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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

International Journal of Analysis and Applications

A Study on Medical Diagnosis Using Neutrosophic Over Complex Sets and Artificial Neural Networks Under Uncertain Environments

Prabakaran Raghavendran, Nidal Anakira, Yamini Parthiban, Abed Al-Rahman M. Malkawi, Tala Sasa

The present article introduces the idea of Neutrosophic Over Complex Sets, and in a way it kind of explores how they can be used for medical diagnosis tasks that live in uncertain and inconsistent environments. The proposed framework mixes the benefits of neutrosophic sets, over sets, and also complex-valued information into one single mathematical structure, so it can manage indeterminate, contradictory and over-valued complex data without too much fuss. In the proposed setup, the truth-membership, indeterminacy-m …

02.09.2026journal-article

Journal of Clinical Medicine

Hepatic Steatosis in Pulsed Field Ablation for Atrial Fibrillation: Prevalence, Liver Marker Concordance and Acute Procedural Characteristics

Maria Boszko, Bartosz Krzowski, Michał Gawlik, Alicja Skrobucha, Julia Szydlik, Mateusz Wawrzeńczyk, Karolina Mitrzak, Kacper Rutkowski, Karolina Ignaczak, Monika Gawałko, Cezary Maciejewski, Jakub Rokicki, Michał Peller, Michał Marchel, Piotr Lodziński, Grzegorz Styczyński, Marcin Grabowski, Paweł Balsam

Background/Objectives: Hepatic steatosis and metabolic dysfunction-associated steatotic liver disease (MASLD) are cardiometabolic phenotypes relevant to atrial fibrillation (AF), but their prevalence and acute procedural relevance in pulsed field ablation (PFA) are poorly defined. We estimated the prevalence of hepato-renal index (HRI)-detected hepatic steatosis, assessed liver marker concordance, and explored acute procedural characteristics. Methods: In this single-centre prospective study, 99 consecutive eligibl …

02.09.2026journal-article

Allergy

Classification of Seasonal Allergic Rhinitis Patients by Prospective Patient‐Recorded Symptoms: The @ IT .2020 Project

S. Dramburg, C. J. Hernandez Toro, U. Grittner, E. Potapova, A. Travaglini, S. Tripodi, S. Arasi, S. Pelosi, F. Monnati, A. Acar Şahin, X. Aggelidis, A. Barbalace, A. Bourgoin, B. Bregu, M. A. Brighetti, E. Caeiro, S. Caglayan Sozmen, L. Caminiti, D. Charpin, M. Couto, L. Delgado, A. Di Rienzo Businco, C. Dimier, M. V. Dimou, J. A. Fonseca, O. Goksel, D. Hernandez, T. M. Hoffmann, D. T. Jang, F. Kalpaklioglu, B. Lame, R. Llusar, M. Makris, A. Mazon, E. Mesonjesi, A. Nieto, A. B. Öztürk, L. Pahus, G. Pajno, I. Panasiti

ABSTRACT Background Seasonal allergic rhinitis (SAR) has been so far classified according to frequency and severity by retrospective information based on the ARIA (Allergic Rhinitis and its Impact on Asthma) classification. Electronic symptom diaries (e‐Diaries) are feasible tools to collect prospective patient‐reported data. Objective To test the consistency between prospectively recorded symptoms and retrospective ARIA classification and to generate a new SAR classification based on prospective e‐Diary data. Meth …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Impact of Diabetes Mellitus on Drug-Induced Liver Injury during Antituberculosis Therapy: A Prospective Cohort Study

Ruina Chen, Yu Wu, Xiaoyan Xu, Jingru Cheng, Yan Jiang, Xiaomin He, Hongqiu Pan, Meiling Zhang, Lihuan Lu, Honggang Yi, Shaowen Tang

ABSTRACT. Drug-induced liver injury (DILI) is a significant concern during antituberculosis (anti-TB) treatment, and its association with diabetes mellitus (DM) remains inconsistent. This study investigated whether DM influences anti-TB DILI occurrence in Chinese patients. A prospective cohort study enrolled patients receiving anti-TB treatment at four hospitals. Patients were grouped by DM status and followed up until treatment completion. Propensity score matching (PSM) was performed at a 1:1 ratio to ensure comp …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Paracapillaria philippinensis Infection in India: A Report of Four Cases

Ashis Kumar Choudhury, John Titus George, Nicholas Vijay Rao, Amit Kumar Dutta, Dipti Masih, Samuel George Hansdak, Ravikar Ralph, Sitara Swarna Rao Ajjampur

ABSTRACT. Capillaria philippinensis (recently renamed Paracapillaria philippinensis [ P. philippinensis ]) is a nematode infection endemic to Southeast Asia and Egypt and is rarely reported in India. This disease can be fatal if it is not diagnosed early and treated appropriately. Four cases of P. philippinensis infection identified over a decade from a single center in India are reported. All patients presented with diarrhea and reported symptoms such as abdominal pain, vomiting, and pedal edema, suggesting malabs …

02.09.2026journal-article

JAMA Surgery

Blood or Crystalloids for Hemorrhagic Shock—Response to the Agency for Healthcare Research and Quality

Julia R. Coleman, Reynold Henry, Nakul Raykar, John B. Holcomb

This Viewpoint evaluates the Agency for Healthcare Research and Quality report on prehospital blood transfusion and fluid interventions for hemorrhagic shock and argues that its claims of scientific equipoise stem from methodologic challenges instead of clinical equivalence of blood transfusion and crystalloid therapy.

02.09.2026journal-article

Journal of Functional Biomaterials

Data-Driven Development of Biomedical Hydrogels for Controlled Drug Delivery: Clinical Applications and Emerging Machine-Learning Approaches

Elham Eskandarnia, Ayah Binrajab, Adnan Alsaei, Fatema Rahimi, Nasser Alahmed, Ahmad Zarwi, G. Roshan Deen

Hydrogels are hydrated three-dimensional polymeric networks with biomedical potential because they can encapsulate therapeutic agents and provide localised, sustained, or stimulus-responsive drug delivery. Their performance is determined by interacting variables, including polymer composition, synthesis route, crosslinking chemistry, drug loading, swelling, degradation, and the biological microenvironment. This multidimensional design space often makes hydrogel development slow and dependent on trial-and-error expe …

02.09.2026journal-article

Current Opinion in Clinical Nutrition & Metabolic Care

Iron deficiency during pregnancy and lactation

Laura Wasserfallen, Diego Moretti

Purpose of review Iron deficiency persists as the most common nutritional deficiency worldwide and is highly prevalent among women of reproductive age. Pregnancy substantially raises iron requirements, increasing the risk of complications for mother and newborn particularly in low-income and middle-income countries. We summarize current evidence on the determinants, physiological adaptations, diagnostic thresholds, and management of iron deficiency during pregnancy and lactation, focusing on recent developments. Re …

02.09.2026journal-article

Diagnostics

Diagnosis of Extensive DCIS with Progressive Microcalcifications over a Period of 11 Years

Menelaos Zafrakas, Theodoros Argyriou, Panayiota Papasozomenou, Christos Emmanouilides

A 53-year-old woman presented complaining of enlargement of her right breast; 12 years earlier she was treated elsewhere for an invasive ductal carcinoma of the right breast with breast-conserving surgery, adjuvant chemotherapy, anti-HER2 therapy, radiotherapy and endocrine therapy. One year postoperatively, a group of microcalcifications was seen in the ipsilateral breast on mammography. In the following years, the area of microcalcifications progressively increased, but instead of vacuum-assisted biopsy, the trea …

02.09.2026journal-article

The Clinical Teacher

Professional Identity Formation in the Transition From Undergraduate to Postgraduate Medical Education: A Scoping Review

Juliana Sá, Ana L. Da Silva, Pia Strand, Simon Kitto

ABSTRACT Background The transition from undergraduate to postgraduate medical education is a crucial phase of professional development, requiring trainees to assume greater clinical responsibility and adapt to new social norms. This transition influences professional identity formation (PIF), which is important for safe practice, well‐being and resilience. We conducted a scoping review to map studies of PIF during this transition and synthesise the key findings of this body of literature. Methods We searched five d …

02.09.2026journal-article

Journal of Laparoendoscopic & Advanced Surgical Techniques

Clinical Outcomes of Magnesium-Based Balloon-Expandable Biodegradable Stenting for Benign Biliary Strictures: A Single-Center Retrospective Cohort Study

Mariano Eduardo Giménez, Chiara Innocenzi, Ignacio Corteggiano, Juliana Maria Racedo, Lucas Fehlauer, Samantha Robert, Pablo Acquafresca, Eduardo Houghton, Mariano Palermo

Background: Benign biliary strictures, most commonly anastomotic after hepaticojejunostomy or related to bile duct injury, are conventionally managed with balloon dilation, multiple plastic stents, or covered metal stents, all of which typically require repeated procedures. Magnesium-based balloon-expandable biodegradable stents (UNITY-B) have been proposed as a single-step alternative, but dedicated cohort data are limited. Methods: We retrospectively reviewed 22 consecutive UNITY-B stent-placement procedures perf …

02.09.2026journal-article

Siberian Journal of Clinical and Experimental Medicine

The impact of intraoperative epiaortic scanning of the ascending aorta on the tactics and outcomes of coronary artery bypass grafting (literature review)

S. L. Andreev, Yu. Yu. Vechersky, V. V. Zatolokin, B. N. Kozlov

This review evaluates the use of intraoperative epiaortic scanning (IES) of the ascending aorta in coronary artery bypass grafting. The diagnostic advantages of IES 3 over traditional palpation and transesophageal echocardiography are discussed, allowing for the detection of atherosclerotic plaques, including mobile and ulcerated ones. Clinical trial data are presented, demonstrating that the use of IES leads to a change in surgical tactics in 5–15% of cases (avoidance of aortic manipulation, use of contactless dev …

02.09.2026journal-article

Evidence-Based Chinese Medicine and Technology Assessment

How can traditional Chinese medicine trials achieve global credibility

Ying Wang, Gordon Guyatt

Abstract Traditional Chinese medicine (TCM) needs credible evidence that meets international evidence-based medicine standards to achieve global credibility and acceptance. A fundamental and crucial task is to conduct high-quality randomized controlled trials (RCTs). To achieve global credibility, TCM RCTs should meet universal standards of scientific rigor, such as addressing clinically important questions, achieving sufficient sample size and minimizing risk of bias, and enhance generalizability through appropria …

02.09.2026journal-article

Healthcare

Knowledge and Self-Reported Clinical Approaches Regarding Medication-Related Osteonecrosis of the Jaw Among Final-Year Dental Students, General Dentists, and Specialist Dentists: An Exploratory Cross-Sectional Study

İsmail Çapar, Çiğdem Şeker

Background/Objectives: Medication-related osteonecrosis of the jaw (MRONJ) must be recognized promptly by dental professionals at every career stage, yet whether this recognition differs across professional levels remains unclear. This study compared final-year dental students, general dentists, and specialist dentists in terms of their awareness, pharmacological knowledge, and self-reported clinical approaches to MRONJ. Methods: This cross-sectional, exploratory study used a 25-item online questionnaire administer …

02.09.2026journal-article

Journal of Chemical Technology and Metallurgy

EFFECT OF ULTRASONIC TREATMENT AND CALCINATION TEMPERATURE OF RICE HUSK ASH ON THE CHARACTERISTICS OF SILICA-CHITOSAN COMPOSITES

Ani Purwanti, Fajar Yulianto Prabowo

This study investigates the effect of calcination temperature and ultrasonic treatment during the extraction of silica from rice husk ash and its implications for the characteristics of silica-chitosan composites. Rice husk ash was calcined at temperatures of 500, 600, and 700°C, followed by extraction using 2M NaOH solution with and without ultrasonic treatment. The extracted silica was subsequently combined with chitosan to form silica-chitosan composites. Characterization was carried out using X-ray fluorescence …

02.09.2026journal-article

Regional Anesthesia & Pain Medicine

When gastric point-of-care ultrasound is indeterminate: an educational review and suggested reporting framework

Stephen C Haskins, Cristian Arzola, Yuriy Bronshteyn, Hari Kalagara, David Hardman, Oliver Panzer, Marissa M Weber, Eric Heinz, Jan Boublik, Javier Cubillos, Nadia Hernandez, Joshua Zimmerman, Anahi Perlas

Gastric point-of-care ultrasound (POCUS) is increasingly used to support aspiration-risk assessment when fasting history, comorbidities, medication exposure, or procedural urgency make clinical assessment uncertain. Its value depends on more than identifying gastric contents when images are clear. A useful examination must be attempted, completed, interpreted, and connected to a safe clinical decision. This article uses a focused secondary analysis of the 65 studies included in the original narrative review of gast …

02.09.2026journal-article

European Journal of Nutrition & Food Safety

Next-generation Probiotics for Human Health: A Critical Narrative Review of Mechanisms, Clinical Translation, Safety and Precision Microbiome Therapeutics

Sandhya Dhyani, Himani Belwal, Neetu Dobhal

The term next-generation probiotic (NGP) is increasingly used for health-associated gut commensals and rationally engineered microorganisms developed from microbiome science rather than from the historical food-fermentation route that produced most conventional probiotics. This expansion has created a translational opportunity, but also a recurrent evidential problem: taxonomic association, mechanistic plausibility, preclinical efficacy, human safety and clinical benefit are often treated as if they formed a single …

02.09.2026journal-article

BMC Medical Imaging

Automated whole-brain MRI segmentation combined with clinical scores for the diagnosis of sepsis-associated encephalopathy: a case-control study

Shasha Shao, Yanyan Liu, Jiale Yang, Daixing Zhou, Chengdong Peng, Dong Liu, Junshuai Wang, Jun Feng

Abstract Background Sepsis-associated encephalopathy (SAE) is a serious complication of sepsis that can lead to high mortality and poor neurological outcomes. Current diagnostic methods, whether based on clinical scores or brain images, remain inaccurate. We aimed to formulate a multimodal model that incorporated three-dimensional (3D) magnetic resonance imaging (MRI) neuroanatomical characteristics with clinical scores to improve SAE detection. Methods In this retrospective case-control study, 35 healthy controls …

02.09.2026journal-article

PLOS One

A multicenter prospective validation cohort does not support the use of kidney/psoas [18F]FDG uptake in the diagnosis of kidney allograft subclinical rejection

Pierre Lovinfosse, Antoine Bouquegneau, Annick Massart, Lissa Pipeleers, Catherine Bonvoisin, Laurens Carp, Hendrik Everaert, Alexandre Jadoul, Amélie Dendooven, Caroline Geers, Stéphanie Grosch, Pauline Erpicum, Rachel Hellemans, Laurence Seidel, Laurent Weekers, Roland Hustinx, François Jouret

Background Subclinical kidney allograft acute rejection (SCR) corresponds to “the unexpected histological evidence of acute rejection in a stable patient”. The diagnosis of SCR relies on surveillance biopsy. Positron emission tomography (PET/CT) after injection of F 18 -fluorodeoxyglucose ([ 18 F]FDG) has been proposed as a non-invasive screening approach. In the present multicenter prospective study, we assess the diagnostic yield [ 18 F]FDGPET/CT to rule out SCR in stable KTR at 3 months post KTx. Methods From 01 …

02.09.2026journal-article

Evidence-Based Dentistry

Does preoperative ibuprofen reduce pain during treatment of deep caries in children?

Marcin Baranowski, Greig D. Taylor

Abstract A Commentary on Bilmez Selen M, Kuru B. Effect of preoperative ibuprofen on pain perception and pulse rate in paediatric patients with deep caries: a randomised controlled trial. Eur J Paediatr Dent. 2026:1. https://doi.org/10.23804/ejpd.2026.2598 . Design A prospective, parallel single-blinded randomised controlled trial aimed to evaluate the effect of pre-operative ibuprofen administration on pain control during vital pulp therapy (VPT) procedures for a mandibular molar diagnosed with reversible pulpitis …

02.09.2026journal-article

Clinical Journal of Sport Medicine

Effects of Upper Extremity Strength Exercises in Subacromial Impingement Syndrome: A Systematic Review

Meltem Koç, Ayşen Canan Pakeloğlu, Samin Salehpour Marandi, Kılıçhan Bayar

Objective: This study aimed to evaluate the effects of upper extremity strengthening exercises in individuals with subacromial impingement syndrome (SAIS). Design: Systematic review. Inclusion criteria were (1) randomized controlled trials (RCTs) and quasi-experimental studies published in English; (2) participants aged 18 years or older diagnosed with subacromial or shoulder impingement syndrome; (3) studies comparing strengthening exercise interventions with other exercise programs, treatment protocols, or standa …

02.09.2026journal-article

Transfusion Medicine

Not all anti‐ CD38 antibodies are created equal: The epitope of felzartamab is partially DTT ‐resistant

Anja Zeretzke, Philipp Trummer, Cora P. Habicht, Clemens Schneeweiss

Abstract Objectives To evaluate anti‐CD38 antibody candidates for their ability to bind to DTT‐treated CD38 and red blood cells (RBCs). Background Dithiothreitol (DTT) treatment of RBCs is routinely used to denature CD38 and mitigate interference from anti‐CD38 antibodies, such as daratumumab and isatuximab, in immunohematology testing. However, new anti‐CD38 antibodies are in development, some of which may be directed against linear or otherwise DTT‐resistant epitopes. Methods/Materials Anti‐CD38 antibody candidat …

02.09.2026journal-article

Physics in Medicine & Biology

Real-time MRI-ultrasound image translation under limited paired data using a physically motivated conditional GAN

Jiajun Chen, Kun Chen, Yuliang Wu, Tiexiang Wen

Abstract Objective . Magnetic resonance imaging (MRI) and ultrasound (US) provide complementary anatomical and intraoperative information, yet their large appearance discrepancy makes cross-modality synthesis challenging. This study proposes a fast and physically consistent bidirectional MRI-US translation framework based on a conditional generative adversarial network (GAN). Approach . The generator adopts a VGG19-informed U-Net with residual bottleneck blocks and a self-attention module to capture long-range anat …

02.09.2026journal-article

Clinical and Translational Oncology

Clinical outcomes of stereotactic body radiotherapy in oligometastatic disease: a national real-world cohort study

Macarena Teja, Fernando López Campos, Álvaro Pinto, Israel J. Thuissard, María González, David Esteban, Abrahams Ocanto, Castalia Fernández, Daniela Gonsalves, Lisselott Torres, María Isabel Garrido, Escarlata López, Jaume Fernández, Loubna Aakki, Antonio Ristori, José Begara, Sigfredo Elias Romero Zoghbi, Jon Andreescu, Ana Belén Bezares, María Mateos, Miguel Ángel Berenguer, Daniel Rivas, Elisabet González del Portillo, Cristina Andreu, Esther Holgado, Shankar Siva, Constantinos Zamboglou, Felipe Couñago

Abstract Purpose We conducted the first multicentre Spanish real-world study assessing the efficacy and safety of stereotactic body radiotherapy (SBRT) in oligometastatic patients treated in routine clinical practice. Methods This retrospective, multicentre observational study included oligometastatic patients with primary solid tumours treated with SBRT between 2020 and 2024 across 12 Spanish radiotherapy centres. The primary endpoint was 1-year progression-free survival (PFS). The secondary endpoints included ove …