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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Clinical Spine Surgery

Cervical Paraspinal Muscle Atrophy Is Associated With Internal Carotid Artery Stenosis

Bruno Verna, Ali E. Guven, Marco D. Burkhard, Erika Chiapparelli, Anna-Maria Mielke, Vidushi Tripathi, Thomas Caffard, Artine Arzani, Jiaqi Zhu, Jennifer Shue, John A. Carrino, Andrew A. Sama, Federico P. Girardi, Frank P. Cammisa, Alexander P. Hughes

Study Design: Retrospective cross-sectional study. Objective: The objective of our study is to assess the relationship between carotid artery stenosis (CAS) and muscle morphology. Summary of Background Data: Paraspinal muscle degeneration, marked by fatty infiltration (FI) and reduced functional cross-sectional area (fCSA), contributes to spine instability, chronic pain, and disc degeneration. While abdominal aortic calcification is linked to lumbar muscle atrophy, cervical vascular-muscle associations remain under …

02.09.2026journal-article

Hospital Pharmacy

Pharmaceutical 3D Printing From Personalized Medicine to Super-Compounding Pharmacies: A Narrative Review

Michele Favia, Giulio De Vivo, Paola Cristina Cappelletto, Gabriele Bagaglini

Objectives: This narrative review explores how pharmaceutical 3-dimensional printing (3DP) can transform solid dosage form manufacturing from industrial mass production to truly personalized medicine, particularly for vulnerable cohorts such as pediatric, geriatric, and rare disease patients for whom conventional strengths and dosage forms are often inadequate and prompt unsafe manipulations like tablet splitting. It further aims to critically appraise the main 3DP technologies applicable in pharmacy – fused deposi …

02.09.2026journal-article

Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science

Cross-load robustness evaluation of deep and handcrafted learning frameworks for bearing fault diagnosis

Rohit Mishra, Bhagat Singh, Yogesh Shrivastava

This paper introduces a comprehensive leakage-free methodology for bearing fault diagnosis by three of the most representative feature learning approaches: Raw Signal Convolutional Neural Network (Raw CNN), Fast Fourier Transform (FFT) based hybrid MLP-CNN, and handcrafted statistical descriptor based Multilayer Perceptron (MLP). The vibration data collected from the Case Western Reserve University (CWRU) bearing set for four operating conditions (0, 1, 2, and 3 HP) was used. To eliminate information leakage, all m …

02.09.2026journal-article

European Spine Journal

Validation of a modular low-fidelity training model for biportal endoscopic spine surgery

Camille Niederhauser, Guillaume Haering, Blaise Pellegrini, Elias Ben Rayana, Sara Paravina, Nasim Lotfinejad, Mahmoud Messerer, Juan Barges-Coll, Dominique Rothenfluh

Abstract Objective Spinal endoscopy is associated with a steep learning curve, in part owing to its limited depth perception, which increases the need for training models. This study aimed to investigate construct and predictive validity of the Endobox as a low-fidelity training model for biportal endoscopy. Methods To assess construct validity, we compared the performances of expertsand novices across four Endobox exercises. Performances were evaluated based on completion time and number of attempts, using a 0º en …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

FEATURES OF GEOPHYSICAL METHODS FOR STUDYING HYDRAULIC FRACTURE PARAMETERS IN VERTICAL AND DIRECTIONAL WELLS

R.R. Murtazin

The paper presents a comprehensive systematic analysis of modern geophysical methods for evaluating hydraulic fracture parameters in vertical and deviated wells. The main existing approaches are reviewed, including well testing, microseismic monitoring, and a suite of production geophysics techniques: cross-dipole broadband acoustic logging (BAL), thermometry, radioactive tracers, and non-radioactive tagged (NRT) proppant technology. A comparative analysis of the information content and reliability of each method i …

02.09.2026journal-article

Journal of Clinical Medicine

Nature and Preoperative Prediction of Difficult Non-Channeled Video-Laryngoscopic Tracheal Intubation in Otorhinolaryngological Surgery: A Retrospective Cohort Study of 1932 Adults

Darhae Eum, Hyoung Woo Chang, Myoung Hwa Kim, Jinmok Kim, Wyun Kon Park, Hyun Joo Kim

Background/Objectives: Video laryngoscopy improves the glottic view, yet difficult intubation still occurs. Whether it reflects a poor view or arises despite an adequate one is rarely quantified in otorhinolaryngological surgery. We described this pattern and its preoperative predictors. Methods: In a single-center retrospective cohort of 1932 adults undergoing otorhinolaryngological surgery with non-channeled video laryngoscopy (2018–2021), difficult intubation was defined a priori as two or more laryngoscopic att …

02.09.2026journal-article

Journal of Cutaneous and Aesthetic Surgery

Clinicodemographic and anatomical predictors of squamous cell carcinoma

Fatih İçbudak, Melih Kaan Saridal

Objectives: To evaluate the clinicodemographic characteristics and anatomical distribution of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and identify independent predictors of SCC. Material and Methods: A retrospective analysis of 374 patients (BCC = 209, SCC = 165) was performed. Variables included age, sex, and tumor localization. High-risk locations were the lip, scalp, and temporal regions. Univariate and multivariate logistic regression analyses were performed. Age was analyzed continuously a …

02.09.2026journal-article

Healthcare

Patient Shielding in Computed Tomography: Analysis of Influencing Factors and a Conceptual Framework for Decision-Making

Yating Qiao, Hui Liu, Qiang Zhou, Fei Tuo

Background: Although lead shielding during computed tomography (CT) examinations has served as routine clinical practice, its actual efficacy and execution remain controversial, showing noticeable divergences across national policies and international clinical guidelines. This discrepancy highlights a disconnect between clinical habits and evolving technical evidence. Methods: This narrative review examines the operational, institutional, legal, and cognitive constraints sustaining these divergent practices. Result …

02.09.2026journal-article

LUMEN ET VIRTUS

A CRIAÇÃO OBRIGATÓRIA DE COMISSÕES DE IA E TELEMEDICINA NOS HOSPITAIS: O NOVO MODELO DE GOVERNANÇA CLÍNICA EXIGIDO A PARTIR DE AGOSTO DE 2026

Domingos Fernandes Jalacassa, Christopher Raimundo, Caroline Victória Quadros De Azevedo

A Resolução nº 2.454, de 2026, do Conselho Federal de Medicina, cuja vigência se inicia em 26 de agosto de 2026, instituiu uma exigência inédita na governança hospitalar brasileira: as instituições de saúde que adotam sistemas próprios de inteligência artificial aplicados à prática clínica devem constituir Comissão de IA e Telemedicina, sob coordenação médica e subordinada à diretoria técnica, com estrutura que reúna governança, auditoria e apoio jurídico, e com a função de supervisionar e auditar as tecnologias em …

02.09.2026journal-article

Pathogens

Surgical Treatment of Tuberculous Pleural Empyema in Children and Adolescents: A Retrospective Cohort Study

Dmitry B. Giller, Alexandr D. Chuishchev, Inga I. Enilenis, Vadim V. Koroev, Oleg S. Kesaev, Galina V. Shcherbakova, Patimat G. Gadzhieva, Ludmila P. Severova, Nadezhda I. Klevno, Alexey V. Kazakov, Olga P. Frolova, Olga V. Butylchenko, Alexandr N. Ilyukhin, Valeriya A. Basangova, Evelina Y. Morozova, Ivan I. Martel

Background: While non-specific pleural empyema in children can be successfully managed with conservative drainage and thoracentesis in 80–84% of cases, tuberculous pleural empyema (TB empyema) exhibits high resistance and frequently requires extensive thoracic surgery. The choice of surgical scope depends directly on disease stage and secondary complications. Methods: We conducted a retrospective cohort study of 85 pediatric patients (aged 4 to 17 years) with confirmed TB empyema treated between 1984 and 2022, and …

02.09.2026journal-article

Scientific Reports

Supportive care needs among patients with breast and cervical cancer at a tertiary cancer treatment center in ethiopia: a cross-sectional study

Bedilu Deribe Derese, Eva Johanna Kantelhardt, Thomas Frese, Betty Ferrell, Muluken Gizaw, Sefonias Getachew, Abigiya Wondimagegnehu, Adamu Addissie, Eric Sven Kroeber, Lesley Taylor, Susanne Unverzagt

Abstract The rising incidence of cancer diagnoses alongside improving survival rates in low- and middle-income countries (LMICs) has substantially increased the demand for comprehensive supportive care. This study aimed to assess the supportive care needs of patients diagnosed with breast or cervical cancer at Hawassa University Comprehensive Specialized Hospital Cancer Treatment Center, Ethiopia. A hospital-based cross-sectional study was conducted among 349 patients with breast or cervical cancer between December …

02.09.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

High Rates of Return to Soccer After Primary Hip Arthroscopic Labral Repair for Femoroacetabular Impingement Syndrome

Akeem Henry, Louis Kang, John‐Rudolph Smith, Malik Dancy, Gavin Ward, Bruce A. Levy, Mario Hevesi, Aaron J. Krych, Kelechi R. Okoroha

Purpose To evaluate return‐to‐sport (RTS) outcomes and patient‐reported outcomes in soccer players after primary hip arthroscopic labral repair for femoroacetabular impingement syndrome. Methods All patients undergoing primary hip arthroscopy with labral repair for femoroacetabular impingement syndrome from 2011 to 2022 were retrospectively reviewed. Patients who had a minimum 2‐year follow‐up, played soccer, and had no prior hip surgery were included. Patient‐reported outcome measures and RTS were collected at the …

02.09.2026journal-article

Reviews in Endocrine and Metabolic Disorders

Radiomics and artificial intelligence in pituitary adenomas (PitNETs): from imaging biomarkers to clinical translation

Sabina Ruiz, Anna Oliva, Roger Mateu, Ariadna Izquierdo, Joshua Bernal, Gemma Monté-Rubio, Elena Valassi, Maria de la Iglesia-Vayá, Jesús A. Alzate, Paloma Puyalto, Manel Puig-Domingo

Abstract Pituitary neuroendocrine tumors (PitNETs) are common intracranial neoplasms with heterogeneous hormonal activity, invasiveness, and treatment response. Conventional MRI is central to diagnosis, but is limited in quantifying tumor heterogeneity and predicting clinically relevant features such as consistency, molecular subtype, proliferation, and clinical outcomes. To review current evidence on MRI-based radiomics and artificial intelligence (AI) in PitNETs, focusing on clinical applications, methodological …

02.09.2026journal-article

Frontiers in Medicine

Real-world effectiveness and safety of tenofovir amibufenamide in treatment-naïve chronic hepatitis B: a 48-week retrospective cohort study

Jiarui Zheng, Yuxuan Song, Bo Feng, Yandi Xie

Objectives Tenofovir amibufenamide (TMF) is a newly recommended first-line nucleos(t)ide analogues for chronic hepatitis B (CHB) in China. However, real-world evidence on its safety and effectiveness are limited. This study aimed to evaluate the short-term virological efficacy, biochemical response, as well as safety profile of TMF over 48 weeks in a real-world cohort of CHB individuals. Methods In this single-center retrospective cohort study, 129 treatment-naïve CHB patients were administered TMF at 25 mg daily. …

02.09.2026journal-article

Endocrines

Vitamin D Supplementation in Infertile Men: Beyond Pooled Effects—A Critical Meta-Analysis of Heterogeneous Clinical Responses

Dragoș Puia, Marius Ivănuță, Mihaela Corlade-Andrei, Hicham Tory, Adrian-Gabriel Majeru, Bogdan Doroftei, Ramona Ștefăniu, Vlad Cristiana Elena, Cătălin Pricop

Introduction: Male infertility is a complex global health challenge, with emerging evidence suggesting that vitamin D plays a pivotal role in testicular function and spermatogenesis. This systematic review and meta-analysis aimed to evaluate the impact of vitamin D supplementation on semen parameters and reproductive hormones in infertile men. Methods: A comprehensive search of electronic databases (PubMed, Cochrane Library, and Web of Science) was conducted to identify randomized controlled trials (RCTs) investiga …

02.09.2026journal-article

World Journal of Otorhinolaryngology - Head and Neck Surgery

Progress and Prospects in Otorhinolaryngology—Head and Neck Surgery in Ethiopia

Daniel G. Eyassu, Eliyas Asfaw, Christian Schaaff, Cody L. Messick, Assaye Nibret, Seid Temam, Nardos Getachew Bulfeta, Kassaw Ketemaw, Gebrewahd Alemu, Michael Kebede, Joshua P. Wiedermann

ABSTRACT Introduction This paper aims to explore the current state of otorhinolaryngology—head and neck surgery (ORL‐HNS) training and practice in Ethiopia, identify major barriers to development, and also highlight the optimistic prospects for the future, with strategies to build a self‐sustaining ORL‐HNS specialty capable of meeting the growing needs of the Ethiopian population. Methods This study employed a mixed‐methods approach, combining quantitative data from a cross‐sectional survey, qualitative data from s …

02.09.2026journal-article

European Journal of Medical Research

Association of admission LDL cholesterol with clinical profile and 3-months outcomes after ischaemic stroke

Marino Costa, Kateryna Antonenko, Charlotte Berger, Marieta Peycheva, Marina P. Krasteva, Arsany Hakim, Eike I. Piechowiak, Moritz C. Kielkopf, Thomas R. Meinel, Marcel Arnold, Hakan Sarikaya, Mirjam R. Heldner

Abstract Background and aim We investigated whether admission LDL-C levels are associated with clinical profile and outcomes after acute ischaemic stroke by comparing patients stratified into five LDL-C groups. Patients and methods We retrospectively analyzed consecutively included patients ≥18 years admitted to the Bernese Stroke Centre (02/2015–03/2023). Patients were stratified into five LDL-C groups: >3.0 mmol/L (n=493), 2.6–3.0 mmol/L (n=225), 1.8–2.6 mmol/L (n=490), 1.4–1.8 mmol/L (n=254) and

02.09.2026journal-article

Science Translational Medicine

Metabolic reallocation in spinal cord oligodendrocytes drives chronic pain in mice through neuronal Aβ 42 production

Yannick Fotio, Saeed Al Masri, Zechuan Shi, Johnny Le, Sudeshna Das, Varvara I. Rubtsova, Alex Mabou Tagne, Cholsoon Jang, Vivek Swarup, Daniele Piomelli

Recent evidence implicates a metabolic switch in afferent spinal circuits as a key driver of the transition from acute pain– to chronic pain–related behaviors in mice after tissue injury, yet the cellular substrates and functional consequences remain incompletely defined. Using a combination of pharmacological and genetic approaches, we investigated whether metabolic reprogramming in spinal cord cell populations constitutes a causal mechanism linking peripheral injury to the progression to pain chronicity. After pe …

02.09.2026journal-article

Journal of Occupational & Environmental Medicine

ACOEM Guidelines Independent Medical Examinations and Consultations

Christopher H. Stewart-Patterson, Charl Els, Ronald Zipper, Douglas W. Martin, Barry Gelinas, Kurt T. Hegmann

This guideline offers an overview of independent medical examinations and consultations. These typically occur in complex medical cases requiring an independent, non-partisan opinion or a re-assessment of a diagnosis. The legal requirements regarding independent medical examinations vary by jurisdiction, but it is critical that physicians performing these examinations or consultations both be sufficiently experienced in the area of inquiry and abide by strict ethical standards. A comprehensive consultation or indep …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

The Weather–Child Morbidity Link and the Modifying Effect of Maternal Education and Sanitation: Evidence from Sub-Saharan Africa

Emmanuel Skoufias, Katja Vinha

ABSTRACT. A database of historic rainfall and temperature standardized anomalies was constructed for sub-Saharan Africa (SSA) over the period 2000 to 2020 and merged with the harmonized versions of 51 rounds of Demographic and Health Surveys for 19 countries in SSA. Multivariable logit models of the determinants of the probability of reported incidence of fever, diarrhea, and coughing among children under 5 years of age were estimated with explanatory variables, including the quintiles of rainfall and temperature a …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

A Sustainable Treatment Protocol for Organophosphate Poisoning in Rural Kenya for Facilities without Intensive Care Units and Where Transfer Is Not Possible

Jerome Koleski, Sommer Aldulaimi, Jonathan Nthusi

ABSTRACT. Organophosphate poisoning is a common method of attempting suicide in developing countries, particularly in rural areas. The current WHO protocols emphasize intubation and transfer to a facility with intensive care. Both recommendations are beyond the resources of many rural hospitals in developing countries and their poor patients. Because organophosphate poisoning is a commonly seen condition in Kenya and because intubation is beyond the equipment and training of many rural hospitals, a protocol involvi …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Arbovirus Circulation among Patients with Acute Encephalitis: West Nile Virus Infection among Humans in Bangladesh, 2022

Syeda Tasnuva Maria, Mallick Masum Billah, Quazi Ahmed Zaki, Sharmin Sultana, Francisco Averhoff, Gavin Cloherty, Nick Walsh, Tahmina Shirin

ABSTRACT. West Nile virus (WNV) is an emerging infectious disease causing neuroinvasive diseases, including meningitis and encephalitis. Although infection has been documented in birds in Bangladesh, WNV has not been detected in humans. Since 2007, the Institute of Epidemiology, Disease Control and Research in Bangladesh has conducted hospital-based acute encephalitis syndrome (AES) surveillance to monitor Japanese encephalitis (JE), which is typically detected in 2% to 3%. Our study aimed to determine the presence …

02.09.2026journal-article

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine

Contemporary Evaluation and Management Strategies for Tricuspid Regurgitation

Sajjad Ahmadi-Renani, Stephan von Haehling, Constanze Schmidt, Sepideh Taghavi, Marzieh Mirtajaddini, Razieh Omidvar, Nasim Naderi

Background: Tricuspid regurgitation (TR) is a common but historically under-recognized valvular heart disease. Although mild to moderate TR was long considered benign, accumulating evidence indicates that clinically significant TR is associated with right ventricular failure, hepatic congestion, recurrent hospitalization, and increased mortality. Aims: This review aims to provide a comprehensive overview of contemporary evaluation and management strategies for TR across its clinically relevant spectrum, with partic …

02.09.2026journal-article

Chronic Illness

How organizational conditions shape development and assessment of patient-Centered lifestyle interventions targeting hard-to-reach patients with cardiac disease or type 2 diabetes

Sanne Lykke Lundstrøm, Karin Burns, Nana Folmann Hempler, Nina Ingemann Christensen, Ulla Toft, Ole Snorgaard, Louise Meinertz Jakobsen

Objectives This study explores how organizational conditions affect the development and implementation of dialogue-based methods for patients with cardiac disease or type 2 diabetes, focusing on hard-to-reach groups. Methods Utilizing audio recordings, transcripts, and field notes from 2018-2019, we applied the Theoretical Domains Framework to analyze how individual and group processes influenced the development and implementation of initiatives. Results The study identified five key themes: environmental context a …