Vollständiger Abstract
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Abstract Purpose We conducted the first multicentre Spanish real-world study assessing the efficacy and safety of stereotactic body radiotherapy (SBRT) in oligometastatic patients treated in routine clinical practice. Methods This retrospective, multicentre observational study included oligometastatic patients with primary solid tumours treated with SBRT between 2020 and 2024 across 12 Spanish radiotherapy centres. The primary endpoint was 1-year progression-free survival (PFS). The secondary endpoints included overall survival (OS), local control (LC), and acute and late adverse events by CTCAE v.5.0. Results 300 patients with 451 treated lesions were included. Median age was 69 years. After a median follow-up of 22 months, 1- and 2-year PFS were 45.1% and 36.3% respectively, with a median PFS of 11 months (95% CI, 9–13). The 1- and 2-year OS were 92% and 82.9% (median not reached), and 1- and 2-year LC were 90.5% and 85.5% respectively. Multivariable analyses showed significantly better PFS and OS in prostate cancer patients. Repeat and induced oligometastatic patients showed worse PFS than those with synchronous disease (HR 2.86, 95% CI 1.59–5.13; p
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Macarena Teja, Fernando López Campos, Álvaro Pinto, Israel J. Thuissard, María González, David Esteban, Abrahams Ocanto, Castalia Fernández, Daniela Gonsalves, Lisselott Torres, María Isabel Garrido, Escarlata López, Jaume Fernández, Loubna Aakki, Antonio Ristori, José Begara, Sigfredo Elias Romero Zoghbi, Jon Andreescu, Ana Belén Bezares, María Mateos, Miguel Ángel Berenguer, Daniel Rivas, Elisabet González del Portillo, Cristina Andreu, Esther Holgado, Shankar Siva, Constantinos Zamboglou, Felipe Couñago
- Quelle
- Clinical and Translational Oncology
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 1699-3055
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Zitierfähiger Nachweis
Macarena Teja, Fernando López Campos, Álvaro Pinto, Israel J. Thuissard, María González, David Esteban, Abrahams Ocanto, Castalia Fernández, Daniela Gonsalves, Lisselott Torres, María Isabel Garrido, Escarlata López, Jaume Fernández, Loubna Aakki, Antonio Ristori, José Begara, Sigfredo Elias Romero Zoghbi, Jon Andreescu, Ana Belén Bezares, María Mateos, Miguel Ángel Berenguer, Daniel Rivas, Elisabet González del Portillo, Cristina Andreu, Esther Holgado, Shankar Siva, Constantinos Zamboglou, Felipe Couñago (2026). Clinical outcomes of stereotactic body radiotherapy in oligometastatic disease: a national real-world cohort study. Clinical and Translational Oncology. https://doi.org/10.1007/s12094-026-04557-5
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