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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Allergy

Clinical phenotypes, endotypes, and biomarker profiles of immediate rituximab hypersensitivity reactions: a prospective pharmacovigilance study

Narapong Yotinnoratham, Wannada Laisuan, Kumutnart Chanprapaph, Silada Kanokrungsee, Chavachol Setthaudom, Supornchai Onpun, Pungjai Mongkolpathumrat, Supranee Buranapraditkun, Apinya Chungcharoenpanich, Nichapha Dechapaphapitak, Supa Oncham, Nattakirana Tongdee, Sananya Khamkaew, Ratchaya Lertnawapan, Jettanong Klaewsongkram

Background Rituximab (RTX) has been associated with immediate hypersensitivity reactions (HSRs) involving multiple phenotypes and endotypes. Objective To characterize the clinical phenotypes and endotypes of immediate RTX HSRs. Methods A prospective study was conducted as part of a pharmacovigilance program from July 2020 to December 2021. Participants who experienced immediate RTX HSRs were enrolled. Skin testing, basophil activation testing (BAT), IFN- γ ELISpot assays, and IgG anti-drug antibody (ADA) ELISA assa …

03.09.2026journal-article

Frontiers in Medicine

Ab interno trabeculotomy with vs. without cataract surgery for POAG: a retrospective study

Lei Zhang, Junjie Bian

Purpose To compare the 12-month efficacy and safety of ab interno trabeculotomy combined with phacoemulsification vs. ab interno trabeculotomy alone in patients with primary open-angle glaucoma(POAG). Methods A retrospective analysis was performed on clinical data from patients diagnosed with POAG between January 2021 and January 2025 who underwent either combined surgery (combined group, 39 cases)or ab interno trabeculotomy alone (ab interno trabeculotomy-only group,44 cases). The primary outcome measures were pos …

03.09.2026journal-article

Pediatric Blood & Cancer

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich

ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA protocol for vessel thrombosis and mechanical valve obstruction in infants and children, and to characterize D‐dimer kinetics by indication. Methods This retrospecti …

03.09.2026journal-article

Journal of Developmental Biology

Diaphragmatic Mitochondrial Myopathy in a Patient-Derived Mouse Model of Barth Syndrome

Kristen Tentler, Paige L. Snider, Catalina Matias, Jeffrey J. Brault, Simon J. Conway

Barth syndrome (BTHS) is a rare, X-linked genetic disorder caused by mutations in the enzyme TAFAZZIN (TAZ), resulting in insufficient cardiolipin (CL) remodeling and mitochondrial dysfunction. While BTHS respiratory distress and breathing difficulties are commonly reported, the precise role of intrinsic respiratory tissue vulnerabilities has only recently begun to be appreciated. Historically, BTHS respiratory distress is frequently attributed to secondary consequences like cardiomyopathy or generalized skeletal m …

03.09.2026journal-article

IPS Journal of Basic and Clinical Medicine

Kidney Function Responses to Ethanol Extracts of Chia Seed (Salvia hispanica L.) and Tiger Nut (Cyperus esculentus L.) in Alloxan-Induced Diabetic Rats

Chinyere S. Nwaka, Andrew C. Nwaka

Diabetic nephropathy is a common and progressive complication of poorly controlled diabetes mellitus, and there is growing interest in plant-derived agents that can slow or reverse this damage. This study evaluated the effect of ethanol extracts of chia seed (Salvia hispanica), tiger nut (Cyperus esculentus), and their combination on kidney function parameters in alloxan-induced diabetic rats. Sixty-three male Wistar rats were assigned to nine groups (n = 7): normal control (A), diabetic untreated (B), diabetic rat …

03.09.2026journal-article

Revista Portuguesa de Doenças Infecciosas (RPDI)

Protocolo de utilização de soluções de bloqueio com antibiótico em cateter venoso central

Luisa Graça, Betânia Abreu Faria, Joana Laranjinha, Charlene Viana, Catarina Silva, Marcelo Costa, Sandra Teixeira, Susana Ribeiro, Diana Gaspar, Joana Alves, Ana Cláudia Carvalho

Introdução: Perante uma infeção associada a cateter venoso central, a remoção do cateter é a opção privilegiada para o controlo do foco. Quando tal não é possível, o uso de soluções de bloqueio de altas concentrações de antibiótico (ou lock) associa-se a uma melhor resposta do que a antibioterapia sistémica isoladamente. A eficácia desta técnica está dependente do agente de infeção e das soluções utilizadas. Objetivos: Uniformizar a prescrição e aplicação da solução de bloqueio com antibiótico e, assim, maximizar a …

03.09.2026journal-article

Journal of Pure and Applied Microbiology

Evaluating the Diagnostic Accuracy of Serological Tests for Brucellosis in Clinical Specimens

Hiba Sami, Kashish Noor, Parvez A. Khan, Lubna Zafar, Aamir Bin Sabir, Latif Zafar Jilani, S. Zeeshan Ahmad Hashmi, Haleema Ahmad, Adil Raza, Nazish Fatima

Brucellosis, a prevalent zoonotic disease in India, causes nonspecific symptoms. Humans contract it via infected animals or by consuming unpasteurized dairy products. This study evaluates the effectiveness of ELISA, Rose Bengal Plate Test (RBPT), and SAT in diagnosing brucellosis from clinical samples. A prospective study was conducted involving 218 patients with unknown fever, arthritis, and neurological symptoms. A detailed history was collected using a pre-designed questionnaire. This study aims to evaluate the …

03.09.2026journal-article

Nursing Education Perspectives

Monitoring Nursing Students’ Stress Levels During High-Fidelity Simulation Using an Electronic Wristband Device

Ayse Akalin, Dennis Demedts, Florence D’haenens, Maaike Fobelets, Joeri Vermeulen, Sandra Tricas-Sauras

Simulation can effectively enhance the clinical reasoning skills of nursing students. However, it can also lead to increased stress levels with a potential impact on learning outcomes. We monitored nursing students’ stress using the E4 © wristband and evaluated the effects of a brief debriefing intervention on stress and overall satisfaction during simulation. Using a randomized controlled study design, we collected quantitative data and real-time stress measurements. Tailored debriefing interventions have the pote …

03.09.2026journal-article

American Journal of Audiology

Survey of Audiologists' Clinical Practice Patterns and Perceptions of Electrophysiological Assessments

Kelsey Mankel, Caitlin N. Price, Allie Austin, Mira Milman

Purpose: Electrophysiological assessments in audiology are used for neurodiagnostic evaluations, newborn hearing screenings, and estimating auditory thresholds when behavioral responses are unobtainable or unreliable. Nonetheless, evidence suggests that many electrophysiological tools remain underutilized. This study examined current practice patterns, perceptions, and barriers related to electrophysiological testing among audiologists in the United States. Method: An online survey distributed between January and A …

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03.09.2026journal-article

Greenation Computer and Information Review

Analysis of the Security of Off-Site Medical Record Storage in Relation to Patient Information Confidentiality at Hospital X

Ujang Rahmat, Yayang Ayu Nuraeni

This study employed a qualitative descriptive design to examine how the security of off-site medical record storage protects patient information confidentiality, particularly when records are stored outside the hospital because of limited filing-space capacity. Three informants were purposively selected: the Head of the Medical Records Unit, a Medical Records Filing Officer, and a Medical Records Archiving Officer. Data were collected through observation, interviews, and documentation. Data analysis followed the Mi …

03.09.2026journal-article

JAMA Oncology

Bicistronic CD19/CD22 CAR T-Cell Therapy in Pediatric B-Cell Acute Lymphoblastic Leukemia

Xinyu Wan, Yanjing Tang, Jiaoyang Cai, Lili Song, Tianyi Wang, Wenjie Li, Liu Yang, Xiang Wang, Chengjuan Luo, Hua Zhu, Kang An, Meng Su, Jing Zhang, Jing Yang, Wenhua Shi, Chengming Fei, Weidong Shen, Rujun Jia, Xiaomin Yang, Junqian Tang, Junxian Wu, Jiakang Gu, Jiayi Mo, Jun Huang, Yue Li, Geyao Zhou, Lixia Ding, Jianwei Liang, Jun Wang, Zichao Zhou, Xiaodong Wang, Qing Cao, Jian Zhang, Hong Ren, Juan Qian, Peifang Xiao, Hailong He, Hui Jiang, Shaoyan Hu, Ningling Wang

Importance CD19-directed chimeric antigen receptor (CAR) T-cell therapy induces high remission rates in relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL), but relapse, which is often due to antigen loss, remains a major challenge. Dual-targeting CD19/CD22 CAR T-cell strategies may be associated with reduced antigen-negative relapse and improved remission durability. Objective To evaluate the safety and efficacy of bicistronic CD19/CD22 CAR T-cell therapy in pediatric patients with relapsed or refra …

03.09.2026journal-article

Acupuncture & Electro-Therapeutics Research: International Journal of Integrated Medicine

Development of a Nomogram Prediction Model for Activities of Daily Living Improvement After Acupuncture Combined With Physiotherapy and Occupational Therapy in Patients With Ischaemic Stroke

Fang Li, Longlong Su, Peng Zhang

Objective To develop a nomogram for predicting ADL improvement among patients with ischaemic stroke receiving acupuncture combined with physiotherapy (PT) and occupational therapy (OT) and to identify independent predictors of poor ADL improvement. Methods A total of 253 patients with ischaemic stroke were retrospectively included, comprising a development cohort of 190 patients admitted between April 2024 and April 2026 and an earlier, nonoverlapping temporal validation cohort of 63 patients admitted between Decem …

03.09.2026journal-article

Dementia

Social Interactions Between People Living With Dementia and Staff in Health and Social Care Settings: A Scoping Review

Stephanie Janka-Spurlock, Georgia Page, Gary Hodge, Helen Lloyd, Susie Pearce

Dementia is an umbrella term for progressive conditions affecting memory, thinking, communication and other cognitive functions. These changes can make social interaction challenging, particularly in unfamiliar or overstimulating environments . Although social interactions between staff and people living with dementia are recognised as an aspect of care, existing literature across health and social care settings largely focuses on general care needs and experiences rather than social interaction specifically. Conse …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Effect of Health Education Intervention on Knowledge of Environmental Waste Management Among Residents of Bauchi State, Nigeria

Mohammed Inuwa

The study assessed the knowledge of environmental waste management among residents of Bauchi State, Nigeria. To achieve the two objectives ware identified to guide the paper The knowledge of environmental waste management among residents of Bauchi State, Nigeria before and after Health Education Intervention and attitude towards waste management among residents of Bauchi State, Nigeria before and after Health Education Intervention and in line with the research questions what are the knowledge of waste management a …

03.09.2026journal-article

Healthcare

Depressive Symptoms After Mechanical Thrombectomy in Ischaemic Stroke: A Longitudinal Descriptive Study with Gender Differences

Sara Ramírez Rozas, Maria Lara Martínez-Gimeno, Laura Carrasco San Andres, Francisco Gómez-Esquer, Jesús Esteban-Hernández, María-Gema Cid-Expósito

Introduction: Stroke accounts for one-third of global mortality each year; in Spain, it is the second leading cause of death. One of the most commonly reported complications is post-stroke depression, which affects up to 30% of patients who suffer a stroke. When an ischaemic stroke occurs, the treatment of choice is mechanical thrombectomy; this is an endovascular procedure whereby the thrombus causing the ischemia is removed, thereby reducing sequelae, in most cases, which is why it is of interest to examine its i …

03.09.2026journal-article

Acta Scientiae Veterinariae

Presumptive Post-Chemotherapy Polyarthritis in a Maltese Dog: Clinical Characteristics and Outcome

Jiyoon Jung, Chanjoong Lee, Kiyeon Son, Joonghyun Song

Background: Post-chemotherapy polyarthritis is a recognized chemotherapy-related complication in human oncology but has not been clearly documented in dogs. Non-septic arthritis has been mentioned only once as an adverse effect of chemotherapy in dogs without detailed clinical features. In human medicine, post-chemotherapy polyarthritis has been reported across multiple chemotherapy protocols including doxorubicin. This report describes the 1st presumptive case of doxorubicin-associated non-septic inflammatory poly …

03.09.2026journal-article

Cosmetics

Effect of Topical HealFast Silver Ointment on Pain and Early Wound-Healing Parameters After Caesarean Section: A Randomized Placebo-Controlled Clinical Trial

Wafaa Uthman Ahmed, Bafreen hawez Hamadameen, Dastan Abdullah Salih, Shukur Wasman Smail, Abubakr Mohammed Amin, Mohammed Awat Ali

Background: Caesarean section is associated with postoperative pain and wound-related morbidity. Topical agents that promote early wound healing may enhance postoperative recovery. This randomized, placebo-controlled clinical trial evaluated the effect of HealFast Silver Ointment on pain and early wound-healing parameters after Caesarean section. Methods: Two hundred women who underwent Caesarean section were randomly allocated into two groups: a placebo group and a HealFast Silver Ointment group, each consisting o …

03.09.2026journal-article

Brazilian Journal of Implantology and Health Sciences

ASSOCIAÇÃO DA TIRZEPATIDA NA CONSOLIDAÇÃO DE FRATURAS: UM ESTUDO ORTOPÉDICO

Thiago Henrique Queiroz de Oliveira, Lucas Zampronha Correia, Matheus Moreno de Oliveira, Edvard José dos Santos Neto, Edinson Enrique Castillo Lobo Pregrado, Mateus Souza e Silva, Ana Julia De Luiz Comis, Juliana Fernandes Areal Carrizo, Tiago Nascimento Bispo

A consolidação óssea constitui um processo biológico complexo, dependente da interação entre células osteogênicas, mediadores inflamatórios, vascularização e metabolismo sistêmico. Nesse contexto, medicamentos que atuam sobre vias metabólicas relacionadas ao tecido ósseo têm despertado interesse na ortopedia. A tirzepatida, agonista dual dos receptores do peptídeo semelhante ao glucagon-1 (GLP-1) e do polipeptídeo insulinotrópico dependente de glicose (GIP), apresenta efeitos metabólicos relevantes, incluindo melho …

03.09.2026journal-article

Public International and Private International Law

The Impact of Del Credere on Financial Stability in International Trade: Legal Regulation and Application Practice

Vladimir V. Kruglov

The article examines the del credere institution in the context of its impact on the financial stability of international trade entities. The research focuses on current Russian legislation, current judicial practice, and international trade standards. The article provides a comparative analysis of normative, doctrinal, and authorial definitions of del credere, highlighting the controversial nature of this institution. A special focus is placed on the analysis of del credere's functions in the context of current sa …

03.09.2026journal-article

Public International and Private International Law

A Comparative Legal Analysis of the Regulation of Digital Financial Assets in Various Jurisdictions

Mekhriban E. Gulieva

In the era of digitalization and the widespread adoption of digital instruments, such as digital assets and payment instruments, monitoring compliance with national legislation by relevant executive authorities is particularly important. Competent and consistent application of procedural principles of control and supervision by relevant governmental bodies is essential for achieving a balance in relations between governmental bodies and society, as well as business members, while reducing excessive pressure on busi …

03.09.2026journal-article

Sports Medicine - Open

Reliability, Device Agreement and Validity of Load–Velocity Profiles: A Systematic Review with Meta-analysis

Nina Claassen, Stanislav Dimitri Siegel, Mareike Sproll, Niklas Lebelt, Alyssa Virginia Bargende, Anne Marieke Fasold, Konstantin Warneke

Abstract Background For a valid one-repetition maximum (1RM) prediction via load–velocity (LV) relationships, high reliability and accuracy must be assumed. Objective Since individual study results indicate ambivalent prediction, this systematic review and meta-analysis was designed to provide a updated and comprehensive overview, extending knowledge about the validity and reliability of commercially available velocity sensors in Part I and the validity and reliability of velocity-based 1RM prediction models in Par …

03.09.2026journal-article

Healthcare

Organization and Quality of Emergency Thoracic Surgical Care in Multidisciplinary Hospitals of Almaty, Kazakhstan: A Multicomponent Study Combining Hospital Data, Patient-Reported Experience, and Healthcare Professional Perspectives

Sultan Zhanbyrbaev, Maksut Kulzhanov, Aueskhan Dzhumabekov, Alfiya Igissenova, Gulstan Esetova, Nadira Aitambayeva, Gulbanu Berdiyarova, Nazerke Narymbayeva, Aigul Tazhiyeva

Background: Emergency thoracic conditions remain an important cause of hospitalization, emergency surgery, and mortality, requiring well-organized multidisciplinary thoracic surgical services. Objectives: To comprehensively evaluate the organization of emergency thoracic surgical care in multidisciplinary hospitals in Almaty using retrospective hospital data together with patient and healthcare professional-reported assessments. Methods: A multicomponent study was conducted comprising three complementary components …

03.09.2026journal-article

Occupational Medicine

Non-pharmacological intervention for shift nurses’ sleep: systematic review and meta-analysis

A Y L Lee, L A Tse

Abstract Background Nurses working rotating shifts often experience poor sleep quality due to circadian rhythm disruption. Previous reviews primarily focused on managerial changes to improve nurses’ alertness during night shifts. Although some studies found that individual-level non-pharmacological interventions may significantly alleviate sleep problems, past reviews focused only on aromatherapy. Aims To understand current trends and synthesise the effectiveness of non-pharmacological interventions for improving s …

03.09.2026journal-article

Uludağ Üniversitesi Tıp Fakültesi Dergisi

Retrospective Evaluation of Demographic and Clinical Features of Gastrointestinal Stromal Tumors

Nihal Yücel Çamcı, Nesrin Uğraş, Adem Deligönül, Özkan Kanat

This study aimed to retrospectively examine the demographic, clinical, and pathological characteristics; prognostic risk factors; treatments administered; clinical course; and survival times of patients diagnosed with gastrointestinal stromal tumors (GIST) and treated and followed up at Department of Medical Oncology at the Bursa Uludağ University Faculty of Medicine in Bursa. Medical records of 54 patients diagnosed with GIST between 2002 and 2017 were reviewed retrospectively through the hospital record system. T …