Transferrin Receptor-Mediated Nanoparticle Delivery Across the Blood-Brain Barrier for Glioblastoma Therapy

Vollständiger Abstract

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Glioblastoma (GBM) remains the most aggressive of primary brain tumours, with short patient survival despite improvements in surgical resection, radiotherapeutic and chemotherapeutic strategies. One of the main challenges for therapy is to transport anticancer drugs in a broad spectrum, prevent their premature systemic clearance and avoid harmful effects on the healthy part of tissues or organs, such as the blood-brain barrier (BBB), an important structure that limits therapeutic access to most anticancer drugs at tumour sites. Currently, transferrin receptor (TfR)-mediated transcytosis is one of the most feasible strategies to enhance the delivery of nanoparticles across the blood-brain barrier (BBB) into the brain among methods targeting the brain. These nanocarriers are dual-targeted, as TfR is overexpressed on brain endothelial cells as well as glioblastoma cells, thereby improving drug accumulation while minimising systemic toxicity. This review summarises the biology underlying TfR-mediated transport, r