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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Science Translational Medicine

Tissue origins and immune correlates of viral rebound in SIV-infected rhesus macaques after ART discontinuation

Irena V. King, Malika Aid, Emek Kose, Taina T. Immonen, Charles A. Goodman, Christine M. Fennessey, Alessandro Colarusso, Victoria E. K. Walker-Sperling, Erica N. Borducchi, Romas Geleziunas, William J. Rinaldi, Melissa J. Ferguson, Louis J. Picker, Jeffrey D. Lifson, Brandon F. Keele, Dan H. Barouch

Most persons living with HIV-1 who discontinue antiretroviral therapy (ART) demonstrate viral rebound, but the tissue-level events that lead to rebound viremia remain poorly understood. Here, we report the origin, dynamics, and correlates of viral rebound in 16 rhesus macaques (RMs) infected with molecularly barcoded SIVmac239M, treated with ART for 70 weeks, and necropsied on day 12 after ART discontinuation. Barcode analysis of plasma during daily post-ART sampling identified 1 to 38 rebounding viral lineages per …

02.09.2026journal-article

Aesthetic Surgery Journal

A Modified Delphi Study on the Ethics and Governance of Live Injecting at Aesthetic Conferences. Is There a Better and Safer Alternative?

Greg J Goodman, Mark R Magnusson, Eqram Rahman, Sarah G Boxley, Narendra Kumar, Andrew Clark, Hema A Sundaram, Frank Lin, Michael Clague, Niamh Corduff, Sarah Hart, Peter Callan, Stefania Roberts, Cara B McDonald, Alice Rudd, Katy Wallace, Antoinette Ciconte, Anita Patel, Sean Arendse, Aakriti Gupta, Terence Poon, Catherine E Porter, Philip Bekhor, Lee-Mei Yap, Firas Al-Niaimi, Adrian Lim, Howard M Studniberg, Maeve A Ahern, Angelo Tsirbas, Richard Webb William, Zallmann Michaela, Somia Naveen

Abstract Background Live clinical demonstrations at aesthetic medicine conferences is common, yet concerns regarding patient safety, commercial influence, and ethical governance. This study established a consensus-based governance framework for live injecting and compared expert and attendee perspectives. Methods A two-stage modified Delphi process involved an international expert panel (n=31) alongside a cross-sectional attendee survey of conference (n=218). Round 1 included 46 statements addressing clinical safet …

02.09.2026journal-article

Journal of Genetic Counseling

Unacknowledged Burdens and Clinical Assets of BIPOC Genetic Counseling Students: Qualitative Evidence to Inform Supervision

Yeabsira Tufa, Kimberly Zayhowski, Joselyn Saenz Diaz, Nikkola Carmichael

ABSTRACT As the genetic counseling profession works to diversify its predominantly white workforce, understanding the experiences of Black, Indigenous, and People of Color (BIPOC) students is central to equity efforts. While BIPOC students bring invaluable cultural and linguistic diversity that improves patient care, they often navigate clinical training environments that lack diversity and psychological safety. This article draws on data from a longitudinal constructivist qualitative study to examine how racial an …

02.09.2026journal-article

Operative Neurosurgery

Representation and Educational Content of Spine Surgery in Operative Videos: A 10-Year Journal-Based Analysis

Daniel Faraj, William Rabon, H. Forbes Fowler, Chad J. Urquhart, Zoe Robinow, Michael A. Galgano

BACKGROUND AND OBJECTIVES: Video-driven education offers a powerful tool for illustrating intricate techniques and critical anatomic insights for surgical residents. Surgical procedures of the spine require a wide field of view, making their capture difficult. The objective of this study is to quantify the representation and educational content of published spine videos in peer-reviewed journals. METHODS: From 2015 to 2026, 1581 videos were identified across 4 peer-reviewed journals that routinely publish spine sur …

02.09.2026journal-article

Science Translational Medicine

Elevated translocator protein in skull bone marrow is linked to human chronic pain

Mehrbod Mohammadian, Nikos Efthimiou, Katherin Gabriel, Ludovica Brusaferri, Joya Cooper-Hohn, Minhae Kim, Jennifer P. Murphy, Zeynab Alshelh, Grace Grmek, Jack H. Schnieders, Courtney A. Chane, Thomas G. Carmichael, Danika Yang, Julia J. Schubert, Federico E. Turkheimer, Rafael A. Cazuza, Peter M. Grace, Ciprian Catana, Steven M. Stufflebeam, Robert R. Edwards, Vitaly Napadow, Kimberly Sullivan, Matthias Nahrendorf, Theodore J. Price, Jodi M. Gilman, Marco L. Loggia

The skull bone marrow (SBM) is emerging as a critical hub for neuroimmune signaling, yet its role in chronic pain is unknown. Using integrated positron emission tomography/magnetic resonance imaging, here, we show that the levels of 18-kilodalton translocator protein (TSPO), a putative marker of immune cell density, are elevated in the SBM of individuals with chronic pain [ n = 125; chronic low back pain (cLBP), n = 88; knee osteoarthritis (KOA), n = 37] compared with healthy controls ( n = 22). These elevations we …

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02.09.2026journal-article

Clinical and Experimental Dermatology

Subcutaneous nodules of the face: an unusual presentation of Darier–Roussy disease

Sofia Hermosilla, Isidora Wajner, Alberto Lara, Claudio Toloza, Carlo Lozano, Eduardo Rozas, Antonio Guglielmetti, José Hono

Subcutaneous sarcoidosis (Darier–Roussy disease) is an uncommon form of cutaneous sarcoidosis that predominantly affects the extremities. Facial involvement is rare and may represent a diagnostic challenge. We describe a woman presenting with nodules of the cheek and lips, whose histopathological and radiological findings led to the diagnosis of systemic sarcoidosis. This case expands the clinical spectrum of subcutaneous sarcoidosis and emphasizes the need to consider sarcoidosis in the differential diagnosis of g …

02.09.2026journal-article

Indian Journal of Surgical Oncology

Patient-Reported Body Image, Pain, and Satisfaction After Breast-Conserving Surgery, Mastectomy, and Mastectomy With Reconstruction: A Cross-Sectional Cohort Study

Noam Weiner, Eran Sharon, Tal Kind, Helit Nakar, Tomer Mimouni, Yehonatan Noyman, Lior Har-Shai, Assi Levi

Abstract Background Surgical treatment for breast cancer may affect long-term body image, pain, and satisfaction, yet the relative contribution of surgical approach and patient-level factors remains uncertain. We evaluated patient-reported outcomes after breast-conserving surgery, mastectomy without reconstruction, and mastectomy with reconstruction. Methods In this cross-sectional cohort study, 230 women treated between 2015 and 2021 at a single Israeli tertiary center completed an investigator-developed Hebrew te …

02.09.2026journal-article

Physics in Medicine & Biology

GATE/Geant4 simulation of key dosimetric correction factors for alanine dosimetry in 12 C ion beams

Pascal Saße, Jessica Stolzenberg, Kilian-Simon Baumann, Vanessa Delfs, Ralf-Peter Kapsch, Hugo Palmans, Bjoern Poppe, Hui Khee Looe

Abstract Objective: Alanine has been used frequently as a reference dosimeter in clinical dosimetry. However, its high LET dependence poses a challenge for practical applications. Determination of the required beam quality correction factors requires Monte Carlo simulations. This makes the application of alanine infeasible if dedicated Monte Carlo tools or computing resources are not available. This work sets out to determine generalized alanine correction factors in clinical 12 C beams. Approach: Mathematical expr …

02.09.2026journal-article

Physics in Medicine & Biology

Lu-176 based time skew correction method for TOF-PET detectors

Eiji Yoshida, Fujino Obata, Taiga Yamaya

Abstract Objective. Time calibration is an important procedure for correcting time shifts inherently included in TOF-PET. In this work, we developed a time skew (TS) correction method that uses the intrinsic radioactivity originating from the natural decay of 176 Lu, a constituent element of the scintillator. Approach. The TOF-PET detector has a one-to-one optical coupling between the scintillators and photosensors, enabling independent readout of each channel. For electrical TS correction caused by the electronic …

02.09.2026journal-article

Skin Health and Disease

Dermatology residency education in the treatment of testosterone-induced acne and androgenic alopecia in trans men: a cross-sectional survey of academic dermatologists in the USA

Thinh Q Nguyen, Zachary Neubauer, Angela Zaladonis, Sherry Yang

This cross-sectional survey study explores the experience, comfort and knowledge of dermatology residents and attendings in managing testosterone-induced acne (TiAV) and androgenic alopecia (TiAGA) in trans men. While most respondents reported some level of comfort treating these conditions, objective knowledge scores were modest and revealed gaps across both conditions, particularly TiAGA. Our findings suggest that current LGBTQIA+-focused education may be perceived as adequate but may not translate into knowledge …

02.09.2026journal-article

Journal of Pressure Vessel Technology

Controlling Mechanism of Local Rapid Cooling Heat Treatment to Reduce Internal Cladding Residual Stress of Pressure Vessels

Yun Luo, Yanbin Liu, Yao Zhang, Wenbin Gu, Wenchun Jiang, Qian Zhang

Abstract Due to different material parameters between the cladding layer and the base metal, significant tensile residual stresses still remain within the internal cladding layer after traditional heat treatment, seriously affecting the service safety of pressure vessels. Local rapid cooling heat treatment is an effective method to reduce the tensile residual stress in the cladding layer until a compressive stress state is achieved. In this paper, the influence of local rapid cooling heat treatment process paramete …

02.09.2026journal-article

Journal of Medical Internet Research

Consumer and Patient Health Information Seeking With Generative AI Tools: Scoping Review of Facilitators and Barriers

Lilach Alon, Inbar Levkovich

Background Generative AI (GenAI) tools powered by large language models (LLMs) are increasingly used by the public to seek health information. Unlike traditional web search, these systems generate conversational responses that may alter how users assess credibility, manage uncertainty, verify information, and decide whether to consult clinicians. As GenAI becomes more embedded in everyday health information practices, a clearer synthesis of the emerging empirical evidence is needed. Objective This scoping review ma …

02.09.2026journal-article

Acta Poloniae Pharmaceutica - Drug Research

Multidrug-Resistant Acinetobacter baumannii: an Overview of Therapeutic Options and Treatment Regimens

Paweł Sacha, Mateusz Modzelewski, Łukasz Korczak, Elżbieta Tryniszewska

Acinetobacter baumannii, a Gram-negative coccobacillus, is an opportunistic pathogen originating from the natural environment (soil, water, and plants). This bacterium is common in the human skin microbiota and is capable of colonizing diverse environments (e.g., hospital environments). A. baumannii is a bacterium naturally resistant to multiple antibiotic classes. In recent years, due to its ability to acquire resistance genes from other bacteria, it has become a critical threat, particularly in intensive care uni …

02.09.2026journal-article

Cancers

Impact of Post-Primary Treatment Hormone Replacement Therapy on Survival in Women with Cervical Cancer

Hee Joong Lee, Banghyun Lee

Background/Objectives: The effects of hormone replacement therapy (HRT) after primary treatment on survival outcomes in women with cervical cancer (CC) remain unclear. This nationwide cohort study evaluated the association between post-primary treatment HRT and overall survival (OS) in women with CC. Methods: We identified 15,261 women aged ≤60 years with CC who received primary treatment using the Korean Health Insurance Review and Assessment Service database. HRT users were defined as women who received HRT presc …

02.09.2026journal-article

Frontiers in Digital Health

VHealth-MFusion: a fusion-based multimodal deep learning framework for pneumonia tele-diagnosis in virtual hospital environments

Sara A. Alsalamah, Albatoul Althenayan, Mariam Almutairi, Shada AlSalamah, Hessah A. Alsalamah, Thamer Nouh, Bassam Mahboub, Laila Salameh, Moteeb Al Moteri, Chang-Tien Lu

Introduction Virtual hospital systems support remote triage and diagnosis across distributed healthcare environments by integrating radiographic imaging with structured clinical information for clinical decision making. However, many existing diagnostic frameworks do not fully address real world challenges commonly encountered in scalable virtual healthcare settings. These challenges include severe class imbalance, incomplete clinical attributes, heterogeneous multimodal inputs, and variability in data quality acro …

02.09.2026journal-article

QJM: An International Journal of Medicine

Targeting the Nrf2-SLC7A11/GPX4 Pathway to Inhibit Ferroptosis: Mechanism of Yiqi Fumai Formula in Acute Decompensated Heart Failure

Lu Fan, Yunfeng Jia, Yanyang Li, Zhihan Yang, Yiming Zuo, Haomin Zhang, Xuezheng Liu, Shichao Lv

Abstract Objective To elucidate the mechanism of Yiqi Fumai Formula (YQFM) in acute decompensated heart failure (ADHF) via the Nrf2/SLC7A11/GPX4 pathway in regulating ferroptosis. Methods Network pharmacology was employed to predict the underlying mechanisms of YQFM in ADHF. Rat models of ADHF were established, incorporating agonists or inhibitors of key ferroptosis pathways. The therapeutic mechanism of Yiqifumai Formula was investigated by assessing cardiac structure/function, myocardial injury biomarkers, lipid …

02.09.2026journal-article

Journal of Ophthalmology and Advance Research

Primary Orbital Mucinous Carcinoma in a Human Immunodeficiency Virus (HIV) Patient: A Case Report

Zahra A Markatia, George A Villatoro, Taimur Siddiqui, Debra J Shetlar, Michael T Yen

Mucinous carcinoma is a rare malignancy marked by abundant mucin production, typically found in organs like the breast, colon, and ovary, with orbital involvement being exceptionally rare. This case report presents a 55-year-old male with a history of well-controlled Human Immunodeficiency Virus (HIV) infection, oral squamous cell carcinoma, and recurrent papillomas of the conjunctiva and oropharynx, who developed a firm, enlarging mass in the left superomedial anterior orbit. Histopathology after surgical resectio …

02.09.2026journal-article

Journal of Clinical Medicine

Male Breast Cancer: An Analysis of Clinicopathological Features, Treatment Patterns, and Survival Outcomes over 10 Years from a Tertiary Center

Hüseyin Tepetam, Cemal Ugur Dursun, Mustafa Mert Hanilce, Solen Nasifoglu, Nursena Ciflik, Duygu Gedik, Sermin Kokten, Sule Karabulut Gul

Background/Objectives: Male breast cancer (MBC) is a rare malignancy accounting for less than 1% of all breast cancers, and current treatment recommendations are largely extrapolated from studies in women. We aimed to evaluate the clinicopathological characteristics, treatment patterns, survival outcomes, and prognostic factors of male breast cancer patients treated at a tertiary referral center. Methods: We retrospectively reviewed 45 patients with histopathologically confirmed MBC treated between January 2015 and …

02.09.2026journal-article

Journal of Clinical Medicine

Spermatocytic Tumor Arising in a Cryptorchid Testis: A Case Report and Narrative Review

Laurențiu Augustus Barbu, Stelian-Stefaniță Mogoantă, Liliana Cercelaru, Marius Cristian Marinaș, Nicolae-Dragoș Mărgăritescu, Mihai Popescu, Valentina Căluianu, Gabriel Florin Răzvan Mogoș, Liviu Vasile, Tiberiu Stefăniță Țenea Cojan

Background: Spermatocytic tumor (ST) is a rare non-GCNIS-derived testicular germ cell neoplasm that predominantly affects older men and generally follows an indolent course. Its occurrence in a cryptorchid testis is exceptionally uncommon. Methods: A narrative literature review was conducted using the PubMed database, including studies published up to August 2026. The search used combinations of the terms “spermatocytic tumor”, “spermatocytic seminoma”, “cryptorchidism”, “undescended testis”, “immunohistochemistry” …

02.09.2026journal-article

Journal of Clinical Medicine

Periodontitis and Glycaemic Dyscontrol Substantially Increase the Risk of Medication-Related Osteonecrosis of the Jaw: A Preclinical Study in Female Rats

João Martins de Mello-Neto, Luan Felipe Toro, Letícia Chaves Ferreira, Vinícius Franzão Ganzaroli, Leandro Lemes da Costa, Rodrigo Isaías Lopes Pereira, Arthur Michellim Kirasuke, Ana Beatriz Carreto, Isabella Zacarin Guiati, Valdir Gouveia Garcia, Letícia Helena Theodoro, Edilson Ervolino

Background/Objectives: There is limited understanding of how periodontitis progresses in individuals with diabetes who are undergoing antiresorptive drug therapy, particularly given that both are risk factors for medication-related osteonecrosis of the jaw (MRONJ). This study evaluated the effect of therapy with an oncological dose of zoledronate on the progression of experimental periodontitis (EP) in diabetic female rats. Methods: One hundred and eight female rats (12 months old) were assigned to four groups: VEH …

02.09.2026journal-article

Surgical and Radiologic Anatomy

Preoperative CT-based 3D analysis of middle colic vein anatomy for complete mesocolic excision in right-sided colon cancer: a retrospective cohort study from a prospective clinical trial

Vladimir Zivanovic, Dejan Ignjatovic, Javier Armando Luzon, Bojan Vladimir Stimec

Abstract Purpose Complete mesocolic excision requires central mesenteric dissection near the middle colic vein (MCV) confluence, where anatomic variability may increase operative risk. However, MCV multiplicity, confluence patterns, and relationships to the middle colic artery (MCA) are not sufficiently defined. Methods We performed a retrospective secondary analysis of 300 consecutive three-dimensional vascular reconstructions from a prospectively maintained database of patients undergoing surgery for right-sided …

02.09.2026journal-article

European Spine Journal

Large language models in the vertical integration of spine surgery workflow: a scoping review

Edwin H. Y. Lui, Ralph J. Mobbs

Abstract Purpose To evaluate current evidence regarding the clinical reliability and reasoning capabilities of Large Language Models (LLMs) and Multimodal Large Language Models (MLLMs) within the spine surgery workflow. This scoping review utilizes a novel Vertical Integration Maturity Scale (VIMS) to map model maturity across five stages of the vertical workflow, identifying persistent research gaps and technical prerequisites for clinical implementation. Methods A systematic search was conducted across PubMed, Em …

02.09.2026journal-article

Clinical Journal of the American Society of Nephrology

Effects and Safety of Henagliflozin on Cardiac Structure in Dialysis Patients with Heart Failure with Preserved Ejection Fraction

Hao Yan, Wei Wang, Wangshu Wu, Ying Li, Yinghui Qi, Yijun Zhou, Weiming Zhang, Shang Liu, Huihua Pang, Yan Fang, Zhenyuan Li, Zhiqing Qiao, Renhua Lu, Meng Jiang, Wei Fang, Jun Pu, Leyi Gu, on behalf of the HELD-HF study investigators

Background Few effective drug treatments exist for dialysis patients with heart failure with preserved ejection fraction (HFpEF). This study aimed to evaluate the effects of henagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on cardiac structure, and its safety in such population. Methods In this multicenter, randomized, double-blind, placebo-controlled trial, dialysis patients with HFpEF were randomly assigned (1:1) to receive henagliflozin or placebo for 24 weeks. All enrolled participants receive …