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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

The Indonesian Biomedical Journal

Computational Predicted Mechanism of Tiliroside Compound Against Triple-Negative Breast Cancer Using Network Pharmacology and Induced-Fit Docking Approach

Tegar Achsendo Yuniarta, Dwi Syah Fitra Ramadhan, Zulfikar Ali Hasan, Mansur Mansur

BACKGROUND: Triple-negative breast cancer (TNBC) progression is driven by dysregulation of multiple interconnected signaling pathways rather than a single molecular abnormality, but current treatment strategies TNBC primarily rely on single-target therapy, highlighting the need for therapeutic candidates that may target multiple signaling pathway of TBNC. Tiliroside, a naturally occurring flavonoid glycoside, has demonstrated promising anticancer activity; however, its predicted effects on TNBC-associated oncogenic …

31.08.2026journal-article

Oncogenesis

NKCC1 as a regulator of stemness and redox balance in colorectal cancer

Pierre Adam, Catherine Salée, Pauline Bomboire, Marty Stepniak, Arnaud Lavergne, Charlotte Massot, Carla Coimbra Marques, Emmanuel Decker, Benjamin Koopmansch, Frederic Lambert, Philippe Delvenne, Edouard Louis, Marie-Alice Meuwis

Abstract Na⁺-K⁺-2Cl − cotransporter 1 (encoded by SLC12A2 ) is a solute carrier overexpressed in colorectal cancer (CRC), but its functional role remains unclear. Here, we identify NKCC1 as a marker of normal intestinal stem cells, supported by its crypt-base localization, single-cell transcriptomics, and patient-derived organoids, while analyses of public colorectal cancer single-cell datasets further link NKCC1 expression to cancer stem cell populations. Surprisingly, analysis of CRC patient datasets revealed tha …

31.08.2026journal-article

Innovative Approaches in Health Science Journal

Short-Term Changes in Recorded Anxiety and Systolic Blood Pressure After a Dhikr-Based Relaxation Intervention in Cancer Patient

Andi Sulfikar, Andriana Arfah, Musdalipah, Syahrul Said, Titi Iswanti Afelya, Indah Restika BN, Ridwan

Background: Anxiety is common during cancer care, and spiritually congruent supportive interventions may be acceptable to patients who request them. Evidence from local implementation settings remains limited. Objective: To evaluate short-term changes in recorded anxiety severity and systolic blood pressure after a dhikr-based relaxation intervention among hospitalized adults with cancer. Methods: This evidence-based practice implementation project used a one-group pretest-posttest evaluation. Sixteen participants …

31.08.2026journal-article

Journal of the Foot & Ankle

Avaliação pós-operatória de pacientes submetidos ao tratamento minimamente invasivo para ruptura aguda do Tendão de Aquiles

Jorge Mitsuo Mizusaki, Sérgio Damião Santos Prata, Marco Antônio Giglioli Rizzo, Luis Gustavo Da Silva Landgraf, Guilherme Calheiros Peluzo Abreu

Objetivo: Avaliar os resultados clínico-funcionais de pacientes submetidos ao tratamento minimamente invasivo da ruptura aguda do tendão de Aquiles utilizando o dispositivo Tenolig® associado ao protocolo de reabilitação de Alfredson. Métodos: Estudo realizado com 20 pacientes com tempo de lesão inferior a cinco dias submetidos ao tratamento cirúrgico minimamente invasivo da ruptura aguda do tendão de Aquiles com o dispositivo Tenolig®. Os critérios de exclusão compreenderam rerrupturas prévias, cirurgias anteriore …

31.08.2026journal-article

Bioinformation

Cancer prevention and screening awareness among informal caregivers in India: A cross-sectional survey

Indu Aggarwal

Informal caregivers of cancer patients often have inadequate awareness and uptake of cancer prevention and early detection practices despite their important role in health promotion. Therefore, it is of interest to assess the knowledge, attitudes and practices related to cancer prevention and screening among caregivers attending a tertiary cancer center in Delhi, India. Moderate awareness of cancer risk factors was observed, but participation in recommended screening programs remained low, particularly among non-he …

31.08.2026journal-article

International Journal of Innovative Technologies in Social Science

PATIENT COMPLIANCE IN ORTHODONTIC TREATMENT: THE ROLE OF BEHAVIORAL, SOCIAL, AND DIGITAL FACTORS – A NARRATIVE REVIEW

Maria Torchalska, Martyna Smogór, Monika Maria Szerszeń

Objectives: This narrative review aimed to summarize current evidence on factors influencing patient compliance in orthodontic treatment, with particular focus on behavioral, psychological, social, treatment-related and digital technology-related determinants. Methods: A narrative literature review was conducted using full-text scientific publications available in PubMed, Scopus and Google Scholar. The search included studies published between 1990 and 2026 and used keywords related to patient compliance, adherence …

31.08.2026journal-article

Revista Multidisciplinar de Estudios Generales

Factores familiares asociados a la adherencia al tratamiento antihipertensivo en adultos atendidos en atención primaria de salud

María Raquel Díaz Intriago, Erik Steven Suarez Gonzalez

La hipertensión arterial constituyó una de las principales enfermedades crónicas no transmisibles y representó un importante problema de salud pública debido a su elevada prevalencia, el riesgo de complicaciones cardiovasculares y las dificultades para lograr una adecuada adherencia al tratamiento. En este contexto, los factores familiares desempeñaron un papel relevante en el cumplimiento terapéutico de los pacientes atendidos en atención primaria de salud. El objetivo de la investigación fue analizar la asociació …

30.08.2026journal-article

International Journal of Innovative Technology and Exploring Engineering

Deep Learning-Based Lung Cancer Detection Using CT Scan Images: A Comparative Study of VGG16, ResNet50, and DenseNet121

Suhas Mohite, Amol Kadam, Sunil Kadam, Chetan More, Vinod Patil, Sandip Chavan

Lung cancer is a major problem because it kills more people every year than any other type of cancer. If we can find the abnormal areas early, people are much more likely to recover. Doctors usually use a type of scan called a CT scan to look for these abnormal areas. The problem is that reviewing all the scan images is very tedious, and even experienced doctors can miss something. We wanted to see whether computers could help with this task. We tried using three kinds of computer programs, VGG16, ResNet50 and Dens …

30.08.2026journal-article

Jurnal Kejuruteraan

Lignin Extraction from Coconut Pith by Alkaline and Organosolv Treatment: Characterization and Optimization of Lignin Yield and Purity

Mai Syadiah Khidzir, Siti Musliha Mat Ghani, Abdul Rahman Abdul Rahim, Khairirahanna Johari

Effective coconut pith lignin (CPL) extraction remained an obstacle since lignin must be removed without causing significant destruction of cellulose fibers. This work seeks to solve these challenges by improving the extraction procedure for CPL to generate a material appropriate for industrial uses, such as anti-corrosion coatings, that take advantage of lignin’s distinct features. A comprehensive technique based on response surface methodology (RSM) and central composite design (CCD) was used to optimize three cr …

30.08.2026journal-article

JEADV Clinical Practice

Sun Protection Behaviours in Skin Cancer Survivors: A Systematic Review and Meta‐Analysis

Shubham Kumar, Pratima Pandey, Asif Jan, Daniel Dubwa

ABSTRACT Background Skin cancer, including melanoma and non‐melanoma skin cancer (NMSC), is one of the most prevalent cancers worldwide. Although sun protection behaviors, such as sunscreen use, protective clothing, and shade‐seeking, are crucial in preventing skin cancer recurrence and secondary malignancies, adherence to these behaviors among survivors remains suboptimal. Objectives This systematic literature review and meta‐analysis aim to examine the prevalence and associated factors of sun protection behaviors …

30.08.2026journal-article

Journal of Lab Animal Research

Etiology, Therapeutic Challenges, Drug Interactions, and Future Directions of Gastric Ulcer Progression to Gastric Cancer

Hadis Farokhmoradi, Parsa Jahani, Sima Saravani, Seyedeh Maryam Moallem, Mohammad Amin Ghasemzadeh, Parsa Taher

Gastric cancer remains one of the leading causes of cancer-related mortality worldwide, and chronic gastric ulceration represents an important precursor lesion in a subset of patients. This narrative review aimed to synthesize evidence published between 2015 and 2026 on the etiology and pathogenesis of gastric ulcer, current therapeutic strategies, the preclinical roles of laboratory animals, treatment failures, and the transition from gastric ulcer to gastric cancer. The progression from chronic inflammation to ma …

30.08.2026journal-article

Sanoatda raqamli texnologiyalar

NEFT VA GAZ KORXONALARIDA TEXNIK SUVNI TOZALASH VA TAYYORLASH TEXNOLOGIYASI SAMARADORLIGINI OSHIRISHNING ILMIY ASOSLARI

Jasurbek Mixlio'g'li Tangirov, Saidaziz Shoxsuvorovich Xabibullayev, Nuritdin Sayfullayevich Amirqulov, Doston Muzaffaro'g'li Muradullayev

Ushbu maqola neft va gaz sanoati korxonalari murakkab tarkibli oqova va texnik suvlarini chuqur tozalash hamda qayta foydalanish texnologiyasining samaradorligini oshirishning nazariy va amaliy masalalariga bag‘ishlangan. Tadqiqotda gidrodinamik flokulyatsiya, modifikatsiyalangan granulalangan filtratsiya va nanostrukturalangan polimer membranalar bazasidagi gibrid tozalash tizimining ilmiy-metodologik va kimyoviy-fizikaviy qonuniyatlari yoritib berilgan. Tajriba neft va gaz sanoati korxonalari sharoitlarida o‘tkaz …

30.08.2026journal-article

International Journal of Medical Sciences and Pharma Research

Bone Marrow Infiltration in Breast Cancer: Diagnostic and Prognostic Perspectives- A Narrative Review

Emmanuel Ifeanyi Obeagu, Bibek Giri

Bone marrow infiltration (BMI) by breast cancer cells is an early and critical step in the metastatic cascade that significantly impacts patient prognosis. The bone marrow microenvironment serves as a sanctuary for disseminated tumor cells, allowing them to survive, evade treatment, and potentially lead to disease recurrence. Understanding the mechanisms and clinical significance of BMI is essential for improving detection and therapeutic strategies in breast cancer management. Diagnostic approaches for identifying …

30.08.2026journal-article

International Journal of Molecular Sciences

1-Hydroxypyrene Promotes Bladder Cancer Progression and Tumor-Associated Immunosuppression via MIF

Yiting Liu, Zongyu Li, Yingchun Kuang, Ke Chen, Lilong Liu

This study examined how 1-hydroxypyrene (1-OHP) affects bladder cancer (BCa) progression and tumor-associated immunosuppression. Public transcriptomic data and target-prediction databases were used to screen for targets related to 1-OHP and BCa. Machine learning was then used to narrow down the candidate genes. Molecular docking and single-cell RNA sequencing were also used to examine the selected targets and related pathways. The role of the main target was tested in vitro. CCK-8, colony formation, EdU, and Transw …

30.08.2026journal-article

Doklady BGUIR

Numerical and Analytical Implementation of the Method for Calculating Optimal Modes of Laser Heat Treatment of Electronic Materials

A. Kupo, E. Shershnev, V. Emelyanov, A. Kovaliou

A modification of the method of parametric optimization of non-stationary thermal conduction processes is proposed in relation to the problems of laser heat treatment of a wide class of materials used in electronic engineering, including semiconductors, dielectrics and superhard materials. Using the Matlab computer mathematics package, a computational algorithm has been developed for the automatic construction of the optimal heating mode according to the specified quality criterion, which makes it possible to signi …

30.08.2026journal-article

Current Oncology

Impact of Decision Aids for Shared Decision-Making for Patients with Early Stage Breast Cancer: A Systematic Review

Serena Sdinami, Lorenzo Conti, Benedetta Capetti, Valeria Sebri, Paola Zagami, Roberto Grasso, Carmen Criscitiello, Giuseppe Curigliano, Gabriella Pravettoni

Objectives: To systematically review the evidence on the effectiveness of patient decision aids (PDAs) for women with early stage breast cancer, focusing on decision-making outcomes, psychological variables, and quality of life. Methods: A systematic review was conducted in accordance with PRISMA guidelines. PUBMED, EMBASE and SCOPUS databases were searched to identify quantitative, qualitative and mixed-methods studies evaluating PDAs designed to support treatment decision-making in women with early stage breast c …

30.08.2026journal-article

Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi

An ablation analysis of feature selection strategies for machine learning–based breast cancer recurrence prediction

Şeyma Aymaz

Breast cancer recurrence after treatment remains a critical clinical problem that directly affects patient management and survival outcomes. In this study, a machine learning–based classification framework is proposed to predict breast cancer recurrence risk. Experiments were conducted on the Wisconsin Prognostic Breast Cancer and Recurrent Breast Cancer datasets. During the data preprocessing stage, missing values were imputed, categorical variables were transformed into numerical representations, and all features …

30.08.2026journal-article

Applied System Innovation

Spatial Heterogeneity in Cancer Incidence: Assessing Behavioral and Environmental Associations Using Machine Learning and Multiscale Geographically Weighted Regression

Yuhang Xie, Zhe Zhang, Chanam Lee, Marcia G. Ory, Ipek Nese Sener, Bahar Dadashova, Gisou Salkhi Khasraghi, Jinsil Hwaryoung Seo, Galen Newman, Chunwu Zhu, Wenjin Wang, Xuemei Zhu

Cancer incidence exhibits substantial spatial disparities associated with environmental, behavioral, built-environment, healthcare access, and socioeconomic conditions, yet the extent to which these county-level associations vary geographically and across spatial scales remains insufficiently understood. This study evaluates an explainable spatial epidemiology workflow that integrates Random Forest (RF), SHapley Additive exPlanations (SHAP), permutation importance, Ordinary Least Squares (OLS), Geographically Weigh …

30.08.2026journal-article

Basic & Clinical Pharmacology & Toxicology

Regional Variation in ADHD Treatment and Diagnosis Among Children and Adolescents in Denmark

Heidi Sonne, Anton Pottegård, Anna Sofie Kjærgaard Hansen, Mickael Bech, Helene Kildegaard

ABSTRACT Geographic variation in ADHD treatment and diagnosis among children and adolescents is well documented, yet the system‐level factors driving such differences remain poorly understood. We examined nationwide patterns of ADHD medication use and diagnoses in Denmark in 2024 and assessed whether municipal socioeconomy, regional hospital waiting times or private child psychiatrist capacity contributed to geographic variation. In this register‐based cross‐sectional study, we included all Danish residents aged 4– …

30.08.2026journal-article

physica status solidi (a)

Multilayer WS 2 /Borophene/Au/MXene/Cu Metasurface Terahertz Biosensor With Machine Learning‐Augmented Prediction for Label‐Free Brain Tumor Detection

Hassan Nasiri, Amuthakkannan Rajakannu

High‐performance terahertz metasurface biosensor is numerically developed for label‐free brain tumor detection. The sensor employs six multilayer elliptical resonators integrating WS 2 , borophene, Au, MXene, and Cu on a graphene‐coated SiO 2 substrate. Three material configurations are compared, with the hybrid WS 2 /borophene/MXene/Cu structure (Case 3) enabling plasmon–exciton (plexcitonic) coupling and delivering the best performance. Full‐wave FEM simulations in COMSOL incorporate dispersive material models, g …

30.08.2026journal-article

Pharmaceutics

Aerosolized Quercetin-Loaded Chia Seed Polysaccharide Nanoparticles: Design of Experiments and Machine-Learning-Guided Optimization for Enhanced Lung Cancer Cell Delivery

Sara Hasan, Seyedeh Negin Kassaee, Derek J. Richard, Nazrul Islam, Emad L. Izake

Background/Objectives: The recent advances in pulmonary delivery have shifted the paradigm to the development of inhalable drug-loaded polysaccharide particles that can be positioned at the respiratory interface while reducing the systemic exposure. Quercetin has broad anticancer activity but remains difficult to translate because of its poor aqueous solubility, limited bioavailability and rapid metabolic loss. Here, we report quercetin-loaded chitosan/Salvia hispanica polysaccharide nanoparticles as a natural poly …

30.08.2026journal-article

International Journal of Research in Ayurveda and Pharmacy

FORMULATION AND EVALUATION OF MUCOADHESIVE HERBAL ORAL GEL CONTAINING SCUTELLARIA BAICALENSIS EXTRACT FOR THE TREATMENT OF ORAL INFLAMMATORY CONDITIONS

Aditya Uttam Waghmare, Pratik Sanjeev Gunale, Kiran C. Rodage, Sameer Shafi, Dharashive VM, Kavita Shivkumar Sirgire

The present study aimed to formulate and evaluate a mucoadhesive herbal oral gel containing Scutellaria baicalensis extract for the treatment of oral inflammatory conditions. The plant extract, rich in flavonoids such as baicalin and baicalein, exhibits significant anti-inflammatory, antimicrobial, and antioxidant properties. Herbal gel formulations (F1-F6) were prepared using Carbopol 940 as a gelling agent with varying concentrations to optimise physicochemical and release characteristics. The formulations were e …

30.08.2026journal-article

Advanced Science

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo

ABSTRACT Developing effective therapies for triple‐negative breast cancer (TNBC) requires the identification of key molecular regulators. Here, among the major m6A modulators, we find that only the reader YTHDC1 is specifically overexpressed in TNBC and correlates to unfavorable prognosis. Mechanistically, YTHDC1 orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress in TNBC cells. It not only stabilizes GLUT3 mRNA to sustain glucose uptake …