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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Clinical Spine Surgery

Assessing Global Upper Extremity Function Before and After Decompressive Surgery in Patients With Degenerative Cervical Myelopathy (DCM)

Angie Zhang Lung, John Hong, Vicky Chan, Maya N. Hatch, Jay J. Han, Yu-Po Lee, Nitin N. Bhatia, Michael Oh

Study Design: A total of 20 patients with degenerative cervical myelopathy (DCM) and a plan for surgical decompression were recruited in this pilot study to assess a new outcome measure. Patients were evaluated preoperatively and 3 months, 6 months, and 1 year postoperatively using a 3-dimensional motion-tracking application (reachable workspace) to calculate an upper extremity (UE) relative surface area (RSA) and standard measurements [modified Japanese Orthopedic Association (mJOA), 12-Item Short Form Health Surv …

03.09.2026journal-article

Journal of Clinical Pathology

Anaplastic lymphoma kinase immunohistochemical positivity in high-grade pulmonary neuroendocrine carcinoma: an actionable signal or merely a shadow?

Ullas Batra, Sabeena Choudhary, Ritwika Choudhury, Alka Yadav, Mansi Sharma, Abhinav Dewan, Sunil Pasricha, Anurag Mehta, Priyanka Venkataraman

Aims Anaplastic lymphoma kinase (ALK) rearrangements are actionable drivers in non-small cell lung carcinoma (NSCLC), but the biological significance of ALK-immunohistochemistry (IHC) positivity in high-grade pulmonary neuroendocrine carcinoma (NEC) remains unclear. This study evaluated the diagnostic and therapeutic implications of discordant ALK IHC and genomic findings and the role of multimodal molecular testing in resolving them. Methods We retrospectively analysed eight South Asian patients (Indian and Nepali …

03.09.2026journal-article

Military Medicine

Military Medical Training for Role 1 and Role 2 Combat Casualty Care Skills: A Narrative Review

Jennifer L Patton, Kiffin R Smallegan, Emily R Latimer, Anna R Prendergast, Gary J Jimenez Pena, Angela K Phillips

Abstract Introduction Military medics are often tasked to train other medics. While there is ample content of what to train, there exists a lack of trainer education or emphasis on how to train others effectively. Current military medical training is highly variable, often relying on anecdotal methods, with limited evaluation of training effectiveness. Although the importance of readiness training is well recognized, little attention has been devoted to identifying evidence-based approaches for training military me …

03.09.2026journal-article

Clinical Anatomy

Integrating Professional‐Values‐Oriented Education Into PBL Teaching: Practice Based on Case Discussions in Anatomy Curriculum

Liu He, Yunwen Hu, Chengjun Hu

ABSTRACT This study, conducted among first‐year undergraduates, investigates the feasibility of integrating professional‐values‐oriented education into the discussion‐based human anatomy teaching module via the problem‐based learning (PBL) model. Over a three‐year reform period, PBL cases combining clinical scenarios with professional‐values‐oriented elements were designed and implemented specifically for this human anatomy module; the effectiveness of this approach was subsequently evaluated through a systematic a …

03.09.2026journal-article

Clinical and Translational Discovery

Gene therapy for hereditary deafness: Progress, challenges and translational implications from OTOF to GJB2

Jiahui Zhao, Mengzhao Xun, Yu Sun

Abstract Background Hereditary deafness is a common sensory disorder in infants and children. Gene therapy has achieved major clinical breakthroughs in OTOF ‐related deafness, establishing proof of concept for treating monogenic hearing loss. In contrast, GJB2 ‐related hearing loss remains more challenging because of its broad cochlear expression, complex supporting‐cell targets, developmental involvement, and narrow therapeutic window. Methods We reviewed recent advances in hereditary deafness gene therapy, focusi …

03.09.2026journal-article

Ege Tıp Dergisi

Can preoperative thrombocytopenia be a risk indicator for emergency surgery due to liver transplant complications?

Emrah Şahin, Ender Anılır, Abuzer Dirican, Bülent Ünal

Aim: This study aimed to investigate the effect of preoperative thrombocytopenia and other risk factors on the need for emergency surgery due to complications following living donor liver transplantation (LDLT), and to evaluate the impact of emergency surgery on patient survival.Materials and Methods: The data of 270 patients who underwent LDLT for end-stage liver disease between July 2021 and October 2023 were analyzed retrospectively. Patients were divided into two groups: those requiring postoperative emergency …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

A refined phenomenological model of viscoelastic clot formation and lysis in trauma-induced coagulopathy

Guanyun Liu, Amanda E. Shick, Maya Shamash, Caroline M. Cook, Mario L. Molina, Mitchell J. Cohen, Amor A. Menezes

Background Hyperfibrinolysis is strongly associated with early post-injury mortality, but the condition is preventable with timely detection and targeted interventions. Unfortunately, current hyperfibrinolysis diagnostic assays such as thromboelastography (TEG) are time-consuming, making them infeasible for use in real-time treatment strategies to guide adjustable, precise, and personalized interventions. Computational models offer a fast alternative to current practice for ascertaining patient hemostatic state fro …

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Validation of synthetic M-protein materials for external quality assessment: homogeneity, commutability, and stability

Moniek M. Bioch, Theo Rispens, Corrie M. de Kat Angelino, Anke J. ten Haaken-Meijer, Miranda van Berkel, Marc H.M. Thelen, Joannes F.M. Jacobs

Abstract Objectives Accurate quantification of M-proteins is important for clinical management of monoclonal gammopathies. Reliable assessment of trueness on M-protein quantification in External Quality Assessment (EQA) schemes is difficult due to the lack of reference methods and materials for target value assignment. We propose a strategy to produce targeted synthetic M-protein EQA materials by spiking known amounts of human(ised) therapeutic monoclonal antibodies (t-mAb) into null serum. This paper validates hom …

03.09.2026journal-article

Supportive Care in Cancer

Goal-directed nutritional support in preserving muscle mass and optimising recovery in treatment of oesophageal cancer: results of a prospective non-randomised cluster trial

Iris Barth, Iris Stelwagen, Linda B. M. Weerink, Dorienke Gort-van Dijk, Hanna Meinders, Milos Milovanovic, Jan Willem Haveman, Marc J. van Det, Gerard Dijkstra, Marjo J. E. Campmans-Kuijpers

Abstract Purpose Oesophageal cancer (OEC) treated with neoadjuvant chemoradiotherapy (CRT) followed by oesophagectomy is associated with muscle loss and impaired recovery. We aim to evaluate whether a goal-directed nutritional support protocol (GDNS) is associated with muscle loss and improved survival after CRT and oesophagectomy compared with usual care. Methods Adults with OEC undergoing CRT and oesophagectomy were included. In this trial, a tertiary centre provided GDNS, and a secondary hospital offered usual c …

03.09.2026journal-article

Journal of the Endocrine Society

Intermediate risk thyroid cancer management: physician survey

Annu R Suresh, Amanda Kung, Jiling Chou, Jacqueline Jonklaas

Abstract Context Variability exists in use of radioactive iodine (RAI) treatment in intermediate risk (IR) thyroid cancer. Objective The study surveyed clinicians about their use of RAI in theoretical cases of patients with IR thyroid cancer. Design A survey presented patient cases with pathology results and two variations consisting of baseline thyroglobulin levels of ≤5 ng/mL and >5 ng/mL. Respondents were queried as to their use of RAI therapy in each case. Univariate Bayesian cumulative ordinal regression model …

03.09.2026journal-article

Frontiers in Medicine

Spirituality, religious affiliation, and health in Germany: a cross-sectional study including Bayesian network modeling

Christian S. Kessler, Michael Jeitler, Miriam Ortiz, Benno Brinkhaus, Maren M. Michaelsen, Julia K. Schiele, Florian Jeserich, Tido von Schoen-Angerer, Michael Teut, Manfred Wischnewsky

Background Spirituality has been proposed as a relevant dimension of health, yet its distribution in the general population and its associations with health-related factors remain insufficiently characterized. This study examined how self-reported spirituality and religious affiliation are distributed in Germany and how they are associated with chronic disease burden, health-related quality of life, nutrition-related attitudes, and attitudes toward traditional, complementary, and integrative medicine (TCIM). Method …

03.09.2026journal-article

Frontiers in Medicine

Artificial intelligence in personalized computed tomography dose optimization: a systematic review of techniques and clinical outcomes

Nora Almuqbil

Introduction Artificial intelligence (AI) for personalized computed tomography (CT) dose optimization has gained increasing attention due to its potential to reduce radiation exposure while maintaining image quality. CT dose optimization tailors according to individual patient characteristics, including age, weight, body composition, and clinical condition. The study aims to evaluate AI techniques in CT dose optimization, focusing on reducing radiation exposure while maintaining image quality. Methods The relevant …

03.09.2026journal-article

Clinical Microbiology Reviews

Emerging tick-borne viral diseases in East Asia: pathology-driven insights into pathogenesis and disease causality

Yuichiro Hirata, Yusuke Sakai, Tadaki Suzuki

SUMMARY Tick-borne viral infections have emerged as a significant and growing public health concern. In East Asia, severe fever with thrombocytopenia syndrome (SFTS) has served as a prototypical disease in which pathological analyses have substantially advanced the understanding of disease pathogenesis. SFTS is characterized by profound immune dysregulation driven by viral tropism for plasmablast-lineage B cells, leading to cytokine storm and hemophagocytic syndrome. Complementary analyses of human clinical specime …

03.09.2026journal-article

Clinical Journal of the American Society of Nephrology

A Randomized Pilot Trial of a Nephrologist Communication Tool for Discussing Conservative Management

Susan P. Y. Wong, Olivia Gaughran, David K. Prince, Jane Schell, Daniel Y. Lam, Dawn Bates, Grady Paden, Erin K. Kross

Background: It is difficult for patients to make informed decisions about kidney failure unless they know all their treatment options. Conservative management is an important option infrequently presented alongside other kidney failure treatments by nephrologists. Methods: We conducted a randomized pilot trial testing the feasibility and acceptability of a communication tool, called Conservative Kidney Management Jumpstart Tool, in assisting nephrologists with discussing conservative management with their patients. …

03.09.2026journal-article

PLOS One

IFC-HFlowVAE: A self-enhancing generative framework with structural anchoring for imbalanced clinical data augmentation

Lu Yuwen, Shuyu Chen

Class imbalance and limited minority-class samples remain major challenges for developing reliable clinical diagnostic models, as insufficient observations often fail to capture complex minority-class distributions. Existing augmentation methods either rely on heuristic interpolation or suffer from instability when learning sparse and heterogeneous medical tabular data. This study proposes IFC-HFlowVAE, an iterative feedback and consensus framework built upon a flow-enhanced heterogeneous variational autoencoder fo …

03.09.2026journal-article

Clinical Dermatology Review

Epidemiological Spectrum of Palmoplantar Dermatoses in Central India: A Hospital-based Cross-sectional Study

Surbhi Kashyap, Ajeet Singh, Satyaki Ganguly, Ritul Choudhary, Praveen Kumar

Abstract Context: Palmoplantar dermatoses are the skin disorders affecting the palms and soles – areas characterized by distinct anatomical, physiological, and environmental exposures. The clinical impact of these disorders is greater, owing to their often-visible nature, chronic course, and association with pain, functional impairment, and psychosocial distress. Aims: A comprehensive analysis of the clinical spectrum of palmoplantar dermatoses at a tertiary care setting in Central India, with particular focus on d …

03.09.2026journal-article

Magnetic Resonance Materials in Physics, Biology and Medicine

Age-dependent macromolecule signals in the human motor cortex and thalamus: implications for metabolites quantification at 7 T

Xinyu Liu, Gianna Nossa, Ying Xiao, Selin Scherrer, Sven Egger, Benedikt Lauber, Wolfgang Taube, Ulrike Dydak, Lijing Xin

Abstract Objective Macromolecular (MM) signals overlap with metabolite signals, but MM content differences across age and brain region and their influences on brain metabolites quantification have remained elusive. While most studies assume universal MM content when assessing neurochemical levels, region- and age-related MM differences could result in inaccurate quantification of metabolites. This study assesses MM differences linked to specific brain regions and age by analyzing their influence on metabolite signa …

03.09.2026journal-article

General Thoracic and Cardiovascular Surgery

Impact of preoperative nutritional status on longitudinal changes in pulmonary function and prognosis after lung cancer surgery

Kentaro Miura, Daisuke Nakamura, Sachie Koike, Shuji Mishima, Yukihiro Terada, Shunichiro Matsuoka, Hirotaka Kumeda, Takashi Eguchi, Kazutoshi Hamanaka, Kimihiro Shimizu

Abstract Objective Preoperative nutritional status is a known prognostic factor in lung cancer surgery. However, its effect on postoperative pulmonary function over time remains unclear. This study evaluated the association between preoperative nutritional status and longitudinal respiratory changes andoutcomes after curative resection. Methods Patients who underwent resection for non-small cell lung cancer between January 2020 and December 2024 were prospectively analyzed. Patients were classified by prognostic nu …

03.09.2026journal-article

International Journal of Clinical Pharmacy

A qualitative analysis to identify implementation strategies for a deprescribing clinical practice guideline using the CFIR-ERIC Matching Tool: perspectives from consumers and professional stakeholders

Hui Wen Quek, Xisco Reus, Kenneth Lee, Veronika Seda, Leon Adams, Osvaldo P. Almeida, Gillian E. Caughey, Jennifer Gowan, Kerryn Hart, Andrew Heredia, Anne-Marie Hill, Lisa Kalisch Ellett, Dina LoGiudice, Arduino A. Mangoni, Anthony Marinucci, Treasure McGuire, Nilufeur McKay, Vasi Naganathan, Christopher Ng, Maz Osborne, Kevan R. Polkinghorne, Constance D. Pond, Sepehr Shakib, Angela Shiu, Andrew Stafford, Tim Whitmore, Christopher Etherton-Beer, Amy Page

Abstract Introduction Deprescribing is the planned withdrawal or dose reduction of medicines when harms outweigh benefits or when they are no longer required. Following publication of the Clinical Practice Guideline for Deprescribing in Older People in September 2025, supporting its uptake into routine practice is a critical next step. Aim This study aimed to identify implementation strategies, informed by stakeholder-perceived barriers, to support the implementation of deprescribing guidelines. Method A qualitativ …

03.09.2026journal-article

Clinical Pediatrics

The Doctor Will Zoom You Now: An Experiential Telemedicine Assessment for Pediatric Residents

Heather B. Howell, Jonathan Lebowitz, Jeffrey Wilhite, Chanelle Coble-Sadaphal, Meaghan McGrath, Rachel Ramsey, Lisa Altshuler, Sondra Zabar, Purnahamsi V. Desai

There has been increased use of telemedicine in clinical practice, but telemedicine curricula are not standard in pediatric residency training. We developed a 2-case, Virtual Objective Structured Clinical Exam (VOSCE) for pediatric residents with telemedicine learning objectives. Resident competency was assessed using a behaviorally anchored checklist, and residents completed a pre/post self-assessment. Less than half of the residents met mastery for the following behaviors: confirmation of patient identifiers, opt …

03.09.2026journal-article

PLOS Digital Health

Implementation of an opioid use disorder (OUD) machine-learning phenotype in real-time for the ADAPT clinical trial

Huan Li, Mark Iscoe, John Lutz, Carolina Diniz Hopper, Sabrina Fried, Josue Minaya, Caroline Raymond King, Olga Reykhart, Hyung Paek, Daniella Meeker, Edward R. Melnick, R. Andrew Taylor

We developed and deploy a real‑time, electronic health record‑integrated machine learning phenotype to identify emergency department patients with opioid use disorder for prospective clinical trial screening and buprenorphine initiation. We conducted a multi‑phase study across three emergency departments in a single United States health system from 2014 to 2025. Using visit‑level data available at or before triage, we trained a random‑forest classifier to estimate opioid use disorder risk and embedded scoring in th …

03.09.2026journal-article

Journal of Pediatric Hematology/Oncology

Oral Cyanocobalamin Treatment in Infants Under 1 Year With Nutritional Vitamin B12 Deficiency: A Retrospective Comparison of 500 and 1000 µg Dose Regimens

Gökçe P. Reis İskenderoğlu, Erol Erduran, Nilgün Eroğlu, Ayşenur Bahadır

Background: Vitamin B12 deficiency is a significant health problem in infancy, particularly in developing countries. Oral treatment has emerged as an alternative to intramuscular therapy, but optimal dosing in infants remains unclear. Methods: This retrospective study included 93 infants aged 1 to 12 months diagnosed with nutritional vitamin B12 deficiency. Patients received either 500 or 1000 µg oral cyanocobalamin. Laboratory parameters were evaluated at baseline, 2 months, and 4 months. Results: Both treatment g …

03.09.2026journal-article

Veredas do Direito

DIAGNOSIS OF THE LEVEL OF ADOPTION OF GREEN LOGISTICS PRACTICES IN FREIGHT TRANSPORT COMPANIES IN LÁZARO CÁRDENAS, MICHOACÁN

María Del Mar Plancarte Muñoz, Ofelia Barrios Vargas, Luis Fernando Hernández Díaz, Samuel David Soriano López, Samuel Fernando Cárdenas Betancourt

The objective of this research was to diagnose the level of adoption of green logistics practices in federal freight transportation companies operating in Lázaro Cárdenas, Michoacán. A quantitative, descriptive, non-experimental, and cross-sectional study was conducted using a structured questionnaire that assessed the dimensions of fleet management, route optimization, energy efficiency, environmental management, and information technologies. The results show a moderate level of adoption of green practices. The sa …