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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Antibacterial Activity of the Leaf and Bark Extracts of Anacardium Occidental on Selected Pathogenic Microorganisms

Adebola Adewojo

The increasing prevalence of antibiotic resistance necessitates exploring alternative therapeutic options, such as medicinal plants. This study investigates the antibacterial activity of methanolic and ethanolic extracts of Anacardium occidentale (cashew) leaves and bark against selected pathogenic microorganisms, including Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. The phytochemical screening revealed the presence of bioactive compounds like phenolics, flavonoids, and saponins, which cont …

03.09.2026journal-article

Biology

Deconstructing the Alternative Lengthening of Telomeres: Integromics Prioritizes Five Master Hubs Dictating Clinical Survival and Therapeutic Vulnerabilities

Isaac Armendáriz-Castillo, Santiago Guerrero, Andrés Herrera-Yela, Jhommara Bautista, Andrés López-Cortés

The Alternative Lengthening of Telomeres (ALT) pathway drives replicative immortality in aggressive malignancies, particularly sarcomas and gliomas. Clinical ALT stratification has relied on screening for structural ATRX and DAXX mutations. However, this genotypic approach fails to capture the dynamic macro-reprogramming required to sustain ALT. Here, we established and validated a 28-gene transcriptomic signature that captures the ALT-associated transcriptomic phenotype of the ALT phenotype. Using multivariate Cox …

03.09.2026journal-article

Health Affairs Scholar

Telehealth Use Among U.S. Adults With Type 2 Diabetes: Differences In Medication Fill Patterns And Care Processes

Terrence T Liu, John Thomas Menchaca, Alexander Chaitoff, Boomer Olsen, Julia E Szymczak, Jorie Butler, Kensaku Kawamoto, Renuka Tipirneni, Molly B Conroy

Abstract Introduction The expansion of telehealth following the COVID-19 pandemic has enhanced access to care, but questions remain about how well telehealth supports the delivery of comprehensive, guideline-concordant care for type 2 diabetes. Methods We conducted an observational cross-sectional study using nationally representative survey data from the 2021–2023 Medical Expenditures Panel Survey to make unadjusted descriptive comparisons between adults with any diabetes-related telehealth use and those receiving …

03.09.2026journal-article

Frontiers in Medicine

Complete blood count-derived myeloid-lymphoid inflammatory phenotype in rheumatoid arthritis complicated by acute myocardial infarction: an age- and sex-balanced retrospective study

Jing Zhang, Ji Li, Yuwei Wang, Lina Zhang, Di Jin, Sheng-Guang Li, Yuhua Yan

Background Rheumatoid arthritis (RA) is associated with excess cardiovascular morbidity, including acute myocardial infarction (AMI). Routine complete blood count (CBC)-derived inflammatory indices are clinically accessible, but their value for characterizing cardiovascular comorbidity in RA remains incompletely defined. We examined whether CBC-derived markers form a coordinated myeloid-lymphoid inflammatory phenotype associated with AMI in patients with RA. Methods We retrospectively analyzed 110 healthy controls, …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Systemic immune-inflammation index as a prognostic marker in heart failure with non-dialysis chronic kidney disease: a two-cohort derivation and validation study with head-to-head comparison against natriuretic peptides

Tao Chen, Manyang Chen, Mingzhu Hong, Minghui Zhu, Can Chen

Introduction Heart failure (HF) and chronic kidney disease (CKD) frequently coexist and share chronic low-grade inflammation, oxidative stress, and thrombotic activation. Natriuretic peptides remain the cornerstone of HF prognostication, but their interpretation is confounded by reduced renal clearance, leading to false elevations and attenuated prognostic specificity in CKD. The systemic immune-inflammation index (SII), derived from routine blood counts, integrates neutrophil-driven inflammation, lymphocyte-mediat …

03.09.2026journal-article

European Journal of Ageing

Self-reported social and motivational factors in health-related future intentions amongst older adults

Maria A. Nygaard, Eva Rubínová, Julia L. Allan, Júlia Stasová, Louise H. Phillips

Abstract Prospective memory (PM), the ability to form a specific intention and remember to carry it out at an appropriate future time, is critical in health-related contexts and has been found to decline significantly with age. Further, motivation plays a vital role in PM and previous research indicated that older adults are particularly motivated by the social relevance of PM tasks. However, little is known about the role of perceived social impact in older adults’ health intentions. The current study aimed to exp …

03.09.2026journal-article

Cell and Gene Therapy Insights

Accelerating AAV biosafety and characterization decisions with validated NGS workflows

Andrew Hillhouse

Confirming product identity, genome integrity and freedom from adventitious agents requires a single test to hold up across genomes as small as an AAV vector and as large as a human genome, against regulatory guidance that continues to evolve (ICH Q5A(R2)). Here is how FUJIFILM Biotechnologies built validated NGS workflows covering library preparation, genome integrity, sensitivity testing and adventitious agent detection, cutting biosafety testing turnaround from up to 8 weeks to 1–2 weeks.

03.09.2026journal-article

Frontiers in Immunology

Development and external validation of a clinical-genetic risk identification model for rheumatoid arthritis-associated interstitial lung disease

Wei Fan, Wei Bo, Xuanhua Yu, Xiaojuan Gao, Jinmei Huang, Yi Zhang, Shufan Wu, Xuyan Chen, Liangjing Lu, Hanlin Yin

Objective This study aimed to develop and externally validate a clinical risk identification model for prevalent rheumatoid arthritis-associated interstitial lung disease (RA-ILD) using multicenter Chinese patient cohorts. We also evaluated the discriminative value of MUC5B polymorphisms (rs35705950 and rs868903) in a combined clinical-genetic model for this purpose. Methods A multicenter, two-phase design was adopted. A total of 446 patients with rheumatoid arthritis (RA) from five medical centers were retrospecti …

03.09.2026journal-article

Frontiers in Neuroscience

Amino acid profiles and clinical phenotypes in young children with autism spectrum disorder

Ilaria Serati, Luca Lalli, Andrea Riccardo Dallapiccola, Pietro Baso, Martina Tosi, Francesca Brustia, Maria Paola Canevini, Michele Mussap, Livia Pisciotta, Emilia Ricci, Maura Rossi, Marco Di Dario, Maria Cristina Straface, Amanda Papa, Sabrina Fede, Salvatore Fazzone, Elena Spada, Federica Gioia, Roberto Longo, Pierangelo Veggiotti, Gianvincenzo Zuccotti, Cristina Cereda, Bruno Mario Cesana, Simona Ferraro

Introduction In 394 children with autism spectrum disorder (ASD), we investigated the association between plasma amino acid (AA) concentrations and clinical phenotypes. Methods Multivariable logistic regression models were used to evaluate the associations between 22 AAs and clinical features, reporting odds ratios. Results The median age at diagnosis was 3.5 years (interquartile range: 2.8–4.6 years) for boys and 3.1 years (interquartile range: 2.3–3.8 years) for girls; 81.5% of the participants were boys. A 25-un …

03.09.2026journal-article

Frontiers in Public Health

SSR-stacking: a hybrid GNN–ensemble framework for high-myopia classification under simulated baseline-SE missingness

Na Zhao, Runze Zheng, Zhaoyu Huang, Cairui Li, Jinhao Lu, Chao Dai, Zhan Tang, Jian Wang

The increasing burden of childhood myopia creates a need for screening models that remain informative when routinely collected clinical measurements are incomplete. We propose SSR-Stacking, a hybrid framework integrating Graph Neural Networks (GNN) with Ensemble Learning for classification of final-follow-up high-myopia status under simulated missingness of baseline spherical equivalent (SE). Unlike traditional models, we construct a Social-Environment Graph based on school-class affiliations to represent classroom …

03.09.2026journal-article

BMC Health Services Research

Artificial intelligence literacy among hospital administrative staff: a qualitative descriptive study

Gökhan Coşkun, Yeliz Cankurtaran

Abstract Background Artificial intelligence (AI) is increasingly being integrated into healthcare organizations, creating a growing need for AI literacy among healthcare personnel. However, the AI literacy of hospital administrative staff remains relatively underexplored. This study examines the level and perceptions of AI literacy among hospital administrative staff and explores participants’ views regarding AI literacy. Methods This qualitative descriptive study was conducted with 20 administrative staff members …

03.09.2026journal-article

Pilot and Feasibility Studies

FASTINA – protocol for a randomised feasibility trial of time-restricted eating to improve response to multiple myeloma therapy

Anna Franziska Hamm, Jan Vorwerk, Mona Maria Merz, Martin Smollich, Christina Schwitlick, Kay Horn, Inke Regina König, Theo Leitner, Lorenz Oelschläger, Helal Ahmed, Felix Sommer, Nikolas von Bubnoff, Cyrus Khandanpour

Abstract Multiple myeloma (MM) is an incurable plasma cell malignancy with relapses and diminishing response durations. Preclinical studies suggest that time-restricted eating (TRE)-related metabolic changes may enhance chemosensitivity by exploiting cancer cell vulnerabilities to nutrient deprivation. Clinical data in solid tumours remain limited and heterogeneous, mainly supporting feasibility and possible toxicity reduction rather than definitive efficacy. While efficacy has been explored in breast cancer patien …

03.09.2026journal-article

Frontiers in Surgery

Optimizing ambulatory groin hernia repair in public healthcare frameworks: a prospective analysis of predictive factors for discharge failure

Jihen Krichen, Asma Sghaier, Rana Dhouib, Slah Souii, Maissa Tioumi, Sihem Sindi, Bilel Faidi, Khalil Ben Salah

Background Outpatient groin hernia repair is widely recommended globally due to clinical and socioeconomic efficiency, yet it remains underutilized in developing healthcare systems like Tunisia. This study aimed to evaluate the feasibility of a newly implemented day-surgery clinical pathway for groin hernias and identify specific predictors associated with outpatient discharge failure. Methods A prospective, observational cohort study was conducted at a Tunisian tertiary hospital between September 2023 and April 20 …

03.09.2026journal-article

Journal of Pure and Applied Microbiology

A Systematic Review on the Applications of Yeast Derived Pigments in the Food Industry for Enhancing Health Benefits

Rajashree Bhattacharyya, Deep Prakash Parasar, Smita Sarma, Pritam Bardhan, Suresh Deka, Songeeta Singha, Manash Pratim Kashyap

Natural colouring agents or biopigments, particularly those derived from microorganisms, present an exciting opportunity for extensive research and industrial application. The use of these naturally derived pigments has gained remarkable momentum in the food industry, driven by the increasing consumer preference for safe, functional, and eco-friendly additives. Historical and traditional food practices also reveal a strong foundation for the use of natural colourants in various food products across different cultur …

03.09.2026journal-article

International Journal of Asian Social Science Research

Heterogeneous Effects of Socioeconomic Status on Health Outcomes among Middle-Aged and Older Adults: Evidence from Five Waves of CHARLS

Yuhan Xie

This paper uses data from five waves of the China Health and Retirement Longitudinal Study (CHARLS) (N = 37,710) to measure the health of middle-aged and older adults from the four dimensions of Activities of Daily Living (ADL), self-rated health, mental health, and the number of chronic diseases. It uses principal component analysis to construct a comprehensive socioeconomic status (SES) index, and uses negative binomial regression model, generalized ordered logit and linear regression model to test the impact of …

03.09.2026journal-article

Clinical and Translational Imaging

Dynamic PSMA total-body PET/CT in prostate cancer: technical principles and clinical potential

Yongkang Shuai, Irene Brusa, Riccardo Mei, Stefano Fanti

Abstract Background The incidence of prostate cancer continues to rise worldwide. While conventional static PET/CT provides semi-quantitative metrics, total-body PET/CT enables voxel-level dynamic imaging and parametric imaging, demonstrating great potential for clinical applications in prostate cancer. Therefore, this review synthesizes the technical principles of dynamic PSMA total-body PET/CT and its emerging clinical applications in prostate cancer, providing a novel clinical insight for individualized patient …

03.09.2026journal-article

Gastric Cancer

Clinical impact of CT-defined sarcopenia on long-term oncological outcomes in gastric cancer: validation of muscle mass cut-offs established according to EWGSOP recommendations

Jasmin Hasanovic, Paul Friedrich Esslinger, Veronika Lummer, Heiner Nebelung, Leo Misera, Ralf-Thorsten Hoffmann, Johanna Kirchberg, Marius Distler, Jürgen Weitz, Daniel E. Stange, Felix Merboth

Abstract Background Sarcopenia is an important prognostic factor in gastrointestinal malignancies, but CT-based definitions vary. This study evaluated recently published computed tomography (CT)-based cut-offs for skeletal muscle index (SMI) and psoas muscle thickness normalized to height (PMTH), derived from a young, presumably healthy reference population according to recommendations of the European Working Group on Sarcopenia in Older People (EWGSOP), in patients undergoing surgery for gastric cancer. Methods Th …

03.09.2026journal-article

Child Development

Impact of children's language ability on self-report assessment of mental health: Testing measurement invariance using moderated non-linear factor analysis

Zoe Campbell, Mark Boyes, Elien Vanluydt, Noah Padgett, Elizabeth Hill, Suze Leitão, Sarah Griffiths

Abstract Children with language difficulties are at elevated risk of mental health problems, yet tools commonly used to assess mental health rely heavily on language. It is unclear if children's language ability influences their self-report measures. We tested language-related measurement invariance using moderated non-linear factor analyses. We used self-report data from children (10–11 years) with a wide range of language abilities, living in the UK, on the Revised Child Anxiety and Depression Scale–25 (RCADS–25; …

03.09.2026journal-article

Frontiers in Public Health

Fitness for work and the aging workforce: medical assessment as a de facto mechanism of retirement in the United Kingdom after the abolition of the default retirement age

Alida Langlois

Background Fitness for work is the judgement that a person is medically able to perform a role safely. This review considers the concept to have been shaped for a younger workforce expected to leave employment at a fixed retirement age. As populations have aged and mandatory retirement ages have been abolished, it is the instrument that remains available for questions it was not designed to answer. Methods This review traces the origins of the concept and examines what fitness for work means when applied to an agin …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Aberrant myocardial calcium cycling: pathogenic mechanisms and targeted therapeutics for heart failure

Chunxiao Zhao, Jiahao Liu, Juanjuan Xin, Qun Liu, Ying Zhang, Xiaochun Yu, Junhong Gao

Cardiovascular diseases rank as the global primary cause of mortality. Heart failure (HF) represents a progressive cardiac syndrome triggered by structural or functional myocardial damage that compromises ventricular systolic output. Intracellular calcium homeostasis underpins cardiomyocyte excitation-contraction coupling. Calcium overload and dysregulated calcium handling act as central pathogenic forces driving HF progression. Sympathetic β 1 -adrenergic receptor (β 1 -AR) and parasympathetic M 2 muscarinic acety …

03.09.2026journal-article

Frontiers in Public Health

Traditional Chinese medicine reimbursement reform in China: implementation progress, policy constraints, and optimization strategies

Fazheng Zhao, Yichi Chen, Xin Tong

Introduction As the inheritance, innovation, and development of TCM advance, medical insurance reimbursement policies are intended to improve access, guide service structure, and support high-quality development. This study examines the implementation progress, policy constraints, and optimization paths of TCM reimbursement reform in China. Methods The study analyzes publicly available national and regional policy documents, together with secondary literature, to synthesize the policy design, implementation arrange …

03.09.2026journal-article

Biotechnology and Applied Biochemistry

A Comprehensive Review of Exopolysaccharides From Lactic Acid Bacteria: Production, Characterization, and Applications in Food and Health

Hafsa Arshad, Rao Mubashar Ali, Shahgull, Sahar Fazal, Aqsa Qasim Zafar, Laiba Mahmood, Mishal, Muhammad shoaib

ABSTRACT Lactic acid bacteria (LAB) produce exopolysaccharides (EPSs), which are beneficial in food and health applications because of their varied structural and functional characteristics. These EPSs are attracting a lot of interest. Homopolysaccharides (HoPSs) and heteropolysaccharides (HePSs) are two types of LAB‐derived EPS that differ in their monosaccharide compositions and physicochemical properties. These biopolymers are produced through processes, such as extracellular synthesis and Wzx/Wzy‐dependent mech …

03.09.2026journal-article

Sinéctica

Apoyo social informal, violencia de género y salud mental en estudiantes universitarias

María de Monsserrat López-Moreno, Lidia Karina Macías-Esparza

Gender-based intimate partner violence affects women’s mental health and constitutes a challenge for higher education institutions. This study identified the types of support sought by female university students who had experienced intimate partner violence and analyzed the responses of their informal support networks. A sequential mixed-methods quan→QUAL design with qualitative priority was employed. Participants included ten students from the Centro Universitario de la Ciénega and nine members of their informal s …

03.09.2026journal-article

Journal of Community Health

Assessing Bias in Medication Administration in Relation to Incarceration History in a New Orleans Student Clinic Population

Haley Watts, Diane Hurwitz, Jonathan Hurley, Ellen Terry, Christopher Saker, Thomas Stall, Vidhatri Raturi, Anjali Niyogi, Helen Pope

Abstract Formerly incarcerated individuals experience a disproportionate burden of disease and face greater barriers to accessing healthcare. This population also represents a significant proportion of patients seen in New Orleans’ student-run clinics. This study examines the chief complaints among formerly incarcerated patients and evaluates whether prescribing patterns differ for this group, with the aim of identifying potential biases in treatment practices. Data for this study were obtained from REDCap surveys …