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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Frontiers in Pediatrics

Case Report: Selumetinib as a neoadjuvant treatment for the removal of a PN

Ciavarelli Patricia, Mezmezian Mónica Beatriz, Daniel Yedlin, Paloma Amarillo

Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that presents with benign tumors of the peripheral nerve sheath, named plexiform neurofibromas. Progressive tumor growth may cause pain, physical disfigurement, and compression of adjacent structures, potentially impairing normal development during childhood. We report the case of a 13-year-old patient with a plexiform neurofibroma in the right foot, which had been growing since the first months of life and compromised the talocalcaneal joint, …

01.09.2026journal-article

Slovenian Journal of Public Health

Why Organised Cancer Screening Works: Lessons from Slovenia and the Next Phase of Evidence-Based Implementation

Mateja Krajc, Urška Ivanuš

Abstract Slovenia's experience shows that cancer screening becomes effective only when a test is embedded in an organised, population-based programme that reaches the target population equitably, assures quality across the whole pathway and uses individual- and programme-level data for improvement. Since the national roll-out of Programme ZORA for cervical cancer screening in 2003, followed by DORA for breast cancer screening in 2008 and Programme Svit for colorectal cancer screening in 2009, Slovenia has built a c …

02.09.2026journal-article

Journal of Coloproctology

Adenoma Detection Rate in Sedated Colonoscopies Performed at Mehrgan Hospital, Kerman (2020–2024): Association with Demographic Factors and Colorectal Cancer Occurrence

Sadreddin Lahsaee, Mohammad RezazadehKermani, Shahnaz ShahabiNasab, Zahra Sarabandi, Fatemeh Asadi, Fatemeh Ahmadi

Abstract Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer-related death worldwide. The adenoma detection rate (ADR), based on pathology-confirmed adenomas, is a key quality indicator for colonoscopy and a surrogate marker for its effectiveness in CRC prevention. We conducted a retrospective cross-sectional study of all sedated colonoscopies performed at Mehrgan Hospital, Kerman, Iran, between 1399 and 1403 (2020–2024). Patient demographic data (age, sex) …

01.09.2026journal-article

Energy & Fuels

Evolution of Pore-Fracture Structure and Coupled Damage–Seepage Characteristics of Coal Induced by LCO2 Phase-Transition Treatment: A 3D Digital Core Study

Xianke Wang, Yonggang Qiao, Nan Fan, Danping Yuan, Shida Zhang, Yongliang Mu

Abstract This study combines micro-CT scanning with Avizo-based three-dimensional reconstruction technology to quantitatively characterize the evolution of pore-fracture structures in coal during LCO2 phase-transition treatment and systematically investigates the coupled response of damage evolution and seepage behavior under different stress conditions based on digital coal core models. Results show that LCO2 phase-transition treatment significantly reconstructs the coal pore-fracture network, promoting the develo …

01.09.2026journal-article

Current Bioactive Compounds

Antitumor Potential of Extracts Derived from Aerial Parts of Sigesbeckia orientalis L.: Cytotoxic Activities In Vitro and DMBA-induced Tumor Model in Swiss Mice

Thuy Nguyen Thi, Le Ba Vinh, Thanh Tung Bui, Van Khanh Nguyen, Huyen Nguyen Thi, Hong Khanh Do Thi, Hong Minh Phan, Van Anh Bui Thi, Nguyen Thuc Thu Huong, Phuong Thanh Mai

Background: Sigesbeckia orientalis L., a member of the Asteraceae family, is an annual herb traditionally used to treat various ailments, such as rheumatism and joint pain. Recent studies have increasingly focused on its potential pharmacological effects through various in vitro, in silico, and in vivo models. However, there are limited reports on its potential anti-tumor applications. Objective: This study aimed to investigate the cytotoxic effects of various extracts of S. orientalis on cancer cell lines and to e …

01.09.2026journal-article

Arab Media Renewal Journal

معالجة الأزمات الإنسانية في الصحافة الرقمية المصرية والأمريكية: دراسة تحليلية مقارنة

شروق حسنين قاسم

استهدفت الدراسة رصد وتحليل معالجة الصحافة الرقمية الأمريكية والمصرية للأزمات الإنسانية، بالتطبيق على موقعَي «اليوم السابع» المصري، و»USA Today» الأمريكي، وذلك في إطار نظرية المسؤولية الاجتماعية، ونظرية المشاركة الديمقراطية. وقد اعتمدت الدراسة على استخدام منهج المسح، وأسلوب المقارنة المنهجية، بالاعتماد على استمارة تحليل المضمون لجمع بيانات الدراسة، التي شملت (603) موضوعًا صحفيًا إنسانيًا تم نشرها خلال فترتين زمنيتين مختلفتين، هما (يناير-أبريل 2017) و(يناير-أبريل 2022) بموقعي الدراسة.وأظهرت النتائج تقاربًا في الحجم ا …

01.09.2026journal-article

Frontiers in Environmental Chemistry

Vetiver biochar application for heavy metal sequestration in water treatment: bridging perfumery waste and environmental sustainability

Sameer Neve, Viravid Na Nagara, Zhiming Zhang, Rupali Datta, Dibyendu Sarkar

Converting industrial byproducts into functional adsorbents supports circular and sustainable approaches to water treatment. This study evaluated biochar derived from spent vetiver ( Chrysopogon zizanioides ) roots, a byproduct of the perfumery essential-oil industry, for the competitive adsorption of copper (Cu), cadmium (Cd), zinc (Zn), and lead (Pb). Vetiver root biochar produced at 500 °C for 60 min exhibited a high surface area of 308.2 m 2 /g and a yield of 53.8%. Batch adsorption experiments were performed i …

01.09.2026journal-article

Frontiers in Immunology

Intrathecal IgG synthesis as a biomarker for CNS involvement in anti-GQ1b antibody syndrome: a case report and hypothesis-generating treatment framework

Han Zhou, Xiuming Guo

Anti-GQ1b antibody syndromes span a clinical continuum from peripheral Guillain-Barré syndrome (GBS) to central Bickerstaff brainstem encephalitis (BBE), but reliable biomarkers of central nervous system (CNS) involvement that could guide treatment intensity are lacking. We report a 37-year-old woman with a relapsing GBS–Miller Fisher syndrome (MFS)–BBE overlap phenotype. In the first episode (March 2024), plasma exchange, intravenous methylprednisolone and IVIG were administered after anti-GD1a IgG was detected. A …

01.09.2026journal-article

Welding Journal

Examining Stress Modification in Dissimilar and Similar Metal Welds through Ultrasonic Impact Treatment

American Welding Society, HAMID EISAZADEH, JEFFREY R. BUNN, ANDREW PAYZANT, PARIS CORNWELL, DARYUSH K. AIDUN

Residual stress (RS) from welding poses major challenges, especially in dissimilar joints such as 1018 steel and 304 stainless steel, where thermal expansion mismatches intensify tensile stress. Conventional post-weld heat treatments, although effective for homogeneous materials, often require substantial energy, specialized equipment, and extensive processing time, making them less practical for dissimilar metal weld applications. This study explores an alternative, energy-efficient method — ultrasonic impact trea …

01.09.2026journal-article

Nature Communications

Global incidence of esophageal cancer by histological and anatomical subtypes

Claire Chenwen Zhong, Junjie Huang, Zehuan Yang, Zhaojun Li, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno, Wanghong Xu, Minmin Wang, Yinzi Jin, Zhi-Jie Zheng, Mellissa Withers, Martin CS Wong

Abstract Esophageal cancer is a major contributor to the global cancer burden, yet comprehensive global assessments of its burden across subtypes are lacking. This study examines the incidence, risk factors, and trends of esophageal cancer by histological and anatomical subtypes, with stratification by sex and age across different countries, using GLOBOCAN 2022 estimates, Cancer Incidence in Five Continents data, and country-level socioeconomic, lifestyle, and metabolic risk-factor indicators. Here we show that Eas …

01.09.2026journal-article

Metabolites

Advances in Exercise-Mediated Regulation of the Gut Microbiota via the Muscle–Gut Axis: Implications for Tumor Immunity and Treatment Responses

Tao Pang, Xinyi Zhou, Zhe Ge

The gut microbiota can influence tumor immunity and treatment responses through microbial metabolism, intestinal barrier regulation, and immune–inflammatory signaling, but whether exercise engages these mechanisms through the muscle–gut axis remains uncertain. This review integrates evidence from exercise physiology, microbial metabolism, and tumor immunology to examine how exercise-associated host signals may reshape the intestinal ecological niche and microbial function. Three candidate muscle–gut axes are propos …

01.09.2026journal-article

Frontiers in Surgery

Endoscopic diagnosis and treatment of colon cancer: current evidence and future directions

Huimei Gong, Hongyu Li, Zhiwen Zheng, Hanbin Zhu, Yanni Zhang

Colorectal cancer remains a major cause of cancer morbidity and mortality, while screening and advances in endoscopic imaging have increased detection of lesions that may be amenable to organ-preserving treatment. Accurate assessment of morphology, optical pattern, and invasion depth is central to selecting among endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), endoscopic full-thickness resection (EFTR), and surgery. This structured narrative review synthesizes contemporary evidence and m …

01.09.2026journal-article

Tributaries journal for Studies and Researches In sports sciences

أثر برنامج علاجي في تحسين وظائف الركبة وجودة الحياة لدى المصابات بهشاشة العظام

امال محمد إبراهيم بابكر, عاتقة الأمين, رحمة إبراهيم

تهدف هذه الدراسة إلى التعرف على أثر برنامج علاجي حركي لمدة ثمانية أسابيع في تحسين وظائف مفصل الركبة وجودة الحياة لدى النساء المصابات بهشاشة مفصل الركبة (Osteoporosis). استخدمت الدراسة المنهج شبه التجريبي بتطبيق القياس القبلي والبعدي على عينة مكوّنة من (30–40) سيدة تتراوح أعمارهن بين (45–65) عامًا، والمشخّصات بهشاشة مفصل الركبة من الدرجة الأولى أو الثانية. اشتمل البرنامج العلاجي على تمارين للمرونة، وتمارين تقوية العضلات، وتمارين التوازن، إضافة إلى تمارين وظيفية موجهة للمفصل، بواقع ثلاث جلسات أسبوعيًا. أظهرت النتائج …

02.09.2026journal-article

Therapeutic Advances in Infectious Disease

Doravirine and islatravir for HIV-1 treatment: A systematic review and meta-analysis with GRADE assessment

Muhammad Tayyab Azam, Muhammad Hussain Azam, Muhammad Arif Khan, Muhammad Hassan Azam, Zain Ul Abideen Shahid, Shahzad Ashraf, Syeda Momina Umer, Rabeea Arshad, Hasibullah Aminpoor, Hammad Javaid

Background Two-drug antiretroviral regimens are increasingly explored to simplify HIV-1 treatment while maintaining durable viral suppression. Doravirine combined with Islatravir (DOR/ISL) represents a novel non-integrase strand transfer inhibitor (non-INSTI) regimen. However, comprehensive synthesized evidence remains limited. Objectives To systematically evaluate the efficacy and safety of fixed-dose Doravirine (100 mg) plus Islatravir (0.25 or 0.75 mg) for HIV-1 treatment in adults. Design Systematic Review and …

01.09.2026journal-article

Acta Radiologica

Danish Pancreatic Cancer Group consensus guidelines on the management of pancreatic IPMN

Bahareh Abdolalizadeh, Claus Fristrup, Lars Peter Larsen, Eva Fallentin, Caroline Ewertsen

Background Intraductal papillary mucinous neoplasms (IPMNs) are the most common pancreatic cystic neoplasms and are increasingly detected incidentally. Although they carry malignant potential, most lesions follow an indolent course, creating a clinical challenge in balancing early cancer detection with the risks of overtreatment. Existing international guidelines differ in surveillance strategies, thresholds for intervention, and recommendations for discontinuation. Purpose To present Danish multidisciplinary conse …

01.09.2026journal-article

RadioGraphics

Navigating PI-RADS 3 Lesions: Reducing Uncertainty and Guiding Prostate Cancer Diagnostic Decision Making

Refky Nicola, Eduardo Thadeu de Oliveira Correia, Paulo de Moraes Antunes, Cynthia Lopes Pereira de Borborema, Ivo G. Schoots, Leonardo Kayat Bittencourt

PI-RADS category 3 lesions represent uncertainty and equivocal findings, and incorporating prostate-specific antigen density into a risk-based diagnostic pathway may optimize the balance between avoiding unnecessary prostate biopsies and reducing the number of missed clinically significant prostate cancers.

02.09.2026journal-article

The Oncologist

16 ABBV-CLS-484: A Novel Oral PTPN2/1 Inhibitor for Cancer Immunotherapy

Hans Hammers, Emiliano Calvo, Benedito A Carneiro, Michael R Harrison, Eric Jonasch, David Braun, Do-Youn Oh, Kartik Seghal, Ulka Vaishampayan, Noboru Yamamoto, Leisha A Emens, Jie Tang, Anh Nguyen, Nidhi Prem, Damian Trujillo, Cathleen Hartman, Marcia Paddock, Jonathan Powell, David McDermott

Abstract Background ABBV-CLS-484 is a first-in-class oral PTPN2/N1 inhibitor with a dual mechanism of action that both increases the immunogenicity of tumor cells and augments the antitumor T cell response. It has monotherapy efficacy in multiple preclinical tumor models, with comparable activity to anti-PD-1 in many cases. Notably, it has good antitumor activity in combination with PD-1 specific antibodies in syngeneic animal models known to be refractory to PD-1 blockade. Methods M20-431 is a first-in-human Phase …

01.09.2026journal-article

Revista Mexicana de Investigación Médica

Telemedicina oncológica: ¿una alternativa satisfactoria?

Iván Romarico González Espinoza, Víctor Daniel Ordoñez Flores, Abraham Castro Ponce, Edgar Martínez Romero, Lisseth Guevara Vázquez, Gabriela Juárez Salazar, Galo Ismael Iñíguez López, Silvia Ávila Hernández, Lissett Barucha Salazar Villanueva, Farid Alejandro Carrasco Gutiérrez

Introducción: la telemedicina ha emergido como una alternativa eficaz para ampliar el acceso a la atención oncológica, particularmente en poblaciones con barreras geográficas o limitaciones físicas. No obstante, aún se desconoce si esta modalidad ofrece un nivel de satisfacción comparable al de la atención presencial. Este estudio tuvo como objetivo comparar la satisfacción general entre pacientes atendidos de manera presencial y aquellos atendidos mediante telemedicina, en un centro oncológico privado en el Estado …

01.09.2026journal-article

Oncology Reviews

Lipid metabolic reprogramming in clear cell renal cell carcinoma: focus on high-density lipoprotein-related pathways

Lize Wu, Huaying Xue, Yifei Wu, Ningning Shen, Zhiqing Yang, Lifang Gao, Wenxia Ma, Chen Wang

Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent solid tumors characterized by lipid metabolic reprogramming, with extensive lipid droplet accumulation in tumor cells as a hallmark feature. Traditionally, this phenotypic trait is attributed to enhanced fatty acid synthesis, increased triglyceride (TG) storage, and impaired β-oxidation. However, emerging transcriptomic and lipidomic evidence suggests that cholesterol metabolism is also profoundly reprogrammed in ccRCC, particularly via increased …

01.09.2026journal-article

Medicina Fluminensis

Provedba Nacionalnog programa ranog otkrivanja raka dojke u Primorsko-goranskoj županiji

Ines Vrljić, Iva Sorta-Bilajac Turina, Aleksandar Džakula

Rak dojke velik je javnozdravstveni problem kod žena, s visokom incidencijom i značajnijim mortalitetom na svjetskoj i europskoj razini. Rano otkrivanje bolesti kroz organizirane programe probira dokazano smanjuje smrtnost i omogućuje učinkovitije liječenje. Nacionalni program ranog otkrivanja raka dojke (Program) u Republici Hrvatskoj provodi se od 2006. godine, s ciljem smanjenja smrtnosti i povećanja udjela dijagnosticiranih slučajeva u ranom stadiju bolesti. Primorsko-goranska županija (PGŽ) bila je „pionir“ u …

01.09.2026journal-article

Frontiers in Oncology

ZEB1 directly activates IL-6 to promote triple-negative breast cancer stemness in an epigenetically constrained context

Weiyue Zhang, Yifan Zhou, Wei Ma, Huimin Jiang

ZEB1 is a key driver of breast cancer pathogenesis and therapy resistance, largely through its ability to promote cancer stem cells (CSCs). Although tumor-secreted cytokines such as IL-6 are known to support tumor progression, how their expression is regulated by upstream transcriptional factors such as ZEB1 remains incompletely understood. Here, we identify IL-6 as a direct transcriptional target of ZEB1 and reveal an epigenetic dimension associated with this regulation. Mechanistically, ZEB1 binds to specific E2- …

01.09.2026journal-article

Nanotechnology

Targeted therapy of colon cancer with aptamer-functionalized albumin nanoparticles loaded with disulfiram

Yacong An, Zhen Yu, Ting Li, Xundou Li, Qiping Jiang

Abstract Chemotherapy remains the primary treatment for most patients with metastatic colorectal cancer (mCRC), yet its efficacy is often limited by severe adverse effects. Drug repurposing offers a promising strategy to accelerate oncology drug development. Disulfiram (DSF), a licensed anti-alcoholism agent, has demonstrated broad-spectrum anticancer activity in preclinical models. However, its clinical translation for oncology is hindered by poor aqueous solubility, rapid metabolism, and lack of tumor selectivity …

01.09.2026journal-article

Cancer Reports

An In Vitro and In Vivo Assessment of the Anti‐Breast Cancer Activity of Erythrina excelsa Baker (Fabaceae) Bark Extracts

Jonas Walantini, Marius Trésor Kemegne Sipping, Merline Nguedia Ymele, Roland Nhouma Rebe, Joël Abel Gbaweng Yaya, Derek Tantoh Ndinteh, Dieudonné Njamen, Stéphane Zingue

ABSTRACT Background Breast cancer remains a topic of interest due to its high mortality rate among Cameroonian women. The barks of Erythrina excelsa are traditionally used for medicinal purposes in the management of various conditions including cancer. Aims This study evaluated the phytochemical composition, antioxidant properties, and anticancer effects of Erythrina excelsa bark extract in vitro and in vivo. Methods and Results Phytochemical profiling and antioxidant assays (DPPH, FRAP) were conducted to determine …

01.09.2026journal-article

Peer Review

Are fluoroquinolones still viable for empirical UTI treatment? Evidence from southeastern Brazil

Patrícia Guedes Garcia, Janita Soraia de Oliveira Da Silva, Natália Maria da Silva Fernandes, Lucas Fernandes Suassuna, Luciana Debortoli de Carvalho, Taleessa Vieira Gomes, Ana Carolina Apolonio, André Luiz Silva Alvim, Marcio Roberto Silva

Urinary tract infections frequently require empirical antimicrobial therapy, although increasing fluoroquinolone resistance may limit their use. This retrospective cross-sectional study evaluated local susceptibility patterns and factors associated with resistance in urine cultures from outpatients attending a university hospital in southeastern Brazil during 2024. Of 1,958 cultures, 418 (21.35%) showed significant bacterial growth. Escherichia coli was the predominant pathogen (48.3%), followed by Klebsiella spp. …