Clinicodemographic and anatomical predictors of squamous cell carcinoma

Vollständiger Abstract

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Objectives: To evaluate the clinicodemographic characteristics and anatomical distribution of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and identify independent predictors of SCC. Material and Methods: A retrospective analysis of 374 patients (BCC = 209, SCC = 165) was performed. Variables included age, sex, and tumor localization. High-risk locations were the lip, scalp, and temporal regions. Univariate and multivariate logistic regression analyses were performed. Age was analyzed continuously and categorically (80 years). Model performance was assessed using receiver operating characteristic analysis. Results: The mean age was 68.2 ± 12.8 years in the BCC group and 70.5 ± 12.7 years in the SCC group ( p = 0.082). SCC was more frequent in males (72.1% vs. 56.0%, p = 0.003). In multivariate analysis, male sex (odds ratio [OR]: 1.87, p = 0.012) and high-risk localization (OR: 3.30, p < 0.001) were independent predictors of SCC. Age ≥80 years was also associated with SCC (OR: 2.54, p = 0.008), whereas age 60–80 years was not ( p = 0.352). The optimal probability cutoff for SCC was 0.608 (sensitivity: 41.3%, specificity: 89.7%; area under the receiver operating characteristic curve [AUC] = 0.660). Conclusion: Male sex and high-risk anatomical localization are strong predictors of SCC. Age exhibits a nonlinear association, with increased SCC risk only in patients >80 years.