

Frontiers in Public Health

Visual art experience and psychological distress among university students: parallel indirect effects through presence and search for meaning

Huanqin Lv

Purpose University students often experience academic pressure, interpersonal challenges, and uncertainty about future development, making psychological distress an important concern for health promotion in higher education. Visual art experience may provide opportunities for emotional expression, aesthetic immersion, self-reflection, and meaning-making. However, its association with psychological distress and the possible statistical indirect roles of presence of meaning and search for meaning remain insufficientl …

03.09.2026journal-article

Frontiers in Public Health

Perceived digital health information support and self-rated health among Chinese adults: physical activity mediation and chronic health condition moderation

Xiaochu Yang, Xiang Fu, Zexin Wu, Linying Xiao, Ming Luo

Background Digital health resources provide new opportunities for health information seeking, decision-making, and self-management. Yet residents differ in how they understand, evaluate, and use online health information. This study focuses on perceived digital health information support, namely the perceived usefulness of internet-based information for medical understanding and health-related decision support. Evidence remains limited on how this perceived support relates to self-rated health through physical acti …

03.09.2026journal-article

Frontiers in Immunology

Combination of tofacitinib and tacrolimus therapy in refractory interstitial lung disease associated with anti-synthetase syndrome: a case series of six patients

Qiuyu Fan, Wei Huang, Shaohui Song, Huiqin Yang, Ya Liu, Chao Jia, Yu Xiao, Liang Zou

Objective This study aimed to assess the efficacy and safety of tofacitinib and tacrolimus (TAT) combination therapy for treating refractory interstitial lung disease (ILD) associated with anti-synthetase syndrome (ASyS-ILD). Method Patients with refractory ASyS-ILD who were treated with TAT at Wuhan No. 1 Hospital were included in the study from January 2020 to May 2024. A retrospective analysis of the clinical data from these patients is presented. Result A total of six patients, one male patient and five female …

03.09.2026journal-article

Frontiers in Oncology

Adjuvant therapy in chromophobe renal cell carcinoma: current evidence and unmet needs

Niovi Bejjani, Joseph Kattan

Objectives Chromophobe renal cell carcinoma (chRCC) is a rare subtype of kidney cancer with biological and clinical features that differ significantly from clear cell renal cell carcinoma (ccRCC). While adjuvant treatments have evolved for ccRCC, chRCC has been excluded or understudied in clinical trials, which has led to insufficient histology-specific data to guide postoperative treatment. This research aimed to summarize and critically appraise the current evidence regarding adjuvant therapies for chRCC, highlig …

03.09.2026journal-article

Frontiers in Oncology

Deep learning model using contrast-enhanced CT imaging features and clinical variables to predict surgical risk after hepatic resection for hepatocellular carcinoma

Kimika Kato, Yasuhito Mitsuyama, Hiroji Shinkawa, Takuma Okada, Atsushi Sugimoto, Ryota Tanaka, Sadaaki Nishimura, Jun Tauchi, Masahiko Kinoshita, Genki Watanabe, Kohei Nishio, Takeaki Ishizawa

Background Accurate preoperative risk assessment is crucial for patients undergoing hepatic resection for hepatocellular carcinoma (HCC). Conventional prediction methods are limited by the inability to capture complex relationships among multiple factors, and existing deep learning (DL) approaches focus on individual surgical outcomes. In this study, we developed and evaluated a DL model that integrates preoperative contrast-enhanced computed tomography (CT) imaging features and clinical variables to predict intrao …

03.09.2026journal-article

Frontiers in Medicine

Facial discoid lupus erythematosus complicated by a Candida tropicalis fungal granuloma in a patient with rhupus syndrome: a case report of successful treatment with oral itraconazole

Lingling Dong, Ting Zhang, Tong Hua, Yan Wang, Zhenhua Nie, Qingkang Lyu, Zuotao Zhao

Discoid lupus erythematosus (DLE) is a chronic cutaneous subtype of lupus erythematosus characterized by inflammatory lesions that are highly susceptible to secondary infection, particularly in immunocompromised individuals. Cutaneous fungal granulomas caused by Candida tropicalis and superimposed on pre-existing DLE lesions are exceedingly rare and pose substantial diagnostic challenges. We report the case of a 48-year-old female patient with a 2-year history of rheumatoid arthritis (RA), who presented with facial …

03.09.2026journal-article

Frontiers in Education

Associations between student organization involvement and college student mental health in the United States

Brandy Reeves-Doyle, Olutosin Sanyaolu, Karly Scott-Hillis Geller

Introduction The mental health of college students is a growing concern. Loneliness, belonging, and psychological distress are associated with stress, anxiety, and depression among college students. Student organization involvement is positively associated with student mental health, including lower depression. Therefore, it is worthwhile to explore the relationship between mental health and student organization involvement. This study examines the associations between student organization involvement, loneliness, …

03.09.2026journal-article

Journal of Dance Medicine & Science

Dance as Rehabilitation in Parkinson’s Disease: A Scoping Review of Motor, Non-Motor, and Cognitive Outcomes

Simran Rooprai, Nicholas Ramcharran, Caitlin van den Hoorn, Jenna Smith-Turchyn, Nicole D. Anderson, Joseph FX DeSouza

Introduction: Dance is a multimodal experience, integrating movement and music, with cognitive and psychosocial effects, potentially providing a non-pharmacological care approach for persons with Parkinson’s disease (PwPD). While numerous studies have investigated motor outcomes following dance interventions, less is known about the degree to which cognitive and non-motor outcomes are explored. The objective of this scoping review was to explore the scope and characteristics of dance-based interventions for PD, foc …

03.09.2026journal-article

Frontiers in Immunology

CD19 expression is preserved following CD19-directed monoclonal antibody therapy with tafasitamab

Johannes Duell, Diana Alvarez Arias, Wolfram Klapper, Sarah Reinke, Florian Eisele, Thomas Stauffer Larsen, Max S. Topp, Beth Rumberger, TaeHyung Kim, Andreas Rosenwald, Hilka Rauert-Wunderlich

Introduction The potential risk of eliminating or reducing CD19 expression following CD19-targeted therapies has raised questions about the optimal treatment sequencing strategies for B-cell malignancies. This study assessed CD19 expression and mutational status in samples from patients with relapsed or refractory B-cell malignancies who received tafasitamab, an anti-CD19 monoclonal antibody. Methods Biopsy and peripheral blood samples were collected from a total of 100 patients with relapsed or refractory B-cell m …

03.09.2026journal-article

Journal of Public Health and Preventive Medicine

Research Progress on the Impacts of Social Isolation and Loneliness on the Health of the Elderly

Elisa M. Carter, Ryan D. Simmons, Megan L. Henderson, Julia A. Bennett

Social isolation and loneliness have emerged as critical public health concerns affecting older adults worldwide. Despite being distinct concepts—social isolation referring to the objective lack of social connections and loneliness representing the subjective distress of feeling alone—both conditions are associated with profound adverse effects on physical and mental health. This narrative review synthesizes current research on the conceptual definitions, measurement tools, health impacts, intervention strategies, …

03.09.2026journal-article

Journal of Clinical Medicine

Long-Term Effects of Right Ventricular Pressure and Volume Overload: A Comparative Analysis in an Ovine Model

Hamida Al Hussein, Hussam Al Hussein, Simina-Elena Ghiragosian-Rusu, Simona Gurzu, Rita Szodorai, Carmen Sircuta, Marius Stefan Marusteri, Bogdan Cordos, David Emanuel Anitei, Andrei Atudorei, Sergiu Crisan, Dan Simionescu, Klara Brinzaniuc

Background/Objectives: Pressure overload (PO) and volume overload (VO) represent important mechanisms underlying right ventricular (RV) failure; however, long-term comparative data regarding their distinct pathophysiological consequences remain limited. This study aimed to compare the long-term effects of PO versus VO in a large animal model. Methods: Juvenile sheep were randomly assigned to either a PO group (n = 7) or a VO group (n = 8). PO was induced by pulmonary artery banding, whereas VO was induced by pulmon …

03.09.2026journal-article

Annals of Human Resource Management Research

Healthcare Human Resource Development: Organizational Support and Work Engagement among Clinical Clerkship Students

Gunawan Eko Nurtjahjono, Hefry Johan Ferdhianzah

Purpose: This study examined work engagement among clinical clerkship students from a healthcare human resource development perspective. Specifically, it analyzes how perceived organizational support and the clinical learning environment influence work engagement during pediatric clinical education and evaluates whether the clinical learning environment functions as a moderating condition in this relationship. Methodology: A quantitative cross-sectional survey involving 251 clinical clerkship students at Rumah Saki …