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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Therapeutic Advances in Infectious Disease

Doravirine and islatravir for HIV-1 treatment: A systematic review and meta-analysis with GRADE assessment

Muhammad Tayyab Azam, Muhammad Hussain Azam, Muhammad Arif Khan, Muhammad Hassan Azam, Zain Ul Abideen Shahid, Shahzad Ashraf, Syeda Momina Umer, Rabeea Arshad, Hasibullah Aminpoor, Hammad Javaid

Background Two-drug antiretroviral regimens are increasingly explored to simplify HIV-1 treatment while maintaining durable viral suppression. Doravirine combined with Islatravir (DOR/ISL) represents a novel non-integrase strand transfer inhibitor (non-INSTI) regimen. However, comprehensive synthesized evidence remains limited. Objectives To systematically evaluate the efficacy and safety of fixed-dose Doravirine (100 mg) plus Islatravir (0.25 or 0.75 mg) for HIV-1 treatment in adults. Design Systematic Review and …

01.09.2026journal-article

Welding Journal

Examining Stress Modification in Dissimilar and Similar Metal Welds through Ultrasonic Impact Treatment

American Welding Society, HAMID EISAZADEH, JEFFREY R. BUNN, ANDREW PAYZANT, PARIS CORNWELL, DARYUSH K. AIDUN

Residual stress (RS) from welding poses major challenges, especially in dissimilar joints such as 1018 steel and 304 stainless steel, where thermal expansion mismatches intensify tensile stress. Conventional post-weld heat treatments, although effective for homogeneous materials, often require substantial energy, specialized equipment, and extensive processing time, making them less practical for dissimilar metal weld applications. This study explores an alternative, energy-efficient method — ultrasonic impact trea …

01.09.2026journal-article

Tributaries journal for Studies and Researches In sports sciences

أثر برنامج علاجي في تحسين وظائف الركبة وجودة الحياة لدى المصابات بهشاشة العظام

امال محمد إبراهيم بابكر, عاتقة الأمين, رحمة إبراهيم

تهدف هذه الدراسة إلى التعرف على أثر برنامج علاجي حركي لمدة ثمانية أسابيع في تحسين وظائف مفصل الركبة وجودة الحياة لدى النساء المصابات بهشاشة مفصل الركبة (Osteoporosis). استخدمت الدراسة المنهج شبه التجريبي بتطبيق القياس القبلي والبعدي على عينة مكوّنة من (30–40) سيدة تتراوح أعمارهن بين (45–65) عامًا، والمشخّصات بهشاشة مفصل الركبة من الدرجة الأولى أو الثانية. اشتمل البرنامج العلاجي على تمارين للمرونة، وتمارين تقوية العضلات، وتمارين التوازن، إضافة إلى تمارين وظيفية موجهة للمفصل، بواقع ثلاث جلسات أسبوعيًا. أظهرت النتائج …

01.09.2026journal-article

Arab Media Renewal Journal

معالجة الأزمات الإنسانية في الصحافة الرقمية المصرية والأمريكية: دراسة تحليلية مقارنة

شروق حسنين قاسم

استهدفت الدراسة رصد وتحليل معالجة الصحافة الرقمية الأمريكية والمصرية للأزمات الإنسانية، بالتطبيق على موقعَي «اليوم السابع» المصري، و»USA Today» الأمريكي، وذلك في إطار نظرية المسؤولية الاجتماعية، ونظرية المشاركة الديمقراطية. وقد اعتمدت الدراسة على استخدام منهج المسح، وأسلوب المقارنة المنهجية، بالاعتماد على استمارة تحليل المضمون لجمع بيانات الدراسة، التي شملت (603) موضوعًا صحفيًا إنسانيًا تم نشرها خلال فترتين زمنيتين مختلفتين، هما (يناير-أبريل 2017) و(يناير-أبريل 2022) بموقعي الدراسة.وأظهرت النتائج تقاربًا في الحجم ا …

01.09.2026journal-article

Frontiers in Surgery

Endoscopic diagnosis and treatment of colon cancer: current evidence and future directions

Huimei Gong, Hongyu Li, Zhiwen Zheng, Hanbin Zhu, Yanni Zhang

Colorectal cancer remains a major cause of cancer morbidity and mortality, while screening and advances in endoscopic imaging have increased detection of lesions that may be amenable to organ-preserving treatment. Accurate assessment of morphology, optical pattern, and invasion depth is central to selecting among endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), endoscopic full-thickness resection (EFTR), and surgery. This structured narrative review synthesizes contemporary evidence and m …

01.09.2026journal-article

Acta Radiologica

Danish Pancreatic Cancer Group consensus guidelines on the management of pancreatic IPMN

Bahareh Abdolalizadeh, Claus Fristrup, Lars Peter Larsen, Eva Fallentin, Caroline Ewertsen

Background Intraductal papillary mucinous neoplasms (IPMNs) are the most common pancreatic cystic neoplasms and are increasingly detected incidentally. Although they carry malignant potential, most lesions follow an indolent course, creating a clinical challenge in balancing early cancer detection with the risks of overtreatment. Existing international guidelines differ in surveillance strategies, thresholds for intervention, and recommendations for discontinuation. Purpose To present Danish multidisciplinary conse …

01.09.2026journal-article

Oncology Reviews

Lipid metabolic reprogramming in clear cell renal cell carcinoma: focus on high-density lipoprotein-related pathways

Lize Wu, Huaying Xue, Yifei Wu, Ningning Shen, Zhiqing Yang, Lifang Gao, Wenxia Ma, Chen Wang

Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent solid tumors characterized by lipid metabolic reprogramming, with extensive lipid droplet accumulation in tumor cells as a hallmark feature. Traditionally, this phenotypic trait is attributed to enhanced fatty acid synthesis, increased triglyceride (TG) storage, and impaired β-oxidation. However, emerging transcriptomic and lipidomic evidence suggests that cholesterol metabolism is also profoundly reprogrammed in ccRCC, particularly via increased …

01.09.2026journal-article

Cancer Reports

An In Vitro and In Vivo Assessment of the Anti‐Breast Cancer Activity of Erythrina excelsa Baker (Fabaceae) Bark Extracts

Jonas Walantini, Marius Trésor Kemegne Sipping, Merline Nguedia Ymele, Roland Nhouma Rebe, Joël Abel Gbaweng Yaya, Derek Tantoh Ndinteh, Dieudonné Njamen, Stéphane Zingue

ABSTRACT Background Breast cancer remains a topic of interest due to its high mortality rate among Cameroonian women. The barks of Erythrina excelsa are traditionally used for medicinal purposes in the management of various conditions including cancer. Aims This study evaluated the phytochemical composition, antioxidant properties, and anticancer effects of Erythrina excelsa bark extract in vitro and in vivo. Methods and Results Phytochemical profiling and antioxidant assays (DPPH, FRAP) were conducted to determine …

01.09.2026journal-article

Nanotechnology

Targeted therapy of colon cancer with aptamer-functionalized albumin nanoparticles loaded with disulfiram

Yacong An, Zhen Yu, Ting Li, Xundou Li, Qiping Jiang

Abstract Chemotherapy remains the primary treatment for most patients with metastatic colorectal cancer (mCRC), yet its efficacy is often limited by severe adverse effects. Drug repurposing offers a promising strategy to accelerate oncology drug development. Disulfiram (DSF), a licensed anti-alcoholism agent, has demonstrated broad-spectrum anticancer activity in preclinical models. However, its clinical translation for oncology is hindered by poor aqueous solubility, rapid metabolism, and lack of tumor selectivity …

01.09.2026journal-article

npj Systems Biology and Applications

Encapsulated multicellular breast cancer spheroids exhibit behavioural plasticity under non-negotiable mechanical stress

Sukanya Gayan, Saili S. Shinde, Asadullah, Anisha Karmakar, Shamik Sen, Tuli Dey

Abstract Cancerous growth, along with other known biological and biochemical signals, also depends on the biomechanical pressure wielded by the adjacent extracellular matrix (ECM). The dynamic relationship between the growing tumor and the ECM influences tumor growth, aggressiveness, and dormancy. Additionally, with time, the stroma also becomes subject to tumor-mediated remodeling through deformation and deposition cycles. In recent years, many studies have identified the dialog between the ECM and the tumor as on …

01.09.2026journal-article

Peer Review

Are fluoroquinolones still viable for empirical UTI treatment? Evidence from southeastern Brazil

Patrícia Guedes Garcia, Janita Soraia de Oliveira Da Silva, Natália Maria da Silva Fernandes, Lucas Fernandes Suassuna, Luciana Debortoli de Carvalho, Taleessa Vieira Gomes, Ana Carolina Apolonio, André Luiz Silva Alvim, Marcio Roberto Silva

Urinary tract infections frequently require empirical antimicrobial therapy, although increasing fluoroquinolone resistance may limit their use. This retrospective cross-sectional study evaluated local susceptibility patterns and factors associated with resistance in urine cultures from outpatients attending a university hospital in southeastern Brazil during 2024. Of 1,958 cultures, 418 (21.35%) showed significant bacterial growth. Escherichia coli was the predominant pathogen (48.3%), followed by Klebsiella spp. …

01.09.2026journal-article

RadioGraphics

Navigating PI-RADS 3 Lesions: Reducing Uncertainty and Guiding Prostate Cancer Diagnostic Decision Making

Refky Nicola, Eduardo Thadeu de Oliveira Correia, Paulo de Moraes Antunes, Cynthia Lopes Pereira de Borborema, Ivo G. Schoots, Leonardo Kayat Bittencourt

PI-RADS category 3 lesions represent uncertainty and equivocal findings, and incorporating prostate-specific antigen density into a risk-based diagnostic pathway may optimize the balance between avoiding unnecessary prostate biopsies and reducing the number of missed clinically significant prostate cancers.

01.09.2026journal-article

Frontiers in Oncology

ZEB1 directly activates IL-6 to promote triple-negative breast cancer stemness in an epigenetically constrained context

Weiyue Zhang, Yifan Zhou, Wei Ma, Huimin Jiang

ZEB1 is a key driver of breast cancer pathogenesis and therapy resistance, largely through its ability to promote cancer stem cells (CSCs). Although tumor-secreted cytokines such as IL-6 are known to support tumor progression, how their expression is regulated by upstream transcriptional factors such as ZEB1 remains incompletely understood. Here, we identify IL-6 as a direct transcriptional target of ZEB1 and reveal an epigenetic dimension associated with this regulation. Mechanistically, ZEB1 binds to specific E2- …

01.09.2026journal-article

Medicina Fluminensis

Provedba Nacionalnog programa ranog otkrivanja raka dojke u Primorsko-goranskoj županiji

Ines Vrljić, Iva Sorta-Bilajac Turina, Aleksandar Džakula

Rak dojke velik je javnozdravstveni problem kod žena, s visokom incidencijom i značajnijim mortalitetom na svjetskoj i europskoj razini. Rano otkrivanje bolesti kroz organizirane programe probira dokazano smanjuje smrtnost i omogućuje učinkovitije liječenje. Nacionalni program ranog otkrivanja raka dojke (Program) u Republici Hrvatskoj provodi se od 2006. godine, s ciljem smanjenja smrtnosti i povećanja udjela dijagnosticiranih slučajeva u ranom stadiju bolesti. Primorsko-goranska županija (PGŽ) bila je „pionir“ u …

02.09.2026journal-article

The Oncologist

16 ABBV-CLS-484: A Novel Oral PTPN2/1 Inhibitor for Cancer Immunotherapy

Hans Hammers, Emiliano Calvo, Benedito A Carneiro, Michael R Harrison, Eric Jonasch, David Braun, Do-Youn Oh, Kartik Seghal, Ulka Vaishampayan, Noboru Yamamoto, Leisha A Emens, Jie Tang, Anh Nguyen, Nidhi Prem, Damian Trujillo, Cathleen Hartman, Marcia Paddock, Jonathan Powell, David McDermott

Abstract Background ABBV-CLS-484 is a first-in-class oral PTPN2/N1 inhibitor with a dual mechanism of action that both increases the immunogenicity of tumor cells and augments the antitumor T cell response. It has monotherapy efficacy in multiple preclinical tumor models, with comparable activity to anti-PD-1 in many cases. Notably, it has good antitumor activity in combination with PD-1 specific antibodies in syngeneic animal models known to be refractory to PD-1 blockade. Methods M20-431 is a first-in-human Phase …

02.09.2026journal-article

Journal for ImmunoTherapy of Cancer

Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer

Wenxin Lian, Hui Yang, Yuqi Zhang, Chenchen Liu, Chunyao Fang, Mengyue Xu, Yixing Yang, Yan Wang, Runqiu Jiang, Jing Xu, Wen Gao

Background Metabolic reprogramming within the tumor microenvironment is a pivotal barrier to effective immune checkpoint blockade (ICB). While programmed death ligand 1 (PD-L1) is well characterized as a ligand inhibiting T-cell function, its intrinsic ‘reverse signaling’ role in regulating tumor metabolism and shaping the immune landscape remains poorly understood. Here, we investigated the metabolic determinants of resistance to anti-programmed cell death protein 1 (anti-PD-1) therapy and the underlying molecular …

01.09.2026journal-article

Revista Mexicana de Investigación Médica

Telemedicina oncológica: ¿una alternativa satisfactoria?

Iván Romarico González Espinoza, Víctor Daniel Ordoñez Flores, Abraham Castro Ponce, Edgar Martínez Romero, Lisseth Guevara Vázquez, Gabriela Juárez Salazar, Galo Ismael Iñíguez López, Silvia Ávila Hernández, Lissett Barucha Salazar Villanueva, Farid Alejandro Carrasco Gutiérrez

Introducción: la telemedicina ha emergido como una alternativa eficaz para ampliar el acceso a la atención oncológica, particularmente en poblaciones con barreras geográficas o limitaciones físicas. No obstante, aún se desconoce si esta modalidad ofrece un nivel de satisfacción comparable al de la atención presencial. Este estudio tuvo como objetivo comparar la satisfacción general entre pacientes atendidos de manera presencial y aquellos atendidos mediante telemedicina, en un centro oncológico privado en el Estado …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Malignant Myoepithelioma Arising from the Upper Arm With Brachial Plexus Involvement: A Rare Case

HAYATO TATSUMI, TOSHIHIRO MATSUO, TAKASHI NISHISAKA, YUI HATTORI, KOJI NISHIDA, RYOUSUKE MATSUSHITA, MASAHIRO YOSHIKAWA, SATOSHI AKI, NOBUO ADACHI

Background/Aim: Malignant myoepitheliomas (MMs) are infrequent, and the site of upper arm is extremely rare. To our knowledge, only two cases occurred in the upper arms according to previous reports. Case Report: A 73-year-old male presented with a growing mass in his left upper arm one year prior to surgery. After a needle biopsy, histopathological analysis revealed the mass to be a myxoid sarcoma but did not reach to definite diagnosis. The tumor was excised from the brachial plexus. The brachial artery and vein …

03.09.2026journal-article

Journal of Applied Clinical Medical Physics

Evaluation of inter‐fractional anatomical variations due to compression belt placement reproducibility using MR‐guided radiotherapy treatment fraction images

Olivia Shay, David Solis, Morgan Aire, Christopher Schneider, Krystal Kirby

Abstract Background Abdominal compression (AC) using a belt‐based system is widely employed in radiation therapy to limit respiration‐induced target motion for abdominal and hepatic malignancies. While AC has demonstrated efficacy in reducing intrafraction motion amplitude, the interfractional anatomical consequences of daily compression belt (CB) placement variability remain poorly characterized. A clearer understanding of this variability is necessary to determine whether online adaptive radiotherapy (oART) is re …

01.09.2026journal-article

Nutrition Reviews

Validity of Nutrition Screening Tools for Risk of Malnutrition Among Pediatric Oncology Populations: A Systematic Review and Meta-Analysis

Melda Kangalgil, Buket Meral, Ebru Küçük Erdöl

Abstract Context The lack of standardized procedures for malnutrition risk screening in the pediatric oncology population. Objective This systematic review and meta-analysis aimed to evaluate the validity of nutritional screening tools for identifying the risk of malnutrition in pediatric oncology patients. Data sources A systematic review of studies identified in 4 databases (Web of Science, Scopus, OVID and CINAHL) were searched from inception to April 2025. Data Extraction Two reviewers independently screened st …

01.09.2026journal-article

PLOS Medicine

Effect of a person-centered care intervention on return and sustained reengagement after treatment interruptions from HIV care in Zambia: A post-hoc analysis of a stepped-wedged cluster randomized trial

Aaloke Mody, Kombatende Sikombe, Sandra Simbeza, Njekwa Mukamba, Laura K. Beres, Jake M. Pry, Anjali Sharma, Jacob Mutale, Alida Zulu Dube, Musunge Mulabe, Lloyd Mulenga, Suilanji Sivile, April Ratliff, Charles W. Goss, Charles B. Holmes, Carolyn Bolton Moore, Izukanji Sikazwe, Elvin H. Geng

Background Poor client-provider interactions lead to reinforcing cycles of treatment interruptions (TIs) from HIV care and fear of return, undermining sustained retention. We previously demonstrated a multi-component person-centered care intervention (PCC) targeting healthcare worker (HCW) behavior improved client experience and retention in HIV care. To understand mechanisms of improved retention, we evaluated the effect of the PCC intervention on return after TIs and sustained retention after return in a post-hoc …

01.09.2026journal-article

Current Oncology

Post-Treatment Trajectories of Retained Totally Implantable Venous Access Ports After Anticancer Therapy: A Conditional Landmark Cohort Study

Zeyang Fan, Tiantian Li, Kai Yang

Background: Retained totally implantable venous access ports (TIVAPs) pose a clinical management challenge after completion of intravenous anticancer therapy, particularly when future treatment needs remain uncertain. We aimed to characterize longitudinal post-treatment TIVAP trajectories after a day-90 conditional landmark, with elective removal prespecified as the primary first event. Methods: This retrospective cohort study included patients who were alive and event-free, retained the original TIVAP, had no docu …

01.09.2026journal-article

Journal for ImmunoTherapy of Cancer

Normal-immunopeptidome denominator: a safety atlas for immunotherapies targeting non-canonical and aberrantly expressed tumor antigens

Li-zhen Chen

Proteogenomic cancer antigen discovery now extends beyond somatic mutations to include unmutated, aberrantly expressed, and non-canonical sources. We distinguish two orthogonal dimensions: molecular origin (canonical or non-canonical) and normal-tissue distribution (tumor-specific antigen, tumor-associated antigen, or lineage-specific antigen). Importantly, non-canonical origin does not imply tumor specificity. For human leukocyte antigen (HLA)-restricted immunotherapy, selectivity must be established at the level …