EUVIMEDEuropean Health Evidence
Uhr 10/10Sources Journal Tree
Easy Demo

EUVIMED Themenbrowser · Onkologie · Seite 76

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Thoracic Cancer

Delayed Occurrence of Lung Cancer Leptomeningeal Metastasis and Era‐Associated Post‐ LM Survival: A 14‐Year Single‐Center Cohort Study

Xiaoxing Gao, Jie Gao, Qiuyue Ye, Chen Wei, Qing Zhou, Xiaoyan Liu, Minjiang Chen, Jing Zhao, Hanping Wang, Xiaoyan Si, Wei Zhong, Yan Xu, Mengzhao Wang

ABSTRACT Introduction Leptomeningeal metastasis (LM) is a devastating complication of lung cancer. We investigated the clinical and molecular evolution of LM in the modern targeted‐therapy era and factors associated with post‐LM survival. Methods We retrospectively analyzed 201 patients with cytologically confirmed lung cancer LM diagnosed between November 2012 and May 2026. Patients were classified by LM diagnosis date (2012–2016 vs. 2017–2026). Intervals from lung cancer and Stage IV diagnosis to LM were compared …

31.08.2026journal-article

Frontiers in Oncology

Immune checkpoint inhibitor-related intestinal pseudo-obstruction and multisystem immune-related adverse events in a post-gastrectomy patient: a case report and literature review

Zhening Liu, Chao Wang, Yulei Shen, Yanfen Shi, Jianghui Duan, Huijing Dong, Yangbo Xu, Yumin Zheng, Huijuan Cui

Background Immune checkpoint inhibitors are increasingly recognized to be associated with multisystem immune-related adverse events. Cases presenting predominantly with intestinal pseudo-obstruction (IPO) are rare, prone to misdiagnosis, and may indicate broader immune-mediated toxicity. Case presentation We report the case of a patient with gastric cancer who developed intestinal pseudo-obstruction and multisystem immune toxicity during postoperative adjuvant chemotherapy plus nivolumab. The patient’s symptoms imp …

31.08.2026journal-article

Cancer Immunology Research

A High Density of Impaired Tertiary Lymphoid Structures Is Associated with Higher Tumor Stage and Recurrence in Non–Muscle-Invasive Bladder Cancer

Sarah Péricart, Marie Tosolini, Mathieu Roumiguie, Axelle Saint, Laetitia Largeaud, Pauline Gravelle, Nathalie Van Acker, Pierre Brousset, Bernard Malavaud, Camille Laurent

Abstract Tertiary lymphoid structures (TLS) have emerged as critical immune niches within the tumor microenvironment across various cancers. However, their structural organization and functional roles in non–muscle-invasive bladder cancer (NMIBC) remain poorly characterized. In this study, we comprehensively characterized TLS in NMIBC using en bloc resected primary diagnostic specimens, which enabled high-resolution spatial mapping and quantitative histological assessment across a large cohort of primary tumors (97 …

31.08.2026journal-article

Restorative Dentistry & Endodontics

Diagnostic accuracy of ChatGPT-5 in evaluating root canal treatment and periapical pathosis on periapical radiographs

Waleed Almutairi, Mujahid Alnasser, Hanan Alharbi, Obadah Austah

Objectives: Artificial intelligence (AI) chatbots such as ChatGPT-5 (OpenAI) are increasingly used for dental radiograph interpretation, especially among patients seeking self-assessment. However, their diagnostic accuracy in endodontics remains unclear. Methods: This cross-sectional STARD-AI-compliant study analyzed 271 anonymized periapical radiographs of endodontically treated posterior teeth, classified as straightforward (n = 167) or complex (n = 104), using standardized ChatGPT-5 prompts. Diagnostic criteria …

31.08.2026journal-article

Discover Oncology

Repurposing FDA-approved drugs targeting signature genes associated with cancer of unknown primary: an orphanoinformatics approach

Raushan Kumar Chaudhary, Shruti S Mole, Aswin Mohan, Rajesh Raju

Abstract Background Cancer of unknown primary (CUP) is a rare and aggressive metastatic cancer characterized by an undefined primary site of tumor origin with poor overall survival (favorable group: 10–16 months and unfavorable group: 6–7 months). Thus, the current study aimed to identify and repurpose a drug targeting the signature gene involved in CUP pathogenesis. Methods The relevant dataset for CUP was identified from the GEO database using a systematic search. Oncogene and tumor suppressor genes in CUP were u …

31.08.2026journal-article

Medicine Insights

A Discussion on Chronomedicine in the Treatment of Constipation Based on the Najia Method of Midnight-Noon Ebb-Flow Theory

Xiaoru Zhou, Jing Liu, Yaming Xu, Ruihui Wang

This paper systematically discusses the diagnostic and therapeutic principles of applying chronomedicine to the management of constipation from the perspective of the Najia method of midnight-noon ebb-flow theory. Also known as biological clock therapy, chronomedicine employs midnight-noon ebb-flow acupuncture to select acupoints according to the diurnal waxing and waning of qi and blood as well as the opening-closing rhythm of meridians, serving as an important component of traditional Chinese medicine chronoacupu …

31.08.2026journal-article

Journal of Gynecology and Reproductive Health

Bridging the Gap in Cancer Prevention: Impact of a Structured Cancer Awareness and Counselling on Cancer Knowledge, Risk Perception, and Screening Awareness Among Adult Women an Observational Pre-Post-Test Study

Sunita Ghike, Anand Pathak, Kamlesh Madankar, Jueely Pathak, Sharayu Chaoji, Pradnya Pathak, Narendra Ghike, Malini Joshi

Background: Cancer is a major global public health challenge, accounting for nearly 20 million new cases and 9.7 million deaths worldwide in 2022. In India, breast, cervical, and oral cancers constitute a substantial proportion of cancers among women. Despite the availability of effective preventive measures and screening programmes, awareness regarding cancer risk factors, early warning signs, hereditary cancer, genetic counselling, and screening remains inadequate, resulting in delayed diagnosis and poorer outcom …

31.08.2026journal-article

Molecules

Nano-Metal Hydrogen Therapy Targeting Immune Cells Drives Synergistic Anti-Tumor Effects

Yuxuan Ding, Min Ma, Jianing Wang, Zixin Zhang, Jingyu Wu, Linxiang Zhou, Xiaoyan Cao, Libing Liu

Hydrogen is employed as a therapeutic gas in the treatment of stroke, tissue repair, and cancer, owing to its excellent biocompatibility, antioxidant properties, anti-inflammatory effects, and regulation of cellular metabolism. Moreover, nanometallic materials generate hydrogen through pH-responsive, light-responsive, ultrasound-responsive, and electrical stimulation and play a pivotal role in cancer therapy by activating anti-tumor immune responses, reversing immunosuppressive microenvironments, inducing immunogen …

31.08.2026journal-article

Biomolecules

Cannabinoids in Cancer: Molecular Mechanisms of Tumor Cell Death and Translational Opportunities

Alaa A. El Moghrabi, Ali Al Khatib, Israa Ahmad Cheikh, Charbel Al Hage, Dima Ismail, Mariam Zhour, Philip Mwesigwa, Nadine Darwiche

Cannabinoids are terpenophenolic compounds derived from Cannabis sativa L. that exert a broad range of biological and pharmacological activities. Increasing evidence highlights their potential as modulators of cancer progression specifically through the suppression of tumor cell growth, angiogenesis, and metastasis across multiple tumor models. This review provides a comprehensive overview of the molecular mechanisms by which natural and synthetic cannabinoids induce regulated cancer cell death. Current evidence de …

31.08.2026journal-article

Health Expectations

Bridging Lived and Expert Experience: A Qualitative Study Exploring Lived‐Experience Experts' and Researchers' Experiences of Public Engagement in Cancer Research

Piotr Teodorowski, Beth J. Maclin, Joi Miner, Jonathan B. Green, Daniel G. Garza, Marcus Arana, Edward Duncan, Jonine Figueroa, Sarah S. Jackson, Liz Forbat

ABSTRACT Background Public engagement has the potential to make research more impactful, and it has increased in recent years in cancer research. Yet, there is limited understanding of how this process of bringing lived experience into research works, and of what leads to tokenistic and non‐tokenistic engagement. Aims and Objectives To explore public engagement in cancer research in the United States from the perspective of both lived‐experience experts and researchers. Methods A qualitative study consisting of int …

31.08.2026journal-article

Genes, Chromosomes and Cancer

Malignant MITF ‐Rearranged PEComa With Novel EEF1A1::MITF Fusion

Sierra Raney, Arivarasan Karunamurthy, Jonhan Ho, Robert Bubar, Maedeh Mohebnasab, John Skaugen, Mohamed Elmoryah, Benjamin Nacev, Richard McGough, Ivy John

ABSTRACT MITF ‐rearranged PEComas are rare, and their relationship to MITF ‐altered melanocytic tumors remains incompletely characterized. We report a malignant superficial soft tissue neoplasm of the thigh in a 45‐year‐old woman harboring a novel EEF1A1::MITF fusion. The tumor was composed of epithelioid to plump spindle cells arranged in sheets, nests, and short fascicles with prominent capillary vasculature. Significant cytologic atypia, brisk mitotic activity, and necrosis were present. The tumor cells showed d …

31.08.2026journal-article

Neuro-Oncology Advances

Nationally Recruited Telehealth Group-Based Cognitive Behavioral Therapy for Insomnia in Patients with Primary Brain Tumors: A Randomized NIH ORBIT Phase IIc Study

Ashlee R Loughan, Autumn Lanoye, Kelcie Willis, Amber Fox, Mary Bridgman, Nolan Wages, Youngdeok Kim, Alicia Zukas, Christopher Kleva

Abstract Background Sleep disturbance is common and undertreated in adults with primary brain tumors. Cognitive Behavioral Therapy for Insomnia (CBT-I) is the first-line, non-pharmacological treatment, yet its benefit in neuro-oncology has yet to be evaluated. This Phase IIc pilot assessed feasibility, acceptability, and meaningful effects of telehealth group-based CBT-I versus treatment as usual (TAU) in neuro-oncology. Methods Adults with primary brain tumors and chronic insomnia were randomized 1:1 to six weekly …

31.08.2026journal-article

The Indonesian Biomedical Journal

Concordance of KRAS Mutation in Tumor Tissues and Fecal Samples of Colorectal Carcinoma Patients

Ahmad Bahrudin, Reno Rudiman, Andriana Purnama, Kiki Lukman, Yunia Sribudiani, Prapanca Nugraha

BACKGROUND: Colorectal cancer (CRC) is a major global health problem associated with high cancer-related mortality. Profiling of Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation status has become a decisive predictive biomarker in the management of CRC. However, KRAS mutation testing is commonly performed using tumor tissue obtained through invasive biopsy or surgery; therefore, fecal DNA analysis might offer a promising non-invasive alternative. This study was conducted to evaluate the concordance of KRA …

31.08.2026journal-article

Life

Primary Hepatic Perivascular Epithelioid Cell Tumors: From Diagnosis to Treatment

Anna Paspala, Panagiotis Dorovinis, Dimitrios K. Vlachos, Myrto D. Keramida, Dionysios Prevezanos, Konstantinos Kossenas, Nikolaos Machairas, Stylianos Kykalos, Evgenia Kotsifa, Tatiana Driva, Apostolos Angelis, Stratigoula Sakellariou, Georgios C. Sotiropoulos

Primary hepatic perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms that involve both melanocytic and smooth muscle differentiation. Primary hepatic PEComas remain a challenging condition for radiologists, pathologists, and surgeons. Our review provides an updated, clinically oriented synthesis of the available evidence on primary hepatic PEComas, integrating recent developments in diagnosis, imaging, histopathology, molecular biology, prognostic stratification, surgical and systemic treat …

31.08.2026journal-article

Indian Journal of Medical and Paediatric Oncology

Clinical Utility of Human Papillomavirus ctDNA for Treatment Monitoring and Recurrence Prediction in Locally Advanced Cervical Cancer: A Systematic Review

Dilfuza Mirzaeva, Sharodiya Das, Laziz Y.T. O'g'li, Djurayeva Z. Baratovna, Dilshod Tolibov, Xalmuxamedov B. Taxirovich, Dilorom Dinmukhammadieva, Sourav Bhattacharjee

Abstract Locally advanced cervical cancer (LACC), defined as FIGO 2018 stages IB3-IVA, is associated with relapse rates between 30 and 60% after definitive chemoradiotherapy (CRT). The current strategy for monitoring is based on physical examinations and imaging, which could be confounded by radiation-induced fibrosis, and existing biomarkers like squamous cell carcinoma antigen lack sensitivity in detecting minimal residual disease (MRD). Circulating tumor DNA derived from human papillomavirus (HPV ctDNA) has rece …

31.08.2026journal-article

Ahi Evran Medical Journal

Changes to the American Cancer Society's 2025 cervical cancer screening guidelines

Selda Songur Dağlı

This editorial letters the updated American Cancer Society (ACS) cervical cancer screening guidelines and discusses their implications for national screening programs. Key updates include endorsing self-collected vaginal swabs for HPV screening to overcome accessibility and privacy barriers, alongside revised criteria for safely discontinuing screening at age 65. Adopting self-sampling options in national screening workflows offers a vital pathway to increase participation rates toward the World Health Organization …

31.08.2026journal-article

Rheumatology Science and Practice

Long-term efficacy of netakimab in the treatment of radiographic axial spondyloarthritis: Results of a systematic review and simulated indirect comparisons

A. M. Lila, T. V. Dubinina, O. N. Mironenko, A. A. Lazarev, K. V. Sapozhnikov, K. A. Katilova, D. G. Tolkacheva

The aim – to compare the long-term efficacy of netakimab with other registered drugs in the Russian Federation to treat radiographic axial spondyloarthritis over a period of up to 3 years. Materials and methods . A systematic literature search was conducted in PubMed and Embase databases. 19 publications evaluating the results of 11 clinical trials were selected. The simulated treatment comparison method according to NICE DSU TSD 18 (National Institute for Health and Care Excellence Decision Support Unit Technical …

31.08.2026journal-article

Surface Review and Letters

EXPERIMENTAL INVESTIGATION ON EFFECT OF HEAT TREATMENT AND NANOPARTICLE SUSPENSION IN DIELECTRIC FLUID ON EDM OF Ti-6Al-4V

VIVEK RATHORE, BHARAT SINGH

This study investigates how heat treatments (annealing and quenching) and nanoparticle-mixed dielectric fluids (NPMDF) affect the electrical-discharge machining (EDM) performance of Ti-6Al-4V alloy. Machining characteristics such as material removal rate (MRR), tool wear rate (TWR), and surface roughness (SR) were evaluated, alongside microstructural analysis and micro-Vickers hardness (MVH) validation. EDM experiments were conducted using three dielectric fluids: base transformer oil (non-NPMDF), Al 2 O 3 -NPMDF, …

31.08.2026journal-article

Veterinary Medicine and Science

Successful Treatment of Mycobacterium caprae Infection in Two UK Cats

Emily Clark, Danielle Gunn‐Moore, Conor O'Halloran

ABSTRACT A 4‐year‐old, male‐neutered Savannah cat (Case 1) and a 3‐year‐old female‐neutered British shorthair cat (Case 2) were each investigated for chronic coughing, lethargy and weight loss. Thoracic imaging revealed diffuse broncho‐interstitial changes and multifocal soft‐tissue nodules (Case 1), and two cavitating masses in the left lung (Case 2). Bronchoalveolar lavage cytology (BAL) in both cases identified macrophagic inflammation with acid‐fast bacilli and was culture (Case 1) or PCR (Case 2) positive for …

31.08.2026journal-article

Revista Mexicana de Urología

Pseudotumor fibroso paratesticular que simula neoplasia testicular: reporte de caso

Hugo Rivera-Astorga, Roberto Carlos Sarabia-Estrada, Ximena Yamilette Cruz De La Cruz, Yuki Francisco Nagano-Palacios, Itzel María Montoya-Fuentes

Introduction: paratesticular fibrous pseudotumor is a rare benign fibroinflammatory lesion that represents a diagnostic challenge because of its ability to mimic a malignant testicular neoplasm. Case presentation: a 43-year-old man with a history of blunt testicular trauma five years earlier presented with a painless left testicular mass of six months’ duration and progressive enlargement. Physical examination revealed a firm 3.0 × 2.0 cm mass without palpable lymphadenopathy. Serum tumor markers were within normal …

31.08.2026journal-article

Journal of Oncology Pharmacy Practice

Topical Recombinant Human Epidermal Growth Factor (rhEGF) gel plus urea ointment in the management of capecitabine-induced hand-foot syndrome: A case series with literature review

Jianjun Zhou, Ruoxi Chen, Deen Shi, Jiaqi Wang

Introduction Capecitabine-induced hand-foot syndrome (HFS) is a frequent and clinically relevant toxicity that may impair quality of life and lead to chemotherapy dose reduction or interruption. This study aimed to evaluate the effectiveness, safety, and clinical predictors of response to topical recombinant human epidermal growth factor (rhEGF) gel combined with urea ointment in patients with capecitabine-induced HFS. Methods This retrospective case series included a total of 83 patients with colorectal adenocarci …

31.08.2026journal-article

Toxics

Impacts of Wastewater Treatment Processes on the Occurrence Characteristics of Microplastics—Taking Four Wastewater Treatment Plants in Northern Henan Province as Examples

Yiping Guo, Jinhong Li, Shihang Ni, Qianqian Zhang, Li Guo, Bingtao Liu, Peng Liu, Weigao Zhao, Yupeng Li, Hanzhong Jia

As emerging persistent contaminants, microplastics (MPs) are ubiquitous in aquatic environments. Wastewater treatment plants (WWTPs) act as critical sinks and sources of MPs, and their MPs removal efficiency can strongly influence aquatic ecological safety. To investigate how different process configurations affect MPs occurrence and removal performance, four municipal WWTPs equipped with diverse biological and advanced treatment processes were sampled and analyzed. MPs were extracted via density flotation combined …

31.08.2026journal-article

Clinical Case Reports

Abrocitinib Treatment in Diffuse Alopecia Areata: A Case Report and a Literature Review

Xiaojing Zhang, Jianbo Zhong, Liming Wu, Ping Yang, Xingyun Zhao, Yingzhi Luo, Yunmi Qiu

ABSTRACT Alopecia areata is an autoimmune disease with diverse clinical manifestations. This case report describes a patient with diffuse alopecia areata who responded well to oral abrocitinib, resulting in complete hair regrowth. The patient achieved complete recovery without any observed adverse effects.

31.08.2026journal-article

Molecular Pharmaceutics

Bletilla striata Polysaccharide-Derived Nanomicelles for Co-Delivery of Andrographolide and Coixol: A Novel Strategy for Synergistic Targeted Treatment of Gastric Cancer

Yuhao Zhou, Zhongqun Yue, Tingting Feng, Fangxia Zhang, Jing Guan, Juanjuan Luo, Yanan Tan, Ying Zhou, Yue Zhu, Zuhua Wang

Abstract Gastric cancer is a highly prevalent malignant tumor of the digestive system worldwide. Although andrographolide (AG) and coixol (CX) possess potential anti-gastric cancer effects, their clinical application is restricted by low bioavailability and poor targeting ability. Based on the meridian tropism theory of traditional Chinese medicine and the concept of “integrated drug and carrier”, this study constructed Bletilla striata polysaccharide-vitamin E succinate (BSP-VES) polymeric micelles co-loaded with …