EUVIMED Themenbrowser · Onkologie · Seite 77
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Clinical Case Reports
ABSTRACT Alopecia areata is an autoimmune disease with diverse clinical manifestations. This case report describes a patient with diffuse alopecia areata who responded well to oral abrocitinib, resulting in complete hair regrowth. The patient achieved complete recovery without any observed adverse effects.
Journal of Oncology Pharmacy Practice
Introduction Capecitabine-induced hand-foot syndrome (HFS) is a frequent and clinically relevant toxicity that may impair quality of life and lead to chemotherapy dose reduction or interruption. This study aimed to evaluate the effectiveness, safety, and clinical predictors of response to topical recombinant human epidermal growth factor (rhEGF) gel combined with urea ointment in patients with capecitabine-induced HFS. Methods This retrospective case series included a total of 83 patients with colorectal adenocarci …
Rheumatology Science and Practice
The aim – to compare the long-term efficacy of netakimab with other registered drugs in the Russian Federation to treat radiographic axial spondyloarthritis over a period of up to 3 years. Materials and methods . A systematic literature search was conducted in PubMed and Embase databases. 19 publications evaluating the results of 11 clinical trials were selected. The simulated treatment comparison method according to NICE DSU TSD 18 (National Institute for Health and Care Excellence Decision Support Unit Technical …
Genes, Chromosomes and Cancer
ABSTRACT MITF ‐rearranged PEComas are rare, and their relationship to MITF ‐altered melanocytic tumors remains incompletely characterized. We report a malignant superficial soft tissue neoplasm of the thigh in a 45‐year‐old woman harboring a novel EEF1A1::MITF fusion. The tumor was composed of epithelioid to plump spindle cells arranged in sheets, nests, and short fascicles with prominent capillary vasculature. Significant cytologic atypia, brisk mitotic activity, and necrosis were present. The tumor cells showed d …
Indian Journal of Medical and Paediatric Oncology
Abstract Locally advanced cervical cancer (LACC), defined as FIGO 2018 stages IB3-IVA, is associated with relapse rates between 30 and 60% after definitive chemoradiotherapy (CRT). The current strategy for monitoring is based on physical examinations and imaging, which could be confounded by radiation-induced fibrosis, and existing biomarkers like squamous cell carcinoma antigen lack sensitivity in detecting minimal residual disease (MRD). Circulating tumor DNA derived from human papillomavirus (HPV ctDNA) has rece …
Ahi Evran Medical Journal
This editorial letters the updated American Cancer Society (ACS) cervical cancer screening guidelines and discusses their implications for national screening programs. Key updates include endorsing self-collected vaginal swabs for HPV screening to overcome accessibility and privacy barriers, alongside revised criteria for safely discontinuing screening at age 65. Adopting self-sampling options in national screening workflows offers a vital pathway to increase participation rates toward the World Health Organization …
Revista Mexicana de Urología
Introduction: paratesticular fibrous pseudotumor is a rare benign fibroinflammatory lesion that represents a diagnostic challenge because of its ability to mimic a malignant testicular neoplasm. Case presentation: a 43-year-old man with a history of blunt testicular trauma five years earlier presented with a painless left testicular mass of six months’ duration and progressive enlargement. Physical examination revealed a firm 3.0 × 2.0 cm mass without palpable lymphadenopathy. Serum tumor markers were within normal …
Surface Review and Letters
This study investigates how heat treatments (annealing and quenching) and nanoparticle-mixed dielectric fluids (NPMDF) affect the electrical-discharge machining (EDM) performance of Ti-6Al-4V alloy. Machining characteristics such as material removal rate (MRR), tool wear rate (TWR), and surface roughness (SR) were evaluated, alongside microstructural analysis and micro-Vickers hardness (MVH) validation. EDM experiments were conducted using three dielectric fluids: base transformer oil (non-NPMDF), Al 2 O 3 -NPMDF, …
Life
Primary hepatic perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms that involve both melanocytic and smooth muscle differentiation. Primary hepatic PEComas remain a challenging condition for radiologists, pathologists, and surgeons. Our review provides an updated, clinically oriented synthesis of the available evidence on primary hepatic PEComas, integrating recent developments in diagnosis, imaging, histopathology, molecular biology, prognostic stratification, surgical and systemic treat …
Health Expectations
ABSTRACT Background Public engagement has the potential to make research more impactful, and it has increased in recent years in cancer research. Yet, there is limited understanding of how this process of bringing lived experience into research works, and of what leads to tokenistic and non‐tokenistic engagement. Aims and Objectives To explore public engagement in cancer research in the United States from the perspective of both lived‐experience experts and researchers. Methods A qualitative study consisting of int …
Neuro-Oncology Advances
Abstract Background Sleep disturbance is common and undertreated in adults with primary brain tumors. Cognitive Behavioral Therapy for Insomnia (CBT-I) is the first-line, non-pharmacological treatment, yet its benefit in neuro-oncology has yet to be evaluated. This Phase IIc pilot assessed feasibility, acceptability, and meaningful effects of telehealth group-based CBT-I versus treatment as usual (TAU) in neuro-oncology. Methods Adults with primary brain tumors and chronic insomnia were randomized 1:1 to six weekly …
Veterinary Medicine and Science
ABSTRACT A 4‐year‐old, male‐neutered Savannah cat (Case 1) and a 3‐year‐old female‐neutered British shorthair cat (Case 2) were each investigated for chronic coughing, lethargy and weight loss. Thoracic imaging revealed diffuse broncho‐interstitial changes and multifocal soft‐tissue nodules (Case 1), and two cavitating masses in the left lung (Case 2). Bronchoalveolar lavage cytology (BAL) in both cases identified macrophagic inflammation with acid‐fast bacilli and was culture (Case 1) or PCR (Case 2) positive for …
The Indonesian Biomedical Journal
BACKGROUND: Colorectal cancer (CRC) is a major global health problem associated with high cancer-related mortality. Profiling of Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation status has become a decisive predictive biomarker in the management of CRC. However, KRAS mutation testing is commonly performed using tumor tissue obtained through invasive biopsy or surgery; therefore, fecal DNA analysis might offer a promising non-invasive alternative. This study was conducted to evaluate the concordance of KRA …
Molecular Pharmaceutics
Abstract Gastric cancer is a highly prevalent malignant tumor of the digestive system worldwide. Although andrographolide (AG) and coixol (CX) possess potential anti-gastric cancer effects, their clinical application is restricted by low bioavailability and poor targeting ability. Based on the meridian tropism theory of traditional Chinese medicine and the concept of “integrated drug and carrier”, this study constructed Bletilla striata polysaccharide-vitamin E succinate (BSP-VES) polymeric micelles co-loaded with …
Sensors
As a common benign bone tumor, the pathological diagnosis of chondrogenic tumors needs to accurately analyze the calcification pattern of the cartilage matrix, key spatial topology information, and other important indicators. However, chondrogenic tumors are a heterogeneous group of tumors and a rare disease: doctors lack sufficient reference data and experience in diagnosis. At the same time, complex spatial structural information also increases the difficulty of diagnosis, which leads to inconsistencies in the di …
İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi
Aim: This study aimed to investigate the effect of individuals’ health perceptions on their attitudes toward cancer screening and to examine the relationship between these two variables.Method: We implemented a descriptive, cross-sectional, and correlational design. The sample consisted of 351 adults who applied to a family health center in Muğla, Turkey, between January and August 2025. Data were collected using a Personal Information Form, the Health Perception Scale, and the Attitude Scale for Cancer Screening. …
Korean Journal of Adult Nursing
Purpose: This study examined sociodemographic, clinical, and symptom-related factors associated with current employment among cancer survivors and described sex-based differences in occupational continuity. Methods: This cross-sectional study used data from the 2019 and 2021 Korea National Health and Nutrition Examination Survey. The sample included cancer survivors aged 19 to 65 years who did not have multiple primary cancers or missing data (n=289). Employment status was categorized as employed or non-employed. S …
Periodontology 2000
Abstract Objectives To update the evidence on the comparative effectiveness of self‐applied dentifrices for the treatment of dentin hypersensitivity (DH) using systematic review and network meta‐analysis methodology. Materials and Methods Randomized controlled trials evaluating self‐applied dentifrices in adults with a diagnosis of DH were identified through literature searching of OvidSP versions of Medline, EMBASE and the Cochrane Library from November 2022–July 2025, supplemented by records obtained in a previou …
Medicine Insights
To systematically evaluate the clinical efficacy of thalidomide combined with traditional Chinese medicine (TCM), compared with monotherapy (either thalidomide or TCM monotherapy), in patients with Behçet's disease, and to perform a meta‐analysis. Randomized controlled trials (RCTs) published from the inception of the databases to August 1, 2026, were systematically searched in the China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP Database, PubMed, Web of Science, and Cochrane Library. Patients in t …
Turkish Journal of Pediatric Disease
Febrile neutropenia (FN) is a frequent and potentially life-threatening complication of chemotherapy in pediatric oncology. Refugee and immigrant children are often considered to be at higher risk for adverse infectious outcomes due to socioeconomic disadvantage, substandard living conditions, and language barriers. This study aimed to compare FN episodes and short-term clinical outcomes between refugee/immigrant and Turkish pediatric oncology patients managed within a universal healthcare system. Materials and Met …
Proceedings of the National Academy of Sciences
Inducing antigen-specific immune tolerance is a long-standing aim in organ-specific autoimmune diseases including multiple sclerosis (MS). We developed a therapy based on autologous red blood cells (RBCs) as tolerizing carriers of autoantigens and tested these in an open-label, dose-escalation, phase Ib clinical trial with clinical, imaging, and mechanistic readouts. RBCs coupled with seven immunodominant myelin peptides (pcRBCs) were safe and well tolerated. Several clinical and imaging readouts remained stable, w …
Cancer Discovery
Abstract Pancreatic intraepithelial neoplasia (PanIN) precedes pancreatic cancer, a deadly disease characterized by an extensive tumor microenvironment. How the microenvironment evolves during cancer progression is largely unknown, as PanINs are microscopic and nondiseased pancreas samples are exceedingly rare, while adjacent normal samples are disrupted by the presence of malignancy. Leveraging donor organs and spatial technologies, we mapped the evolution of PanIN to cancer. The PanIN epithelial component falls o …
Frontiers in Oncology
Background Plant essential oils exhibit anticancer properties. However, the antitumor effects of Magnolia salicifolia essential oil remain unexplored. Methods We evaluated the antitumor activities of M. salicifolia essential oil and its volatile components in 4T1 murine breast cancer cells. Cell viability was assessed using the MTT assay. The concentration of the volatile components was analyzed using gas chromatography (GC)-mass spectrometry (MS). Morphological changes in the cells were examined using fluorescence …
World Nutrition Journal
Introduction: Head and neck cancer (HNC) patients are at high risk of malnutrition and functional decline. Protein and branched-chain amino acids (BCAA) are key nutrients for muscle protein synthesis and may influence functional capacity. This study examined the association between protein and BCAA intake and functional capacity in malnourished HNC patients receiving chemoradiotherapy. Methods: A cross-sectional study was conducted at a radiotherapy outpatient clinic among malnourished HNC patients undergoing chemo …
