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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Public Health

High-magnification inpatient cases under DIP payment reform: prevalence, cost burden, and risk factors in an NHC-administered hospital in China

Jianjun Lu, Zhuochen Lin, Ziyi Xin, Junfeng Liu, Yuting Gu, Ying Xiong, Wujun Zhang

Background The nationwide rollout of Diagnosis-Intervention Packet (DIP) payment reform in China aims to enhance inpatient cost efficiency, yet high-magnification cases impose escalating financial burdens on tertiary hospitals. This study characterized the cost profiles and independent determinants of high-magnification cases under DIP to inform precision cost governance and medical insurance policy optimization. Methods This retrospective observational study included 191,490 consecutive inpatient admissions from a …

03.09.2026journal-article

Frontiers in Clinical Diabetes and Healthcare

Moisturizer formulations for diabetic foot xerosis: a systematic review and meta-analysis of randomized controlled trials

Karin Borgström, Sebastian Björklund, Petri Gudmundsson, Anna Ericsson, Stefan Acosta

Background Foot xerosis in people with diabetes increases the risk of skin fissuring, ulceration and complications like amputation, sepsis and death. Preventive skin care is therefore important, yet evidence-based guidance on the most effective formulations remains limited. This systematic review aimed to identify effective ingredients and formulations to treat diabetic foot xerosis. Methods A literature search was conducted in Medline, Cinahl, Embase, CENTRAL and Scopus. Randomized controlled trials (RCTs) involvi …

03.09.2026journal-article

Journal of the National Comprehensive Cancer Network

Comparative Cost-Effectiveness Analysis of First-Line Immunotherapy for Advanced Melanoma Based on 10-Year Clinical Outcomes

Guiyuan Xiang, Yin Sun, Xue Yang, Yao Liu

Background: Recently, the CheckMate 067, KEYNOTE-006, and RELATIVITY-047 trials demonstrated the long-term efficacy and safety of 5 first-line therapies for advanced melanoma, including nivolumab + relatlimab, with >10 years of follow-up. However, the long-term economic outcomes are still unclear. This study aimed to assess the comparative cost-effectiveness of these strategies from a US health care perspective using more than a decade of clinical trial data. Methods: Based on the data from clinical trial reports, …

03.09.2026journal-article

Frontiers in Digital Health

A pilot study of at-home online cognitive screening prior to primary care wellness visits for older adults

Louisa Thompson, Charles Eaton, Sarah Prieto, Molly Lawrence, Stephanie Czech, Jennifer Rosenbaum, David Anthony, Rabin Chandran, Lauren Kelly, Ivy Ngo, Arnold Goldberg, Caitlin Gillooly, Caroline Richardson, A. Rani Elwy, Richard N. Jones, Dorene M. Rentz

Background Improved methods of cognitive testing are urgently needed for primary care settings faced with a growing older adult population and higher rates of dementia. We tested the feasibility and acceptability of a novel online cognitive test that can be completed at home prior to an annual exam. Methods 32 older adults completed testing at home on personal devices 1–4 weeks prior to an annual exam with their primary care provider. Additional cognitive screening was completed in-clinic to provide preliminary val …

03.09.2026journal-article

Nutrients

Unmetabolized Folic Acid: Biology, Epidemiology, and Clinical Consequences: A Systematic Review

Richard E. Frye, Daniel A. Rossignol

Background: Mandatory folic acid (FA) fortification prevents neural tube defects but generates unmetabolized folic acid (UMFA) in blood, because hepatic dihydrofolate reductase (DHFR) reduces FA only slowly. Whether UMFA itself, as distinct from high total folate, carries biological consequences is unresolved. Methods: We systematically searched six databases (January 1995–May 2026; PROSPERO CRD420261407616) and included 65 publications describing 61 unique primary studies, yielding 71 analytic contributions (15 me …

03.09.2026journal-article

AI

Forecasting Gas-Dynamic Processes and Phenomena in Coal Mines Using Ensemble Model of Artificial Intelligence

Alexander Ivannikov, Igor Temkin, Ilya Savelev

Predicting emergencies caused by uncontrolled and sometimes sudden changes in methane concentration within working and adjacent zones of coal mines remains a critical and challenging task, the solution for which can greatly enhance mining safety. This study presents a hybrid machine-learning model trained on real and synthetic data for accurate methane concentration forecasting and risk-level classification. The authors propose an ensemble method comprising staged data preprocessing, generation of physically meanin …

03.09.2026journal-article

Clinical Pharmacology & Therapeutics

Integrating Patient‐Centric Clinical Pharmacology and MID3 to Advance Biologic Development in Immune‐Mediated Inflammatory Diseases

Sihem Ait‐Oudhia, Li Zhang, Dipak S. Pisal, Brian Cicali

Advances in biologics and model‐informed drug discovery and development (MID3) are transforming the treatment of immune‐mediated inflammatory diseases (IMIDs). By integrating pharmacokinetics and pharmacodynamics, MID3 enables mechanism‐based, patient‐centered strategies to optimize therapies, strengthen benefit–risk assessment, and advance precision medicine. Innovations such as cytokine inhibitors, bispecific antibodies, antibody–drug conjugates, and mRNA therapies have expanded treatment options across dermatolo …

03.09.2026journal-article

Emergency Medicine Australasia

Using Sydney Triage to Admission Risk Tool With Artificial Intelligence ( START ‐ AI ) to Predict Inpatient Admitting Specialty for Emergency Department Patients: Single Centre Deep Learning Analysis

Michael Dinh, Elizabeth Corbett, Thuy Truc Ngo, Eliot Salmon, Saleem Ahmed Khan, Farhana Pethani, Nicholas Moore, Irena Koprinska

ABSTRACT Objective To investigate whether the Sydney Triage to Admission Risk Tool with Artificial Intelligence (START‐AI) model could be used to predict specific inpatient admitting teams based on clinical notes. Methods This was a pre‐trained language model analysis using electronic medical record data from an inner‐city tertiary referral hospital emergency department (ED) in Sydney, Australia. All adult patients who were admitted to an inpatient ward between January 2023 and June 2025 were included. A fine‐tuned …

03.09.2026journal-article

Clinical Dermatology Review

An Observational Study on Mucocutaneous Eruption Secondary to Mycoplasma pneumoniae: Alphabet Soup of Reactive Infectious Mucocutaneous Eruption or Mycoplasma pneumoniae-induced Rash and Mucositis

Swapnil Shah, Shibhani Sudheer Hegde, Chetan D. Rajput, Sandeep Kulkarni

Abstract Background: In 2015, diagnostic criteria for Mycoplasma pneumoniae -induced rash and mucositis (MIRM) were recommended, and currently, reactive infectious mucocutaneous eruption (RIME) is preferred. Due to the relatively recent introduction of this disorder, clinicians are still not extensively primed regarding the morphology and diagnosis of MIRM. Materials and Methods: A retrospective study was undertaken in a referral children’s hospital in Western India over 6 months where children concomitantly affect …

03.09.2026journal-article

LAW AND BUSINESS

On Digital Currency as Property for the Purposes of Inclusion in the Debtor’s Bankruptcy Estate in Insolvency Cases

Yana A. Perepelkina

This article notes the differences between digital currency and things and property rights, highlighting legislator’s and courts’ approaches to defining digital currency as property under Article 128 of the Civil Code of the Russian Federation. It notes a tendency of the courts to consider digital currency as other property not only for the purposes of protecting the public interests and the interests of non-participants of the digital currency circulation, particularly when it is included in a debtor’s bankruptcy …

03.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

LONG COVID THROUGH A ONE HEALTH LENS: CLINICAL, SOCIAL, AND ENVIRONMENTAL FACTORS IN THE AMAZON

Ailson Almeida Veloso Junior, Luiz Fábio Magno Falcão, Junior da Silva Gomes, Yasmin Roque Sousa, Yasmin Barreiros da Silva, Valeria Gonçlaves da Mata, Naylane de Farias Caldas, Gabriele Farias Martins, Valeria Gonçalves da Mata

Objective: To characterize persistent manifestations following COVID-19 and analyze their associations with clinical, social, environmental, and psychosocial factors among individuals from the Brazilian Amazon from a One Health perspective. Methods: This observational, cross-sectional, analytical epidemiological study included a retrospective component addressing acute SARS-CoV-2 infection. The analysis comprised 98 participants. High symptom burden was exploratorily defined as four or more post-COVID manifestation …

03.09.2026journal-article

Prohominum

Soberanía Digital en tiempos de crisis: El rol vital de las infraestructuras regionales de Acceso Abierto en Latinoamérica

Carlos Authier, Sergio Santamarina

El artículo analiza la soberanía digital en Latinoamérica frente al dominio de las infraestructuras de comunicación científica del Norte Global. Explica que el sistema de identificadores persistentes DOI, gestionado por Crossref, no es un artefacto neutral, sino un proyecto estratégico nacido para preservar el control comercial sobre la propiedad intelectual. Esta arquitectura genera una "carga asfixiante" para la región: por un lado, el drenaje de fondos públicos a través de los Article Processing Charges (APC) y, …

03.09.2026journal-article

Journal of Intensive Care Medicine

Hypoxic Hepatitis in Critically Ill Patients: Incidence, Clinical Characteristics, and Outcomes — A Systematic Review and Meta-Analysis

Carlos David Trevilla Martínez, Yeison Cruz Castillo, Mariela Denise Fermin Madera, Supritha Chintamaneni, Brenda Tatiana Camacho Ramirez, Laura A. Gray, Gabriela Flores Monar, Bansi Sutariya, Camila Sanchez Cruz, Ernesto Calderón-Martinez, Sushovan Guha, Rashmi Advani

Background Hypoxic hepatitis (HH), also termed ischemic hepatitis and historically described as shock liver, is an acute liver injury syndrome in critically ill patients characterized by a rapid and marked rise in aminotransferases in the setting of circulatory, cardiac, or respiratory failure, after exclusion of other causes of acute hepatic injury. Despite its clinical relevance, the true incidence and prognostic significance of HH remain unclear. This systematic review and meta-analysis aimed to determine the po …

03.09.2026journal-article

BUSINESS LAW

Digital Rights as a Tool for Attracting Investments in Business Projects: Problems of Establishing a Legal Regime

Olga M. Shevchenko

Digital assets that can be used in practice to attract investments in business projects are only partially regulated by Russian law. There are a number of unresolved issues regarding utilitarian digital rights and digital financial assets that have already been regulated by Russian legislation. The dual legal regime of shares issued in the form of digital financial assets, which are both digital rights and securities, does not contribute to the effective protection of shareholders’ rights. It is necessary to explic …

03.09.2026journal-article

LAW AND BUSINESS

Legal Support for the Procedure of Using Artificial Intelligence Technology in Legal Practice

Natalya V. Makarchuk

The article analyzes current approaches to regulating the use of artificial intelligence technology in legal practice, as well as the current Guidelines for the Use of Artificial Intelligence in Legal Proceedings, adopted by the Supreme Court of the Turks and Caicos Islands on August 4, 2025, which are of practical interest given the current legal positions of Russian courts regarding the need to hold parties accountable for the inaccuracy of generated text provided during legal proceedings. The article suggests us …

03.09.2026journal-article

Frontiers in Nutrition

Beyond donor eligibility: nutritional and lifestyle heterogeneity and implications for long-term donor health preservation

Elisa Mazza, Samantha Maurotti, Yvelise Ferro, Francesca Rita Noto, Carmelo Pujia, Nancy Paone, Alessia Sestito, Marta Moraca, Ilda Fatima Martino, Arturo Pujia, Tiziana Montalcini

Background Blood donor eligibility is essential for donation safety, but it may not fully capture nutritional, metabolic, and lifestyle-related vulnerabilities that can affect donor health over time. As transfusion systems increasingly rely on regular donors, identifying modifiable factors that may support long-term donor health and retention is becoming increasingly relevant. This study aimed to characterize nutritional and lifestyle heterogeneity, peri-donation dietary behaviors, and donation-related outcomes in …

03.09.2026journal-article

American Journal of Audiology

Exploring the Continuing Education Experiences and Needs of Hearing Health Care Professionals: A Survey-Based Study

Robin O'Hagan, Janani Rajendra, Chris Allan, Marlene Bagatto, Ioan Aurelian Curca, Matt Lucas, Ewan Macpherson, Christine Meston, Sheila Moodie, Vijay Parsa, David Purcell, Jack Scott, Susan Scollie, Susan Stanton, Danielle Glista

Purpose: Continuing education in hearing health care encompasses a range of opportunities, including formal academic training, professional certification and credentialing, technical or job-specific instruction, professional development events, and personal or general skill enhancement. This study examined the continuing education experiences and needs of hearing health care professionals to inform the design and delivery of future educational initiatives tailored to this workforce. Method: Members of the National …

03.09.2026journal-article

Frontiers in Nutrition

The effects of maternal dietary fiber and short-chain fatty acids on the health of offspring: a mini review

Shaozhi Liu, Senling Feng, Zhongwen Yuan, Zhengrong Mei, Jinjin Yin, Lei Chen, Yongxia Zhang

Maternal nutrition during pregnancy is a critical determinant of offspring long-term health. Dietary fiber has emerged as a key modifiable factor. Through gut microbial fermentation, fiber is converted into short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate. This mini review synthesizes current evidence from molecular, animal, and human studies on the role of maternal SCFAs in programming offspring metabolic and immune health. Mechanistically, SCFAs act via two complementary pathways: acti …

03.09.2026journal-article

Frontiers in Education

When more technology does not mean better learning: digital tool use, instructional quality, and mathematics achievement in everyday classroom settings

Christian Lindermayer, Timo Kosiol, Julia S. Meuleners, Tamara Kastorff, Birgit J. Neuhaus, Stefan Ufer

Meta-analyses highlight that digital tool use can positively affect students’ mathematics achievement. However, these findings mainly derive from controlled studies with well-orchestrated technology integration, whereas evidence from regular classrooms remains scarce—particularly regarding how often digital tools are used in everyday settings and how this relates to students’ mathematics achievement. At the same time, instructional quality—encompassing basic dimensions such as classroom management, cognitive activa …

03.09.2026journal-article

Frontiers in Neuroscience

How physician relationships with neurotechnology companies impact clinical practice: interviews with physicians

Meredith V. Parsons, Judith M. Mwobobia, Erin D. Solomon, Michael Kudom-Agyemang, James M. DuBois, Tristan McIntosh

Introduction Physicians and neurotechnology companies each play a critical collaborative role when integrating neurotechnology into clinical practice. Physicians serve as gatekeepers and decision-makers in adopting neurotechnology, while companies often support the development, training, and maintenance of these devices. Relationships with industry require physicians to navigate complex clinical, ethical, and technological factors that affect their clinical roles. To understand physicians’ relationships with neurot …

03.09.2026journal-article

Frontiers in Public Health

Declining trends but persistent disparities in cervical cancer mortality in the United States, 1999–2023

Jie Liu, Yonglin Liu, Yanjiao Jiang, Xuefeng Wang, Xianwei Zhou

Background Cervical cancer is largely preventable through effective screening and human papillomavirus (HPV) vaccination; however, mortality disparities remain a persistent public health challenge in the United States. This study aimed to examine long-term trends and socio-demographic and geographic inequalities in cervical cancer mortality. Methods We conducted a population-based study of cervical cancer mortality among U.S. women aged ≥25 years from 1999 to 2023 using national mortality data from the CDC WONDER d …

03.09.2026journal-article

Journal of Health Science and Medical Research

Successful Management of the Response to the COVID-19 Pandemic in the Bangkok Metropolitan Administration

Matanee Radabutr, Jureerat Kijsomporn, Payao Phongsakchat, Kanjana Anutariya

Objective: This research aimed to study the successful management of the response to the COVID-19 pandemic in the Bangkok Metropolitan Administration. Material and Methods: A mixed-methods convergent design was conducted. The qualitative component involved 30 semi-structured interviews with healthcare providers from three public health service centers in the Bangkok Metropolitan Administration, using seven open-ended questions until data saturation was reached. The quantitative sample, based on G*Power analysis, co …

03.09.2026journal-article

مجلة الفتح للبحوث التربوية والنفسية

دور الذكاء الاصطناعي في تعليم الرياضيات لدى طلاب المدارس: دراسة وصفية تحليلية من وجهة نظر معلمي الرياضيات في مديرية تربية ذي قار – قسم تربية الناصرية

ريزان محمد عبدالكريم

في ظل التوسع المتسارع في تطبيقات الذكاء الاصطناعي وما يواجهه توظيفها في العملية التعليمية من تحديات وعقبات، يهدف هذا البحث إلى استقصاء واقع توظيف الذكاء الاصطناعي في تعليم مادة الرياضيات من وجهة نظر المعلمين، من خلال التعرف على مستوى ممارساتهم التدريسية المستندة إليه، واستكشاف المعوقات التي تحد من تطبيقه في البيئة المدرسية. واعتمد البحث المنهج الوصفي التحليلي، وطُبّقت أداة الاستبانة على عينة عشوائية بلغت (50) معلماً ومعلمة من مدارس مديرية تربية ذي قار – قسم تربية الناصرية. وقد تألفت الاستبانة من (19) فقرة موزعة على …

03.09.2026journal-article

Journal of Anatolian Environmental and Animal Sciences

Clinical and Radiographic Evaluation of Stabilisation Using a Minimally Invasive Bridge Plate in Femur and Tibia Fractures in Dogs

Kamil Serdar İnal, Can Nacar, Elif Bağatır Kurban, Birsen Deniz Ersoy

Bridge plate fixation performed using a minimally invasive technique, the main fracture fragments are stabilised along the anatomical axis, rather than reducing small fragments, particularly in comminuted fractures. This retrospective study aims to evaluate the clinical and radiographic outcomes of stabilising traumatic femoral and tibial fractures in dogs using a minimally invasive bridge-plate technique. A total of 21 fractures (10 femoral and 11 tibial) from 20 dogs were included in the study. Cases were divided …