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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

BMC Geriatrics

A mixed-methods feasibility study of dog-assisted exercise therapy in geriatric inpatients

Lilly Joschko, Eva Jansen, Stefanie Weinert, Maximilian Hinse, Roland Zerm, Harald Matthes

Abstract Background Animal-assisted therapy (AAT) is a promising complementary approach in geriatric rehabilitation, but evidence on feasibility and patient experiences remains limited. Methods This exploratory, mixed-methods, two-arm randomized controlled parallel-group design (RCT) compared dog-assisted exercise therapy (intervention) to standard exercise therapy (active control) in geriatric inpatients during a two-week rehabilitation program. Quantitative data on mobility (TUG), depression (HADS-D) symptoms, mo …

29.08.2026journal-article

BMC Cancer

Prognostic value of circulating tumor DNA and copy-number alterations in patients receiving tandem [225Ac]Ac-/[177Lu]Lu-PSMA-617 therapy for metastatic castration-resistant prostate cancer: a prospective observational study

Mariam Amghar, Thomas Hielscher, Tobias Rausch, Hilal Özgür, Ulrike Bauder-Wüst, Hendrik Rathke, Frank Bruchertseifer, Alfred Morgenstern, Mareike Roscher, Vladimír Beneš, Clemens Kratochwil, Martina Benešová-Schäfer

Abstract Background Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) demonstrates clinical efficacy in metastatic castration-resistant prostate cancer (mCRPC), yet robust biomarkers for dynamic treatment monitoring and resistance remain lacking. We investigated circulating tumor DNA (ctDNA)-derived tumor fraction (TFx) and genome-wide copy-number alterations (CNAs) as non-invasive biomarkers of treatment response and resistance biology. Methods Seventy-eight patients with advanced mCRPC re …

29.08.2026journal-article

Diabetic Medicine

PPI and researcher perspectives of islet transplantation therapy for type 1 diabetes

Peter M. Jones, Sarah Gatward, Lesley Beadle, Amanda Panizza, Clare Blaydon‐Ellis, Sara Caxaria, Aidan Cruddace, Christine Deal, Ranna Patel, Alexander Silverstein, Lydia F. Daniels Gatward, Tzu‐Wen Hong, Rosie Sullivan, William T. Blackstone Whines, Aileen J. F. King, Shanta J. Persaud

Abstract Aims Islet transplantation offers the potential of a cure for type 1 diabetes ( T1D ), but the limited availability of human donor islets means that this therapy is currently only available to a small group of people with T1D who have intractable hypoglycaemia. The shortage of donor human islets has driven extensive research efforts to generate human islets from pluripotent stem cells ( SC ‐islets), and current protocols are producing SC ‐islets which are showing promising results in early clinical trials. …

29.08.2026journal-article

American Journal of Educational Leadership & Policy Studies

Causal Modeling of Occupational Hazards and Teaching Performance: The Mediating Roles of Job Satisfaction and Stress

Jerry De Leon Taay

Teachers’ working environment plays significant factors on their well-being and effectiveness in delivering quality education. This study investigates causal relationship between occupational hazards and teaching performance together with job satisfaction and stress as mediating variables among the public secondary school teachers in the Division of Oriental Mindoro. The study utilized a descriptive-correlational causal research design employing Structural Equation Modeling (SEM). The respondents of the study were …

29.08.2026journal-article

Probecell Science

Transferrin Receptor-Mediated Nanoparticle Delivery Across the Blood-Brain Barrier for Glioblastoma Therapy

Laxminarayan .

Glioblastoma (GBM) remains the most aggressive of primary brain tumours, with short patient survival despite improvements in surgical resection, radiotherapeutic and chemotherapeutic strategies. One of the main challenges for therapy is to transport anticancer drugs in a broad spectrum, prevent their premature systemic clearance and avoid harmful effects on the healthy part of tissues or organs, such as the blood-brain barrier (BBB), an important structure that limits therapeutic access to most anticancer drugs at …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Emergence hemodynamic changes and postoperative outcomes in hypertensive patients receiving antihypertensive therapy undergoing general anesthesia: an observational study

Nahin Mahmud, Ahsan Habib Khan, Debabrata Banik, Nazmul Huda Naim, M. Fahad

Background: Hypertensive patients undergoing general anesthesia often continue antihypertensive therapy through the perioperative period, yet whether the number of preoperative antihypertensive agents predicts the need for intraoperative anesthetic modulation or postoperative outcome remains unclear. This study aimed to characterise antihypertensive medication burden, anesthetic modulation requirement and postoperative adverse events in hypertensive patients undergoing general anesthesia. Methods: This prospective …

29.08.2026journal-article

Lung India

Impact of extent of lung disease on nutritional, physiological, functional, and psychosocial outcomes of pulmonary rehabilitation in patients with post-tuberculosis sequelae: A prospective study from Western India

Ramakant Dixit, Manudev Mehta

Background: Post-tuberculosis lung disease (PTLD) is increasingly recognized as a major cause of chronic respiratory morbidity in tuberculosis (TB) survivors. Pulmonary rehabilitation (PR) improves functional outcomes in PTLD, but the influence of disease extent on response to rehabilitation is underexplored, particularly in high-burden settings such as India. Methods: This prospective interventional study was conducted at our center, over 6 months. Sixty patients with radiologically confirmed post-tuberculosis seq …

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29.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Wearable inertial sensor assessment of kinematic characteristics during unilateral jump landings in elite volleyball players with patellar tendinopathy: a cross-sectional study

Benjamin Ben Zaki, Gauthier Desmyttere, Stéphane Perrey, Marc Julia, Gilles Dusfour

Abstract Background Patellar tendinopathy (PT) is a prevalent overuse injury in jumping athletes such as volleyball players, with a prevalence reaching up to 45%. It is thought to result, at least in part, from repetitive landing impacts that overload the tendon due to altered neuromuscular control and inadequate force absorption by the muscle-tendon unit. Wearable inertial sensor assessment offers an objective and field-deployable approach to characterize landing kinematics in this population. This study aimed to …

29.08.2026journal-article

Journal of Clinical Psychology

The Impact of Mindfulness as a Session‐Introduction on Symptoms and Alliance in Individual Cognitive‐Behavioral Therapy With Children and Adolescents: A Randomized Controlled Trial

Julia Kalmar, Ines Baumann, Elena Schleiting, Anne Grünert, Eva Vonderlin, Katajun Lindenberg, Andreas B. Neubauer, Thomas Heidenreich, Johannes Mander

ABSTRACT Objectives Mindfulness is increasingly being implemented in child and adolescent therapy. However, little is known about its effectiveness in individual settings within a clinical outpatient context. We investigated the effects of session‐introducing mindfulness interventions (IG‐M) compared to session‐introducing relaxation interventions (CG‐R) and no standardized session‐introduction (CG) on symptomatic outcome and therapeutic alliance in cognitive‐behavioral therapy using a randomized controlled design. …

28.08.2026journal-article

Medical & Biological Engineering & Computing

Impact of EMG-based interfaces for hand motor rehabilitation in stroke: A systematic review with evidence gap map and meta-analysis

Cristian D. Guerrero-Mendez, Natanael Pereira Batista, José Osmar Alves Filho, Carina Marconi Germer, Leonardo Abdala Elias

Abstract Electromyography (EMG)-based interventions have been proposed to improve hand/wrist motor recovery after stroke; however, their clinical value remains uncertain, as evidence for their effectiveness is inconsistent. This systematic review with meta-analysis evaluated the impact of different EMG-based rehabilitation approaches compared with non-EMG-based interventions in individuals with stroke. Seven databases were searched from inception to November 17, 2025, in accordance with PRISMA guidelines. Randomize …

28.08.2026journal-article

Robotics

Hybrid Zero-Shot Interactive Navigation with LLMs: Path Planning Under Dual Constraints of Speech and Environment

Fan Yang, Jing Wu, Timur Kuzu, Hendrik Benz, Katharina Klemt-Albert

This study proposes a novel hybrid interactive navigation framework for mobile robots, designed to enable robots to operate under dual constraints imposed by both the environment and the speech of accompanying humans in challenging future collaborative working scenarios. By leveraging human perceptual capabilities, the proposed framework significantly enhances the obstacle-avoidance capabilities and flexibility of robots. Specifically, an innovative composition algorithm is introduced to integrate traditional costm …

28.08.2026journal-article

Revista Multidisciplinar de Estudios Generales

Estrategias de pausas activas como intervención para disminuir el agotamiento ocupacional en docentes ecuatorianos.

Maria Celeste Valladolid Paz, Jenny Del Rocio Eras Salinas, Xismenia Vanesa Blacio Pereira, Maria Rosenda Loja Cabrera

El presente estudio tuvo como objetivo analizar el efecto de un programa estructurado de pausas activas en la reducción del estrés laboral de docentes ecuatorianos, considerando esta estrategia como una alternativa para fortalecer el bienestar físico, emocional y cognitivo durante la jornada laboral. La investigación se desarrolló bajo un enfoque cuantitativo, de tipo aplicada, con alcance correlacional y diseño no experimental de corte transversal. La población estuvo conformada por 40 docentes ecuatorianos, selec …

28.08.2026journal-article

Proteomes

Integrative Proteomic Analysis Implicates Inhibition of Intracellular Protein Trafficking in Therapy-Induced Migrastasis in Prostate Cancer

Weining Chen, Saadyeh Rashidi, Henry C.-H. Law, Fangfang Qiao, Johnny W. Zigmond, Katelyn L. O’Neill, Nicholas T. Woods, Chittibabu Guda, Raymond C. Bergan

Background: Dysregulated cell migration leading to metastasis remains the primary cause of cancer-related mortality. It has been challenging to understand how cells regulate migration. We have previously created the first selective inhibitor of cell migration, KBU2046. Here, we use it as a probe to identify regulatory processes. Methods: Metastatic and primary human prostate cancer cells were treated for different times and at different concentrations with KBU2046. Immunofluorescent microscopy examined protein loca …

28.08.2026journal-article

International Journal of Biology and Life Sciences

Meta-analysis of the Intervention Effect of Cognitive Behavioral Therapy on Chemotherapy Anxiety Population

Fagang Ma, Yancan Wang, Wei Su, Yangyang Sun, Lin Cheng

Objective This paper primarily analyzes the impact and extent of cognitive behavioral therapy (CBT) on anxiety levels in chemotherapy patients by reviewing and retrieving literature and relevant journals, aiming to provide theoretical support and practical references for clinical nursing. Methods A Meta-analysis was conducted, systematically retrieving literature from databases such as PubMed and CNKI. The time range was set from the initial inclusion date of each database to March 2026. Regarding studies on CBT in …

28.08.2026journal-article

ULAKES JOURNAL OF MEDICINE

DESIGUALDADES ESTRUTURAIS NO CÂNCER OCUPACIONAL BRASILEIRO (2020–2024): PROPOSTAS DE CUIDADO INTEGRAL À LUZ DO MODELO BIOPSICOSSOCIOESPIRITUAL DA ATENÇÃO PRIMÁRIA À SAÚDE

Ailton Gomes da Silva, Bruna Cartapatti Stuchi, Gabrielly Chiesa, Maria Etelvina Pinto-Fochi

Este trabalho analisa os principais agentes carcinogênicos ocupacionais notificados no Sistema deInformação de Agravos de Notificação no Brasil entre 2020 e 2024. A pesquisa busca compreendercomo a exposição a substâncias como amianto, benzeno e radiação ionizante se distribui entre ossetores econômicos e como afeta a saúde de populações trabalhadoras vulneráveis. A abordagemadota os princípios da Atenção Primária à Saúde (APS) com base no modelo biopsicossocioespiritual,além do Método Clínico Centrado na Pessoa e …

28.08.2026journal-article

Journal of Head Trauma Rehabilitation

Psychological Resilience and Adolescent Sport-Related Concussion

Nikolas O. Josafatow-García, Jason B. Tabor, Christina Campbell, Kristina Fraser, Jean-Michel Galarneau, Keith O. Yeates, Carolyn A. Emery, Chantel T. Debert

Objectives: Our primary objective was to investigate the trajectory of resilience from preinjury to acutely after sport-related concussion (SRC; within 10 days of injury) and to time of return to play (RTP) in adolescents. We further sought to determine whether this trajectory differed between sexes. Secondarily, we investigated the associations between resilience and post-SRC symptom burden and length of recovery. Setting: A substudy of the multicenter pan-Canadian SHRed Concussions (Surveillance in High Schools a …

28.08.2026journal-article

Egyptian Rheumatology and Rehabilitation

Comparative study of subclinical synovitis and periarticular bone changes in psoriasis patients: impact of biological therapy

Heba Elsayed Elshok, Abdelkawy A. Moghazy, Mostafa Farouk Balbaa, Amira M. Ibrahim

Abstract Background Psoriasis (PsO) is increasingly recognized as a systemic inflammatory disease associated with subclinical musculoskeletal involvement that may precede psoriatic arthritis (PsA). This study aimed to evaluate the prevalence of subclinical synovitis and periarticular bone changes in PsO patients and to assess the impact of biological therapy compared to conventional treatment modalities. Patients and methods This case–control study included 50 PsO patients without clinical evidence of PsA and 25 ag …

28.08.2026journal-article

Journal of Clinical Medicine

Airway Clearance and Pediatric Pulmonary Rehabilitation in Primary Ciliary Dyskinesia: A Clinical Framework for Children and Adolescents

Jiahui Zhao, Lina Chen, Wenhao Yang, Hanmin Liu

Primary ciliary dyskinesia (PCD) is an inherited motile-cilia disorder. Impaired mucociliary transport promotes persistent secretion retention, infection, inflammation, and bronchiectasis. The central treatment problem is therefore failure of airway clearance rather than infection alone. This narrative review evaluates airway clearance techniques (ACTs), mucoactive adjuncts, and pulmonary rehabilitation for children and adolescents. We prioritize direct pediatric PCD evidence, identify mixed-age or adult PCD findin …

28.08.2026journal-article

Journal of Oral Rehabilitation

Cross‐Sectional Survey of Dental Treatment Needs Among Older Adults Receiving Home‐Visit Dental Care for Eating‐Related Problems in Acute, Convalescent and Community‐Based Care Phases

Naoki Todayama, Hiroyuki Suzuki, Chiaki Matsubara, Yasuyuki Iwasa, Yoko Wakasugi, Akira Goda, Shuhei Takeuchi, Yasushi Tamada, Koichiro Matsuo, Haruka Tohara, Junichi Furuya

ABSTRACT Background Oral health in older adults is often compromised by age‐related changes, such as oral frailty and systemic comorbidities. Consequently, older patients requiring home‐visit dental care, mostly due to eating‐related problems, may show stage‐dependent differences in oral conditions and dental care priorities. Objective To clarify care phase‐specific dental care needs among older patients receiving home‐visit dental care. Methods This multicenter cross‐sectional study included 356 older patients who …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

Assessment of Babysitters' Awareness of Speech and Language Development: A Pilot Study

Agit Şimşek, Zehra Güneş

Objectives: The aim of this pilot study was to evaluate the awareness levels of in-home babysitters caring for children aged 0–48 months regarding early speech and language development, and to examine the relationship between awareness levels and variables such as educational background and professional caregiving experience. Materials and Methods: This study was designed as a cross-sectional and analytical pilot investigation. A total of 41 in-home babysitters actively providing care for children aged 0–48 months …

28.08.2026journal-article

Therapeutic Apheresis and Dialysis

Cell‐Free and Concentrated Ascites Reinfusion Therapy for Refractory Ascites Following Pediatric Liver Transplantation

Itsuki Naya, Naoya Yamada, Yoshihiro Hirata, Yoshiyuki Ihara, Megumi Tamura, Motoki Ebihara, Shoichi Tsuzaka, Rina Matsuda, Shotaro Taki, Shoko Ogawa, Kyoichi Deie, Hiroshi Kawashima, Koichi Mizuta

ABSTRACT Introduction Cell‐free and concentrated ascites reinfusion therapy (CART) has been widely used for malignant ascites and decompensated cirrhosis, but its perioperative application remains unclear. We evaluated CART after pediatric living donor liver transplantation (LDLT). Methods We retrospectively reviewed pediatric LDLT recipients who underwent CART for refractory ascites. Changes in ascites volume, protein recovery rates including albumin and immunoglobulin G (IgG), and adverse events were analyzed. Re …

28.08.2026journal-article

Scientific Notes of Junior Academy of Sciences of Ukraine

Comprehensive rehabilitation centers as an environment for restoring the social functioning of persons with war-related disabilities

А. O. Zapitetskyi

The article examines the role of comprehensive rehabilitation centers as a multifunctional environment for restoring the social functioning of persons with disabilities acquired as a result of war. It substantiates that contemporary wartime challenges have led to a significant increase in the number of individuals who require not only medical and physical rehabilitation but also comprehensive social support, psychological assistance, vocational adaptation, and community integration. Particular attention is paid to …

28.08.2026journal-article

BJOG: An International Journal of Obstetrics & Gynaecology

Vaginal Oestrogen Therapy for Postmenopausal Women Undergoing Prolapse Surgery: A Multicentre Double‐Blind Randomised Placebo‐Controlled Clinical Trial

Eva V. Vodegel, Krista van Rest, Leonie Speksnijder, Astrid Vollebregt, Albert Adriaanse, Eveline J. Roos, Franca Gerards, Wilbert Spaans, Marko Sikkema, Joggem Veen, Flora Vernooij, Marinus van der Ploeg, Jan‐Paul W. R. Roovers, the EVA Study Group

ABSTRACT Objective To determine whether vaginal oestrogen therapy improves outcomes after prolapse surgery in postmenopausal women. Design Double‐blind, randomised, placebo‐controlled trial with 12 month follow‐up. Setting Multicentre, 22 hospitals in the Netherlands. Population Postmenopausal women with POP‐Q stage ≥ 2 scheduled for primary native‐tissue prolapse repair. Methods Women were randomised (1:1) to vaginal oestriol cream (1 mg/g) or identical placebo, started 4–6 weeks preoperatively and continued to 12 …

28.08.2026journal-article

PLOS One

Long-term effects of cognitive behavioural therapy on the quality of life in adult ADHD

Ravian Wettstein, Valentina Navarro-Ovando, Viktoria Janke, Ron Mathôt, Glenn Dumont

This study examined the long-term effects (4–8 years) of Cognitive Behavioural Therapy (CBT), added to pharmacotherapy and psychoeducation (PE), on quality of life (QoL) in adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Although previous findings showed no added QoL benefit of CBT immediately post-treatment, CBT provides skill-building and coping strategies that may yield delayed benefits in terms of ADHD-related functional impairments. We hypothesize that CBT will provide delayed treatment gains and …