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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

The Oncologist

79 Renal Cell Carcinoma Among Native American Patients in Oklahoma: A Single-Institution Experience from an NCI-Designated Cancer Center

Jafer Raza, Anoushka Mullasseril, Abhirami Das, Kai Ding, Maribeth Mead, Saqib Balkhi, Dorothy Rhoades, Mark Doescher, Kelly Stratton, Brian Cross, Andrew McIntosh, Sanjay Patel, Michael Cookson, Adanma Ayanambakkam

Abstract Background Native American (NA) populations in Oklahoma experience disproportionately high incidence (43.7 vs 20.7 per 100,000) and mortality (8.6 vs 4.7 per 100,000) from renal cell carcinoma (RCC) compared with Non-Hispanic White (NHW) populations. However, population-based datasets lack patient-level clinical detail, limiting understanding of outcomes both overall and at academic cancer centers. We characterized disease presentation, treatment patterns, and overall survival (OS) among NA RCC patients tr …

01.09.2026journal-article

IECCMEXICO

Time to Oncological Surgery: Impact of Treatment Delays on Tumor Progression, Clinical Outcomes, and Healthcare Efficiency

Ivana Cárdenas Ayala, Heriberto Inclán Figueroa, Pedro Aníbal Bailón de la O, Jaime Héctor Cisneros Sandoval, Diego Clemente Moreno, Pablo Eduardo Navarro López, Aldo Bolivar Zavala Segovia, Andrea Delgado Cardona

Delays between cancer diagnosis and definitive oncological surgery have become an increasingly relevant concern due to their potential impact on tumor progression, clinical outcomes, and healthcare efficiency. This study analyzed available evidence regarding the relationship between surgical waiting times and oncological outcomes in adult patients with solid tumors, with particular emphasis on breast, colorectal, lung, pancreatic, bladder, and head and neck cancers. A structured integrative review was conducted usi …

01.09.2026journal-article

Advanced Therapeutics

Advancing Preclinical Oncology: Next‐Generation Mouse Models for Decoding Tumor Progression and Metastasis

Abhishek Sharma, Aman Kumar, Preeti Patel, Balak Das Kurmi

ABSTRACT Next‐generation mouse models have transformed preclinical oncology by enabling detailed study of tumor initiation, progression, immune interactions, and metastasis. Traditional systems lacked tumor heterogeneity and immune relevance. Advanced platforms such as genetically engineered mouse models (GEMMs), humanized mice, patient‐derived xenografts (PDXs), and organoid‐based models provide genetic accuracy, patient‐specific biology, and functional immune environments. Recent developments, such as intravital …

01.09.2026journal-article

Journal of Iranian Medical Council

The Role of ceRNA Networks in the Development and Progression of Gastric Cancer

Maryam Askari, Hassan Akrami, Mahdi Bagheri

MicroRNAs or miRNAs bind to miRNA Response Elements (MREs), a location on target transcripts, causing either transcript destruction or translational inhibition. NcRNAs with MREs can compete with mRNA as a miRNA sponge and are involved in a complex regulatory network that regulates the transcription of mRNAs through miRNAs competitive binding. According to the ceRNA hypothesis, ncRNAs, including lncRNAs, circRNAs, and pseudogenes, contend against mRNAs in binding to miRNAs via miRNAs’ MRE. MicroRNA is the most impor …

01.09.2026journal-article

Discover Oncology

Prognostic stratification and treatment patterns in pancreatic adenocarcinoma with mixed subtypes based on an exploratory retrospective cohort study

Xuefeng Hua, Hui Gong, Ziwei Yin

Abstract Background Pancreatic adenocarcinoma with mixed subtypes (p‑AMs) is a rare malignancy, and evidence to guide clinical management remains lacking. This study aimed to develop a prognostic model and explore treatment patterns across risk strata. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, we developed a treatment‑free baseline nomogram based on independent prognostic factors identified by multivariable Cox regression. Patients were stratified into low‑ and high‑risk groups …

01.09.2026journal-article

JNCI: Journal of the National Cancer Institute

Matched targeted therapy use after broad genomic profiling in advanced Non-Small cell lung cancer

Xiao Wang, Jessica B Long, John Rothen, Akintunde O Aremu, Sida Huang, Pamela R Soulos, Timothy J Robinson, Carolyn J Presley, Sarah B Goldberg, Ronac Mamtani, Shi-Yi Wang, Shuangge Ma, Michaela A Dinan, Cary P Gross

Abstract Introduction While broad genomic profiling is increasingly used in advanced NSCLC (aNSCLC), the impact of test results on subsequent guideline-concordant targeted therapy selection remains incompletely understood. Methods Using a merged dataset of two large, nationwide, patient-level databases, we identified patients who were diagnosed with aNSCLC 2017–2023, had potentially actionable genomic profiling findings, and initiated systemic therapy. Patients were categorized into actionability subgroups based on …

01.09.2026journal-article

Journal of Biomolecular Techniques

Cancer Center Shared Resources: A Nexus for Discovery, Innovation, and Impact

Sheenah Mische, Jay W. Fox, Nicholas P. Ambulos

Shared Research Resources (SRRs) are indispensable to modern cancer research, powering discovery through advanced technologies, specialized expertise, and strategic scientific partnership. At NCI-designated Cancer Centers, their role has expanded from core service platforms to drivers of innovation, rigor, and translational impact. In 2024, this evolution led to the creation of the National Alliance of Cancer Center Shared Resources (NACCSR), a national collaboratory uniting Shared Resource leaders to advance best …

01.09.2026journal-article

ASCE MAGAZINE

Tratamiento de Pseudoartrosis Congénita de Tibia mediante Terapia Génica In Situ y Colgajo Libre de Peroné Contralateral: Reporte de un Caso con Seguimiento a 5 Años

Darío Javier Velastegui Andrade, Marcelo Andrés Pinto Proaño, Maria Georgina Pazmiño Beltrán, Nicolas Augusto Vasquez Barreneche, Gustavo Fernando Guastay Guingla

La pseudoartrosis congénita de tibia (PCT) es una enfermedad rara y grave, asociada a neurofibromatosis tipo 1, con tasas de fracaso del 40-60% incluso con múltiples cirugías. Objetivo: Presentar un caso de PCT tratado con terapia génica in situ (transferencia del gen BMP-2 mediante vector adenoviral) y colgajo libre vascularizado de peroné contralateral, con seguimiento a 5 años. Métodos: Reporte de caso único de un paciente de 3 años con PCT tipo II de Crawford en tercio medio de tibia derecha, asociada a neurofi …

01.09.2026journal-article

International Journal of Engineering Research and Science & Technology

Body Area Network-Based System for Swollen Veins Detection and Automated Treatment

Raghul.C, Dr.Vasuki Ramesh

The case study illustrates a Body Area Network (BAN)-based system of detecting and automatically treating swollen veins via biomedical sensors, microcontrollers, and wireless communications. The system incorporates the pressure, temperature, and flow sensors to track the physiology of the vein in real time. Sensor data collected is processed by a NodeMCU or an Arduino architecture via threshold-based algorithms, and the most critical data is presented on an LCD to monitor locally and the data is transmitted over th …

01.09.2026journal-article

Europace

Cryoballoon ablation versus antiarrhythmic drug therapy as initial treatment for persistent atrial fibrillation: the multicenter randomized CEPAF trial

Tianyou Ling, Yazhou Lin, Yangyang Bao, Lin Chen, Wei Xu, Baopeng Tang, Jing Xu, Jingquan Zhong, Wei Li, Zhongbao Ruan, Qi Lu, Suxia Guo, Jingfeng Wang, Bing Han, Kai Tang, Tong Liu, Rui Zeng, Jiangui He, Hong Zhi, Changjian Lin, Yue Wei, Zhijun Wu, Ning Zhang, Qi Jin, Yu Yu, Liqun Wu

Abstract Background and Aims Evidence supporting first-line cryoballoon ablation (CBA) in treatment-naive persistent atrial fibrillation (PersAF) is limited. Consequently, we compared CBA with guideline-directed antiarrhythmic drug (AAD) therapy in this advanced form of disease. Methods This multicenter, prospective, randomized, open-label trial assigned 320 symptomatic, treatment-naive patients with PersAF (1:1) to CBA or AAD therapy. The primary endpoint was the first documented atrial tachyarrhythmia recurrence …

02.09.2026journal-article

Therapeutic Advances in Urology

Biomarker-guided selection of intravesical therapy in high-risk non–muscle invasive bladder cancer: A contemporary review

Willian Ito, Isamu Tachibana

High-risk non–muscle invasive bladder cancer poses therapeutic challenges, with significant rates of recurrence and progression with standard intravesical bacillus Calmette-Guérin (BCG) therapy. Current surveillance strategies lack accurate risk stratification models to predict individual treatment response and personalized treatment options. Simultaneously, there are no well-validated alternatives to replace the current gold-standard approach based on clinical and pathologic features. This review examines emerging …

01.09.2026journal-article

Cancers

Effect of Anesthesia Type on Clinically Significant Prostate Cancer Detection in Transperineal MRI-Targeted Biopsy

Shijie Jin, Dake Pan, Yuzhi Zuo, Yi Zhou, Zhien Zhou, Weigang Yan

Background/Objectives: The transperineal approach is the recommended standard for prostate biopsy. We aimed to determine whether anesthesia type—local anesthesia (LA) versus general anesthesia (GA)—independently influences clinically significant prostate cancer (csPCa) detection in transperineal magnetic resonance imaging (MRI)-targeted biopsy and to evaluate its impact on biopsy–prostatectomy pathological concordance. Methods: This single-center retrospective study included biopsy-naive men undergoing cognitive-fu …

01.09.2026journal-article

American Journal of Physiology-Cell Physiology

Sex-divergent skeletal muscle remodeling emerges early in cancer cachexia

Chris Karagiannis, Alastair A. E. Saunders, Rachel E. Thomson, María Guillán-Fresco, Wayne X. Du, Craig A. Goodman, Paul Gregorevic

By modeling cancer-associated cachexia over a time-course in male and female mice, we show that skeletal muscle remodeling begins before overt wasting is evident. The precachectic interval is marked by suppressed protein synthesis, muscle-local immune remodeling, extracellular matrix disruption, and metabolic vulnerability, with several responses differing by sex. These findings suggest that key features of cachexia emerge early in the disease time-course and may inform clinical approaches for detecting disease bef …

01.09.2026journal-article

Al-Noor Journal of Engineering Management and Computer Science

Green Synthesis of Silver Nanoparticles and Their Efficiency in the Treatment of Wastewater from Al-Batoul Hospital

Huda Zaki Abdulrahman, Zainab Saad Mahdi, Khalil Taha Jadaan

The green synthesis of nanomaterials is of particular interest. It was described as a simple, robust, low cost and ecologically beneficial way. In this work, silver nanoparticles (Ag NPs) was biosynthesized using orange peel extract to treat polluted water at the Diyala River near Al-Batool Hospital. The synthesized AgNPs were characterized using many techniques: X-ray diffraction (XRD) to determine nanomaterial structure; a FESEM (the scanning electron microscope with field emission technique) to analysis nanomate …

01.09.2026journal-article

Respirology Case Reports

Sarcomatoid Mesothelioma Revealed After Treatment for Tuberculous Pleurisy: A Case Report

Daiki Nagayama, Keiki Yokoo, Yousuke Yabushita, Motoki Sekikawa, Masaru Abe, Hiroaki Kato, Ayumi Takayanagi, Bunya Takahashi, Marie Kato‐Shinomiya, Satoshi Ota, Gen Yamada, Kenzo Hiroshima, Hirofumi Chiba

ABSTRACT Differentiating tuberculous (TB) pleurisy from malignant pleural mesothelioma is challenging due to similar clinical presentations. We report an 83‐year‐old man with sarcomatoid mesothelioma initially treated for TB pleurisy. He presented with lymphocyte‐predominant exudative pleural effusion and a positive Interferon‐Gamma Release Assay. Thoracoscopy revealed purulent effusion, but biopsies were non‐diagnostic. Despite empiric anti‐tuberculosis therapy, the effusion persisted. A subsequent surgical biopsy …

01.09.2026journal-article

Medicina Fluminensis

Candida parapsilosis – izazov u liječenju gljivičnih infekcija povezanih s bolničkom skrbi

Ivana Samošćanec, Marko Siroglavić, Sanja Pleško

Gljivične infekcije, osobito kandidijaza, čine jedan od najznačajnijih uzročnika slučajeva bolnički stečene sepse. Povijesno gledano, predominantan uzročnik sistemskih kandidijaza je Candida albicans, dok se ostale vrste kandida izmjenjuju po razini učestalosti, s time da je Candida parapsilosis sve češće na drugom mjestu. Kao komenzal ljudske kože, C. parapsilosis ima mogućnost laganog prijenosa horizontalnim putem među bolničkom populacijom. Svojom sposobnošću stvaranja biofilma i adherencije na umjetne materijal …

01.09.2026journal-article

Otolaryngology–Head and Neck Surgery

Hypoglossal Nerve Stimulation Treatment Outcomes in Patients With Supine‐Dependent Obstructive Sleep Apnea

Jaehee Kim, Shashank Singh, Tyler Allcroft, Navin Rana, Colin Huntley

Abstract Objective To evaluate hypoglossal nerve stimulation (HGNS) treatment response in patients with supine‐dependent obstructive sleep apnea (sOSA) and non‐supine‐dependent obstructive sleep apnea (nOSA). Study Design Single‐institution retrospective cohort study. Setting Academic tertiary care medical center. Methods A retrospective analysis of 45 unilateral HGNS patients was conducted. Supine, non‐supine, and total apnea‐hypopnea indices (AHIs) were collected from electronic medical records. Treatment respons …

01.09.2026journal-article

Cancer Discovery

Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia

Juliano Machado, Vignesh Karthikaisamy, Hermine Mohr, Doris Kaltenecker, Pia Benedikt, Pauline Morigny, Amit Mhamane, Julia Geppert, Amy Rose Fumo, Kerstin Haase, Estefania Simoes, Joanna D.C.C. Lima, Anastasia Georgiadi, Achim Krüger, José Pinhata Otoch, Marc E. Martignoni, Vickie E. Baracos, Mariam Jamal-Hanjani, Marilia C.L. Seelaender, Olga Prokopchuk, Julia Szendrödi, Maria Rohm, Stephan Herzig, Mauricio Berriel Diaz

Abstract Cancer cachexia is a devastating wasting syndrome with no approved therapies. In this study, we identify the tumor-derived glycoprotein ADAMTSL4 as a circulating factor associated with body weight loss in preclinical cachexia models and patients with colorectal and lung cancers. In mice, Adamtsl4 overexpression converted non–cachexia-inducing tumors into cachexia-inducing tumors, whereas its deletion in cachexia-inducing tumors spared fat and muscle, blunted muscle atrophy signatures, and reduced cachexia …

01.09.2026journal-article

Journal for ImmunoTherapy of Cancer

Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy

Lu Wang, Sha Gong, Jun Wang, Yingying Bao, Nan Mei, Xiaohong Lu, Weiwei Chen, Lei Xi, Huanming Zhang, Xin Chen, Pengbo Ning, Xiaohu Fan, Huaiyu Wang

Background Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with dismal outcomes, especially in relapsed/refractory settings. Chimeric antigen receptor natural killer (CAR-NK) cell therapy holds promise but is constrained by the immunosuppressive tumor microenvironment (TME), where adenosine-mediated suppression is a key barrier. Objective To develop a novel CAR-NK construct cotargeting AML cells and the adenosine-rich TME to enhance antileukemia efficacy. Methods Ex vivo expanded primary NK cel …

01.09.2026journal-article

Current Oncology

Emergency Surgery Independently Predicts Postoperative Recurrence in Patients with Pathologic T3N0M0 Colon Cancer: A Retrospective Single-Center Cohort Study

Selahattin Çelik, Salih Karatlı, Esra Zeynelgil, Hatice Ayyıldız Sevim, Tülay Eren

Background and Objectives: Pathologic stage IIA (T3N0M0) colon cancer represents a heterogeneous subgroup of stage II disease with variable recurrence risk despite similar TNM staging. Although several clinicopathological high-risk features are incorporated into current treatment guidelines, the independent prognostic significance of emergency surgery remains incompletely understood. This study aimed to identify clinicopathological predictors of postoperative recurrence, with particular emphasis on the prognostic i …

01.09.2026journal-article

Student's Journal of Health Research Africa

Identification of Risk Factors for Mortality Due to Multidrug-Resistant Tuberculosis Among Patients Managed at the Lufungula Tuberculosis Screening and Treatment Center in the National Police Health Zone, Kinshasa Provincial Health Division: A Survival Analysis.

Jacques, Gerard, Bob Senker Ndimba, Emmanuel, Zebe Mbadu, Jean-Paul, Jules

Introduction: Multidrug-resistant tuberculosis (MDR-TB) is a major public health problem, particularly in sub-Saharan Africa. The Democratic Republic of Congo (DRC) is among the countries with a high burden of tuberculosis and multidrug-resistant tuberculosis. Identifying factors associated with mortality is essential to improving patient management and survival. This study aimed to identify risk factors for mortality among patients with MDR-TB followed at the Lufungula Tuberculosis Screening and Treatment Health C …

01.09.2026journal-article

Medical Research

Advances in the Application of Immunohistochemical Markers in the Subtyping of Non-Small Cell Lung Cancer

Bohui Zhan, Cong Guo

Lung cancer is the most common malignancy worldwide in terms of both incidence and mortality, with non-small cell lung cancer (NSCLC) accounting for approximately 80%–85% of all cases. As most patients are diagnosed at an advanced stage with limited biopsy material, hematoxylin and eosin (H&E) staining alone is often insufficient for precise histotyping. Immunohistochemistry (IHC), by detecting specific molecular markers, can significantly improve the accuracy and reproducibility of NSCLC subtyping. This review sys …

01.09.2026journal-article

Orthopaedic Surgery

Efficacy of a Disposable Skin‐Stretch Closure Device Combined With Vacuum Sealing Drainage in the Treatment of Refractory Skin and Soft Tissue Defects: A Single‐Arm Prospective Study

Hao Guo, Zhengguo Zhu, Jinchang Wang, Zhonghe Wang, Yilin Wang, Jun Zhang, Wei Zhang, Guangping Liu, Zhiguang Chen, Shuangcheng Li, Xingxing Hu, Meijing Dou, Junjun Tang, Peifu Tang, Hua Chen

ABSTRACT Objectives The treatment of refractory skin and soft tissue defects (RSSTDs) has long posed a global challenge for surgeons. Traditional closure methods, such as skin grafting and flap repair, are often associated with significant trauma and a steep learning curve. Skin stretching, which enables the generation of “extra skin,” has emerged as a promising alternative. This study aims to evaluate the efficacy of a disposable skin‐stretch closure (DSSC) device combined with vacuum sealing drainage (VSD) in the …