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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Medicine

Clinically silent early proximal seal failure with suspected interval distal endograft displacement after hybrid zone 2 thoracic endovascular aortic repair in severe arch tortuosity: a case report with 1-year follow-up

Fengsheng Yin, Liang Wang, Lingli Tang, Long Yang

Background Durable hybrid zone 2 thoracic endovascular aortic repair depends on adequate healthy sealing length, appropriate oversizing, and close endograft apposition. Severe arch tortuosity can compromise these requirements even when completion angiography is satisfactory. Case presentation A 46-year-old woman with a primary non-post-surgical distal arch and proximal descending thoracic aneurysm underwent left carotid-subclavian bypass, left subclavian artery origin occlusion, and zone 2 thoracic endovascular aor …

03.09.2026journal-article

Frontiers in Medicine

Acute kidney injury secondary to crystalline cryoglobulinemic glomerulonephritis type I: a case report and literature review

Aichun Liu, Yina Wang, Yu Yan, Shuying Zheng, Bao Dong, Meishun Cai, Xin Li, Chunying Shao, Li Zuo

Background Type I cryoglobulinemia consists of a single monoclonal immunoglobulin and can induce small-vessel vasculitis with renal involvement. Cryoglobulinemic glomerulonephritis is a rare manifestation, pathologically characterized by membranoproliferative glomerulonephritis (MPGN). In this report, we present a case of type I cryoglobulinemic renal injury characterized by crystalline cryoglobulinemic glomerulonephritis type I. Our objective is to provide a detailed insight into the presentation, underlying disea …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

Selective Internal Radiation Therapy for Hepatocellular Malignancies: Existing Evidence and Advances

Priyanka Yadav, Jaya Shukla

Selective Internal Radiation Therapy (SIRT) is a locoregional treatment for primary and secondary liver neoplasms that spares the surrounding parenchyma while selectively delivering a high radiation dose to the tumour tissue. It functions by injecting radioactive microspheres into the hepatic artery supplying the tumour. SIRT has emerged as a valuable locoregional treatment for liver cancers, including unresectable hepatocellular carcinoma (HCC) and some liver-dominant metastases, such as neuroendocrine tumours and …

03.09.2026journal-article

Journal of Paediatrics and Child Health

Effects of a Parent‐Participatory Physical Activity and Psychoeducation Program on Anxiety, Depression, and Social Skills in Children With ADHD

Bumcheol Kim, Dae‐Hyun Jang, Ejin Park, Jaewon Kim

ABSTRACT Objective To examine the effects of a parent‐participatory (PP) physical activity (PA) program combined with psychoeducation (PE) incorporating psychological skills training (PST) components on anxiety, depression, and social skills in children with ADHD. Methods A total of 33 children with ADHD, aged 7–12 years, were allocated to one of three groups: PA combined with PE incorporating PST components (PA + PE, n = 12), PA only ( n = 10), or a control group ( n = 11). The intervention was delivered for 8 wee …

03.09.2026journal-article

Frontiers in Digital Health

Acceptability and feasibility of fitness watches to monitor sleep and physical activity among women living with HIV: broadening the approach to optimizing cardiovascular health

Kathleen M. Powis, Jessica Lee, Matthew Cole, Debra Riservato, Alexandria DiPerna, Mahboobullah Mirza Baig, Murli Purswani, Natalie Lewis-Vass, Claire A. Berman, Mariam Davtyan, Suzanne Siminski, Paige L. Williams, on behalf of the HOPE Study

Background Women with HIV have increased risk of cardiovascular disease compared to women without HIV. Adopting healthy lifestyle habits in early adulthood, including adequate sleep and physical activity, can mitigate this risk. Fitness watches provide objective measures of sleep and physical activity, and may enable proactive interventions to optimize long-term cardiovascular health. However, the acceptability and feasibility of wearable devices for continuous monitoring of these two measures among women living wi …

03.09.2026journal-article

Haematologica

Pediatric-inspired therapy and blinatumomab consolidation improve outcomes in young adults with Philadelphia-like acute lymphoblastic leukemia

Ibrahim Aldoss, Arthur Li, Diana Knobler, Vaibhav Agrawal, Hoda Pourhassan, Paul Koller, Tamer Othman, Monzr M. Al Malki, Amandeep Salhotra, Karamjeet Sandhu, Haris Ali, Ahmed Aribi, Amanda Blackmon, Brian Ball, Idoroenyi Amanam, Salman Otoukesh, Rick Lin, Julio C. Alvarenga Thiebaud, Sunmin Park, Samer Khaled, Jose Tinajero, Dat Ngo, Zhaohui Gu, Lindsey Murphy, Yazeed Samara, Michelle Afkhami, Andrew Artz, Pamela Becker, Ryotaro Nakamura, Anthony Stein, Stephen Forman, Guido Marcucci, Vinod Pullarkat

Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL associated with poor response to induction chemotherapy, suboptimal measurable residual disease (MRD) clearance, and inferior survival outcomes compared to non-Phlike subtypes. We retrospectively analyzed 140 consecutive adult patients with Ph-like ALL treated at our institution. The median age was 33.5 years, and the majority harbored CRLF2 rearrangements (85%). IKZF1plus deletion and JAK mutations were identified in 26% …

03.09.2026journal-article

Frontiers in Public Health

Construction and application of an occupational health risk grading method based on risk matrix and dynamic weighting: a case study of footwear manufacturing enterprises

Hongying Bian, Xin Wang, Yiwen Dong, Ning Kang, Lin Zhang

Background Occupational hazard factors in the footwear manufacturing industry are complex and encompass benzene series compounds, ketones, esters, dust, noise, and other agents. Existing mainstream occupational health risk assessment methods—including the Singapore semi-quantitative risk assessment method (Ministry of Manpower method, hereafter referred to as the MOM method), the exposure ratio method specified in GBZ/T 298-2017 (hereafter referred to as the exposure ratio method), the United States Environmental P …

03.09.2026journal-article

Journal of Intelligent Medicine

Temporal dynamics of visual awareness and target detection revealed by EEG‐based univariate and multivariate analyses

Yichao Huang, Mingliang Liu, Yufeng Ke

Abstract Successful visual processing involves both target detection and visual awareness, but their temporal dynamics remain incompletely understood. Here, we recorded EEG from 17 participants performing a near‐threshold visual task in which targets were defined by a luminance difference between central and peripheral discs. We compared correctly reported target and nontarget trials to examine EEG activity associated with target detection, and seen and unseen target trials to probe activity associated with reporte …

03.09.2026journal-article

F1000Research

Sample size determination across study designs in health professions education research: a methodology guide

Waqar M Naqvi, Anusha Divvi, Shivashankar Kengadaran, Aishwarya A Pashine, Maheshkumar Baladaniya, Aditya Patel, Praveen Kumar Kandakurthi, Ramprasad Muthukrishnan

Abstract Background Sample size determination is one of the least reported elements in the methods sections of health professions education (HPE) research. Underpowered studies miss real effects, whereas overpowered studies waste participants and resources. Guidance remains fragmented across statistical textbooks and discipline-specific papers, with no unified reference for HPE researchers. Methods We developed this guide as a structured narrative synthesis. Sources were identified through targeted database searchi …

03.09.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Assessment of testicular function in boys with hematological malignancies: a prospective longitudinal study

Jimena Lopez Dacal, Silvina Prada, Marcela Soria, Cristina Ferraro, Lourdes Correa Brito, Sofía Suco, Sebastián Castro, Maria Gabriela Ropelato, Maria Gabriela Ballerini, Patricia Bedecarrás, Luis Aversa, Ignacio Bergadá, Rodolfo A Rey, Romina P Grinspon

Abstract Context Survival after pediatric hematologic malignancies has improved substantially, increasing concern regarding endocrine sequelae. While gonadotoxic effects on germ cells are characterized in adult survivors, the early impact of cancer and chemotherapy on hypothalamic–pituitary–testicular axis during childhood and adolescence remains insufficiently studied. Design We conducted a prospective longitudinal cohort study including 63 boys and adolescents with acute lymphoblastic leukemia, acute myeloid leuk …

03.09.2026journal-article

Kybernetes

From landmarks to likes: conceptualizing and measuring the public intangible capital of World Heritage sites

Eva Erjavec, Tjaša Redek, Uroš Godnov

Purpose This study examines whether World Heritage designation acts as public intangible capital that improves tourist destination perceptions. Design/methodology/approach Using 51,000 user-generated reviews from destinations in nine countries, we compare ratings and text sentiment for heritage and non-heritage sites and test for differences by visitor segment using several text-mining approaches, from transformer-based (BERT) sentiment to lexicon averages, aspect-level analysis (architecture, crowding, price) and …

03.09.2026journal-article

Frontiers in Public Health

Governing One Health under climate pressure: policy implementation in Botswana

Thabo Lucas Seleke

Background Climate change is tightening the links between human, animal, and environmental health, especially in settings where systems are already stretched. One Health is now widely recognised in policy circles, but in many cases, it remains more of an intention than something that is consistently practised. Methods This paper draws on a qualitative policy analysis of academic literature, national policy documents, and selected comparative examples from Kenya, Bangladesh, and Germany. The aim was not to be exhaus …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Application of the combined technique of novel transseptal puncture guidewire and steerable sheath in left atrial appendage occlusion: a preliminary feasibility case series

Mei Liang, Wen Jia Wang, Peng Yu Wang, Qing Gu

Objective Transseptal puncture (TSP) is a critical step in left atrial appendage occlusion (LAAO) but presents certain technical challenges. Conventional puncture needles, due to their inherent rigidity, often cause unpredictable needle tip “bouncing” or upward migration at the moment of septal puncture, resulting in a high or suboptimal puncture site, which subsequently compromises the coaxial alignment between the sheath and the left atrial appendage (LAA). This study aims to evaluate the safety and feasibility o …

03.09.2026journal-article

Frontiers in Public Health

Preclinical perspectives on common iron fortificants and their bioavailability in rat models: a systematic review and meta-analysis

Jiejia Zhang, Brian L. Lindshield

Background Numerous preclinical studies on improving iron bioavailability to address iron deficiency anemia have been published; however, no preclinical systematic reviews with pairwise meta-analyses have been conducted. Therefore, it is essential to systematically review, summarize, and evaluate the evidence regarding the effects of iron fortificants in animal studies. Methods The initial articles were identified in four scientific databases (PubMed, Web of Science Core Collection, Scopus, and EBSCO) on 10 January …

03.09.2026journal-article

Frontiers in Medicine

Intrauterine device migration into the bladder with resultant bladder stone formation: a case report

Meilian Chen, Hongmei Xiao, Fei Lai, Yingxue Bai, Yixue Zhou, Xuelian Tan, Limei Wu, Haixia Jiang

Objective To investigate the possible aetiology, clinical characteristics, diagnostic and therapeutic approaches, and prognosis of intrauterine device (IUD) migration into the bladder. Case report A 39-year-old woman presented with recurrent symptoms of urinary urgency and dysuria. Computed tomography scans (CT) revealed that one arm of the IUD had migrated into the bladder, causing bladder stones. The patient underwent transurethral bladder lithotripsy and stone removal, laparoscopic bladder repair, and hysterosco …

03.09.2026journal-article

Frontiers in Public Health

Reframing trauma recovery for public health: introducing the recovery assemblage framework

Victoria Christodoulides, Maike Klein

Psychological trauma represents a major global health challenge, with adverse childhood experiences (ACEs) contributing to long-term difficulties in mental and physical health, relationships, and wellbeing. Despite this, dominant models of trauma recovery are largely grounded in biomedical and individualized paradigms, and prioritize linear pathways focused on symptom reduction and therapeutic outcomes. Such approaches risk locating responsibility for recovery within the individual, overlooking the broader social, …

03.09.2026journal-article

Frontiers in Medicine

Isolated gastrointestinal hereditary angioedema associated with a pathogenic SERPING1 variant arising de novo: a case report

Ziyu Yuan, Weipeng Lin, Yue Zheng, Xizi Yuan, Ming Luo, Lingyu Fu, Haiyan Zhang

Hereditary angioedema (HAE) is a rare genetic disorder typically characterized by cutaneous and submucosal edema. Cases presenting exclusively with gastrointestinal symptoms, devoid of concurrent or historical cutaneous or upper airway manifestations, are uncommon. This atypical presentation poses a considerable diagnostic challenge and often leads to a marked delay in diagnosis, particularly in patients without a family history. We report the case of a 28-year-old female with an over 6-year history of recurrent, s …

03.09.2026journal-article

El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam

Analysis of Non-Menopatic Patient Loyalty at Dr. Rm. Soedjarwadi Regional Mental Hospital, Central Java Province

Asril Aziz Rahmatullah, Sudarwati Sudarwati, Oong Ridhoi

This study aims to analyze the influence of service quality, facilities, rates, location, and hospital image on the loyalty of non-mental patients at Dr. RM. Soedjarwadi Mental Hospital, Central Java Province. This study used a quantitative method with a survey approach. The study population was all non-mental patients who had received services at Dr. RM. Soedjarwadi Mental Hospital, Central Java Province, with the criteria of having received treatment at least twice. Data were collected using a questionnaire compi …

03.09.2026journal-article

Frontiers in Psychology

“Did I look at the blackness, or did I look at the stars?” Meaning making in stories of spirituality, mental health and recovery

Katja Milner, Paul Crawford, Alison Edgley, Mike Slade

This qualitative narrative study explores how adults with lived experience of mental health difficulties draw on spirituality to make meaning and support recovery. Thirty participants were interviewed and asked to share their stories of spirituality, mental health and recovery. A narrative thematic analysis approach was developed to explore the superordinate theme of meaning making which comprised three interrelated themes: (1) Reframing, where spirituality enabled participants to adopt a bigger-picture perspective …

03.09.2026journal-article

Frontiers in Drug Delivery

Hyaluronidase-enhanced delivery in gene therapy and regenerative medicine for improved vector, cell, and cargo access

Patrick E. Sewell, Christopher Jensen

Efficient delivery of gene therapy vectors and regenerative cargo to the central nervous system (CNS) is limited by the hyaluronic acid (HA)-rich extracellular matrix (ECM). Adeno-associated virus (AAV) particles, mesenchymal stem cells (MSCs), multilineage-differentiating stress-enduring (MUSE) cells, and small extracellular vesicles (sEVs) must traverse the HA-rich ECM of the nasal submucosa, the perineural and perivascular compartments, and brain parenchyma to reach CNS targets. Dense ECM imposes viscosity, ster …

03.09.2026journal-article

Health Affairs Scholar

Implementing a Nicotine Cap to Make America Healthy Again

Dana Mowls Carroll, Dorothy K Hatsukami, Olivia A Wackowski, F Joseph McClernon, Eric Donny, Mitch Zeller

Abstract The U.S. Department of Health and Human Services’ (HHS) "Make America Healthy Again" initiative cannot eradicate the root causes of the nation’s chronic disease epidemic without tackling cigarette smoking, which kills over 480,000 Americans and costs $600 billion annually. This commentary reinvigorates a pivotal 2017 FDA framework by urging the current administration to finalize the proposed rule establishing a maximum nicotine cap in all cigarettes and selected combusted tobacco. Evidence demonstrates tha …

03.09.2026journal-article

Scientific Reports

The impact of patients suicide on the mental health of psychotherapists

Annabelle Siebert, Thomas Schnell, Janina Lehmann, Rüdiger Nübling

Abstract A great number of psychotherapists and psychiatrists experience at least one patient suicide during their career. This study aims to build upon previous research findings concerning the impact of experienced patient suicide on the mental health of practicing and trainee psychotherapists in a German sample. A central aspect involves examining the temporal development of perceived distress and identifying short- and long-term emotional effects of suicide through a mixed methods approach to derive correspondi …

03.09.2026journal-article

Annals of Neurosciences

Effectiveness of Cognitive Behavioural Therapy in Reducing Depression and Anxiety Among University Students: An Experimental Study

Bhawna Gurnani, Shubhagata Awasthi

Background Depression and anxiety are among the most prevalent mental health problems affecting university students and are associated with impaired academic performance, emotional distress and reduced quality of life. Cognitive behavioural therapy (CBT) is an evidence-based intervention that has demonstrated effectiveness in reducing symptoms of depression and anxiety; however, intervention-based studies among Indian university students remain limited. Purpose The present study aimed to evaluate the effectiveness …

03.09.2026journal-article

Cardiovascular Drugs and Therapy

Profiling Cardiovascular Disease-Associated Changes in the Composition of High-Density Lipoprotein Particles

Tanith Fester, Carmelita Abrahams, Sandrine Lecour

Abstract Cardiovascular disease remains the leading cause of death worldwide, imposing significant morbidity and healthcare costs. While low serum high-density lipoprotein (HDL)-cholesterol levels have traditionally been linked to cardiovascular risk, most pharmacological interventions aimed at raising HDL-cholesterol levels have not consistently improved cardiovascular outcomes. Epidemiologic and genetic studies further suggest that circulating HDL-cholesterol levels may not directly determine cardiovascular risk, …