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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

International Journal of Molecular Sciences

OX40 (TNFRSF4) Tracks Immune Infiltration in Small Cell Lung Cancer and Shows a Cohort-Specific, Non-Replicated Association with the POU2F3/SCLC-P Subtype: A Multi-Source In Silico Analysis

Mehmet Turan Özer, Faruk Recep Özalp

OX40 (TNFRSF4) is a costimulatory T-cell receptor and OX40 agonists are in clinical development, yet its role in small cell lung cancer (SCLC) is still to be characterised. We analysed the discovery cohort (n = 77, 48 events), GSE60052 (n = 79 tumours; 48 with survival), GDSC1+GDSC2 (61 SCLC cell lines, 542 drugs) and human SCLC single-cell atlas (77,143 cells from primary and metastatic sites, 20 donors), using Cox models, FDR-controlled correlation, nested-model comparison and deconvolution. High TNFRSF4 showed a …

31.08.2026journal-article

INMATEH - Agricultural Engineering

MECHANISM AND EFFICACY EVALUATION OF ATMOSPHERIC PRESSURE DBD PLASMA TREATMENT FOR FORAGE GRASS SEEDS

Jun-hui XI, Xiao-juan ZHAO, Xiang-yang WU, Zhen-hua WANG, Jia-jia SU, Yun-ting HUI, Yan-ying GUO, Yang-yang LIAO, De-cheng WANG

To overcome the problems of low germination rate and irregular emergence caused by dense surface structure, poor water permeability, and dormancy of forage seeds, this study screened the optimal plasma generation mode suitable for continuous treatment of forage seeds under atmospheric pressure and evaluated its efficacy and mechanism. Through a comparative analysis of the uniformity and stability of corona, spark, gliding arc, and dielectric barrier discharge (DBD), the results showed that DBD can generate large-ar …

31.08.2026journal-article

Ciência & Tecnologia

APLICAÇÃO DE POLÍMEROS NO TRATAMENTO DO CALDO NA PRODUÇÃO DE AÇÚCAR

Vitória Viviane De Lima, Leonardo Lucas Madaleno

O uso de auxiliares de sedimentação, como polímeros, na produção de açúcar é importante para obter um caldo de melhor qualidade. Então, nas etapas subsequentes ao tratamento do caldo, produzir cristais de sacarose com características que atendam às exigências do mercado consumidor. O objetivo do presente trabalho foi realizar uma revisão da literatura sobre a aplicação de polímeros no tratamento do caldo da produção de açúcar. Artigos, livros e teses foram consultados na elaboração da revisão. No trabalho, identifi …

31.08.2026journal-article

Journal of Personalized Medicine

Personalized Risk Assessment and Treatment in Ruptured Isolated Posterior Spinal Artery Aneurysm: A Rare Case and Systematic Literature Review

Elisa Garbin, Nicola Cavasin, Luca Basaldella, Salima Magrini

Background: Ruptured isolated spinal artery aneurysms (SAAs) are not common. Posterior spinal artery aneurysms (PSAAs) are less common. Either is rarely the cause of spontaneous spinal subarachnoid hemorrhage (sSAH). Due to a few published reports, the natural course, diagnosis and optimal therapeutic strategy remain debatable and challenging. We report the case of a 60-year-old male presenting with lumbar and abdominal pain, which swiftly became associated with headache, photophobia and worsening neck pain. Spinal …

31.08.2026journal-article

Frontiers in Pharmacology

Magnocurarine inhibits migration and invasion by suppressing mesenchymal marker expression and MAPK signaling in castration-resistant prostate cancer cells

Warathit Semmarath, Punnida Arjsri, Kamonwan Srisawad, Pilaiporn Thippraphan, Intranee Intanil, Sonthaya Umsumarng, Pornngarm Dejkriengkraikul

Background: Magnocurarine is an alkaloid isolated from several traditional Asian medicinal plants, including Magnolia and Harrisonia species. Previous studies have reported its anti-nociceptive, anti-inflammatory, and antimicrobial activities with relatively low cytotoxicity. However, the anticancer activity of magnocurarine, particularly its effects on prostate cancer cell migration and invasion, has not been well characterized. Objective: This study aims to investigate the effects of magnocurarine on the migratio …

31.08.2026journal-article

Pakistan Journal of Pharmaceutical Sciences

Improved transcutaneous delivery of cetirizine hydrochloride for the treatment of post-chemotherapy alopecia: Poke and emulgel approach

Sana Hassan

Abstract: Background: Chemotherapy-induced alopecia negatively impacts the mental health of cancer patients. Topical minoxidil, a widely recommended drug for hair regrowth, causes scalp irritation and contact dermatitis. Oral minoxidil causes multiple cardiovascular and neurological side effects. Cetirizine hydrochloride, an antihistamine with a better safety profile than minoxidil, may stimulate hair follicle activity by modulating prostaglandin levels. Objectives: The present study aimed to develop a cetirizine h …

31.08.2026journal-article

Journal of Powder Materials

Microstructural Evolution and Tensile Response of a Fe–15Cr Oxide Dispersion Strengthened Steel after Hot Rolling and Heat Treatment

Trung Thanh Pham, Woo-Hyeok Kim, Hyun-Cheol Kim, Jeoung Han Kim

Fe-based oxide dispersion-strengthened (ODS) are promising structural materials for Generation IV nuclear systems because of their high-temperature strength, radiation tolerance, and microstructural stability. However, their mechanical performance is difficult to optimize because it depends on a coupled relationship among alloy composition, powder processing, consolidation, thermo-mechanical treatment, oxide dispersion, and deformation substructure. In this study, a machine learning (ML) screening workflow was used …

31.08.2026journal-article

Dentistry Journal

Effectiveness of Photobiomodulation as a Treatment for Xerostomia in Patients with Head and Neck Cancer Undergoing Radiotherapy: A Systematic Review and Meta-Analysis

Tomás Quintero De La Hoz, Yaskara Sanjines Peña, Fernando Quispe Ramírez, Oriana Rivera-Lozada, Joshuan J. Barboza

Background: Radiotherapy-induced xerostomia is a prevalent and disabling complication in patients with head and neck cancer, leading to persistent oral pain, impaired salivary function, and substantial deterioration in quality of life. Photobiomodulation (PBM) has emerged as a supportive therapeutic strategy with potential anti-inflammatory, analgesic, and tissue-preserving effects; however, its clinical effectiveness remains incompletely defined. Methods: We conducted a systematic review and meta-analysis of rando …

31.08.2026journal-article

Current Cancer Drug Targets

Clinicopathological Profiles and Prognosis of Postoperative HER2-Mutant Non-Small Cell Lung Cancer: A Real-World Analysis

Guangjian Yang, Linyan Tian, Xiaoyong Tang, Yan Wang

Background/Introduction: Patients with non-small cell lung cancer (NSCLC) harboring HER2 mutations remain at high risk of recurrence, even following radical resec-tion for early-stage disease. Currently, there is a paucity of research investigating the clini-copathological characteristics and disease-free survival (DFS) outcomes of this specific postoperative population. Methods: This retrospective study investigated the clinicopathological and molecular char-acteristics of 77 patients with surgically resected HER2 …

31.08.2026journal-article

Current Oncology

Patient-Controlled Real-Time Transcutaneous Electrical Acupoint Stimulation at Neiguan (PC6) for Chemotherapy-Induced Nausea and Vomiting in Breast Cancer: An Exploratory Single-Arm Two-Stage Trial

Huiting Liu, Jie Zhou, Junying Du, Qiongying Shen, Chao Lu, Jianxing Zhang, Weiping Zhang, Ran Ran, Jianqiao Fang, Jiongyao Ye, Hong Gao, Junfan Fang

Chemotherapy-induced nausea and vomiting (CINV) remain difficult to control after discharge despite guideline-based antiemetics. This multicenter exploratory single-arm two-stage trial evaluated patient-controlled, real-time transcutaneous electrical acupoint stimulation (TEAS) at Neiguan (PC6) as an adjunct to standard antiemetic therapy in patients with breast cancer. Forty-eight patients who had experienced CINV and were scheduled at enrollment to receive the same chemotherapy and antiemetic regimens during two …

31.08.2026journal-article

Korean Journal of Clinical Oncology

Suppression of MCM2 reduces cancer stem cells and epithelial-mesenchymal transition-related phenotypes in breast cancer cells

Rae-Kwon Kim

Purpose: Minichromosome maintenance protein 2 (MCM2) is a key regulator of DNA replication and has been implicated in tumor progression. While previous studies have demonstrated its role in lung cancer stem cells (CSCs), its role in breast cancer remains unclear. This study aimed to investigate whether MCM2 regulates CSCs and epithelial-mesenchymal transition (EMT) in breast cancer.Methods: MCM2 expression and its prognostic significance were analyzed using public breast cancer datasets. MDA-MB-231 breast cancer ce …

31.08.2026journal-article

Clinical and Experimental Otorhinolaryngology

Human Papillomavirus (HPV)-Infected Epithelial Cells and FBLN1-Positive Fibroreticular Cells Govern the Immunogenic Tumor Microenvironment in HPV-Associated Oropharyngeal Squamous Cell Carcinoma

Doeon Gu, Joonho Shim, Soo Yoon Kim, Hye Jin Kim, Da-Yong Shin, Hyun-Tae Shin, Nayeon Choi, Woong-Yang Park, Man Ki Chung, Sung Yong Choi

Objectives. Oropharyngeal squamous cell carcinoma (OPSCC) exhibits distinct clinical behaviors according to human papillomavirus (HPV) status. HPV-associated OPSCC is typically associated with a more favorable prognosis and improved response to therapy than non-HPV–associated OPSCC; however, the underlying differences in the tumor microenvironment (TME) remain incompletely understood.Methods. To investigate cellular and molecular factors associated with improved outcomes in HPV-associated OPSCC, we performed single …

31.08.2026journal-article

AFRICAN JOURNAL OF REPRODUCTIVE HEALTH

Assessment of anxiety levels and marital relationships among women undergoing infertility treatment: A descriptive observational study

Naima M. Elsayed, Nabila S. Mohamed, Rabab S. Hassan, Eshrak S. Hashem, Randa M. Abobaker

This study aimed to assess anxiety levels and marital relationships among women undergoing infertility treatment. A descriptive observational design was conducted involving 300 infertile women over nine months at Zagazig University Hospital. Data were collected using a Structured Interview Questionnaire, the Female Sexual Function Index (FSFI), and the Taylor Anxiety Scale. Reliability analysis showed high internal consistency (Cronbach's alpha: 0.923 for FSFI; 0.845 for Taylor Scale). Results indicated that 32.6% …

31.08.2026journal-article

Oncogenesis

Compartmentalisation of death receptor signalling in cancer

Victoria Maltret, Elodie Lafont

Abstract Death Receptor (DR) ligands, such as CD95L and TRAIL, are historically considered as key players of tumour immunosurveillance through their ability to induce cell death. Yet, depending on the cellular context, their corresponding DR, CD95 and TRAILR1/2, also initiate various non-cytotoxic pathways and cellular functions and display multiple pro-tumoural functions across various cancer types. To unleash the full potential of the therapeutic targeting of DR signalling, it is therefore essential to understand …

31.08.2026journal-article

Frontiers in Radiology

Slice-level vs. volumetric radiomics for molecular subtyping of breast cancer: impact of patient-level data partitioning on model performance

Laila El Jiani, Zouheir Banou, Fatima Zahra Alaoui, Hasnae Sakhi, El Habib Benlahmar, Sanaa El Filali

Introduction Molecular subtyping of breast cancer, particularly the discrimination between Luminal A and Basal-like tumours, is critical for guiding treatment decisions and establishing prognosis. Radiomics offers a promising complementary, non-invasive imaging biomarker to support biopsy-based subtyping; however, two methodological gaps limit the validity of existing studies: the absence of controlled 2D-vs.-3D feature comparisons, and the systematic underreporting of patient-level data leakage in multi-slice pipe …

31.08.2026journal-article

International Journal of Paediatric Dentistry

Treatment Approaches for Pre‐Eruptive Intracoronal Resorption According to Lesion Grade and Pulp Involvement: A Systematic Review of Case Reports and Case Series

Paulina Radomyska, Natalia Torlińska‐Walkowiak, Renata Śniatała, Justyna Opydo‐Szymaczek

ABSTRACT Objectives Pre‐eruptive intracoronal resorption (PEIR) is a pathological condition lacking standardized treatment guidelines. This systematic review aims to synthesize published evidence on PEIR treatment strategies. Materials and Methods Five databases (PubMed, Web of Science, Scopus, Embase, and Dentistry & Oral Sciences Source) were searched according to a registered PROSPERO protocol (CRD420251018329, 28 March 2025). Eligible studies were case reports and case series describing PEIR treatment and follo …

31.08.2026journal-article

Infection

Effect of kidney function on drug concentrations of first-line anti-tubercular treatment

Divya Datta, Indu Ramachandra Rao, Raghavendra Shetty, Shankar Prasad Nagaraju, Girish Thunga, Rahul Magazine, Shivashankara Kaniyoor Nagri, Nisha Abdul Khader, Pasumarthi Tejashree, Surulivelrajan Mallayasamy, Praveen Kumar Tirlangi, Dharshan Rangaswamy, Srinivas Vinayak Shenoy, Mohan V. Bhojaraja, Attur Ravindra Prabhu

Abstract Background Tuberculosis (TB) and chronic kidney disease (CKD) are interconnected global health concerns. CKD patients have a higher risk of developing TB. Decreased clearance of drugs in kidney disease enhances toxicity risk. Current guidance on medication doses is not based on therapeutic drug monitoring. We measured and compared the concentrations of first-line anti-TB drugs in CKD and those with normal kidney function. Methods A prospective observational study was conducted from September 2020 to Decemb …

31.08.2026journal-article

Supportive Care in Cancer

Evidence supporting endodontic therapy as a safe strategy in patients previously treated with head and neck radiotherapy: a scoping review

Álvaro Souza Wanderley, Wesley Viana de Sousa, Maria Olívia da Costa, Alícia Marcelly Souza de Mendonça Silva, Raylane Farias de Albuquerque, Igor Henrique Morais Silva, Lucas Nascimento Ribeiro, Diana Santana Albuquerque, Marlos Barbosa-Ribeiro

Abstract Purpose To map and synthesize the available scientific evidence supporting the effectiveness and safety of endodontic therapy in patients who underwent head and neck radiotherapy, considering clinical and radiographic outcomes and treatment-related complications, particularly osteoradionecrosis (ORN). Methods This scoping review followed the Arksey and O’Malley framework, informed by the Joanna Briggs Institute Manual for Evidence Synthesis, and was reported according to PRISMA-ScR guidelines. Comprehensiv …

31.08.2026journal-article

European Cells & Materials

ROS-Responsive siFGF19 Delivery Reprograms Pancreatic Stellate Cells and Remodels the Desmoplastic Microenvironment in Pancreatic Cancer

Zhaohong Wang, Shengzhang Lin, Suhua Zheng, Zhengrong Tian, Xihao Zhong, Xinchang Zhang, Shaodong Lin, Beier Wang, Yilun Xie, Hongfei Tong, Qiyu Zhang, Zhonglin Ni

Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stromal fibrosis that limits drug delivery and promotes therapeutic resistance. Pancreatic stellate cells (PSCs), key mediators of desmoplasia, represent a promising yet underexploited therapeutic target. This study aimed to suppress PSC activation and remodel tumor stroma by silencing fibroblast growth factor 19 (FGF19) using a reactive oxygen species (ROS)-responsive small interfering RNA (siRNA) delivery system. Methods: A ROSsensi …

31.08.2026journal-article

Annals of Coloproctology

Surgical and oncologic outcomes of cT4b rectal cancer: a propensity score–matched comparison between a university center and regional hospitals

Takashi Nonaka, Keisuke Noda, Tetsuro Tominaga, Hiroki Katayama, Shintaro Hashimoto, Makoto Hisanaga, Hiroaki Takeshita, Kazuo To, Hidetoshi Fukuoka, Keitaro Matsumoto

Purpose: Surgery for cT4b rectal cancer remains technically demanding, and outcomes may vary substantially across institutions. This study evaluated perioperative and oncologic outcomes of cT4b rectal cancer surgery performed at a university center compared with those at regional hospitals within a collaborative network.Methods: A total of 103 patients who underwent curative-intent surgery for cT4b rectal cancer between 2016 and 2024 were retrospectively reviewed. After 1:1 propensity score matching based on baseli …

31.08.2026journal-article

Revista Panamericana de Salud Pública

Transforming pediatric oncology in Ecuador through the Global Platform for Access to Childhood Cancer Medicines

Marmol Lissette, Liliana Vásquez, Carmen Guerrero, Nilda Villacrés, Daniel A. Antiporta, Manuel Lavayen, Karina Meza, Paola Solís, David Santana, Ricardo Solís, María Del Carmen Trujillo, Gema Solórzano, Lorena Sánchez, Doris Calle, Diana Bonilla, Gissela Sanchez, Luis Espin, Enmanuel Guerrero, Richar Cedeño, Soledad Jimenez, Araceli Morales, Toby Kasper, Santiago Millan, Pablo Alcocer, Christopher Lim, Mauricio Maza, Silvana Luciani, Carlos Rodríguez-Galindo, Sonia Quezada

ABSTRACT Background. Childhood cancer survival exceeds 80% in high-income countries but remains below 50% across much of Latin America. In Ecuador, limited access to diagnosis and essential medicines, and fragmented governance have hindered progress. In 2025, Ecuador became the first country in the Region of the Americas to implement the Global Platform for Access to Childhood Cancer Medicines, an initiative led by the World Health Organization (WHO) and St. Jude Children’s Research Hospital to ensure equitable acc …

31.08.2026journal-article

The Oncologist

Feasibility of EHR-Based Prescreening for an Adjuvant Breast Cancer Trial in a Safety-Net Health System

Hussain Alkhafaji, Lindsay C K Reynolds, Melissa Howell, Jerry D Henderson, Dedra Preece, Kari J Teigen, David E Gerber, Kalyani Narra

Abstract Introduction Racial and ethnic inequities persist in oncology clinical trial participation, while safety-net health systems may face resource and data limitations that complicate candidate identification. We evaluated the feasibility of an electronic health record (EHR)-assisted prescreening workflow for EMBER-4, a phase 3 adjuvant breast cancer trial, at a safety-net health system. Methods Structured Query Language (SQL) queries applied to Epic Clarity identified potential candidates using diagnosis codes …

31.08.2026journal-article

BMC Health Services Research

Translation, cultural adaptation, and descriptive psychometric pilot evaluation of the Swedish Cancer Support Source-caregiver

Maria Samuelsson, Jenny Jakobsson, Benjamin Maus, Carl Magnus Olsson, Marie Louise Möllerberg

Abstract Objective This study aimed to translate the CancerSupportSource-Caregiver (CSS-C), culturally adapt it, and conduct a descriptive pilot evaluation of the psychometric properties of the Swedish version in a sample of Swedish family members of persons diagnosed with cancer. Method Translation and cultural adaptation involved forward-backward translation by professional translators in collaboration with the research team and assessments of comprehensibility and face and content validity by two expert panels c …

31.08.2026journal-article

Ophthalmologica Indonesiana

Characteristics of Conjunctival Melanocytic Tumor Patients in a Tertiary Hospital: A 4-Year Study

Fadhila Khairunnisa Poerwoko, Raja Erinda, Faiza Rizky A.S

Introduction: Conjunctival neoplasms includes melanocytic and nonmelanocytic tumors, and most are benign. Due to their rarity in the general population, it is important to consider the demographic, clinical signs, symptoms, and histopathological features to make the correct diagnosis. This study aims to describe the demographic, clinical, and histopathology of Conjunctival Melanocytic Tumors patients in a Tertiary Hospital. Methods: A retrospective study held from the medical record of patients with diagnosis conju …