The Therapeutic Impact of Music on Memory Rehabilitation for Patients with Cognitive Decline

Vollständiger Abstract

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Cognitive impairment caused by neurodegenerative diseases such as Alzheimer’s poses a challenge to the retention of memories and emotional state. The pharmacological management of such patients has shown poor efficacy in restoring memory functions. However, non-pharmacological management such as music therapy has shown promise for the rehabilitation of patients with cognitive impairment. This report aims to discuss the importance of music therapy for patients with cognitive impairment caused by neurodegenerative diseases, including its neurological and psychological effects on the patients and its therapeutic value for their recovery. The report is a result of a mixed approach to literature review and the use of the COBWEB agent-based simulation platform. In addition, the literature review identified various aspects related to rhythm, melodies, and familiarity of lyrics that have a significant effect on autobiographical memory, emotional regulation, and neural activation. Computational simulations were conducted to understand neurodevelopment, amyloid beta aggregation, and neurodegeneration. The literature review has identified various aspects related to memory recall, mood, agitation, and neural pathways that are activated with the use of music therapy in patients with dementia. Personalized and active musical engagement was identified as particularly effective. Computational modelling was used to further demonstrate the deterioration of neural connectivity during the progression of the diseases. This research further supports the use of music therapy as a low-risk intervention that is accessible and effective as a complementary intervention for memory rehabilitation, emphasizing the potential for this intervention in clinical and long-term care settings.