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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Public Health

Knowledge, perceptions, and support for human milk banking among Saudi mothers: a cross-sectional study

Yahya A. Almutawif, Renad M. Alhamawi

Background Donor Human Milk (DHM) is recommended for preterm infants when a mother’s own milk is unavailable. This study explored Saudi mothers’ knowledge, attitudes, and concerns regarding human milk banking (HMB) and donation, to identify barriers to acceptance and to inform future implementation. Methods A cross-sectional survey of 835 mothers across Saudi regions assessed support for HMB and its association with sociodemographic factors, feeding practices, breastfeeding duration, and knowledge of the benefits o …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Cardiac safety of L-Annamycin: a pooled analysis of five clinical trials

Ziad Zalaquett, Stuart Waymack, Patrick Collier

Background Anthracyclines are highly effective chemotherapeutic agents but are limited by cumulative, dose-dependent cardiotoxicity, leading to strict lifetime exposure thresholds. L-Annamycin is a next-generation liposomal anthracycline designed to preserve antitumor efficacy while reducing cardiotoxicity. Methods We performed a pooled analysis of cardiac safety data from five sponsor- and investigator-initiated clinical trials evaluating L-Annamycin in acute myelogenous leukemia (AML) and metastatic soft tissue s …

03.09.2026journal-article

Frontiers in Medicine

Multidisciplinary wound care in an elderly patient with extensive bullous pemphigoid: a case report

Xiaoyan Chen, Masoud Mohammadnezhad, Yuhua Zhou, Yubing Qin

This case report evaluated the effectiveness of individualised cut-to-fit dressings, guided by moist wound healing principles, in managing multiple refractory wounds in an elderly patient with bullous pemphigoid. A multidisciplinary team collaborated with a wound specialist nurse who tailored and combined dressings according to wound exudate levels, pressure exposure, and skin tension, while reinforcing comprehensive assessment, medication management, skin protection, and health education. During hospitalisation, p …

03.09.2026journal-article

Frontiers in Oral Health

Validation of a commercial intraoral auto-segmentation algorithm against expert-annotated clinical data with comparison to a transparent algorithm

Rojin Adabdokht, Manuel Lagravere Vich, Thanandon Imaromkul, Kridsada Tosakparalerd, Victor de Miranda Ladewig, Wenji Cai, Chitian Ji, Hollis Lai

Introduction Artificial intelligence (AI)-based tooth segmentation has the potential to improve the efficiency and consistency of digital clinical workflows; however, the generalizability of commercially available algorithms on clinical datasets and their interpretability remain limited. Methods This study proposed a two-level evaluation method. It evaluated the performance of a black-box commercial algorithm using an expert-annotated clinical reference dataset of 126 intraoral scans representing diverse clinical p …

03.09.2026journal-article

Frontiers in Education

Application of the BOPPPS model combined with flipped classroom in clinical practice competency training for gastroenterology residents in standardized residency programs

Jiao Li, Juan Yang, Sheng Zheng

Background The bridge-in, objective, preassessment, participatory learning, postassessment, summary (BOPPPS) instructional model and flipped classroom pedagogy are increasingly recognized as effective active learning strategies in medical education. However, their combined application in gastroenterology residency training has not been systematically evaluated. This study investigated the impact of the BOPPPS + flipped classroom model on clinical practice competency, clinical thinking, self-directed learning, and t …

03.09.2026journal-article

Frontiers in Medicine

Work-related distress and professional quality of life in a medical-school workforce: a primary-care occupational-health perspective

Falah Mohammed Almarzooqi, Saif Al-Shamsi, Syed Fahad Javaid, Afaf Alblooshi, Faten AlRadini

Background Work-related distress may present in primary care through nonspecific physical, psychological, or functional complaints. This study assessed professional quality of life in a United Arab Emirates medical-school workforce through primary-care and occupational-health perspectives. Methods A cross-sectional electronic survey was conducted among employees of the College of Medicine and Health Sciences, United Arab Emirates University, between October 2025 and February 2026. The sampling frame comprised 373 e …

03.09.2026journal-article

Journal of Digestive Diseases

Clinical Impact of Endoscopic Ultrasound‐Guided Fine‐Needle Biopsy in Radiologically Suspected Pancreatic Neuroendocrine Tumors

Carolina González‐Abós, Ignacio Gil, Àngels Ginés, Guillem Soy, Oriol Sendino, Iván Archilla, Fabio Ausania

ABSTRACT Objectives Incidental diagnosis of pancreatic neuroendocrine tumors (PNETs) is increasing. Its surgical indication depends on the risk of progression, whereas histological features can be assessed by endoscopic ultrasound‐guided fine‐needle biopsy (EUS‐FNB). However, its systematic use remains a matter of debate. We aimed to analyze the impact of EUS‐FNB on therapeutic management in patients with radiologically suspected PNETs. Methods In this retrospective observational single‐center study, all patients w …

03.09.2026journal-article

Public International and Private International Law

Elements of the Value Added Tax in the Laws of the Islamic Republic of Iran: A Comparative Legal Analysis Covering Islamic Countries and the Russian Federation

Gennady P. Gorbulin

The article uses a comparative legal method to analyze the approaches to establishing elements of value-added tax in the Islamic Republic of Iran, the Gulf Cooperation Council states, Egypt, Indonesia, and the Russian Federation. It identifies both similarities and significant differences in the regulation of subject composition, object of taxation, tax base, tax period, rates, exemptions, and procedural aspects of administration. Special attention is given to the Iranian model, which was developed under the influe …

03.09.2026journal-article

Public International and Private International Law

Criminal Liability for Illegal Entrepreneurship in Russia and Brazil: Theoretical and Practical Issues

Daniil A. Tryshkov

This scientific article provides a comparative legal analysis of the theory and practice of criminal liability for illegal entrepreneurship in the Russian Federation and Brazil. Special attention is paid to improving Russian legislation and law enforcement through the use of Brazilian experience

03.09.2026journal-article

Studia Humanitatis Journal

Sociedad digital y transformación algorítmica del Estado: fundamentos conceptuales y jurídicos para el análisis de la inteligencia artificial en la sanidad pública

Aliaksandra Savostsikava

This article examines the origins and development of artificial intelligence (AI) in the digital society, highlighting its transition into a widely accessible tool with significant implications for all areas of society. Particular attention is paid to the legal challenges arising from the use of AI in public healthcare, including transparency, data protection, algorithmic bias, and liability for harm caused by automated systems.The study analyses international and European approaches to AI governance, including ini …

03.09.2026journal-article

Clinical Oral Investigations

Oral health and functioning in older adults in Switzerland from 1970 to 2025 - a systematic review and meta-analysis

Roberta Borg-Bartolo, Maurus Jaeggi, Martin Schimmel, Hendrik Meyer-Lueckel

Abstract Objectives This systematic review analysed the oral health status, chewing function, and quality of life among individuals aged ≥ 65 years in Switzerland using studies published from 1970 onwards. Materials and methods The electronic databases Embase, MEDLINE via PubMed, Swiss data repositories, and manual searches were screened. Risk of bias was assessed using the Joanna Briggs Institute tools. Meta-analyses were performed using the random-effects models with 95% confidence intervals to assess the prevale …

03.09.2026journal-article

Frontiers in Medicine

Legal, ethical and moral dilemma of human cloning: the conflict between technological progress and human dignity

Jyh-Woei Lin

Human cloning involves creating a genetically identical copy of a human cell, tissue, or embryo. That is, human reproductive cloning, producing a genetic copy of an existing person, has never been successfully done and remains globally banned or restricted. While there is no scientific evidence of successful human reproductive cloning, biotechnology combines cloning methods with genetic engineering to drive advancements in medical research and disease treatment. With the development of genetic engineering and cloni …

03.09.2026journal-article

Universal Library of Medical and Health Sciences

Development and Validation of a Gradient RP-HPLC–DAD Method for the Simultaneous Determination of p-Hydroxybenzoic Acid, Benzoic Acid and Salicylic Acid in Gymnema Sylvestre Leaves and Extract

Kumaraswami Salimath, Ariraman Sevugarajan, Tamil Amuthan

The use and monitoring of preservatives such as p-hydroxybenzoic acid (pHBA), benzoic acid (BA), and salicylic acid (SA) in food and pharmaceutical products require reliable and sensitive analytical procedures. HPLC-based methods have been widely reported for the determination of benzoic acid, salicylic acid, and related preservatives in food and pharmaceutical matrices. In herbal extracts, particularly those prepared using methanolic or alcoholic solvents, trace-level determination of these compounds can be analyt …

03.09.2026journal-article

Frontiers in Medicine

The FT4/FT3 ratio combined with thyroglobulin and parathyroid hormone for distinguishing benign from malignant thyroid nodules: a retrospective study based on histopathological diagnosis

Zhulin Zhang, Yun Lan

Purpose To evaluate the diagnostic value of the FT4/FT3 ratio combined with other laboratory markers in distinguishing malignant from benign thyroid nodules. Methods This retrospective study analyzed 359 patients with thyroid nodules (142 benign, 217 malignant) based on histopathological results. Clinical and laboratory data, including FT3, FT4, FT4/FT3 ratio, thyroglobulin (TG), parathyroid hormone (PTH), and TSH, were collected. Statistical analyses included ROC curves and multivariate logistic regression. Result …

03.09.2026journal-article

Frontiers in Medicine

The “Hand as Foot” teaching method for ocular anatomy: an embodied learning approach

Muge Qi, Xianrong Yang

Background Ocular anatomy is difficult to teach due to complex three-dimensional relationships. Traditional two-dimensional methods limit comprehension, while virtual simulation is often unavailable in underdeveloped regions. The “Hand as Foot” teaching method uses hand gestures to simulate anatomical structures and has been effective in other disciplines. This study introduces this method into ocular anatomy teaching to address three core obstacles: layered wall structure, dynamic circulation/lens accommodation, a …

03.09.2026journal-article

Frontiers in Medicine

Knowledge-guided adaptive educational support for traditional Chinese medicine using large language models and knowledge graphs: integrating Confucian educational principles

Jili Hu, Yuchen Duan, Qingqing Zhou, Denggao Zheng, Yu Li, Chi Qin, Hongxing Kan, Fan Xu

Introduction The Confucian principle of “teaching students in accordance with their aptitude” remains challenging to implement at scale in Traditional Chinese Medicine (TCM) education. We developed an Intelligent TCM Tutoring System integrating a large language model (LLM) with a domain-specific knowledge graph (KG) derived from the Golden Mirror of Medicine and evaluated its system performance and short-term educational outcomes. Methods System outputs were rated by five TCM teachers. In a three-group pedagogical …

03.09.2026journal-article

Current Environmental Health Reports

Assessing the Impact of Cool Roofs on Health and Wellbeing: A Scoping Review

Noah Bunkley, Melanie Stowell, Chris Bullen

Abstract Background Extreme heat poses a threat to the health and wellbeing of millions of people worldwide living in climate-vulnerable housing. Cool roofs are a potential passive-cooling housing retrofit solution that is affordable and scalable to reduce heat exposure and improve community health and wellbeing. Objective To conduct a scoping review to systematically identify and map the research addressing the effect of residential cool roofs on health and wellbeing, identify knowledge gaps, and inform the design …

03.09.2026journal-article

Public International and Private International Law

On the Nature of Interstate Cooperation on the Example of BRICS

Sergey V. Shulga

The article reviews various aspects of the origin of the motives that cause states to cooperate with each other, which was enshrined in the Charter of the United Nations as the jus cogens generalis fundamental principle of international law. An attempt is being made to prove the intrinsic nature of interaction between countries in resolving pressing problems of international security and ensuring a world order worthy of the high level of development of humanity at the present stage of its existence. A brief overvie …

03.09.2026journal-article

Frontiers in Public Health

Future care preparation profiles and self-support ability among rural Chinese older adults: a cross-sectional study

Fangyuan Wang, Xianhong Li, Jiajia Han, Yinghui Guan, Jiaqi Tian, Le Xu, Bing Huang, Jianhui Xie

Background Population aging is accelerating worldwide, and rural older adults may face particular challenges because of limited access to formal care resources. Preparation for future care (PFC) is a multidimensional process involving awareness, avoidance, decision-making, and concrete planning. This study identified latent PFC profiles among rural older adults in China and examined their association with self-support ability. Methods A cross-sectional survey was conducted among 851 older adults from 16 rural villa …

03.09.2026journal-article

Frontiers in Lab on a Chip Technologies

Extracellular vesicle-integrated brain organoid-on-a-chip systems for neuroimmune communication and precision therapy in viral encephalitis

Md. M. N. Azim

Viral encephalitis causes substantial neurological morbidity and mortality through the combined effects of direct viral injury, blood–brain barrier (BBB) dysfunction, and dysregulated communication among neural, vascular, and immune cells. Extracellular vesicles (EVs) are increasingly recognized as mediators of this communication because they transfer proteins, lipids, viral constituents, cytokine-related signals, and regulatory RNAs between neurons, astrocytes, microglia, endothelial cells, and peripheral immune c …

03.09.2026journal-article

Frontiers in Digital Health

Artificial intelligence in surgical decision-making across the perioperative continuum: a scoping review

Wasim I. Alghoul, Bassam Awad, Rasha A. Salama, Radwan Aloti, Ayman Agha, Wed B. Al-Shammari, Mohammed M. Ali, Khaled W. Elayyan, Hussain Azimullah, Hesham A. Hamdy, Mohamed Anas Patni, Nihal Wadid

Background The role of artificial intelligence (AI) in supporting clinical decision-making across the perioperative continuum remains incompletely defined. Although the presence of many AI models that perform well in terms of their predictive performance has been established, their role in the actual surgical decision-making process in the real-world in terms of specialties and perioperative phases has not been fully mapped. Objective To map the existing literature on the application of AI in surgical decision-maki …

03.09.2026journal-article

Frontiers in Medicine

Clinically silent early proximal seal failure with suspected interval distal endograft displacement after hybrid zone 2 thoracic endovascular aortic repair in severe arch tortuosity: a case report with 1-year follow-up

Fengsheng Yin, Liang Wang, Lingli Tang, Long Yang

Background Durable hybrid zone 2 thoracic endovascular aortic repair depends on adequate healthy sealing length, appropriate oversizing, and close endograft apposition. Severe arch tortuosity can compromise these requirements even when completion angiography is satisfactory. Case presentation A 46-year-old woman with a primary non-post-surgical distal arch and proximal descending thoracic aneurysm underwent left carotid-subclavian bypass, left subclavian artery origin occlusion, and zone 2 thoracic endovascular aor …

03.09.2026journal-article

Frontiers in Medicine

Acute kidney injury secondary to crystalline cryoglobulinemic glomerulonephritis type I: a case report and literature review

Aichun Liu, Yina Wang, Yu Yan, Shuying Zheng, Bao Dong, Meishun Cai, Xin Li, Chunying Shao, Li Zuo

Background Type I cryoglobulinemia consists of a single monoclonal immunoglobulin and can induce small-vessel vasculitis with renal involvement. Cryoglobulinemic glomerulonephritis is a rare manifestation, pathologically characterized by membranoproliferative glomerulonephritis (MPGN). In this report, we present a case of type I cryoglobulinemic renal injury characterized by crystalline cryoglobulinemic glomerulonephritis type I. Our objective is to provide a detailed insight into the presentation, underlying disea …