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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Medicine

Risk of hepatitis B reactivation in COVID-19 patients receiving corticosteroid therapy

Hatun Öztürk Çerik, Özlem Aldemir, Bilge Katirci, Burcu Demirhan Kapicioğlu, Zeynep Banu Ramazanoğlu, Arzu Altunçekiç Yildirim

COVID-19 and HBV are significant public health issues, and managing their co-infection remains unclear. Corticosteroid therapy improves survival in severe COVID-19 but may increase the risk of HBV reactivation (HBVr). Evidence regarding the incidence and outcomes of HBVr in COVID-19 patients remains limited. This study aimed to investigate the frequency, determinants, and clinical consequences of HBVr among COVID-19 patients with current or past HBV infection treated with corticosteroids. This retrospective study e …

28.08.2026journal-article

Journal of Pediatric Rehabilitation Medicine

Profile of individuals with full-scale intelligence quotient (FSIQ) scores in the National Spina Bifida Patient Registry (NSBPR)

Heidi Castillo, Sophia Drewry, Amy Heffelfinger, Jennifer T. Queally, Kurt A. Freeman, Vanessa Avemil, Richard Adams, Pamela Murphy, Kathryn Smith, Audrey Roach, Gregory Heuer, William Walker, Jonathan Castillo, Catharine Riley

Purpose Although intelligence quotient (IQ) testing can help identify cognitive issues, data on IQ testing in the spina bifida (SB) population is limited and difficult to collect. This study aimed to identify factors influencing IQ test reporting among individuals in the National Spina Bifida Patient Registry (NSBPR). Methods A descriptive analysis of 1,017 individuals aged 4 to 22 years from five NSBPR clinics was conducted. Characteristics of participants with a full-scale intelligence quotient (FSIQ) score (n=43 …

28.08.2026journal-article

NEW SOLUTIONS: A Journal of Environmental and Occupational Health Policy

Cycles of Change: Understanding Corporate Employees’ Perceptions of Menstrual Leave in Delhi NCR

Nisha, Sunaina Dua, Liza Attrey, Ruchi Kaushik

Menstrual health and hygiene management has emerged as a critical concern in workplace equity and occupational health discourse, yet policies such as menstrual leave remain contested in India. The study explores the perceptions of corporate employees in Delhi NCR on menstrual leave policy. A descriptive study was conducted with 50 corporate employees (40 women, 10 men) in Delhi NCR, selected through purposive and snowball sampling. Data were gathered using gender-specific semistructured interviews and analyzed thro …

28.08.2026journal-article

El-Usrah: Jurnal Hukum Keluarga

Developing a Family-Based Rehabilitation Model for Juvenile Victims of Narcotics Abuse in Indonesia

Riza Chatias Pratama, Rusli Muhammad, Trisno Raharjo

Juveniles involved in narcotics abuse constitute one of the most vulnerable groups within the criminal justice system because they simultaneously experience legal, psychological, and social harms. Although Indonesian narcotics legislation recognizes rehabilitation as an alternative to imprisonment, the existing legal framework does not distinguish rehabilitation mechanisms for juveniles from those applied to adults. This study aims to examine the implementation of rehabilitation sanctions for juvenile victims of na …

28.08.2026journal-article

Bioengineering

Wearable Technologies for Gait Instability Rehabilitation: Mechanisms, Clinical Evidence, and Future Directions

Lijin Liu, Changfa Huang, Zhongyin Ji, Yujie Zhou, Zihua Li, Xueyi Zhang, Zhihong Wu

Wearable technologies are reshaping gait rehabilitation by shifting assessment and therapy from intermittent, clinic-based observation to continuous, data-driven, and adaptive care. This narrative review synthesizes the biomechanical basis of gait instability, the architecture and classification of wearable rehabilitation systems, and the clinical evidence for motion sensors, smart insoles, biofeedback devices, robotic and orthotic wearables, neuromodulatory systems, immersive platforms, and artificial intelligence …

27.08.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

The Therapeutic Impact of Music on Memory Rehabilitation for Patients with Cognitive Decline

Taran Pabla

Cognitive impairment caused by neurodegenerative diseases such as Alzheimer’s poses a challenge to the retention of memories and emotional state. The pharmacological management of such patients has shown poor efficacy in restoring memory functions. However, non-pharmacological management such as music therapy has shown promise for the rehabilitation of patients with cognitive impairment. This report aims to discuss the importance of music therapy for patients with cognitive impairment caused by neurodegenerative di …

27.08.2026journal-article

Stroke

2026 Guideline for Adult Stroke Rehabilitation and Recovery: A Guideline From the American Heart Association and American Stroke Association

Lorie G. Richards, Nneka L. Ifejika, Joel Stein, Mona N. Bahouth, Martha Abshire Saylor, A.M. Barrett, Peii Chen, Anne F. Deutsch, Wendy Dusenbury, Charles Ellis, Janice Eng, Jamie Fleet, Heather R. Ford, Emily S. Grattan, Richard L. Harvey, Corinne A. Jones, Chandramouli Krishnan, Sara Kutzle, Deven Matthews, Nicole Mazwi, Jamila Minga, Dawn M. Nilsen, Elizabeth Noser, Heather R. Porter, Preeti Raghavan, Dorian K. Rose, Elizabeth R. Skidmore, Marie-Pierre St-Onge, Mary Ellen Stoykov, Amelia Tenberg Schettini, Alexandra L. Terrill, David L. Tirschwell, Paul Vilar, Alicen Whitaker-Hilbig, Richard Zorowitz, Warren D. Lo, George F. Wittenberg, Allison E. Gaffey, Dipika Aggarwal, Maria Cecilia Alpasan

AIM: The “2026 Guidelines for Adult Stroke Rehabilitation and Recovery” replaces the 2016 “Guidelines for Adult Stroke Rehabilitation and Recovery.” This updated guideline is intended to provide a comprehensive, up-to-date, evidence-based set of recommendations. The intended audience includes physicians, allied health professionals, and caregivers. METHODS: A comprehensive search for literature published since the 2016 guideline, derived from research involving human participants, published in English, and indexed …

1 Zitationen
27.08.2026journal-article

Cancer Research

Allele-Specific Mechanisms Guide Salvage Therapy to Overcome Daraxonrasib Resistance in Pancreatic Cancer

Daniel Dorbin, Juliannie Herrera, Raven Davidson, Naveen Kumar Chandrashekar, Gabrielle Scheuber, Priyanga Jayakrishnan, Christabelle Rajesh, Grayson Johnson, Jason Yuan, Matthew A. Sochor, John F. Langenheim, Mohammed Aldakkak, Charles Messerly, Jacquelyn Wittmann, Aniko Szabo, Forough Azam Sayahpour, Nathan L. Atallah, Francis C. Peterson, Brian F. Volkman, Mahmoud Ali, Eugene Ke, Douglas B. Evans, Susan Tsai, Nikki K. Lytle, Y. David Seo, Razelle Kurzrock, G. Aaron Hobbs, Mandana Kamgar, Thomas McFall

Abstract Clinical-grade RAS inhibitors raise an unresolved question as to whether KRAS alleles impose constraints on adaptive resistance that can be exploited therapeutically. Using daraxonrasib (RMC-6236), a multi-selective RAS(ON) inhibitor, we compared resistance mechanisms between KRASG12D and KRASG12R, mutants with fundamentally different RAS network dynamics. Daraxonrasib inhibited KRASMUT primarily through steric occlusion of effector binding, while engaging RASWT only modestly (~20%). KRASG12R was marked by …

27.08.2026journal-article

Health, sport, rehabilitation

Differentiating playing roles in professional Counter-Strike 2 by performance indicators: an observational study

Volodymyr Paskiv, Igor Zanevskyy, Volodymyr Koman

Background and purpose. In professional Counter-Strike 2 a single composite rating still carries most of the weight in judging players, even though the game grants no mechanical class asymmetry, so playing roles arise as a codified yet largely unexamined division of labour. We therefore asked whether those roles can be recovered from the standard per-round indicators, and how their differentiation is organised. Material and methods. Under a single twelve-month filter we drew thirty-nine per-round indicators for 105 …

27.08.2026journal-article

Child Language Teaching and Therapy

Negotiating and building SLT–teacher trust relationships for effective interprofessional collaboration when delivering a tier-1 interactive reading program

Paméla McMahon-Morin, Pamela Filiatrault-Veilleux, Marie-Pier Gingras, Wenonah Campbell

Collaboration between teachers and school-based speech-language therapists (SLTs) is essential to high-quality universal tier-1 practices that support children's language and literacy skills in inclusive settings. Trust is central to interprofessional collaboration and successful implementation of new practices. This exploratory qualitative study used a secondary data analysis from two studies, each offering a complementary perspective on how teachers and SLTs negotiate and build trust when they collaborate to impl …

27.08.2026journal-article

AIDS Research and Therapy

Long-term survival analysis of HIV patients receiving antiretroviral treatment in Congo: a 14-year retrospective analysis, 2003–2017

Gilbert Ndziessi, Ange Clauvel Niama, Arkadit Jeandria Nkodia, Merlin Diafouka

Abstract Background Long-term survival of people living with HIV (PLHIV) on antiretroviral therapy (ART) is poorly documented in the Republic of Congo. Methods We conducted a retrospective cohort study of 2,309 adults initiating ART between 2003 and 2017. Survival was estimated using the Kaplan-Meier method, and determinants were assessed using Cox regression. Results The median age of participants was 49 years (IQR 42–57), and women represented 68.6% of the cohort. The 14-year overall survival probability was 83% …

27.08.2026journal-article

Frontiers in Immunology

Immunotherapy-based salvage therapy in advanced soft tissue sarcoma after first-line chemotherapy: a retrospective single-center analysis with emphasis on undifferentiated pleomorphic sarcoma

Zhichao Liao, Junbo Huang, Haotian Liu, Chao Zhang, Ting Li, Hongyu Wang, Yuanxin Liu, Sijia Ren, Zhiwu Ren, Haixiao Wu, Ruwei Xing, Sheng Teng, Jun Zhao, Wanyi Xiao, Gengpu Zhang, Yun Yang, Jilong Yang

Introduction Soft tissue sarcomas (STS) are rare mesenchymal malignancies with limited treatment options in advanced stages. Anthracycline-based chemotherapy remains the standard of care but yields modest outcomes with significant toxicity, underscoring the need for more effective strategies. Methods We retrospectively analyzed 56 patients with advanced STS who received PD-1 inhibitor-based therapy at Tianjin Medical University Cancer Institute and Hospital between January 2021 and January 2026. Treatment regimens …

27.08.2026journal-article

Frontiers in Aging

Grip strength as a systems biomarker of aging: neuromuscular junction constraints and biomarker decoupling in gene therapy

Patrick E. Sewell, Christopher Jensen

Grip strength has emerged as one of the most robust predictors of mortality, disability and healthspan across populations. Yet its predictive validity rests on an often-unstated assumption: that grip strength serves as a passive readout of systemic biological integrity rather than an isolated measure of forearm function. Here we propose that grip strength derives its prognostic power from its position as a convergent output of multiple aging-sensitive physiological systems—including neuromuscular, vascular, metabol …

27.08.2026journal-article

International Journal of Molecular Sciences

Macrophages as Drivers of Resistance to Dabrafenib Plus Trametinib Therapy in Anaplastic Thyroid Cancer

Ricardo Rodrigues, Beatriz Garcia, Miguel Rito, Rúben Roque, Teresa Pereira, Sónia Morgado, Vanessa Tavares, Tiago Nunes da Silva, Valeriano Leite, Branca Maria Cavaco

Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy with poor response to standard therapies. While Dabrafenib plus Trametinib (DT) combination therapy has improved the survival of patients with BRAF-mutant ATC, resistance remains a challenge. Given the association of macrophages with poor prognosis, and that SPRY4 has emerged as a mediator in ATC–macrophage interactions, we investigated their role in DT resistance and evaluated the therapeutic potential of macrophage targeting. Transwell co-cultures of …

27.08.2026journal-article

Fertility Science and Research

Synergistic Impact of Environmental Pollution and Occupational Stress on Sperm DNA Integrity Unveiling Hidden Drivers of Male Infertility

Devuni Vageeshwari

Infertility is the inability of a sexually active couple to conceive within 1 year. It affects 10-15% of couples globally, with male factors accounting for 40-50% of these cases. The decline in semen quality, often with unknown causes, emphasises the need to evaluate sperm count, motility, and morphology when assessing male reproductive health. Environmental, occupational, and lifestyle factors are increasingly recognised as important contributors to male infertility, often linked to oxidative stress and disruption …

27.08.2026journal-article

Frontiers in Endocrinology

Low baseline HbA1c and reduced eGFR are associated with relatively unfavorable body recomposition after SGLT2 inhibitor therapy in type 2 diabetes

Mizuki Gobaru, Nao Hasuzawa, Noboru Kurinami, Nobuhiko Wada, Lixiang Wang, Ayako Nagayama, Kenji Ashida, Yoshinori Moriyama, Hideaki Jinnouchi, Masatoshi Nomura

Aims Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) improve glycemic control and promote weight loss, but their effects on the relative balance between skeletal muscle and fat mass remain incompletely understood. This study examined treatment-associated body composition changes in patients with type 2 diabetes mellitus (T2DM), focusing on muscle-to-fat balance. Methods In this multicenter retrospective cohort study, we analyzed body composition changes 12 …

27.08.2026journal-article

Renal Replacement Therapy

Suspected heparin-resistant contact activation during membrane-based therapeutic plasma exchange: a case report

Atsuto Niwa, Sanae Kikuchi, Yuki Nakai, Ayumi Tomoi, Akinori Kitamura, Jun Matsuoka, Norihiko Tanimoto, Miyuki Nakano, Yoshiki Okuno, Mitsuaki Oki, Shinpei Nogami, Masaomi Sato, Yoshihiro Taniyama, Kentaro Hayashida

Abstract Background Therapeutic plasma exchange (TPE) is recommended for steroid-refractory acute optic neuritis associated with aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder. However, clotting-related events in the extracorporeal circuit can interrupt treatment and jeopardize timely completion of the planned TPE course. Case presentation A 42-year-old woman presented with rapidly progressive bilateral optic neuritis, with no light perception in the right eye and finger count vision in the …

27.08.2026journal-article

Journal of Current Southeast Asian Affairs

Fake news and the dual threat to free speech: Information disorder and securitisation in the Philippines and Singapore

Oliver Benjamin Ward

This article examines how fake news and government responses affect free speech in the Southeast Asian cases of the Philippines and Singapore. It employs the information disorder framework to analyse dis-information production and circulation, and securitisation theory to examine how governments justify anti-fake news legislation. In the Philippines, populist, fragmented politics enabled Rodrigo Duterte's 2016 dis-information campaign, which damaged free speech quality by distorting public debate and undermining sh …

27.08.2026journal-article

Journal of Clinical Oncology

Refined Continuous Risk Index for Accurately Predicting Outcomes of Patients With Chronic Lymphocytic Leukemia After Limited-Duration Therapy

Othman Al-Sawaf, Can Zhang, Mohammad S. Esfahani, Chih Long Liu, Sandra Robrecht, Eugen Tausch, Anke Schilhabel, Matthias Ritgen, Christof Schneider, Martin Peifer, Moritz Fürstenau, Carsten Utoft Niemann, Arnon P. Kater, John F. Seymour, Brenda Chyla, Yanwen Jiang, Barbara Eichhorst, Stephan Stilgenbauer, Michael Hallek, Ash A. Alizadeh, David M. Kurtz, Kirsten Fischer

PURPOSE Measurable residual disease (MRD) status after limited-duration treatment for chronic lymphocytic leukemia (CLL) strongly predicts survival times and is considered a surrogate end point. However, most prognostic indices, including the International Prognostic Index (CLL-IPI), rely solely on pretreatment features. To incorporate dynamic MRD data in prognostic models, the continuous individualized risk index (CIRI) was proposed in 2019. Since developed in the context of chemoimmunotherapy, we here propose a r …

27.08.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

Using AI to Improve Radiation Therapy Planning

Patrik Farkas

In radiation therapy, clinicians must outline nearby organs, known as organs at risk (OARs), to limit unwanted radiation exposure. This process is traditionally done by hand and requires significant time and resources. Artificial intelligence (AI) tools can automatically generate these outlines, potentially improving efficiency. However, their clinical reliability across different treatment sites must be carefully evaluated. We analyzed various patient cases across multiple anatomical sites, including thoracic, hea …

27.08.2026journal-article

American Journal of Hematology

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Benjamin Rolles, Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Jessica M. Stempel, Luca Lanino, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Samuel Urrutia, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine McMahon, Rory M. Shallis, Joshua F. Zeidner, Michael R. Savona, Shougat Barua, Namrata Sonia Chandhok, Constantine Logothetis, Aram Bidikian, Ted M. Getz, Gail J. Roboz, Eunice S. Wang, Amyah C. Harris, Maria L. Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Parisa Abedi, Shai Shimony, R. Coleman Lindsley, Zhuoer Xie, Yazan F. Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach

ABSTRACT Baseline IPSS‐M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo‐HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of response when adjusting for IPSS‐M risk and treatment strategy remains unclear. Hence, we used the VALIDATE database of the International Consortium for MDS (icMDS) to evaluate the impact of International Working Group (IWG) 2023 bes …

27.08.2026journal-article

Angewandte Chemie

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu

ABSTRACT Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) have emerged as promising anticancer modalities due to their noninvasive nature, spatiotemporal precision, and high tumor suppression efficacy. Integrating platinum with these phototherapies addresses key limitations of conventional platinum chemotherapy, specifically systemic toxicity and pervasive drug resistance. Since cancer cell membrane proteins, including receptors and transporters, and subcellular organelles play a pivotal role as th …

27.08.2026journal-article

Journal of Endovascular Therapy

Effects of Atherectomy on Immediate Luminal Gain and Short-Term Patency in Patients With In-Stent Restenosis With or Without Stent Thrombosis

Michal S. Proczka, Crista E. Horton, Michal Macech, John J. Ricotta, Joseph J. Ricotta

Purpose: Atherectomy may provide benefit by debulking lesions before angioplasty in patients with in-stent restenosis or stent thrombosis. This study evaluated immediate luminal gain, measured by intravascular ultrasound, achieved with excimer laser, solid-state laser, and rotational excisional atherectomy when treating femoropopliteal in-stent restenosis or stent thrombosis before angioplasty. Six-month patency was assessed by duplex ultrasound. Materials and Methods: We retrospectively analyzed 120 consecutive fe …

27.08.2026journal-article

Veterinary Sciences

Hemodynamic Effects of Intravenous Ephedrine Administration During General Anesthesia for Radiation Therapy in Cats

Daichi Seki, Seijirow Goya, Kenji Teshima, Yoshiki Yamaya

Ephedrine is used as a vasopressor in cats, but the hemodynamic effects of intravenous (IV) administration have not been characterized. This study evaluated the hemodynamic effects of IV ephedrine in 10 cats that developed hypotension during anesthesia. Cats received either saline (SE) or atropine (AE) before ephedrine for hypotension (mean arterial pressure < 60 mmHg). Hemodynamic variables were analyzed using a linear mixed-effects model. No significant differences were observed between groups in the response rat …