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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

QJM: An International Journal of Medicine

Targeting the Nrf2-SLC7A11/GPX4 Pathway to Inhibit Ferroptosis: Mechanism of Yiqi Fumai Formula in Acute Decompensated Heart Failure

Lu Fan, Yunfeng Jia, Yanyang Li, Zhihan Yang, Yiming Zuo, Haomin Zhang, Xuezheng Liu, Shichao Lv

Abstract Objective To elucidate the mechanism of Yiqi Fumai Formula (YQFM) in acute decompensated heart failure (ADHF) via the Nrf2/SLC7A11/GPX4 pathway in regulating ferroptosis. Methods Network pharmacology was employed to predict the underlying mechanisms of YQFM in ADHF. Rat models of ADHF were established, incorporating agonists or inhibitors of key ferroptosis pathways. The therapeutic mechanism of Yiqifumai Formula was investigated by assessing cardiac structure/function, myocardial injury biomarkers, lipid …

02.09.2026journal-article

JAMA Surgery

An Exosomal Signature for Preoperative Detection of Occult Liver Metastasis in Pancreatic Cancer

Takayuki Noma, Jingyang Yin, Junfeng Zhang, Caiming Xu, Mitsuro Kanda, Song Cheol Kim, Yuji Morine, Mitsuo Shimada, Vincent Chung, Ali H. Zaidi, Daniel Von Hoff, Huaizhi Wang, Ajay Goel

Importance Early liver metastasis (early-LiM) after pancreatectomy represents an aggressive biological phenotype of pancreatic ductal adenocarcinoma (PDAC) and is associated with markedly poor survival. Reliable preoperative biomarkers to identify occult hepatic micrometastasis remain lacking. Objective To develop and externally validate a circulating exosomal microRNA (exo-miRNA)–based machine learning model for preoperative detection of occult early-LiM in PDAC. Design, Setting, and Participants This multicenter …

02.09.2026journal-article

Clinical Journal of the American Society of Nephrology

Effects and Safety of Henagliflozin on Cardiac Structure in Dialysis Patients with Heart Failure with Preserved Ejection Fraction

Hao Yan, Wei Wang, Wangshu Wu, Ying Li, Yinghui Qi, Yijun Zhou, Weiming Zhang, Shang Liu, Huihua Pang, Yan Fang, Zhenyuan Li, Zhiqing Qiao, Renhua Lu, Meng Jiang, Wei Fang, Jun Pu, Leyi Gu, on behalf of the HELD-HF study investigators

Background Few effective drug treatments exist for dialysis patients with heart failure with preserved ejection fraction (HFpEF). This study aimed to evaluate the effects of henagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on cardiac structure, and its safety in such population. Methods In this multicenter, randomized, double-blind, placebo-controlled trial, dialysis patients with HFpEF were randomly assigned (1:1) to receive henagliflozin or placebo for 24 weeks. All enrolled participants receive …

02.09.2026journal-article

European Spine Journal

Large language models in the vertical integration of spine surgery workflow: a scoping review

Edwin H. Y. Lui, Ralph J. Mobbs

Abstract Purpose To evaluate current evidence regarding the clinical reliability and reasoning capabilities of Large Language Models (LLMs) and Multimodal Large Language Models (MLLMs) within the spine surgery workflow. This scoping review utilizes a novel Vertical Integration Maturity Scale (VIMS) to map model maturity across five stages of the vertical workflow, identifying persistent research gaps and technical prerequisites for clinical implementation. Methods A systematic search was conducted across PubMed, Em …

02.09.2026journal-article

Journal of Paediatrics and Child Health

Physiological and Cardiac Effects of Weight Loss in Adolescents With Atypical Anorexia Nervosa Versus Those Undergoing Bariatric Surgery: A Retrospective Comparative Study

Tomer Mevorach, Amit Goldstein, Orly Lavan, Shelly Shteinling, Adi Sela, Silvana Fennig

ABSTRACT Objective Adolescents with atypical anorexia nervosa (AAN) experience cardiac complications at rates comparable to typical anorexia nervosa, despite remaining within or above a normal weight range. The physiological mechanisms underlying this paradox remain poorly understood. This study is the first to compare cardiac outcomes between adolescents with AAN and those who underwent bariatric surgery, a population experiencing similarly rapid and substantial weight loss within a medically supervised context. M …

02.09.2026journal-article

AEM Education and Training

The Airway Dashboard: Harnessing Informatics for Targeted Assessment and Improvement of Airway Performance for Emergency Medicine Residents and Faculty

Christian R. W. Gerhart, Robbie Paulsen, William E. Freeman, Sam Ellsworth, Abby Orr, Aaron J. Lacy

ABSTRACT Background Airway management is a core competency for emergency medicine faculty and residents. Objective evaluation of procedural performance is crucial for assessment of competency and to guide further educational efforts. Here, we describe a dashboard capable of providing personalized, granular data specifically for airway management performance using the electronic medical record (EMR) to create a continuously updated database. Objective of Innovation The objective of this innovation was to utilize dat …

02.09.2026journal-article

British Journal of Midwifery

Patient safety culture in hospital maternity care: an integrative review of midwives and nurses

Nor Amal Hazirah Hassan, Damia Hazimah Asnawi, Amal Amirah Asri, Hanif Abdul Rahman, Khadizah H Abdul-Mumin

Background/Aims Safety is a central element of maternity care. Despite global efforts to reduce maternal harm, preventable adverse events can still take place at hospital maternity services. This integrative review consolidates research on midwives' and maternity nurses' perceptions of patient safety culture, identifying key practices, barriers and facilitators in hospital maternity care. Methods PubMed, Scopus, ProQuest and Google Scholar were searched for studies published between 2014 and 2024 that explored heal …

02.09.2026journal-article

Frontiers in Medicine

Co-occurrence of GATA2 deficiency and probable constitutional mosaic STAG2 alteration in a young adult with myelodysplastic syndrome: a case report

Onda-Tabita Calugaru, Daniel Coriu, Cerasela Jardan, Claudia Tarniceriu, Daniela Cristina Anghel, Iulia Ursuleac

Germline predisposition syndromes are increasingly recognized in young patients presenting with myelodysplastic syndromes (MDS) and bone marrow failure. Among these, GATA2 deficiency represents a well-established cause of hereditary susceptibility to myeloid malignancies, whereas constitutional STAG2 alterations are rare and mainly associated with cohesinopathies and neurodevelopmental disorders. We report the case of a 25-year-old male presenting with hypocellular MDS, recurrent severe infections, lymphedema, cyto …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

STABILIZATION OF MULTIPHASE HYDROCARBON FLOW IN OIL AND GAS GATHERING PIPELINES IN FIELDS WITH COMPLEX TOPOGRAPHY

E.F. Khamatdinov, G.E. Korobkov

Integrated oil and gas gathering and transportation systems have become widely used in the development of remote fields. These areas are often characterized by significant logistical and infrastructural constraints. When organizing joint collection of oil and gas via field gathering pipelines at oil and gas, as well as oil and gas condensate fields, certain factors may arise that adversely affect the stable transportation of multiphase hydrocarbon flows to wellstream treatment facilities.This creates tasks whose so …

02.09.2026journal-article

Archives of Orthopaedic and Trauma Surgery

Platform-specific learning curve and early tibial radiographic agreement of ROSA®-assisted medial unicompartmental knee arthroplasty in an experienced high-volume surgeon: a consecutive case series

Stefano Petrillo, Damiano Ardiri, Matteo Marullo, Sergio Romagnoli

Abstract Purpose To evaluate the platform-specific learning curve and early tibial radiographic agreement of imageless ROSA ® -assisted medial unicompartmental knee arthroplasty (UKA), with short-term clinical findings assessed exploratorily. Methods This retrospective consecutive case series included 30 patients who underwent ROSA ® -assisted medial UKA with the Persona ® Partial Knee implant between January and April 2026 at a high-volume arthroplasty referral centre. A continuous learning-curve cumulative summat …

02.09.2026journal-article

Clinical and Translational Gastroenterology

Impact of hepatitis C viremia on overall survival and hepatic decompensation among patients with unresectable HCC receiving immunotherapy

Eunice Y. Lee, Willis Tang, Jennifer C. Price, Robin K. Kelley, John D. Gordan, Jennifer C. Lai, Lawrence Fong, Neil Mehta, Michael Li

Introduction: Hepatitis C (HCV) is associated with an immunosuppressive liver microenvironment, but whether HCV affects immune checkpoint inhibitor (ICI) outcomes in unresectable hepatocellular carcinoma (HCC) remains unknown. Methods: We performed a single-center retrospective cohort study of patients with unresectable HCC treated with ICIs. In patients with a history of HCV, viremia was defined as a detectable viral load prior to immunotherapy. The primary outcome was overall survival (OS); secondary outcomes wer …

02.09.2026journal-article

Journal of Craniofacial Surgery

Free Fibula Flap With Chimeric Skin Paddles: Technical Tips and Clinical Experience

Ersin Gur, Batuhan Sencan, Ahmet Bicer, Yigit Ozer Tiftikcioglu, Zeyyat Cuneyt Ozek

Introduction: Advanced tumors and trauma may cause composite oromandibular defects involving the mandible, intraoral mucosa, and skin. Although these defects involve multiple components, they can be reconstructed simultaneously with a single flap. The free fibula flap with chimeric skin paddles provides single-stage, appropriate three-dimensional reconstruction of challenging composite defects of the oromandibular region. The authors present our experience with free fibula flaps with chimeric skin paddles for compo …

02.09.2026journal-article

Journal of Electronic Materials

HTL-Free Perovskite Solar Cells with a Carbon Electrode and Enhanced Stability, Through a Scalable Polymer Treatment Method

Maria Bidikoudi, Christina Tiflidis, Elias Stathatos

Abstract Perovskite solar cells with a carbon electrode (C-PSCs) are considered the most promising and viable structure for the upscaling and future commercialization of PSCs. With the ability to be fabricated with industrially compatible methods and with no need for employing hole transport materials, C-PSCs are not randomly moving to the forefront of PSC research at the moment. In this work, hole transport material (HTM)-free C-PSCs have been fabricated under entirely ambient conditions. The devices employ an add …

02.09.2026journal-article

Iranian Journal of Allergy, Asthma and Immunology

Clinical Characteristics, Diagnostic Challenges, and Therapeutic Outcomes in Non-eosinophilic Esophagitis Eosinophilic Gastrointestinal Diseases in Comparison with Eosinophilic Esophagitis

Azizollah Yousefi, Saeed Sepehry Vafa, Mina Mirzad, Fatemeh Elham Mahjoub, Behnam Shahsavand, Ebrahim Babaee, Fereshteh Karbasian, Mohammad Nabavi, Mohammad Hasan Bemanian, Sima Shokri, Saba Arshi, Morteza Fallahpour

Eosinophilic gastrointestinal diseases (EGIDs) are chronic, TH2-mediated conditions. Eosinophilic esophagitis (EoE) is the most common type, while non-EoE EGIDs affect other gut segments. This retrospective study of 111 patients (50 EoE and 61 non-EoE) from 2011 to 2022 compared the clinical aspects of these 2 types. Dysphagia and food impaction dominated in EoE, while abdominal pain, nausea, and diarrhea were more common in non-EoE EGIDs. Atopic comorbidities were frequent. Diagnostic delays>1 year were more commo …

02.09.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Both Radiofrequency Microtenotomy and Physical Therapy Provide Significant Improvements in Patients With Chronic Midportion Achilles Tendinopathy at a Minimum 5‐Year Follow‐Up

Hayat Jirde Ali, Khaled Meknas, Jüri‐Toomas Kartus, Dana Meknas

Purpose To evaluate a minimum 5‐year follow‐up of patients who were treated with either bipolar radiofrequency microtenotomy (RFM) or physical therapy (PT) for midportion Achilles tendinopathy between 2016 and 2018. Methods All subjects who participated in a previous randomized controlled trial (n = 38) between 2016 and 2018 were invited to fill out a questionnaire between January and July 2025 to evaluate the outcomes at a minimum of 5‐year follow‐up. Patients who had undergone further surgical treatment were excl …

02.09.2026journal-article

Water Science & Technology

Antimicrobial resistance control in wastewater treatment plants: from removal efficiency to resistance-risk reduction

Timoth Mkilima

ABSTRACT Flow diagram showing AMR-related constituents moving from municipal, hospital-influenced, and industrial or pha rmaceutical wastewater through primary treatment, biological treatment, solids separation, and disinfection or advanced polishi ng. Outputs include treated effluent, reclaimed water, sludge or biosolids, and residual streams. These connect to receiving wat ers, irrigation or reuse, land application or further handling, and return-to-treatment or separate management pathways. Resista nce-risk endp …

02.09.2026journal-article

CRO (Clinical & Refractive Optometry) Journal

Teprotumumab Treatment for Thyroid Eye Disease in a Patient with Pre-Existing Hearing Loss: Worth the Risk?

Wyatt Hyke, Cheryl Polinsky, Lisa Schifanella

Thyroid eye disease (TED) can lead to reduced vision from corneal scarring or optic nerve compression. Other manifestations of thyroid eye disease that can be troubling for TED patients include proptosis, extraocular muscle restrictions and diplopia, soft tissue swelling, dry eye, and conjunctival injection over the extraocular muscle insertions. Intravenous teprotumumab was approved by the Food and Drug Administration (FDA) in 2020 for the treatment of active TED. Teprotumumab can cause potentially permanent sever …

02.09.2026journal-article

BMC Nephrology

Comment - Louis XIV’s terminal illness clinical chronology favors necrotizing soft-tissue infection

Alexis Demas

Abstract Louis XIV’s rapidly progressive terminal illness may be better explained by necrotizing soft-tissue infection than primary calciphylaxis. Severe distal pain, ascending gangrene, and fatal sepsis within three weeks suggest fulminant infection, plausibly arising from a diabetic foot lesion. Clinical chronology should remain central when evaluating competing retrospective clinicopathological hypotheses.

02.09.2026journal-article

Journal of Orthopaedic & Sports Physical Therapy

Can Clinicians Predict Which Patients Respond Best to a Specific Treatment? A Systematic Review of Low Back Pain Moderators in Primary Care

Tayla Douglas, Hazel Jenkins, Leticia Correa, Leandro Nogueira, Annika Young, Mark Hancock

OBJECTIVE: To synthesise and critically evaluate evidence on treatment effect moderators in the primary care management of low back pain (LBP). DESIGN: Systematic review of randomised controlled trials (RCTs) and secondary analyses of RCTs. LITERATURE SEARCH: Medline, EMBASE, CINAHL and Cochrane Library were searched from inception to August 2025. STUDY SELECTION CRITERIA: RCTs investigating moderators for primary care interventions in non-specific LBP. DATA SYNTHESIS: Data were synthesised by exploring data cluste …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Extrapulmonary Paragonimiasis Diagnosed by Molecular Tools

Da Young Kim, Jun-Won Seo, Na-Ra Yun, Dahae Kwak, Choon-Mee Kim, Dong-Min Kim

ABSTRACT. Paragonimiasis is a parasitic disease that involves the lungs but can manifest in extrapulmonary sites, including the peritoneum or subcutaneous tissue. Diagnosis is limited by nonspecific clinical manifestations and overlapping features with other diseases, such as tuberculosis (TB). A 55-year-old Korean male presented with acute abdominal pain and a recurrent subcutaneous mass in the left thigh. Although TB peritonitis was initially suspected, further diagnostic tests were performed. To confirm the diag …

02.09.2026journal-article

Prävention und Gesundheitsförderung

KI-gestützte Dokumentation und Wissensvermittlung in der klinischen Pflege

Alexander Pauls, Fenja Tjalda Hesselmann, Christine Scheve, Frank Wallhoff, Frauke Koppelin

Zusammenfassung Hintergrund Digitale und KI-gestützte (künstliche Intelligenz) Technologien besitzen das Potenzial, Arbeitsprozesse in der klinischen Pflegepraxis zu entlasten und beim Kompetenzerwerb zu unterstützen. Gerade der Dokumentationsaufwand wird von Pflegefachpersonen (PFP) als zeitintensiv gesehen und ist Gegenstand vieler Entwicklungen in Forschung und Praxis. Im Projekt Data-Driven-Health (DEAL) wurde daher untersucht, wie PFP ein KI-gestütztes Dokumentations- und Informationssystem in einer praxisnahe …

02.09.2026journal-article

Biomedical Physics & Engineering Express

A deformable lead-attention fusion network for multi-label ECG classification integrating clinical metadata

Enjun Zhou, Xiangyong Kong, Hao Wang, Chenrui Bai

Abstract Cardiovascular diseases remain a major global health burden, making accurate electrocardiogram (ECG) analysis essential for timely diagnosis. While deep learning-based methods have made significant progress in automating ECG classification, they are often limited by the variability of ECG signals, the frequent presence of multiple cardiac abnormalities, and the inadequate integration of diverse clinical data. This study proposes Deformable Lead-Path and Multi-Modal Fusion Network (DLM-Net): a robust deep l …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

STUDY OF GROUTING COMPOSITION FOR RESTORING THE TIGHTNESS OF THE PRODUCTION WELL CASING AND ELIMINATING WATER INFLUX

G.S. Dubinsky, V.G. Mukhametshin

This article presents the results of a study of a composite fast-hardening cement slurry based on urea-formaldehyde synthetic resin, designed for effective waterproofing and repair and insulation work. Unlike similar products, this fast-hardening cement slurry effectively cures over a wide temperature range from 20°C to 100°C. The curing time and rate of the analyzed cement slurry are regulated by the hardener concentration and type over a wide time frame, from several tens of minutes to 5-8 hours. The flexural str …