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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Journal of Craniofacial Surgery

Free Fibula Flap With Chimeric Skin Paddles: Technical Tips and Clinical Experience

Ersin Gur, Batuhan Sencan, Ahmet Bicer, Yigit Ozer Tiftikcioglu, Zeyyat Cuneyt Ozek

Introduction: Advanced tumors and trauma may cause composite oromandibular defects involving the mandible, intraoral mucosa, and skin. Although these defects involve multiple components, they can be reconstructed simultaneously with a single flap. The free fibula flap with chimeric skin paddles provides single-stage, appropriate three-dimensional reconstruction of challenging composite defects of the oromandibular region. The authors present our experience with free fibula flaps with chimeric skin paddles for compo …

02.09.2026journal-article

Iranian Journal of Allergy, Asthma and Immunology

Clinical Characteristics, Diagnostic Challenges, and Therapeutic Outcomes in Non-eosinophilic Esophagitis Eosinophilic Gastrointestinal Diseases in Comparison with Eosinophilic Esophagitis

Azizollah Yousefi, Saeed Sepehry Vafa, Mina Mirzad, Fatemeh Elham Mahjoub, Behnam Shahsavand, Ebrahim Babaee, Fereshteh Karbasian, Mohammad Nabavi, Mohammad Hasan Bemanian, Sima Shokri, Saba Arshi, Morteza Fallahpour

Eosinophilic gastrointestinal diseases (EGIDs) are chronic, TH2-mediated conditions. Eosinophilic esophagitis (EoE) is the most common type, while non-EoE EGIDs affect other gut segments. This retrospective study of 111 patients (50 EoE and 61 non-EoE) from 2011 to 2022 compared the clinical aspects of these 2 types. Dysphagia and food impaction dominated in EoE, while abdominal pain, nausea, and diarrhea were more common in non-EoE EGIDs. Atopic comorbidities were frequent. Diagnostic delays>1 year were more commo …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

STUDY OF GROUTING COMPOSITION FOR RESTORING THE TIGHTNESS OF THE PRODUCTION WELL CASING AND ELIMINATING WATER INFLUX

G.S. Dubinsky, V.G. Mukhametshin

This article presents the results of a study of a composite fast-hardening cement slurry based on urea-formaldehyde synthetic resin, designed for effective waterproofing and repair and insulation work. Unlike similar products, this fast-hardening cement slurry effectively cures over a wide temperature range from 20°C to 100°C. The curing time and rate of the analyzed cement slurry are regulated by the hardener concentration and type over a wide time frame, from several tens of minutes to 5-8 hours. The flexural str …

02.09.2026journal-article

Prävention und Gesundheitsförderung

KI-gestützte Dokumentation und Wissensvermittlung in der klinischen Pflege

Alexander Pauls, Fenja Tjalda Hesselmann, Christine Scheve, Frank Wallhoff, Frauke Koppelin

Zusammenfassung Hintergrund Digitale und KI-gestützte (künstliche Intelligenz) Technologien besitzen das Potenzial, Arbeitsprozesse in der klinischen Pflegepraxis zu entlasten und beim Kompetenzerwerb zu unterstützen. Gerade der Dokumentationsaufwand wird von Pflegefachpersonen (PFP) als zeitintensiv gesehen und ist Gegenstand vieler Entwicklungen in Forschung und Praxis. Im Projekt Data-Driven-Health (DEAL) wurde daher untersucht, wie PFP ein KI-gestütztes Dokumentations- und Informationssystem in einer praxisnahe …

02.09.2026journal-article

Biomedical Physics & Engineering Express

A deformable lead-attention fusion network for multi-label ECG classification integrating clinical metadata

Enjun Zhou, Xiangyong Kong, Hao Wang, Chenrui Bai

Abstract Cardiovascular diseases remain a major global health burden, making accurate electrocardiogram (ECG) analysis essential for timely diagnosis. While deep learning-based methods have made significant progress in automating ECG classification, they are often limited by the variability of ECG signals, the frequent presence of multiple cardiac abnormalities, and the inadequate integration of diverse clinical data. This study proposes Deformable Lead-Path and Multi-Modal Fusion Network (DLM-Net): a robust deep l …

02.09.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Both Radiofrequency Microtenotomy and Physical Therapy Provide Significant Improvements in Patients With Chronic Midportion Achilles Tendinopathy at a Minimum 5‐Year Follow‐Up

Hayat Jirde Ali, Khaled Meknas, Jüri‐Toomas Kartus, Dana Meknas

Purpose To evaluate a minimum 5‐year follow‐up of patients who were treated with either bipolar radiofrequency microtenotomy (RFM) or physical therapy (PT) for midportion Achilles tendinopathy between 2016 and 2018. Methods All subjects who participated in a previous randomized controlled trial (n = 38) between 2016 and 2018 were invited to fill out a questionnaire between January and July 2025 to evaluate the outcomes at a minimum of 5‐year follow‐up. Patients who had undergone further surgical treatment were excl …

02.09.2026journal-article

Archives of Orthopaedic and Trauma Surgery

Platform-specific learning curve and early tibial radiographic agreement of ROSA®-assisted medial unicompartmental knee arthroplasty in an experienced high-volume surgeon: a consecutive case series

Stefano Petrillo, Damiano Ardiri, Matteo Marullo, Sergio Romagnoli

Abstract Purpose To evaluate the platform-specific learning curve and early tibial radiographic agreement of imageless ROSA ® -assisted medial unicompartmental knee arthroplasty (UKA), with short-term clinical findings assessed exploratorily. Methods This retrospective consecutive case series included 30 patients who underwent ROSA ® -assisted medial UKA with the Persona ® Partial Knee implant between January and April 2026 at a high-volume arthroplasty referral centre. A continuous learning-curve cumulative summat …

02.09.2026journal-article

JAMA Psychiatry

Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression

Diana K. Orsini, Sara Di Luch, George Tomlinson, Gabrielle F. M. Lovell, Shreya Vasudeva, Nelson B. Rodrigues, Danica E. Johnson, Alastair J. Flint, Cristian-Daniel Llach, Roger S. McIntyre, Rodrigo B. Mansur, Keyvan Karkouti, Amer M. Burhan, Erica Kaczmarek, Noah Chisamore, Anuj Bhatia, Neilesh Soneji, Anahita Joshi, Deep Grewal, Rachel Laframboise, Joshua D. Rosenblat

Importance Antidepressant efficacy of intravenous (IV) ketamine has been demonstrated in major depressive disorder; however, the efficacy and safety of ketamine for bipolar depression remain largely unknown, with limited data available in this specific population. Objective To evaluate the efficacy, safety, and tolerability of adjunctive IV ketamine compared with midazolam for treatment-resistant bipolar I or II depression (TRBD). Design, Setting, and Participants The Ket-BD study (Ketamine for Treatment-Resistant …

02.09.2026journal-article

Journal of Electronic Materials

HTL-Free Perovskite Solar Cells with a Carbon Electrode and Enhanced Stability, Through a Scalable Polymer Treatment Method

Maria Bidikoudi, Christina Tiflidis, Elias Stathatos

Abstract Perovskite solar cells with a carbon electrode (C-PSCs) are considered the most promising and viable structure for the upscaling and future commercialization of PSCs. With the ability to be fabricated with industrially compatible methods and with no need for employing hole transport materials, C-PSCs are not randomly moving to the forefront of PSC research at the moment. In this work, hole transport material (HTM)-free C-PSCs have been fabricated under entirely ambient conditions. The devices employ an add …

02.09.2026journal-article

Clinical Cancer Research

DNMT3B Plays Antagonistic Roles with SMARCB1 and Is a Targetable Vulnerability in Rhabdoid Tumors

Céline Chauvin, Ryszard Wimmer, Ludovica Brunetti, Joanna Cyrta, Ana Boranijasevic, Mamy Andrianteranagna, Julien Masliah-Planchon, Kévin Beccaria, Sandrina Turczynski, Grégory Thomson, Maëva Veyssière, Rachida Bouarich-Bourimi, Zhi-Yan Han, Owen Hoare, Aurore Coulomb, Mylène Bohec, Sylvain Baulande, Gaëlle Pierron, Olivier Delattre, Arnault Tauziède-Espariat, Nicolas Servant, Alexandre Baffet, Franck Bourdeaut

Abstract Purpose: Rhabdoid tumors (RT) are highly aggressive pediatric cancers driven by the biallelic inactivation of the SMARCB1 tumor-suppressor gene, the sole recurrent genetic alteration. SMARCB1 encodes a core subunit of the SWI/SNF chromatin remodeling complex; its loss disrupts epigenetic gene regulation, supporting the classification of RT as prototypical epigenetically driven cancers and highlighting the therapeutic potential of targeting epigenetic modifiers. Notably, previous studies have reported the o …

02.09.2026journal-article

BMC Nephrology

Comment - Louis XIV’s terminal illness clinical chronology favors necrotizing soft-tissue infection

Alexis Demas

Abstract Louis XIV’s rapidly progressive terminal illness may be better explained by necrotizing soft-tissue infection than primary calciphylaxis. Severe distal pain, ascending gangrene, and fatal sepsis within three weeks suggest fulminant infection, plausibly arising from a diabetic foot lesion. Clinical chronology should remain central when evaluating competing retrospective clinicopathological hypotheses.

02.09.2026journal-article

Journal of Orthopaedic & Sports Physical Therapy

Can Clinicians Predict Which Patients Respond Best to a Specific Treatment? A Systematic Review of Low Back Pain Moderators in Primary Care

Tayla Douglas, Hazel Jenkins, Leticia Correa, Leandro Nogueira, Annika Young, Mark Hancock

OBJECTIVE: To synthesise and critically evaluate evidence on treatment effect moderators in the primary care management of low back pain (LBP). DESIGN: Systematic review of randomised controlled trials (RCTs) and secondary analyses of RCTs. LITERATURE SEARCH: Medline, EMBASE, CINAHL and Cochrane Library were searched from inception to August 2025. STUDY SELECTION CRITERIA: RCTs investigating moderators for primary care interventions in non-specific LBP. DATA SYNTHESIS: Data were synthesised by exploring data cluste …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Extrapulmonary Paragonimiasis Diagnosed by Molecular Tools

Da Young Kim, Jun-Won Seo, Na-Ra Yun, Dahae Kwak, Choon-Mee Kim, Dong-Min Kim

ABSTRACT. Paragonimiasis is a parasitic disease that involves the lungs but can manifest in extrapulmonary sites, including the peritoneum or subcutaneous tissue. Diagnosis is limited by nonspecific clinical manifestations and overlapping features with other diseases, such as tuberculosis (TB). A 55-year-old Korean male presented with acute abdominal pain and a recurrent subcutaneous mass in the left thigh. Although TB peritonitis was initially suspected, further diagnostic tests were performed. To confirm the diag …

02.09.2026journal-article

Clinical and Translational Gastroenterology

Impact of hepatitis C viremia on overall survival and hepatic decompensation among patients with unresectable HCC receiving immunotherapy

Eunice Y. Lee, Willis Tang, Jennifer C. Price, Robin K. Kelley, John D. Gordan, Jennifer C. Lai, Lawrence Fong, Neil Mehta, Michael Li

Introduction: Hepatitis C (HCV) is associated with an immunosuppressive liver microenvironment, but whether HCV affects immune checkpoint inhibitor (ICI) outcomes in unresectable hepatocellular carcinoma (HCC) remains unknown. Methods: We performed a single-center retrospective cohort study of patients with unresectable HCC treated with ICIs. In patients with a history of HCV, viremia was defined as a detectable viral load prior to immunotherapy. The primary outcome was overall survival (OS); secondary outcomes wer …

02.09.2026journal-article

Animals

Clinical Findings, Treatment and Long-Term Outcome in 37 Cats with Non-Associative Immune-Mediated Hemolytic Anemia: A Retrospective Observational Study of Two Treatment Cohorts

Lisa-Maria Kulmer, Pavlos G. Doulidis, Iwan A. Burgener, Nicole Luckschander-Zeller

Background: Non-associative immune-mediated hemolytic anemia (IMHA) is uncommon in cats and carries substantial mortality. Glucocorticoids are first-line treatment, and cyclosporin A (CsA) is frequently added, but data on the clinical course and long-term outcome are limited. We describe clinical findings, treatment, adverse events and outcome in cats with non-associative IMHA. Methods: In this retrospective observational single-center study (October 2014–October 2024), 37 cats diagnosed by the 2019 ACVIM consensus …

02.09.2026journal-article

Journal of Tropical Health

Secondary Haemophagocytic Lymphohistiocytosis in a Patient with Metaplastic Breast Carcinoma Receiving Anthracycline-Based Chemotherapy: A Case Report

Kogulan Selvanayagam, Sivakumar Jeyalakshmy

Hemophagocytic lymphohistiocytosis is a rare life-threatening hyperinflammatory syndrome characterized by uncontrolled immune activation and cytokine storm. It may occur secondary to malignancy or immunosuppressive therapies. While often associated with hematological malignancy, hemophagocytic lymphohistiocytosis is exceptionally uncommon in solid tumors like breast carcinoma.We report a case of 69-year-old female with T4bN1M0 metaplastic breast carcinoma (T4bN1M0- Tumor locally spread to skin of the breast, two ax …

02.09.2026journal-article

Experimental & Molecular Medicine

NatD promotes glioblastoma progression through epigenetic activation of FGFR4 signalling

Chan-Woo Kim, Taek-Yeol Jung, Chanil Kim, EungHan Kim, Heui Og Kim, Jiyeon Chae, Hyelee Kim, Ga-Yeon Ko, You-Jung Yeo, Ji-Young Park, Jaehyuk Pyo, Jeong Taeg Seo, Dokyeong Kim, Junseong Park, Seo Jin Kim, Minji An, Seok-Gu Kang, Jong Bae Park, Chul Hoon Kim, Seung-Hyun Jung, Sug Hyung Lee, Ho-Shik Kim, Hyun-Seok Kim

Abstract N-terminal acetyltransferase D (NatD) acetylates histones H4 and H2A at serine 1 and has been implicated in oncogenesis, yet its role in glioblastoma (GBM) remains unexplored. Here, we show that NatD expression is significantly elevated in GBM at both transcript and protein levels. NatD knockdown markedly suppressed proliferation, colony formation, migration, invasion and tumoursphere formation in GBM cell lines and patient-derived models, indicating a critical role in maintaining cancer stem-like properti …

02.09.2026journal-article

Antibiotics

Antibiotics and the Endocrine System: Mechanisms, Adverse Effects, and Clinical Implications

Łukasz Grabarczyk, Julia Oszytko, Maria Derkaczew, Kamil Sobolewski, Paweł Radkowski

Background/Objectives: Antibiotics are widely used in clinical practice, yet their potential effects on endocrine homeostasis remain insufficiently recognized. This review summarizes endocrine adverse effects associated with selected antibacterial agents, their proposed mechanisms, and clinical relevance. Methods: A narrative literature search was conducted in PubMed/MEDLINE, Scopus, and Web of Science from database inception to 10 August 2026. Clinical, pharmacovigilance, case-based, animal, in vitro, and ex vivo …

02.09.2026journal-article

Reproductive Medicine

The Role of Clomiphene Citrate in Gonadotropin Stimulation Protocols in Poor Responders: A Mini-Review of Recent Clinical Evidence

Maria Papadopoulou, Miltiadis Badagionis, Fotios Vlahos, Nikolaos Vlahos, Alexandros Lazaridis, George Mastorakos, Olga Triantafyllidou

Diminished ovarian reserve (DOR) and poor ovarian response (POR) remain among the most challenging conditions in assisted reproductive technology, and no optimal stimulation strategy has been established. Clomiphene citrate (CC), a selective estrogen receptor modulator that augments endogenous gonadotropin secretion and modulates the intraovarian androgenic milieu, has been proposed as an adjuvant to reduce exogenous gonadotropin requirements. This mini-review summarizes clinical evidence published between January …

02.09.2026journal-article

World Journal of Traditional Chinese Medicine

Combining Fecal Metabolomics and Gut Microbiome to Investigate the Anti-Depression Mechanism of Kai–Xin–San

Min-Jie Shi, Zong Hou, Zhong Zheng, Jun-Peng Xing, Hong-Shi Bu, Zhi-Qiang Liu, Yan Xu, Shu Liu

Abstract Objective: Kai–Xin–San (KXS) is a traditional Chinese medicine that has been used for thousands of years to treat depression. However, the underlying mechanisms and full range of effects of KXS on depression remain unclear. Materials and Methods: A growing body of evidence suggests that the gut microbiota may interact with the brain and contribute to the development of mental disorders, such as depression and anxiety. Therefore, in this study, we employed a combined microbiomics and metabolomics approach t …

02.09.2026journal-article

Annals of Plastic Surgery

Final Tongue Size in the Treatment of Macroglossia Associated With Beckwith-Wiedemann Syndrome

Renato da Silva Freitas, Lucas Guimarães Alves, Maitê Mateus, Isabella Correa de Oliveira, Marc Domit Werner Linnenkamp, Isis Juliane Guarezi Nasser, Eduardo Angeli-Freitas

Beckwith-Wiedemann syndrome (BWS) is a rare congenital disorder whose main clinical feature is macroglossia. This frequent manifestation may impair respiratory, feeding, speech, and orofacial developmental functions. When significant functional and/or aesthetic repercussions are evident, surgical excision is the primary management approach, with several techniques described. In this study, we analyzed medical records from 29 patients diagnosed with BWS and macroglossia, and evaluated 26 cases of partial glossectomy …

02.09.2026journal-article

American Journal of Medical Genetics Part A

The Evaluation of Molecular Genetics and Clinical Manifestations in Patients With LZTR1 ‐Associated Noonan Syndrome: A Retrospective Chart Review and Review of Literature

Hager Jaouadi, Şakir Hicazi, Carolyn R. Raski, Lindsey Aschbacher‐Smith, Ghada Hijazi, Amy E. Roberts, Carlos E. Prada, K. Nicole Weaver

ABSTRACT Pathogenic variants in LZTR1 are an established cause of Noonan syndrome (NS) and uniquely exhibit both autosomal dominant (AD) and autosomal recessive (AR) inheritance. However, the phenotypic spectrum and genotype–phenotype correlations remain incompletely defined. We conducted a multi‐center retrospective chart review of patients diagnosed with LZTR1 ‐NS evaluated at three tertiary care centers. Clinical, molecular, and imaging data were systematically collected. A comprehensive literature review (2015– …

02.09.2026journal-article

Current Oncology

Tumour GDF-15 Expression and Clinical Outcomes in Intermediate-Risk Metastatic Clear-Cell Renal Cell Carcinoma Treated with Second-Line Nivolumab

Orhun Akdogan, Betul Ogut, Osman Sutcuoglu, Melike Urganci, Burcu Ulas Kahya, Ipek Isik Gonul, Hatice Azra Begum Salimoglu, Tuba Ugur Tuzcu, Ozan Yazici, Ahmet Ozet, Nuriye Ozdemir

Background: Immune checkpoint inhibitors have improved outcomes in metastatic clear-cell renal cell carcinoma (mRCC), yet clinically applicable tissue biomarkers remain limited. Growth differentiation factor-15 (GDF-15) promotes tumour immune evasion and has emerged as a potential therapeutic target in immuno-oncology. We evaluated the prognostic significance of tumour GDF-15 expression in patients with intermediate-risk clear-cell mRCC treated with second-line nivolumab. Methods: Forty-six patients with intermedia …