Vollständiger Abstract
Worum geht es in dieser Arbeit?
The skull bone marrow (SBM) is emerging as a critical hub for neuroimmune signaling, yet its role in chronic pain is unknown. Using integrated positron emission tomography/magnetic resonance imaging, here, we show that the levels of 18-kilodalton translocator protein (TSPO), a putative marker of immune cell density, are elevated in the SBM of individuals with chronic pain [ n = 125; chronic low back pain (cLBP), n = 88; knee osteoarthritis (KOA), n = 37] compared with healthy controls ( n = 22). These elevations were widespread, generally more pronounced for KOA than cLBP, associated with pain and pain-comorbid symptoms in partially segregated spatial patterns, and supported by preliminary immunohistochemical evidence in human SBM samples from a donor with a history of chronic pain (compared with a healthy donor). Because TSPO is highly expressed in myeloid cells, these results link SBM immune dysregulation with chronic pain and its associated psychological and functional impairments. These findings provide a strong rationale for investigating this previously overlooked structure, which remains largely underexplored in the context of pain.
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Mehrbod Mohammadian, Nikos Efthimiou, Katherin Gabriel, Ludovica Brusaferri, Joya Cooper-Hohn, Minhae Kim, Jennifer P. Murphy, Zeynab Alshelh, Grace Grmek, Jack H. Schnieders, Courtney A. Chane, Thomas G. Carmichael, Danika Yang, Julia J. Schubert, Federico E. Turkheimer, Rafael A. Cazuza, Peter M. Grace, Ciprian Catana, Steven M. Stufflebeam, Robert R. Edwards, Vitaly Napadow, Kimberly Sullivan, Matthias Nahrendorf, Theodore J. Price, Jodi M. Gilman, Marco L. Loggia
- Quelle
- Science Translational Medicine
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 1946-6234, 1946-6242
- Zitationen
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Zitieren
Zitierfähiger Nachweis
Mehrbod Mohammadian, Nikos Efthimiou, Katherin Gabriel, Ludovica Brusaferri, Joya Cooper-Hohn, Minhae Kim, Jennifer P. Murphy, Zeynab Alshelh, Grace Grmek, Jack H. Schnieders, Courtney A. Chane, Thomas G. Carmichael, Danika Yang, Julia J. Schubert, Federico E. Turkheimer, Rafael A. Cazuza, Peter M. Grace, Ciprian Catana, Steven M. Stufflebeam, Robert R. Edwards, Vitaly Napadow, Kimberly Sullivan, Matthias Nahrendorf, Theodore J. Price, Jodi M. Gilman, Marco L. Loggia (2026). Elevated translocator protein in skull bone marrow is linked to human chronic pain. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.aed8729